PPO1

Phenoloxidase 1

684 amino acids

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the oxidation of o-diphenols (N-acetyldopamine, 4-methylcatechol and dopamine). Cannot oxidize monophenols and p-phenols (L-tyrosine, tyramine, gentisic acid and hydroquinone). Binds to the surface of hemocytes and is involved in hemocyte melanization. Activation of the enzyme in response to bacterial lipopolysaccharides (LPS) suggests it may play a role in innate immunity.

Belongs to the tyrosinase family.

79.073 kDa

MSDKNKLLLLFDRPLETVIVPRGPDQEAFDVPVDLLSDRYKAIGVQVSNRFGEETKSKIPVKKISPPPLGEILDLPRQANFSLFIPKHRKIAGRLINIFLGMKDTDDLQSMAIFARERVNPYLFNYCFSVAILHRPDTQDLDIPSFIQTFPDKYLDSQVFSRAREEATLVPEGQRVPIEIPRDYTASDLEVEHRVAYFREDLGINLHHWHWHLVYPFEGAEQVVRKDRRGELFYYMHQQVIARYNLERFCNALKRVTRFTEWKDPIPEAYFPKLDSLVASRAWPARVTDQKLSNLRRDQDQITQDVDDLYRWRDRIYEAIHSGFVQTDGGGRQELTEFGGIDILGNIVESSNLSVNRTLYGDLHNMGHVFISYIHDPDHRHLETFGVMGDSATAMRDPVFYRWHAYIDDLFQQFKGSLPRYTEEQLNYPGITVTGVSVQSQGGAANTLNTFWQQSDVDMSRGMDFQPRGSVFARFTHLNHQPFAYNITVNNASGGNKRGTCRIFLGPKTDERRTAWLFKDQRLLFIELDRFVVNLRQGENTITRNSTESSVTIPFERTFRNLDLSRPVGGEALAQFNFCGCGWPQHMLIPKGTPEGYDCQLFVMISNFDDDQVVQSTEGICNDAMSYCGIKDRLYPDKRSMGYPFDRLPRNNVNTLQEFLTPNMRVQDCVIKFTDRVVVPRPRN

PPO1

Polyphenol oxidase 1

568 amino acids

Copper-containing oxidase that catalyzes both the o-hydroxylation of monophenols and the subsequent oxidation of the resulting o-diphenols into reactive o-quinones, which evolve spontaneously to produce intermediates, which associate in dark brown pigments. Involved in the initial step of melanin synthesis. Melanins constitute a mechanism of defense and resistance to stress such as UV radiations, free radicals, gamma rays, dehydratation and extreme temperatures, and contribute to the fungal cell-wall resistance against hydrolytic enzymes in avoiding cellular lysis. Fungal pigments are also involved in the formation and stability of spores (By similarity).

Belongs to the tyrosinase family.

63.898 kDa

MSHLLVSPLGGGVQPRLEINNFVKNDRQFSLYVQALDRMYATPQNETASYFQVAGVHGYPLIPFDDAVGPTEFSPFDQWTGYCTHGSTLFPTWHRPYVLILEQILSGHAQQIADTYTVNKSEWKKAATEFRHPYWDWASNSVPPPEVISLPKVTITTPNGQKTSVANPLMRYTFNSVNDGGFYGPYNQWDTTLRQPDSTGVNAKDNVNRLKSVLKNAQASLTRATYDMFNRVTTWPHFSSHTPASGGSTSNSIEAIHDNIHVLVGGNGHMSDPSVAPFDPIFFLHHANVDRLIALWSAIRYDVWTSPGDAQFGTYTLRYKQSVDESTDLAPWWKTQNEYWKSNELRSTESLGYTYPEFVGLDMYNKDAVNKTISRKVAQLYGPQRGGQRSLVEDLSNSHARRSQRPAKRSRLGQLLKGLFSDWSAQIKFNRHEVGQSFSVCLFLGNVPEDPREWLVSPNLVGARHAFVRSVKTDHVAEEIGFIPINQWIAEHTGLPSFAVDLVKPLLAQGLQWRVLLADGTPAELDSLEVTILEVPSELTDDEPNPRSRPPRYHKDITHGKRGGCREA