pks1

3-methylorcinaldehyde synthase

2729 amino acids

Non-reducing polyketide synthase involved in the biosynthesis of 3-methylorcinaldehyde, the precursor of xenovulene A which is a secondary metabolite able to displace high affinity ligands from the gamma-aminobutyric acid (GABA) A receptor (PubMed:17912413).

296.115 kDa

MAAHGQTSKRGNNTLLLFGALVQSHDVSTLRSMRESIVVQHGEHSWLVDSIKALPQDFEAALPHLPFFDQATTTTIHQLLVDAVSSFLTGSFETLVSPLPAALLIPLAVATQLAHYVEYSRQSPTGLAEGKEALGFCTGILSAFAVASSHDVCDLAKYGAAAMRLGMLVGLVVDCEDAAAGQGRYRSVSAGWDSEEKHAAMLKIVQSFEEAYVSVHFDKNRATITTSPGTISNLTRQLQKEGLVASDMGLLGRFHFAGSTKPREVTVDQLVSFCNSPAGALFRLPDADSLRLATRINDRDGGLITQGSLHEHALQSILVKLAAWFETFSSATTTQANTGAQNGRARPQIVDFGPQNSVPHSLASTVDINSGNGKTRRVKPADAQSSANSTHTRPWLDTDIAIVGMSCKVPGAENLEEFWDLLVSGKSQHQEISGQEGGRFDFGDTAFRTAADQRRRWFANLVSNHDQFDHRFFKKSARESASMDPQQRHILQVAYQAVEGSGYFNKSSSSTPTNANIGCYVGLCLGDYESNVASHPATAFTATGNLQGFVSGKVSHYFGWTGPAVTVNTACSSSLVAVHLACQAILSGECEAALAGGSHIMTSATWFQNLAGGSFLSPTGACKPFDSKADGYCRGEGVGAVFLKRMSQAMADGDMVLGVVAATGVQQNQNCTPIFVPNAPSLENLFSRVMTKARVKPADISVVEGHGTGTAVGDPAEYDAIRKALGGTTHRSADKPLMLSSVKGLVGHMECTSGVIGMIKLLLMMNKGALPPQASFQSINPALGATPADHMFIPTRPQPWVVPAGGFRAALLNNYGASGSNASAVLVQSPSMSFRPEITVGSRPAAGIKFPFWLAAFDKKSLSRYVKALRKWLCRLDGDQSLASLSFNLARQSNRTMQANLVLTARSIEALDQSLADFENGNDGSFIERTPASSQPTVILCFGGQVSCFVGLDKQVYQDMALVRYYLDRVDAVIQCQGGRSIFPGIFNRSPPSKVDIVHLHTMLFAMQYASARCWIDSGVKPAALVGHSFGTLTALCISGILSLEDTIKAIMCRAKLLNEAWGPDQGGMIAVEGDIDVIEELLDEANKNHDDKPATIACYNGPTSFTLAGSTTAMDAVAAQLKNGAKYSKGMKSKRIYVTHAFHSVLVDPLLEELTQRVADSGVRFRKPIIPVELSTEQHMSESELTSEFMANHMRQPVYFHHAVERLARRYAGGSSPCVFLEAGTNSSVCNMASRALGSTEFVTKSSSLSFHGVNIANCDAGWNKLTDTTVNLWETGVRVHHWAHHGVQQMHQTDIKPLLVPPYQFDPDSRHWIDLKVPRKALMETDEADAGGKKQSDAEKLPETILTFHSSDAVGAQKQARFRVNTMLEEYKQLLRGHMTLETAPILSATLQINLVIEAISSTQPEYKSSKSQPQIQDVVYQSPVCFNSANTLWVEVTNVSGQWMFQVFSTTTQELSPKSTRMVHTKGTVAFKNPGDAEIRRQLMSYERLFSHGRATDLLQNSNASTAPIDEMLGNQSIYRIFSEIVSYGPEFRGLQKMVSRGNETAGHVVHLKHQDSASTEAEPWFDPHLADTFCQLGGLWVNCMMPERERGNGHVYLANGIDQWIRGYPAASTDRPEAFNVFAVNKQASEQLTLTDVFVFNAADGALVEVILGIAYVKIARPSMEKLLARLTEPSWVAGGKTTPQTATKPAAAPVVADHTPRTTESASTVNGVNLDDRKPEGTALPQEMLSDTEELRPKAQGQELQDMIARVKAVMADISGLDISEIKDDSNLADLGIDSLVGMEMTHEIESTLKVELPESEIMSVVDMEGLLQCVAGALGLSMTGASSDTLTASSDSGINSAKSSILSGTSTSTSTGTTDTGSDVGQSMKEPSLMLDTVKKAFAQTKEATDARIKAASNQVSYCSTSLPQQNELSVLLTITALEALGAGFSTARPGSQLTRISHAPGHEQFVTHLYKEIETATQIIKIDGHGAQAVITRTAVPLPDVESRQVALCEQMLRGDPEQVGTMELIKHAGENLHRVLSGETDGAKVIFGSKTGSKLVSQWYAQWPLNRSLIAQMGDFLTAVVAGIQADEDMPFSEINPLRIMETGAGTGGTTKQIVPLLARLGLPVVYTFTDLAPSFVAAARKTWGKEYPWMQFRTLDMEKTPPSVEDGLPLQHFIVSANAVHATKSISATTGNLRKALRTDGFLLMMEMTRTPFWVDLIFGLFEGWWLFEDGRKHALTHEALWDQELSKVGFGYVDWTEGMTAESEIQKIILASADANTRLERVRLPASHTDYHLNQVGVENEARELMVADYVSTLTKEFNKTMTQYTDAGLSLSSRTSQTPMSSQKRCILITGGTGGLGAHLVAEAALLPDVNMVICLNRPNRKQEARERQLVSLEKKGLILSPEALAKITVFETDLSQPGSLGLSDDKYNLLRGNVTHIIHNAWLMHSKWPVRRFEPQLRIMAHMLNLAADIATCQRTQGQRQPGPPVSFVFVSSIATVGYHPVVTNPGNPAVPETRIPISSVLPTGYGEAKYICERMLDATLHQYPAQFRASAVRLGQIAGSEINGHWNSAEHISFLVKSSQSIGALPALPGPMGWTPADYVARGLVEIATQPDNIELYPIYHIENPVRQPWDEALAVLADEMGISSEALPFQEWVQTVRDWPRQGDNTAAGANPAYLLVDFLEDHFLRMSCGGLLLGTAKAREHSPSLAGMGPVSDELLRLFVRSWKEVGFLL

