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PLEKHN1

Gene
PLEKHN1
Protein
Pleckstrin homology domain-containing family N member 1
Organism
Homo sapiens
Length
611 amino acids
Function
Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1 (PubMed:29180010). Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS) (PubMed:18191643). Promotes apoptosis by enhancing BAX-BAK hetro-oligomerization via interaction with BID in colon cancer cells (PubMed:29531808) (By similarity).
Mass
66.409 kDa
Sequence
MGNSHCVPQAPRRLRASFSRKPSLKGNREDSARMSAGLPGPEAARSGDAAANKLFHYIPGTDILDLENQRENLEQPFLSVFKKGRRRVPVRNLGKVVHYAKVQLRFQHSQDVSDCYLELFPAHLYFQAHGSEGLTFQGLLPLTELSVCPLEGSREHAFQITGPLPAPLLVLCPSRAELDRWLYHLEKQTALLGGPRRCHSAPPQRRLTRLRTASGHEPGGSAVCASRVKLQHLPAQEQWDRLLVLYPTSLAIFSEELDGLCFKGELPLRAVHINLEEKEKQIRSFLIEGPLINTIRVVCASYEDYGHWLLCLRAVTHREGAPPLPGAESFPGSQVMGSGRGSLSSGGQTSWDSGCLAPPSTRTSHSLPESSVPSTVGCSSQHTPDQANSDRASIGRRRTELRRSGSSRSPGSKARAEGRGPVTPLHLDLTQLHRLSLESSPDAPDHTSETSHSPLYADPYTPPATSHRRVTDVRGLEEFLSAMQSARGPTPSSPLPSVPVSVPASDPRSCSSGPAGPYLLSKKGALQSRAAQRHRGSAKDGGPQPPDAPQLVSSAREGSPEPWLPLTDGRSPRRSRDPGYDHLWDETLSSSHQKCPQLGGPEASGGLVQWI

Gene
Plekhn1
Protein
Probable pleckstrin homology domain-containing family N member 1
Organism
Mus musculus
Length
610 amino acids
Function
Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (PubMed:27616329). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS) (By similarity).
Mass
66.826 kDa
Sequence
MGNSHCVPQAPRRLRASFSRKPSLKGNREDSARKLAGLFGTEARPDGDTAANRIFHYIPGTDIPGPEHHPENLEQPFLSVFKKGWRRTPVRNLGKVVHYSKVRLRFQHSQDISDCYLELFPSHLYFQAHGSEGLTFQGLLPLTELNICPTDGSREHAFQITGPLPAPLLVLCHSEAELSHWLYHLEKQMALLGLQRCHSAPPQGSLGDKPPWTQLRRAYGCGSMSGAICASRVKLQHLPSQEQWDRLLVLYPASLAIFSEEPEGLSFKGELPLSAIHINLEEKEKEIRSFLIEGHLINTIRVVCASYEDYSQWLLCLRTVSRRDGAHLPPGPESFPGLQKPTQLVGRGRGSLSSNGRSSWKLECPVFPTSQSLPESSVPTTIGFPAPPVPNQTDSNCVSTGQKKMKPSDSSPSPRGRAQREVSGSTVPLPLPLDLTKMSALNLDSGPEAQDHSLDIPHSPLYADPYTPPATSRHKITDIQGLDEFLCAIQTSPGPDLSSPFPPVSVSVPVSESSSGISSSPGPLGSHLLTKKGALQPRASQRHRGSFKSRGPQPSDFPQLVTPAREGKPSSLPPPPDEEAPIWNKTSSPSHPKWPQPRKPAVEGGFIQWI