polr3c

DNA-directed RNA polymerase III subunit rpc3

666 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).

Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.

75.335 kDa

MYEQKVAIDIVKESFGDDVTKVFEFLVQRGKSSYKIINQSLSGKGGLTIKRIKQCLLVLIQHNLVTYEEFLLPLTKDEIEKLVPGEPLPSDSVYEAIIVNAIHRLRFPKFINYIKHSKGDEAAYILEELIDHGRLPMDLLIKQASQIQRVDTFEDQDDITKRFEDTFTKLIMDQFIMRAPRPRPVSDQETSNALSKEAKKVGGGGANGNNVGAHQKKDSDPFALPSVGFSSNGPLSSVDNSANDAESLEILTGKSSTTTIPSQPKKGTAKKTSAKPKSTAINTTATASLGRKRKSRDIYDEDDDEEPDLLVIEENVEINVNDHNSANKNSTTTTTTTTTKTGQHTLKKSKLDQSSSTTTTSSRQQQNGMDQQRIIDESRVLWTINYEQFIIEFKLKACYDFVTEKNNQQSGLLFNAMVKLCKRSIRSNQDSLTSCVYGENILEEYNRDLDSSKKMDKLQIEKYLSIMQASRPSMVTKMVSKSKQSSSSELGAYQVNVGNIIGIIKQKMVESIIKQKFGDNGLRVFKLLLIKNLLEPKQIAELAMIPPNECKALLFNMMQKNIIRLQEIPRSSDHFANRTFYLFFVDLPTIIATFTEDIFKAIYNTRERLKSELEPHKDALEKLTQLDEDQITEDQAKIYKKTDRITQTLLTVILNLDNDLLHLYSF

polr3c

DNA-directed RNA polymerase III subunit RPC3

539 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).

Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.

60.489 kDa

MTAQEVRLCGLLLQEHFGDVVENVGTHLIRNGVLTLRALAHETKLALDLVKKSLCVLVQHGMCTFGPGRRGPAGPVEYHINCEHILHMLRYPRYIYTAKSLYGDTGELIVEEILQRGQMTMSSTVKTVADRLTHNMPEGQSMDYNEVVSAFSRLVETHFLQRCPPMASAESSGTGSAETPPAVTQPSNPESHPDCYKLPYISLSGHGKRRRSSEDGEADQRAAKKAKTDSSECGDEGIHWQVNFERFHLHFRDQAIISAVSCKLDQTSGEIVRTMLRMSEVTTSANAAFTQALSANEIFRALPSNYNIARPILDQYLTLLVDDPMEFVGKAGDSGGGMFVVNLHRALANLARATLESVVQERFGSRSARIFRLLLRKRHLEQKQVEDFAMIPAKEAKEMLYTLLSENLVQLQEIPKTPDHAPSRTFYLYAVNQLPTARLLLQHCYKTVGNLIERRLYETKENKRLLEKSQRIEAILASLQATGAEATQLTEVEEMITAPERQQLESLRHHINKLDSGENQVDETIFLLESYINSTQASR

POLR3C

DNA-directed RNA polymerase III subunit RPC3

534 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628).

Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.

60.612 kDa

MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQVKKALCVLVQHNLVSYQVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYSDTGELIVEELLLNGKLTMSAVVKKVADRLTETMEDGKTMDYAEVSNTFVRLADTHFVQRCPSVPTTENSDPGPPPPAPTLVINEKDMYLVPKLSLIGKGKRRRSSDEDAAGEPKAKRPKYTTDNKEPIPDDGIYWQANLDRFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMSEITTSSSAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLADDPLEFVGKSGDSGGGMYVINLHKALASLATATLESVVQERFGSRCARIFRLVLQKKHIEQKQVEDFAMIPAKEAKDMLYKMLSENFMSLQEIPKTPDHAPSRTFYLYTVNILSAARMLLHRCYKSIANLIERRQFETKENKRLLEKSQRVEAIIASMQATGAEEAQLQEIEEMITAPERQQLETLKRNVNKLDASEIQVDETIFLLESYIECTMKRQ

POLR3C

DNA-directed RNA polymerase III subunit RPC3

533 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF-Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner.

Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.

60.429 kDa

MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQVKKALCVLIQHNLVTYQVHKRGVVEYEAQCNRVLRMLRYPRYIYTAKTLYSDTGELIVEELLLNGKMTMSAVVKKVADRLTETMEDGKTMDYAEVSNTFVRLVDTHFVQRCPLVPATENSDTGPPPPAPTLVVSEKDMYLVPKLSLIGKGKRRRSSDEDATGEPKAKRPKQTTDNKEPIPDDGIYWQANLDRFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMSEVTTPSGAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLADDPLEFVGKSGDSGGGMYVINLHKALGSLATATLESVVQERFGSRCARIFRLVLQKKHLEQKQVEDFAMIPAKEAKDMLYKMLSENFISLQEIPKTPDHAPSRTFYLYTVNILSAARMLLHRCYKSVANLIERRQFETKENKRLLEKSQRVEAIIASMQATGAEEAQLQEIEEMITAPERQQLETLKRNVNKLDACEIQVDETIFLLESYIESTMKR

Polr3c

DNA-directed RNA polymerase III subunit RPC3

533 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF-Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner.

Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.

60.706 kDa

MTQAEIKLCSLLLQEHFGEIVEKIGVHLVRTGSQPLRVIAHDTKASLDQVKKALCVLIHHNLVLYHVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYGDTGELIVEELLLNGKMTMSAVVKKVADRLTETMEDGKTMDYAEVSNAFVRLADTHFVQRCPLVPDTDSSDRGPPPPAPTLVINEKDMYLVPKLSLIGKGKRRRSSDEDATGEPKAKKPRYTDNKEPSPDDGIYWQVNLDRFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMSEITTPSSAPYTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLADDPLEFIGKSGDSGGGMFVINLHKALASLATATLESVIQERFGSRCARIFRLVLQKKHLEQKQVEDFAMIPAKEAKDMLYKMLSENFILLQEIPKTPDHAPSRTFYLYTVNVLSAARMLLHRCYKSIANLIERRQFETKENKRLLEKSQRVEAIMASMQATGAEEVQLQEIEEMITAPERQQLETLKRNVNKLDASEIQVDETIFLLESYIESTMKRQ

Polr3c

DNA-directed RNA polymerase III subunit RPC3

533 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF-Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner.

Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.

60.543 kDa

MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTKASLDQVKKALCVLIHHNLVIYHVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYGDTGELIVEELLLNGKMTMSAVVKKVADRLTETMEDGKTMDYAEVSNAFVRLADTHFVQRCPLVPDTDSSDPGPPPPAPNLVINEKDMYLVPKLSLIGKGKRRRSSDEDAAGEPKAKKPRCTDNEEPTPDDGIYWQVNLDRFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMSEITTPSGAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLADDPLEFIGKAGDSGGGMYVINLHKALASLSTATLESVIQERFGSRCARIFRLVLQKKHLEQKQVEDFAMIPAKEAKDMLYKMLSENFISLQEIPKTPDHAPSRTFYLYTVNVLSAARMLLHRCYKSIANLIERRQFETKENKRLLEKSQRVEAIMASMQATGAEEVQLQEIEEMITAPERQQLETLKRNVNKLDASEIQVDETIFLLESYIESTMKRQ