PKS1

Reducing polyketide synthase PKS1

2528 amino acids

Reducing polyketide synthase (PKS); part of the Tox1A locus, one of the 2 loci that mediate the biosynthesis of T-toxin, a family of linear polyketides 37 to 45 carbons in length, of which the major component is 41 carbons, and which leads to high virulence to maize (PubMed:8953776, PubMed:20192833). One of the PKSs (PKS1 or PKS2) could synthesize a precursor, used subsequently by the other PKS as starter unit, to add additional carbons (PubMed:16529376). Variability in the length of the final carbon backbone C35-47 could be achieved by varying the number of condensation cycles, or use of different starter or extender units or might be due to decarboxylation of the penultimate product, catalyzed by DEC1 (PubMed:12236595). Additional proteins are required for the biosynthesis of T-toxin, including oxidoreductases RED1, RED2, RED3, LAM1 and OXI1, as well as esterase TOX9 (PubMed:20192833).

275.297 kDa

MTVRDSKTGGITPIAVVGMSFRGPGDATNVEKLLNMISEGRESRAEVQAKKWDPEGFYHPDSSRHGTHNVEYGHWFQQDVYNFDAPFFNVSPAEAAALDPQQRMLLECSYEAFENSGTPMSKIVGTDTSVFVSSFATDYTDMLWRDPESVPMYQCTNSGFSRSNLANRISYSFDLKGPSVLVDTACSGGLTALHLACQSLLVGDVRQALAAGSSLILGPEMMVTMSMMKFLSPDGRCYAFDERANGYARGEGVAVLLLKRLEDALADNDTIRAVIRGTGCNQDGKTPGITMPNSVSQEALIRSVYKKAALDPLDTTYVECHGTGTQAGDTTEASALSKVFSPGRRLPLLIGSVKTNIGHLEGASGLAGVVKSILMLEQGVILPNRNFERPNTKIPLEKWNLRVPTTLECWNNVKTRRVSINSFGYGGANVHAILESATDFLRDNSMGTDSTRFASRRSVVVGNVGQTKPAVSLVQDMSSNDRSHEDPTPLLFALSAFDSSAGDAWARSLSIYLSQRQGSDEKTILSSLAYTLSDRRTWHPWKAALSATTIQELITKLEKVRFVNMAPRHNIGFVFTGQGAQWCGMGRELISIFPRFRQSLIACDIALQSFGADFHVIDELEADVESSRINKALYSQPLCTALQIALVDLLVSWGIYAQSVTGHSSGEIAAAYAAGALSLSDAMLVAYARGCATANLAKKGAKGAMAAVSMETQELSHILSALENGKVGIACFNSPTSCTVSGDKSALDELQDVLRQKGVYNRRLIVDVAYHSHHMELIADSYRSAISSIQPLPGSDVKFFSSVTGELLDKNKLGVDYWVSNLVGQVKFAQSLSSLVSSHHGTGTPQIQALIEIGPHAALGGPISQVIDSEPLANPTGYFSALVRKKNAVTTILSLAADLFLSGYPIQLSAVNQNCNSRHTPLVDLPSYSWNHSKAYTAESRISKTYRQRRYPRLDLIGVFDVHSSVLEPRWRQVIRLSELPWLQDHKIQSSILYPVAGYIAMAIEAATQRNQMREMGNDILGYQFRDVAISSALTIPDMPGQVEVFITLRSFSESVRSPSNLWDEFSISSVNDENRWTEHCRGLISVLKSSKLSNLVNGKMQDASTIACQHDLREVFATCCKTEWDVKDMYEHFWETGMQYGPTFANLCDVRCTSNKCIGKVKVPDTAAVMPMKHEAPFIIHPGTLDSIIQTYLPALVQAGHLKSATIPVAIESMFISRNVTRQAGDLLTSYASSTRKDYRYFSTSMSVFADGPSSENQLVITIDDMTLVALDRPNSSEESGEALPLAFNLHWKPDVDMLTEEQLVEMINASTKVKDHIAAKKMKQTAAQLGKEILARVPFEQAQVVGESSRHLWKLLHASLESLSTPDHRGALDEISSLKNVDSTLAQAADRLSNVLTGRVAPSDVASMYDLMEAVRIPELYDNNLPTATYLHLLGHKKPSLRVLTVGPQSGPTSLNLLMLLAELGGGEIPFAVLHHSDAELNIDQTVRSRFPSWADSVGFRDVFNESGASQQNPPIVNETYDIVVAFNVLGSSPGFSKTLSAAAPLLNARGKILLVDNSHKSPMAALVWGPLPSFLSTWVDEKSADSPDVDCAVQSMGYDIYARLCPNVTVIQRAAQVQKAEKTIGLDVLVVTDGEPAGVDLQQLQTLCEDQYAEVHVASLEHARPRPGQACIVLSELSRPVLAAPTAAEWEAVKRITDTCSGIVWVTRGAADNVCSNPQVSLIQGFARTVRAEAGDKPITTLDLDNDKVLSAQAAAAYIAAVFQRMMQGGEDIDVELQERRGILHVARLIEDGDAAKQLQGEATAMELRLDQAGPCRLFAGTPGLLDSLHFTVDDRVQESLETGQIEVQVHATGINFKDVMMAMGQIAVEDLGCECSGVVSAVGDGVVGLRVGDRVACMGPGSFCTQLRVDARLAHRIPHHMELETAAALPITYVTAYHSIHNIAHLRHGETILIHAAAGGLGQALVELSQLVGARVLVTVGSTEKKRLIMQRFRLSEEDILFSRDTSFVHDVMRLTNGRGVDVIMNSLAGESLRQSWTCIAPNGRFVELGQRDITVNSRLDMAPFARNVSFTAYNLAYMLRHDPQAAHEVLAEVLALYDQGKLRGPEPLEKCTFSQLGNAFRKIQTGRHMGKMVAVANPDDMVWYKPPPASRRTLFRPDASYLLVGGVGGLGSATALWMSTRGARHLLLLNRSGADTEAARTTLATLRANGCTATVLACDVADKAQLSSVLAEARSNWPPIRGVIQGAMVLRDSMLANMTLEDYMAVVRPKVQGTWNLQTHLPADLDFFILESSISGIIGNPGQAAYAAANTFLDAFARWRRARCQPATVIDIGAVHGIGYLERNVDVKLSMERQGFAFTDEQLLMRLLEFAISHSSREPHRAQIVTGLGPWHPDTSLPGLNAPLFSRYRMLSCQNSTGSTDVDTLRGILAQSSSFDSAVTIVLSALVDQVVSRTEIPIENVHTTKSLQDYGIDSLVAVELRNWLIKDMDSVVPMLELLGAESLSALAVKIAARSQLISTNNRG

