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PLEKHA8

Gene
plekha8
Protein
Pleckstrin homology domain-containing family A member 8
Organism
Danio rerio
Length
549 amino acids
Function
Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN) to the plasma membrane.
Mass
61.454 kDa
Sequence
MEGVLYKWTNYISGWQPRWFVLEGGTLSYYDSQEDAWKGCKGSIKISVCEIQVHPSDFTRVDLIIPGEQYFYLRAINAAERQKWLVALGTAKACLTDNRTKREKELQENSEALKTKMSELRLYCDLLLQQVNKIQESPLAETSAGSGEGGDETGNLVKSTCTTFLKTLEECMHIASRTFNPDLLSRTPPGSPSVATIKPQKIKSNDPKNLHPGETRKDLINTSGTSAHESGPDNEPPPSPQENISTAHTESGLMEDQNDLIEPNNGSSSSTQDHEEPVEEQQTDGSTEDADHSQEEQQEVSMSPTQNKQEVQEDIQTDLELNETQSENKQEEEDEDKVDTFFSTMSHRFSDIILEEDSGIPTQAFLDSCYAIVPVLDKLGPTVFAPVKIDFVGNIKKIQQKVVSDPESFPTLQSIVLHEVKTEVAQVRNSATEALLWLKRGLKFLKEFLSEINTGVKDVQGALYNAYGKTLRQYHGWVVRGVFALALRAAPSYEGFMAALVSYEGDELKEGFRTGMHRDLDIYLPAMENQLSILDTLYEEYGLESDEIV

Gene
PLEKHA8
Protein
Pleckstrin homology domain-containing family A member 8
Organism
Bos taurus
Length
520 amino acids
Function
Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity).
Mass
58.27 kDa
Sequence
MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSSSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSNKMKHPIVPIHNSLERQMELNSCENGSLNMEINDDEEILVRNKSSLCLKPAETDCSISSEENTDDNITVQGEMMKENGEESLGNHDSDLAQPELHSTSSSPESHWEEDQEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTIKEGDHQKAAFSVGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV

Gene
Plekha8
Protein
Pleckstrin homology domain-containing family A member 8
Organism
Rattus norvegicus
Length
520 amino acids
Function
Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity).
Mass
58.096 kDa
Sequence
MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVATAGVADSEEGIDVGTLLRSTCNTFLKTLEECMQIANAAFTSELLYHTPPGSPQLAVLKSSKMKHPIIPIHNSLERPIELNSCENGSLSVEVNGDEELLMKTKKSSLYLKSTKADCNISSEENTDGNTTVQGERMKEDGEENLESHDRDLAQPGSDSVCSPESPWEDSEEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVARVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTIKEGDHQKEAFSAGMQRDLSLYLPAMEKQLAILDTLYEIHGLESDEVV

Gene
PLEKHA8
Protein
Pleckstrin homology domain-containing family A member 8
Organism
Canis lupus familiaris
Length
519 amino acids
Function
Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
Mass
58.082 kDa
Sequence
MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELNSCENGSLHMEINDGEEILMKNKSSLYLKPEIDCSISSEENTDDNITVQGEIMKEEGEDNLGNHDSSLAQPASDSSSSPPESHWEEGQEIIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTIKEGDHQKAAFSVGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV

Gene
PLEKHA8
Protein
Pleckstrin homology domain-containing family A member 8
Organism
Homo sapiens
Length
519 amino acids
Function
Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
Mass
58.261 kDa
Sequence
MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEILMKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCSPECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV

Gene
Plekha8
Protein
Pleckstrin homology domain-containing family A member 8
Organism
Mus musculus
Length
519 amino acids
Function
Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity).
Mass
57.962 kDa
Sequence
MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVATAGVTDSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYHTPPGSPQLAVLKSSKMKHPIIPIHNSLERSMELNSCENGSLSIEVNGDEEILMKTKSSLYLKSTEVDCSISSEENTDDNVTVQGEIMKEDGEENLESHDKDPAQPGSDSVCSPESPWEDNEEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTIKEGDHQKEAFSAGMQRDLSLYLPAMEKQLAILDTLYEIHGLESDEVV