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PON1

Gene
PON1
Protein
Serum paraoxonase/arylesterase 1
Organism
Oryctolagus cuniculus
Length
359 amino acids
Function
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification.
Similarity
Belongs to the paraoxonase family.
Mass
40.01 kDa
Sequence
MAKLTALTLLGLGLALFDGQKSSFQTRFNVHREVTPVELPNCNLVKGIDNGSEDLEILPNGLAFISAGLKYPGIMSFDPDKPGKILLMDLNEKDPVVLELSITGSTFDLSSFNPHGISTFTDEDNIVYLMVVNHPDSKSTVELFKFQEKEKSLLHLKTIRHKLLPSVNDIVAVGPEHFYATNDHYFIDPYLKSWEMHLGLAWSFVTYYSPNDVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPVTGDLWVGCHPNGMRIFYYDPKNPPASEVLRIQDILSKEPKVTVAYAENGTVLQGSTVAAVYKGKMLVGTVFHKALYCELSQAN

Gene
PON1
Protein
Serum paraoxonase/arylesterase 1
Organism
Homo sapiens
Length
355 amino acids
Function
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Similarity
Belongs to the paraoxonase family.
Mass
39.731 kDa
Sequence
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL

Gene
Pon1
Protein
Serum paraoxonase/arylesterase 1
Organism
Mus musculus
Length
355 amino acids
Function
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification.
Similarity
Belongs to the paraoxonase family.
Mass
39.565 kDa
Sequence
MAKLLALTLVGLVLALYKNHRSSYQTRLNAFREVTPVELPNCNLVKGIETGAEDLEILPNGLTFFSTGLKYPGIKSFDPSKPGKILLMDLNKKEPAVSELEIIGNTLDISSFNPHGISTFTDEDNTVYLLVVNHPDSSSTVEVFKFQEEERSLLHLKTITHELLPSINDIAAIGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVQVVAEGFDFANGIGISLDGKYVYIAELLAHKIHVYEKHANWTLTPLKVLNFDTLVDNISVDPVTGDLWVGCHPNGMRIFFYDAENPPGSEVLRIQNILSEDPKITVVYAENGTVLQGTTVASVYKGKLLIGTVFHKALYCDL

Gene
Pon1
Protein
Serum paraoxonase/arylesterase 1
Organism
Rattus norvegicus
Length
355 amino acids
Function
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification.
Similarity
Belongs to the paraoxonase family.
Mass
39.358 kDa
Sequence
MAKLLGLTLVGLVLALYKNHRSSYQTRLNAFREVTPVDLPNCTLVKGIEAGAEDLEILPNGLTFFSTGLKYPGIKSFDPSKPGKILLMDLNEKEPAVSELAIMGNTLDMSSFNPHGISTFIDEDNTVYLLVVSHPDSSSTVEVFKFQEEERSLLHLKTITHELLPSINDIAAVGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVRVVADGFDFANGIGISLDGKYVYIAELLAHKIHVYEKHANWTLTPLKVLSFDTLVDNISVDPVTGDLWVGCHPNGMRIFFYDSENPPGSEVLRIQSILSEDPKVTVVYAENGTVLQGTTVAAVYKGKLLIGTVFHRALCCDL