PKS1

Non-reducing polyketide synthase 1

2192 amino acids

Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of elsinochromes, pigments consisting of at least four interconvertible tautomers (A, B, C and D) that have a core phenolic quinone to which various side chains are attached and which play an important role in fungal pathogenesis (PubMed:18957608, PubMed:18321192). The non-reducing polyketide synthase PKS1 was proposed to iteratively catalyze decarboxylation between acetyl-CoA and malonyl-CoA subunits for polyketide chain elongation. The released polyketide undergoes cyclization to form an aromatic ring, and proceeds via serial modification steps to produce the heptaketide back- bone of elsinochrome. As elsinochrome has a symmetrical structure, two identical heptaketides are fused to form a core 1,2-dihydrobenzo-perylene ring structure, which can then be successively modified to produce the various derivatives of elsinochrome. Some of these reactions may be cooperatively carried out, at least in part, by the products of RDT1, OXR1 and PKS1. PRF1, embedded within the elsinochrome cluster possibly functions to stabilize some of the biosynthetic enzymes required for elsinochrome production. As prefoldin is a hexamer containing 2 a and 4 b subunits, additional prefoldin subunits, whose coding genes may not immediately link to the elsinochrome biosynthetic gene cluster, are required to fulfill the chaperone function. In addition, no methyltransferase-coding gene exists within the biosynthetic gene cluster, even though elsinochrome has four methyl groups at positions C3, C7, C8 and C12. Apparently, the identified gene cluster does not contain the entire entourage of genes responsible for elsinochrome biosynthesis. Once elsinochrome is synthesized, it must be exported outside the fungal cells, which is probably accomplished by the ECT1 transporter, to avoid toxicity (PubMed:21199563).

