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PPP1R1A

Gene
PPP1R1A
Protein
Protein phosphatase 1 regulatory subunit 1A
Organism
Canis lupus familiaris
Length
171 amino acids
Function
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases (By similarity).
Similarity
Belongs to the protein phosphatase inhibitor 1 family.
Mass
18.999 kDa
Sequence
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTGTQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANFV

Gene
PPP1R1A
Protein
Protein phosphatase 1 regulatory subunit 1A
Organism
Homo sapiens
Length
171 amino acids
Function
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Similarity
Belongs to the protein phosphatase inhibitor 1 family.
Mass
19.011 kDa
Sequence
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTETQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV

Gene
Ppp1r1a
Protein
Protein phosphatase 1 regulatory subunit 1A
Organism
Mus musculus
Length
171 amino acids
Function
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Similarity
Belongs to the protein phosphatase inhibitor 1 family.
Mass
18.718 kDa
Sequence
MEPDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNSLLKSTLSMSPRQRKKMTRTTPTMKELQTMVEHHLGQQKQGEEPEGATESTGNQESCPPGIPDTGSASRPDTPGTAQKSAESNPKTQEQCGVEPRTEDSSAHMLPLDSQGASLV

Gene
Ppp1r1a
Protein
Protein phosphatase 1 regulatory subunit 1A
Organism
Rattus norvegicus
Length
171 amino acids
Function
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Similarity
Belongs to the protein phosphatase inhibitor 1 family.
Mass
18.738 kDa
Sequence
MEPDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEVDEDRIPNPLLKSTLSMSPRQRKKMTRTTPTMKELQTMVEHHLGQQKQGEEPEGATESTGNQESCPPGIPDTGSASRPDTSGTAQKPAESKPKTQEQRGVEPSTEDLSAHMLPLDSQGASLV

Gene
PPP1R1A
Protein
Protein phosphatase 1 regulatory subunit 1A
Organism
Oryctolagus cuniculus
Length
166 amino acids
Function
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Similarity
Belongs to the protein phosphatase inhibitor 1 family.
Mass
18.032 kDa
Sequence
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEVDEDRIPNPLLKPSLAMSPRQRKKMTRTTPTMKELQMMVEHHLGQQEQGEEPEGAAEGTGAQESQPPGTPGTGAESRLGPSATAQKPAQPSPRAQERRGEEPSTAKTSQDSQGASAV