Protein
Bifunctional pinoresinol-lariciresinol reductase 2
Function
Reductase involved in lignan biosynthesis. Catalyzes the enantioselective sequential conversion of (+)-pinoresinol into (+)-lariciresinol and of (+)-lariciresinol into (-)-secoisolariciresinol. Can also convert with a lower efficiency (-)-pinoresinol into (-)-lariciresinol, but not (-)-lariciresinol into (+)-secoisolariciresinol. Abstracts the 4R-hydride from the NADPH cofactor during catalysis.
Similarity
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Sequence
MEESSRVLIVGGTGYIGRRIVKASIALGHPTFILFRKEVVSDVEKVEMLLSFKKNGAKLLEASFDDHESLVDAVKQVDVVISAVAGNHMRHHILQQLKLVEAIKEAGNIKRFVPSEFGMDPGLMEHAMAPGNIVFIDKIKVREAIEAASIPHTYISANIFAGYLVGGLAQLGRVMPPSEKVILYGDGNVKAVWVDEDDVGIYTIKAIDDPHTLNKTMYIRPPLNILSQKEVVEKWEKLSGKSLNKINISVEDFLAGMEGQSYGEQIGISHFYQMFYRGDLYNFEIGPNGVEASQLYPEVKYTTVDSYMERYL