238.122 kDa

MSNVLLLGDQTADQSPLLRKLVLRRNDALVTTFHEQVSVALRDEVSKLPARQRQDIPSFLKLNTLVDLYYQGDKRLPILESTFVALTQLGHYIGYFSENPDRLPYAANTRVLGLCTGSLAATVIVSAKSLSELVSLAVEAVRIAFRAGACVDAAKRVLQQPGEEKEPWSTIVMNLSEKDAQKALDEFHSSTGTSGPSRAYISAISTMAVTISGPPSTTQKLFSESADLSTKNRVSIPIYAPYHAAHLHSERDLQRIIPDSSRALLKKYQPHTLLHSSATGECLVADNTCDLMSLALVDFLREPVRWDRLLEESISQIIATPKAPAKIFTIGVSNVANSMAAALKASGQATVSITDHTSWIVPDDYNSTRGRTQNDKIAIVGMSGRFPSAASVDALWELLEKGLDVHRKIPADRFDADAHCDPSGKSKNKSHTPYGCFIDEPGLFDPRFFNMSPREAAQTDPMGRLALVTAYEALEESGYVPNRTPSTKLHRIGTFYGQTSDDWREINAAENVDTYFITGGVRAFAPGRINYYFKFSGPSFSIDTACSSSLAAIQLACTSLWAGDCDTACAGGLNVLTNPDIFSGLSKGQFLSKTGSCKTYDNDADGYCRGDGCGSVILKRYEDAIADKDNILGCILGAATNHSAEAVSITHPHAGNQEFLFKKVLAEAGVDAHEISYVEMHGTGTQAGDGIEMTSVTNAFAPPNRRRTPDEKLFLGAIKANVGHGEAASGINSLAKVLMMFKKNAIPANVGIKGVMNESFPKDLGERNVHIPLKQVEFPRNGDAPRKIFLNNFSAAGGNTSLLLEDGPVRKPSTVKDPRSTLPITVTARSIASLKRNIDNLKSYLSKTPEASLTSLSYTSTARRIQHNYRIAFPATDINKVSEALDAQIKDSYSPVAITATRVAFCFTGQGSQYTGLGQKLYQDLPSFKADIDQLNQLAESHNLPSFLELFDGTDVATLSPVKVQLGTACIQVALSRMWESWGIKPSAVIGHSLGEYAALHVAGVISASDMVYLVGRRAELLVKDCTPHTHGMLAVKASVDAIRNALGSKMTEVACINGPEETVLCGSSEIVTAANEVLTSKGMKSTKLNVPFAFHSAQVDPILESFRTTASSVSFKKPAVPVLSPLSGDIITDVGVIGPEYLAKHARETVNFSQALESGQKAKIFDGKTAWLEIGAHPVCLGMVKGSVETTATAPSLRRGEDAWKTLANSMCALFLAGVYINFDEYHRAFNDAQELLHLPTYSFDDKKYWLDYHNNWTLTKGEAPQPTKAIEAAPFEAAAPVERTYKKLSDSCQKIIDEEFSANAGRVLVQSDVCQPNLRRVAMGHQVNDTALCPSSLYFDMAMTVADYIYKALRPSAPKIGYNVAHMEVPKPFIIKNVAPPEGQHLQLEAHADLEEGVAKLVFRSVTPNGKQLVVHAHCTVKFEDINTWQEGWENISFMVKSQIENLQRKTRTQEAHVIGRGLAYKLFKVFVNYAKPYRGMEEIILDNQTTEATASVHFQTKPEDGEFFFPAYWCDSMAHLGGFIVNATDLCDSDNYVSVSHGWGSIKVAKEMSANKKYRNYVRMVEKPGNVTQGDVYIFDGDEIIAVVGALKFQKIPRKVLNTFLPPQKAGSAVSAPVAPPAAARPALKQAPRINTQAQPAKAVPKQVTVAAPTPKAAPKKADLKKPAGPTIITRVMHIIAAETDVDSSELVDQAAFENLGVDSLMSLTISARFREELDMDISSTLFTDFPTVGEMKKFFSQYDGEVGTPEQDDSDSDSETSGDASTPMSEVGTPMTIPSSAVSESGKFDLDTAAPASGEVSIARQIVATEMGVEIAEVTDQADLADMGMDSLMSLTILSELREKTGIDLPSTFLMTNPTIEDVENALDMRPKARVAPVAVPAPSNRRPSSPQLDKVNEKLNASRSADISKYPAATSVLLQGNPKIATKKIFFLPDGSGSATSYVSIPNIGSDVCAFGLNCPFMKSPEQWSCGIEICAMVYLKEIKRRKPTGPYIIGGWSAGGVIAYAVAQALLANNEEVEKLLLLDSPCPVNLDPLPARLHIFFNEIGLLGTGDPSKTPKWLLPHFSAAIRSLSDYQPQPTIKPVKTYAIWCREGVAGNPGDPRPPPAEDEDPAPMKWLLNHRTDFTDNGWGKLCGVENMKYGVMGGHHFSMMKPPHVSIFDYSIVDDEANMRQAEDLGQLIKEGLSM

Pks1

Polyketide synthase 1

2162 amino acids

Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:29958281). The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (By similarity). The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (By similarity).

