PLEKHG2

Pleckstrin homology domain-containing family G member 2

1386 amino acids

May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021).

147.969 kDa

MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLSTVGSEGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHIFCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRRQSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLSDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGKLGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQAAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEGPLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTTPALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSWHGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQVPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPHSPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPPPQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAPDAPFHM

Plekhg2

Pleckstrin homology domain-containing family G member 2

1340 amino acids

May be a transforming oncogene with exchange activity for CDC42. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42 (PubMed:11839748). Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (By similarity). Involved in the regulation of actin polymerization (By similarity).

143.376 kDa

MPEGARGLSLPKPSLRLGCGHQGEVCDCAAVSDTPTAQAATTMASPRGSGSSTSLSTVGSEGDPSPACSASRPEPLPEPPIRLHLLPVGIQGSVKPSRLERVAREIVETERAYVRDLRSIVEDYLGPLMDGRALGLNMEQVGTLFANIEDIYEFSSELLEDLEGCSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSVSPPATLWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPDSGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGTFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGPEYTYKGHIFCCNLSVSETPRDPLGFKVSDLTIPKHRHLFQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKHIPEPPTSPLDSPRPRDAPGFTPGRRNPAPSPRLSGSRRGRRQSEPAKEAYVIFPQNDKPQVKHAGSEGELHPSSELQPVSASGLPEDLEDAGPPTLDPSGTSITEEILELLNQRGLRDSGPATHDIPKFPRDSRVPVESEPLPFQSLPSRESSEEEEEEDLETDEREPSPLHVLEGLEGSSAAEIPCIPSLTDIPSEVPSLPEIPEAPCLPCLSDISGVFEVPCLSPTSTVPDIPSLATTPSFPCGSWLPGPLQEAAQPQATRRELLSGSNPGRLSESPSESREGQEDDTEGVSFSAVQREAGTSVQGFPEELEYRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLRGGSTSGKTGMPHSERSASRVRELARLYSERIQQMQRAETRASTNAPRRRPRVLAQPQPSPCPPQEEAEPGALPAFGHVLVCELAFPLNCTQESVPLGPAVLVQAATPLCIQGDDLSGQNLNVSDLSKQGHLSSNSIPPPVPLPGQSNFQNIQVPSTSLLPKQEPPDVQVPTASTLPDTSQLQSQVPAATPSAGHRNCVEIQVQSTTSLPGQECQADTVALSKQEGHEDSQNPNKAPGAEQRDVSIDQGLAVVGGRPVSPLPVCTSSPDQQIPATTPLPLSTDFPDMEGPGALPLPTQEGRPDCSIPCNPLPSLSQDVQVPAVIPVSQLQGLTDTRATVPLSSHKQEDAPECLGPEPSLTDTPAPRLLSSLGQQNTTDGPVSAAAVPLTEQGCSQDLQGLITSPVQTTMELPKPRGLVSRVATSESLDLTPPHSPSLSTRQLLGPSAAALSRYLAASYISQSLARRQGPGGEGTVASQGHWSSSAPTSRAPSPPPQPQPPAPPARRLSYATTVSIQVGGGGRLRPAKAQVRLNHPALLAAPHPGAVGPSQGPGGS