Protein
N-fatty-acyl-amino acid synthase/hydrolase PM20D1
Function
Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration. In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they promote proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the bodily dissipation of chemical energy as heat through thermogenic respiration.
Similarity
Belongs to the peptidase M20A family.
Sequence
MAGGCGRRRVVVCAVALGLSAAVLALTAVVLLRAYVLRSPAIPRLWARRGSTAAFSASERRELKEALRGAVRIPTVSLSSEDFNTTAMAEFGDYIRKAFPAVFSSKFIQHEIIGEYSHLFTVQGSDSEMMPYMLLAHMDVVPAPPEGWDFPPFSAAEHEGFIYGRGTLDNKNSAIGILQALEFLLRRNYRPRRSFYVGIGHDEEVFGQKGALKIAALLESRGVKLSFLLDEGSAILDGIIAGVKKPVALIAVTEKGLMTLNFTVEKEPGHSSFPPKETSIGILATAVSRLEQNPMRSLFGRGPELMTMEHLASEFNFPLNLIMSNLWLFSPIVSRVLAWKPSTNALIRTTTAVTMFNAGIKFNVIPPSARATVNFRIHSGEKAKEVLETVRNTVADDRVKIDVIEALDPLPISPWDDQTFGVHVFQRTILDTFPNVDSVVPGTCIGNTDSRHFTNVTNAIYRFNPVLLKSDDLPRIHGLNERISVESYEKQVEFLFQLIKNCDVDKLPEPHANSHEL