235.429 kDa

MEHVIIKQPDTGGDSVRIFVFGDQTSCNLSNLQPLLLKRSNIYLVSFVDQVNCALRHEIARLTTAERRSFPAFSSIQNLVTRGLQKERSVALESTLATIYQLCCFFNYFGDGQKSYPTGPNTHVSGLCIGALSAAAVSSSRSLDELVQAGIEAVLVSLKVGLLVSRTAALFSHQASANSSCSSSASWSYTVPDSQLPLALAEEAIASYTDKTNIPPLSSPYISARGQNSWTVSGPPAVLQGFLRSSQVVEAPRLTPLAVHAPYHAPHIFSVSDVENVIQAVGPVSSLSSKLPFISTSSCGSLSSGTRFQDLLFRAVEGILILPLDLRAAAENMRQVFEAVEDVSRCALIPISTGVCTSLKMSFSPVLADCVSIVDSIMEGTAADGGSKSAPATNPGDSKIAIIGMSGRFPEAADVEAFWAVLYKGLDVHRPVPKDRYDGELYYDPTGKKKNTCKVMHGCWINEPGLFDAKFFNISPKEAEQSDPGQRLALTTAYEALESAGVVAGRTPSTQRDRVGVFYGMTSDDYREVRASVCKPQCKPFPYTKANLTTGGNRAFTPGKINYFFKYCGPSVSVDTACSSSLAAIHLACNSIWRNECDTAVAGGTNVMSNPDSFVGLDRGHFLSRKGNCNNFDDEADGYCRADAVATVVLKRLEDAMADHDPILGVISGAHTNHSAESVSITRPHSGAQEEIFSKLLCESGVHPHQVSYVEMHGTGTQAGDATEMTSVLNCFAPSTGPRRLPHESLHLGSAKANVGHSESASGVTSLIKVLLMMEKNMIPPHCGIKSKINHRFPTDLEQRNVHIAKTATRWGRRREFDNIRRVFVNNFSAAGGNTALLVEDYPPLAAASSQRDSRTAHVVTTSAKCIQSLRGNLEKLKAFVQKTSSSESFMSKLSYTTTARRMHHPFRVAIPAAKPEELLSALDTELRRDSCRCSSESAVAFVFSGQGSQYGAMGKHLLHYTIFRGEIDSYDILAQRHGFPSIMPLVDGSVAIEHLEPLVVQLGTVCVQMALASLWIAFGMQPSYVVGHSLGHFAALKVSGALTASDTIYLVGMRARLLQNKCSIGSHAMLAVRSSAEDVQAYLDADVHDIACINSPQDTVVSGRVDDIDRLSERLLDKGIKATRVNVPFAFHSSQVEPILDELGAIASQVKFHSPCVPIGCPLQGKSLLPGETLTSEASHVKRHCRQTVNFRGILQSAKSDGLVSEKTAWIEIGPHTVCSMLVKANINHDVTAVPSLMRSHDGWQVLASSLATLYSKGLSVAWDEYHHDFECCKEVLRLPAYSWDNKRYWIEYVHDWLLTRGDPPVPAAAPSPAPVSSFSTASVHRIVRESVDRETVALTAECEFTSEQLREVVYGHVVNGNRVCTSSLYADFGVTLGTYILDKYRADLKDHSVDVQEMVVNKPLVHKEGLPMLLRIDVVHDMTASKSATMSIYSINAKGNKTVDHAKSSLCFGESRAWLRSWDSTQYYVERSIEWLKEKADQGLNSRLSSGVIYKLFSSLVEYSSAYKGMKEAIVNTEDFEATALVQFQVDEGNFRCNPMWVDSCGQLAGFLMNGHSKTPLDQVFINHGWQSFRTVRKFCKDKTYRTYVRMRCIEGTTYAGDVYIFDDEGIVGVCGSITFQGVPRRVLDAAMPAPKSPNKTRDHASPNATISRAKPPQGSSPASSAQLAQHSSIEPLKLDAALKSATTAIDPMHAVLRILSEEIGIPLTSLQYDLVFADYGVDSLLSLTISGRLREELDLDIESSVFETCATVGDFAVHLGLDTLASYQSSGESNVSGGVSPRSDSVAAMSSDVTTPPAQSPLGSMSSSPCEDLCAIIAEEIGVSMSVIKSDANLGELGMDSLMSLTVLSRLREELDLDLEGDFFVAHPTYSSFKHVFEQEIEPEIGLGESADLKKYHATSTLLQGSPKSALYTLFLLPDGSGSATSYATISAVGRDICVYGLNCPWLKSAEKLVQFGLKGLASLYVGEIRRRAPHGPYNLGGWSAGGICAYEAAIQFTREGEAVERLILLDSPNPIGLEKLPPRLFDFVNGLGLFGEGKAPDWLLAHFLAFIDALDQWKPVPWDKALDSTTPPPMTYILWAEDGLCKGIDARPEYRDDDPREMRWLLENRTNFGGNSWDILLGEGRLLTERIQDANHFTMLRRGKNAERVAAFIRSAFK

Pks1

Polyketide synthase 1

2149 amino acids

Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:29958281). The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (By similarity). The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (By similarity).

