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PLCZ

Gene
PLCZ
Protein
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Organism
Sus scrofa
Length
636 amino acids
Function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Mass
73.702 kDa
Sequence
MENKWFLSMVRDDFKGGKINLEKAQKLLEKLDIQCNTIHVKCIFKDNDRLKQGRITIEEFRTIYRIIAHREEIIEIFNAYPENRKILFERNLIDFLTQEQYSLDINRSIVYEIIQKYEPIEEVKQAHQMSFEGFTRDMGSSECLLFNNECGSVYQDMTHPLSDYFISSSHNTYLISDQIMGPSNLWGYVSALVKGCRCLEIDCWDGSQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFITSDYPVVLSLENHCSLSQQEVMADNLQSVFGDALLSDVLDDCPDRLPSPEALKFKILVRNKKIGTLKETHERKGFDKHGQVQECEEEEEAEQEEEENEVRDSEILDILQDDLEKEELKRGVGIKFFKKKKVKIATALSDLVIYTKVEKFRSFHYSRLYQQFNETNSIGETQARKLSKLRASEFILHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLENGNSGYILKPHFLRDGKSIFNPNKAPINSNPITLTIRLISGIQLPPSYHSSSNKADTLVIIEIFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIQVPELALIRFVVENQGLITGNEFLGQYTLPVLCMNKGYRRVPLFSKMGESLEPASLFIYVWYIR