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PMT4

Gene
PMT4
Protein
Dolichyl-phosphate-mannose--protein mannosyltransferase 4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
762 amino acids
Function
Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a homodimeric complex to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. Specifically acts on secretory proteins with an ER-luminally oriented Ser/Thr-rich region flanked by a membrane anchor such as FUS1, AXL2, GAS1, KEX2, MID2, WSC1, WSC2, OPY2, PRM5, RAX2, or YNL176.
Similarity
Belongs to the glycosyltransferase 39 family.
Mass
87.966 kDa
Sequence
MSVPKKRNHGKLPPSTKDVDDPSLKYTKAAPKCEQVAEHWLLQPLPEPESRYSFWVTIVTLLAFAARFYKIWYPKEVVFDEVHFGKFASYYLERSYFFDVHPPFAKMMIAFIGWLCGYDGSFKFDEIGYSYETHPAPYIAYRSFNAILGTLTVPIMFNTLKELNFRAITCAFASLLVAIDTAHVTETRLILLDAILIISIAATMYCYVRFYKCQLRQPFTWSWYIWLHATGLSLSFVISTKYVGVMTYSAIGFAAVVNLWQLLDIKAGLSLRQFMRHFSKRLNGLVLIPFVIYLFWFWVHFTVLNTSGPGDAFMSAEFQETLKDSPLSVDSKTVNYFDIITIKHQDTDAFLHSHLARYPQRYEDGRISSAGQQVTGYTHPDFNNQWEVLPPHGSDVGKGQAVLLNQHIRLRHVATDTYLLAHDVASPFYPTNEEITTVTLEEGDGELYPETLFAFQPLKKSDEGHVLKSKTVSFRLFHVDTSVALWTHNDELLPDWGFQQQEINGNKKVIDPSNNWVVDEIVNLDEVRKVYIPKVVKPLPFLKKWIETQKSMFEHNNKLSSEHPFASEPYSWPGSLSGVSFWTNGDEKKQIYFIGNIIGWWFQVISLAVFVGIIVADLITRHRGYYALNKMTREKLYGPLMFFFVSWCCHYFPFFLMARQKFLHHYLPAHLIACLFSGALWEVIFSDCKSLDLEKDEDISGASYERNPKVYVKPYTVFLVCVSCAVAWFFVYFSPLVYGDVSLSPSEVVSREWFDIELNFSK

Gene
PMT4
Protein
Dolichyl-phosphate-mannose--protein mannosyltransferase 4
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
755 amino acids
Function
Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of AXL2, responsible for bud site selection, as well as of the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for biofilm formation.
Similarity
Belongs to the glycosyltransferase 39 family.
Mass
86.658 kDa
Sequence
MSQTLKKRGGNSSGRKSPTTSNIEFDDKKTEFDLNAIVPPKEPEYKYLAALTLVTLLAIYTRFTKLGTPNKVVFDEVHFGKFASYYLERTYFFDLHPPFAKLLIAFVGWLIGYDGKFKFEAIGDSYIENNVPYIAYRSLSAIQGAAIVPIMFLTMKTLGFSVAACLFSSIIVCFDNAQVTDSRLILLDATLILSVALTIFSYSKFSTFRKQSFSSKWWTWLLATGVSLSCVISTKYVGVFTYLTIGIAVIHELWILLDYRKGLTLQEFAKHFFARLWALIIVPFCIYLYWFYLHFAILTRSGPGDAFMSSEFQETLLESPLAAHSKPVQYFDQITIKHKDTGAFLHSHQHEYPLRYEDGRISSNGQQVTCVVQENAANDPNNQWEIVPTSEGANKGTKVYTNDIVRFRHVGTGGYLLTHDVASPLKPTNEEFTVVYDDVAQQRYNETLFRLRLHVPGSNPKKEKNKKEIKTLATDLRILHVDTVVAMWTHNDELLPEWAFNQQEVSGNKKIPDKDNIWNFDLITNLQSTDPRNQYVPKKVKTLPFLRKWWELQMLMFHHNNQLSSEHPFATQPGEWPLALSGVSFYNDNTEKKQIFFIGNIIGFWLEVCFLSIYIGILLADQITRRRNVHVLSDRARSRLYNTLGFLFVGWAAHYLPFFLMNRQKFLHHYLPAHLVAALFSGGLVEFICSNNSARPNGKPVGVNKYKIIAVVAACSTAIIWFFFYFRPLTYGDVYLTPEEVKARQWLDIKLHYGK

Gene
PMT4
Protein
Putrescine N-methyltransferase 4
Organism
Nicotiana tabacum
Length
419 amino acids
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Putrescine methyltransferase family.
Mass
45.899 kDa
Sequence
MEVISTNTNGSTIFKNGAIPMNGHQSGTSKHLNGYQNGTSKHQNGHHNGTSEHRNGHQNGISEHQNGHQNGTSEHRNGHQNGISEHQNGHQNGTSEHQNGHQNGTSEQQNGTISHDNGNELLGNSNSIKLGWFSEFSALWPGEAFSLKVEKLLFQGKSDYQDVMLFESATYGKVLTLDGAIQHTENGGFPYTEMIVHLPLGSIPNPKKVLIIGGGIGFTLFEMLRYPTIEKIDIVEIDDVVVDVSRKSFPYLAANFNDPRVTLVLGDGAAFVKAAQAGYYDAIIVDSSDPIGPAKDLFERPFFEAVAKALRPGGVVCTQAESIWLHMHIIKQIIANCRQVFKGSVNYAWTTVPTYPTGVIGYMLCSTEGPEVDFKNPINPIDKETTQVKSKLAPLKFYNSDIHKAAFILPSFARSMIES