234.89 kDa

MNHVTIKQSDTRADPFRVFIFGDQSSCNLSNLQLLLFKKSNVYLASFIDQVNLTLRHEIARLTAAERQSFPAFSSIQNLVARALKKDTSVALESTLATIYHLCCFLNYFGDGQEAYPTGPTTHVSGLCIGALAAAAVSSSKSLAELVQAGIDAVRVSLKVGLLVARTAALFSHQESNGTSSSPWSYAVPDSQLPLALAEEAIESYQAKTNIPPLSLPYISAKGQNSWTVSGPPAIVQHFLETSQFEKTLRLTRLAVHAPYHAPHIFSAIDVQHIIRAVGPVSSFSSKLSFISSSSSRNLPTGLNFQDLLCRAVEDILILPLDLREAAENIRLVLEATDNVQQCALFPISTGVCPSLKQSFSPATASRVSIVDCIMERATADAGPKSTSGPKPSESKIAIIGMSGRFPESADVEAFWDLLHQGLDVHRPVPPDRYNGELYYDVTGKRKNTCKVMHGCWINEPGLFDAKFFNISPKEAEQSDPGQRLALATAYEALEAAGVVADRTPSTQRDRVGVFYGMTSDDYREVSCGQNVDTYFIPGGNRAFTPGKINYFFKYCGPSVSVDTACSSSLAAIHLACNSIWRNECDTAIAGGTNVMSNPDSFVGLDRGYFLSRTGNCHTFDDEADGYCRADAVGTVILKRLEDAIADHDPILGVISGALTNHSADAVSITRPHSGAQEEIFSKLLTESGVHPHQVSYIEMHGTGTQAGDATEMTSVLNCFAPSTSPRRLPHESLHLGSTKANVGHSESASGVSALIKVLLMMEKNIIPPHCGIKGKINHKFPTDLDQRNVHIARTATQWNRRNEFNNIRRAFVNNFSAAGGNTALLVEDYPLLIADSSQQDARTAHVVTVSAKCIKSLKGNLENLKKFVQKQASTQGFLPKLSYTTTARRMHHPFRVAIPAANSEQLLSALDEELKHDGYTCSSESPVAFVFSGQGSQYSAMGQHLLHFTIFRDEVHAYDILARRHGFPSIMPLIDGSVDIEDLEPLVVQLGTVCVQMALASLWMALGMRPAYVVGHSLGHYAALKVAGVLTASDTIYLVAMRARLLQNKCSRGSHAMLAIRSSADEIQAHLDEGIHDIACISGPQDTVVSGCIDDIDRLSQKLTDKGIKATRVNVPFAFHSAQVDPILDELEATASQVEFHAPRVAIGCPLLGKTFKAGETPSLEANHIRRHCRETVNFLDVLRSAKDDGFVSEKTAWIEIGPHTVCSKLVKANISQDIVAVPSLMRNKDGWQVLASSVAALYRHGSSVAWDEYHHDFEACKQVLRLPAYSWDNKVYWIDYVHDWLLTRGDPPVQAAASLPAPPSSFSTASVHRIVHESVDKGKLTLTAECEFTNEQLREVVYGHVVNGNRVCSSSLYTDFGVTLGSYILEKYRPDLQDHAVDVQDMVVNKALVHKEGPTMLLRIDVVLDMTDSKAASMSIYSVNSKGNKTAEHAQSSLHFERPKVWLKSWDSTQYYVERSIEWLKEKADQGLNSRMSSGVIYKLFSSLVDYSTAYKGMQEAIVNTEDFEATALVRFQVDEGNFRCNPMWVDSCGQLAGFLMNGHAKTPKDQVFINHGWQSFRTVRKFSKDKTYRTYVRMRCIEGTTYAGDVYIFDDEGIVGVCGSITFQGIPRKVLNTAMPPPKSQNEAPVRSAPAKPAAKPPKSASSEHSGHFARHSNIEPLKLDAALKSATTARNPMLAVFKIVSEEIGIPSASVDNGLVFADYGVDSLLSLSISGRLREELDLDVESSAFETCATLADLATHLGLDTFSSDQSSGQSSSSGGLSPRSDSIGEITSSATTPPSLSPRGSVSGSQCKDVCAILAEEIGVSMSEITNDTDLGALGMDSLMSLAVLSRLREELELDLEGDFFVSHPNFSSFKHMFQQGHGDEVESEPSAELKQYRATSTLLQGNPKSALYTLFLLPDGSGSSFSYAPINAVRKDVCVFGLNCPWLKSAEKLVQFGLKGLATLYVEEIRRRAPHGPYNLGGWSAGGICAYEAAIQFTREGETVERLILLDSPNPIGLEKLPARLFDFVNGLGLFGDGKAPDWLLAHFLAFIDALDEWKPVPWDKALGGGNSPPPRTYILWAEDGICKDTDARPEYRDDDPREMKWLLENRTNFGGNNWDVLLGQQSLAIERIQDANHFTMLRKGKNSERVAAFIRSTFG

Pks1

Polyketide synthase 1

2148 amino acids

Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:29958281). The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (By similarity). The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (PubMed:20382249).

