PRDM8

PR domain zinc finger protein 8

689 amino acids

Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily.

71.663 kDa

MEDTGIQRGIWDGDAKAVQQCLTDIFTSVYTTCDIPENAIFGPCVLSHTSLYDSIAFIALKSTDKRTVPYIFRVDTSAANGSSEGLMWLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWYGKELTELLLLCPSRSHNKMNGSSPYTCLECSQRFQFEFPYVAHLRFRCPKRLHSADISPQDEQGGGVGTKDHGGGGGGGKDQQQQQQEAPLGPGPKFCKAGPLHHYPSPSPESSNPSAAAGGSSAKPSTDFHNLARELENSRGGSSCSPAQSLSSGSGSGGGGGHQEAELSPDGIATGGGKGKRKFPEEAAEGGGGAGLVGGRGRFVERPLPASKEDLVCTPQQYRASGSYFGLEENGRLFAPPSPETGEAKRSAFVEVKKAARAASLQEEGTADGAGVASEDQDAGGGGGSSTPAAASPVGAEKLLAPRPGGPLPSRLEGGSPARGSAFTSVPQLGSAGSTSGGGGTGAGAAGGAGGGQGAASDERKSAFSQPARSFSQLSPLVLGQKLGALEPCHPADGVGPTRLYPAAADPLAVKLQGAADLNGGCGSLPSGGGGLPKQSPFLYATAFWPKSSAAAAAAAAAAAAGPLQLQLPSALTLLPPSFTSLCLPAQNWCAKCNASFRMTSDLVYHMRSHHKKEYAMEPLVKRRREEKLKCPICNESFRERHHLSRHMTSHN

Prdm8

PR domain zinc finger protein 8

687 amino acids

Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (PubMed:19646955). Histone methyltransferase activity has not been confirmed in other species. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (PubMed:19646955). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (PubMed:22284184). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (PubMed:26023183).

Belongs to the class V-like SAM-binding methyltransferase superfamily.

70.886 kDa

MEDSGIQRGIWDGDAKAVQQCLTDIFTSVYTTCDIPENAIFGPCVLSHTSLYDSIAFVALKSTDKRTVPYIFRVDTSAANGSSEGLMWLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWYGKELTELLLLCPSRAHKMNGSSPYTCLECSQRFQFEFPYVAHLRFRCPKRLHSTDANPQDEQGGGLGTKDHGGGGGGKEQQQQQQQQQQEAPLIPGPKFCKAGPIHHYPASSPEASNPPGSAGASSAKPSTDFHNLARELENSRGNSSCVAAPGVGSGGSGHQEAELSPDGVATGGCKGKRRFPEEAAAEGGGAGLAGGRARFSERPLATSKEELVCTPQQYRAAGSYFGLEENGRLFAPPSPETGEAKRSAFVEVKKAGRAVGLQEEAAATDGAGGTAEDPDAGGGVAGGGSNGSSTPAAGSPGAPEKLLAPRPGGSLPGRLEGGSPARGSAFTSVSQLGGGGGAGTAGTAGGSGGGQTAASDERKSAFSQPARSFSQLSPLVLGQKLGALEPCHPGDGVGPTRLYPAAADPLAVKLQGAADLNGACGPLASGGGGGLPKQSPFLYATAFWPKSSAAAAAAAAAAAGPLQLQLPSALTLLPPSFTSLCLPAQNWCAKCNASFRMTSDLVYHMRSHHKKEYAMEPLVKAAAGGETQVPHLQRVLQGASPPVPAHDLA