234.782 kDa

MNHVTIKQSDTRADPFRVFIFGDQSSCNLSNLQLLLFKKSNVYLASFIDQVNLTLRHEVARLTAAERQSFPAFSSVQNLVARALKKDTSVALESTLATIYHLCCFINYFGDGQEAYPTGPTTHVSGLCIGALAAAAVSSSKSLAELVQAGIDAVRVSLKVGLLVARTAALFSHQESNGTSSSPWSYAVPDSQLPLALAEEAIESYQAKTNIPPLSLPYISAKGQNSWTVSGPPAIVQHFLETSQFEKTLRLTPLAVHAPYHAPHIFSAIDVQHIIRAVGPVSSFSSKLAFISSSSSRNLPTGLKFQDLLYRAVEDILILPLDLREAAENIRLVLEATDNVQQCALFPISTGVGPSLKQSFSSAMASRVSIVDCIMERVAADAGPKSTSGPKPSESKIAIIGMSGRFPESADVEAFWDLLHQGLDVHRPVPPDRFNGELYYDVTGKRKNTCKVMHGCWINDPGLFDAKFFNISPKEAEQSDPGQRLALATAYEALEAAGVVADRTPSTQRDRVGVFYGMTSDDYREVSCGQNVDTYFIPGGNRAFTPGKINYFFKYCGPSVSVDTACSSSLAAIHLACNSIWRNECDTAIAGGTNVMSNPDSFVGLDRGYFLSRTGNCHTFDDEADGYCRADAVGTVILKRLEDAIADHDPILGVISGALTNHSADAVSITRPHSGAQEEIFSKLLTESGVHPHQVSYIEMHGTGTQAGDATEMTSVLNCFAPSTSPRRLPHESLHLGSTKANVGHSESASGVSALIKVLLMMEKNIIPPHCGIKGKINHKFPTDLDERNVHIAKTATQWNRRNELNNIRRAFVNNFSAAGGNTALLVEDYPLLIADSSQQDARTAHVVTVSAKSIKSLKGNLENLKKFVQKQASTEGFLPKLSYTTTSRRMHHPFRVAIPAANSEQLLSALDEELKHDSYTCCSESPVAFVFSGQGSQYSSMGQHLLHFTIFRDEVHAYDILAQRHGFPSIMPLIDGSVDIEDLEPLVVQLGTVCVQMALASLWMALGMRPAYVVGHSLGHYAALKVAGVLTASDTIYLVAMRARLLQNKCSRGSHAMLAIRSSVAEIQAHLDEGIYDIACINGPQDTVVSGCIDDIDRLSQKLMDKGIKATRVNVPFAFHSAQVDPILDELEAIASQVEFHAPRVAVGCPLLGKTFKAGETPSLEAKHIRRHCRETVNFLDVLRSAKDDGFVSDKTAWIEIGPHTVCSNLVKANINQDITAVPSLMRNKDGWQVLASSVATLYRHGSSVAWDEYHHDFEACKQVLRLPAYSWDNKLYWIDYVHDWLLTRGDPPVQAAASLPAPPLTFSTASVHRIVHESVEKGKLTLTAECEFTNEQLREVVYGHVVNGNRVCSSSLYTDFGVTLGSYILEKYRPDLQGHAVDVQDMVVNKALVHKEGPTMLLRIDVVLDTTDSKAASMSIYSVNSKGNKTADHAQSSLHFEQPKVWLKSWDSTQYYVERSIEWLKEKADQGLNSRMSSGVIYKLFSSLVDYSTAYKGMQEAIVNTEDFEATALVRFQVDEGNFRCNPMWVDSCGQLAGFLMNGHAKTPKDQVFINHGWQYFRTVRKFSRDKTYRTYVRMRCVEGTTYAGDVYIFDDEGIVGVCGSITFQGIPRKVLNTAMPPPKSQNEAPVRSGPAKPAAKPPRSASSEHSGHFARHANIEPLKLDAALKSATTARNPMLPVFKIVAEEIGIPSASVDNGLVFADYGVDSLLSLSISGRLREELDLDVESSAFETCATLADLAAHLGLDTFSSDQSSGQSSSFGGLSPRSDSIGEITSSVTTPPSLSPRSSVSGSQCKDVCAILAEEIGVSMGEITNDTDLGALGMDSLMSLAVLSRLREELELDLEGDFFVSHPNFSSFKHMFQQGHGDEVGPEPSAELKQYRATSTLLQGSPKSALYTLFLLPDGSGSSFSYAPINAVRKDVCVFGLNCPWLKSAEKLVQFGLKGLATLYVEEIRRRAPHGPYNLGGWSAGGICAYEAAIQFTREGETVERLILLDSPNPIGLEKLPARLFDFVNGLGLFGDGKAPDWLLAHFLAFIDALDEWKPVPWDKALGGNSPPPMTYILWAEDGICKGTDARPEYRDDDPREMKWLLENRTNFGGNNWDVLLGQQSLSIERIQDANHFTMLRKGKNTERVAAFIRSTFG

Pks1

Polyketide synthase 1

2148 amino acids

Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:29958281). The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (By similarity). The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (By similarity).

235.786 kDa

MEHVTIKQSGTRADPFRVFIFGDQSSCNLSNLQLLLLKKSNIYLASFVDQVNFTLRHEIARLTTAERQSFPAFSSIQNLVTRALKKDKSVALESTLATIYHLCCFLNYFGDGQEAYPTGPNTHISGLCIGALAAAAVSSSKSLAELVQAGIDAVRVSLKVGLLVARTAALFSHQEPNGTSSSPWSYAVPDSQLPLAFAEEAIESYQVKTKIPPLSLPYISAKGQNSWTVSGPPEIVQHFLESSKFEKTLRLTPLAVHAPYHAPHIFSARDVEHIIHAVGPVSNISSKLSFISSSSSCNLPNGVKFQDLLYRAVEDILILSLDLREAAENIRLVLEATDDVQQCVLFPISTTVCPSLKQSFSPVLASRVSIVDCIMESVAANAGPKSTSGPKPSDSKIAIIGMSGRFPESADVEAFWDLLYQGLDVHRPVPPDRFNGESYYDVTGKRKNTCKVMHGCWINEPGLFDAKFFNISPKEAEQSDPGQRLALATAYEALESAGVVADRTPSTQRDRVGVFYGMTSDDYREVSCGQNVDTYFIPGGNRAFTPGKINYFFKYCGPSVSVDTACSSSLAAIHLACNSIWLNECDTAIAGGTNVMTNPDSFVGLDRGYFLSRTGNCHTFDDEADGYCRADAVGTVILKRLEDAIADHDPILGIISGAYTNHSADSVSITRPHSGAQEEIFSKLLTESGVHPHQVSYIEMHGTGTQAGDATEMTSVLNCFAPSTHPRRLPHESLHLGSTKANVGHAESASGVSALIKVLLMMEKNIIPPHCGIKGKINQKFPTDLDERNVHIAKTATQWNRRDEFNNIRRAFVNNFSAAGGNTALLVEDYPLPTVDSSQEDSRTAHVVAVSAKCVKSLKGNLENLKKFVQKQSSIEGFLPKLSYTTTARRMHHPFRVAIPAASSDQLLSALDQELKHESYRCTSESPVAFVFSGQGSQYSAIGRHLLHFTIFRDEVNSYDILAQRHGFPSIMPLIDGSVDIEDLEPLVVQLGTVCVQMALASLWIAFGMRPAYVVGHSLGHYAALKVAGVLTASDTIYLVAMRARLLQNKCSRGSHTMLAIRSSADEMQAYLDEDIYDIACINGPQDTVVSGCIDDIDRLSQKLMDNRIKVTRVNVPFAFHSAQVDPILDELEAIASQVEFHTPRVAIGCPLLGKTFVAGETSSLGADHIKRHCRETVNFRDILRSAKGDGLISEKTAWIEIGPHTVCSTLLRANINQDIVAVPSLMRNKDGWQVLASSVATLYRHGLPVDWDEYHHDFEACKQVLRLPAYSWDNKVYWIHYVYDWLLTRGDPPVQAAASLPAPPSSFSTASVHRIVHESVDKGKLTLTAECEFTSEQLREVVYGHVVNGNRVCSSSLYTDFGVTLGLYILETYRPDLKDHSVDVQDMVVNKALVHKEGSTMLLRINVILDMTDGKAASMSIYSVNSKGDKTADHAQSSLHFEQPKVWLRNWDSTQYYVERSIEWLKEKADQGLNSRMSSGVIYKLFSSLVDYSTAYKGMQEAIVNTEDFEATALVRFQVDEGNFRCNPMWVDSCGQLAGFLMNGHAKTPKDQVFINHGWQSFRTVRKLSKDKTYRTYVRMRCIEGTTYAGDVYIFDNEGIVGVCGGITFQGIPRKVLNTAMPPPKSQNEAQVHSSPAKSRPKPPGSASSVHSGRLARHTNIEPLKLDAALKSATAARDPMQALFKIVSEEIGIPSASVQNDLVFADYGVDSLLSLSISGRLREELDLDVESSVFETCATLADLATHLGFDTFSSDQSSGQSSSCGGLSPRSDSTGEITSNATTPPSLSPRGSVSGSQCKDVCAILAEEIGVSMSEITNDTDLGELGMDSLMSLAVLSRLREELELDLEGDFFVSHPKFSSFKHMFQQGHEDEIEPEPSAELKQYRATSTLLQGNPKSALYTLFLLPDGSGSSFSYAPINAVRKDVCVYGLNCPWLKSAEKLVQFGLKGLATLYVEEIRRRAPHGPYNLGGWSAGGICAYEAAIQFTREGETVERLILLDSPNPIGLEKLPARLFDFVNGLGLFGDGKAPDWLLAHFLAFIDALDEWKPVPWDKALGSNTPPPMTYILWAEDGICKGTDARPEYRDDDPREMKWLLENRTNFGGNNWDVLLGEPALSIERIQDANHFTMLRKGKNTERVAAFIRSTFG

Pks1

Polyketide synthase 1

2148 amino acids

Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:29958281). The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (By similarity). The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (By similarity).

234.471 kDa

MNHVTIKQSDTRADPFRVFIFGDQSSCNLSNLQLLLFKKSNVYLASFIDQVNLTLRHEVARLTAAERQSFPAFSSVQNLVARALKKDTSVALESTLATIYHLCCFINYFGDGQEAYPTGPTTHVSGLCIGALAAAAVSSSKSLAELVQAGIDAVRVSLKVGLLVARTAALFSHQESNGTSSPPWSYAVPDSQLPLALAEEAIESYQAKTNIPPLSLPYISAKGQNSWTASGPPAIVQHFLETSQFEKTLRLTPLAVHAPYHAPHIFSAIDVQHIIRAVGPVSSFSSKLSFISSSSSRNLATGLKFQDLLYRAVEDILILPLDLREAAENIRLVLEATDNVQQCALFPISTGVGPSLKQSFSPAMASRVSIVDCIMERVAADAGPKSTSGPKPSESKIAIIGMSGRFPESADVEAFWDLLHQGLDVHRPVPPDRFNGELYYDVTGKRKNTCKVMHGCWINDPGLFDAKFFNISPKEAEQSDPGQRLALATAYEALEAAGVVADRTPSTQRDRVGVFYGMTSDDYREVSCGQNVDTYFIPGGNRAFTPGKINYFFKYCGPSVSVDTACSSSLAAIHLACNSIWRNECDTAIAGGTNVMSNPDSFVGLDRGYFLSRTGNCHTFDDEADGYCRADAVGTVILKRLEDAIADHDPILGVISGALTNHSADAVSITRPHSGAQEEIFSKLLTESGVHPHQVSYIEMHGTGTQAGDATEMTSVLNCFAPSTSTRRLPHESLHLGSTKANVGHSESASGVSALIKVLLMMEKNIIPPHCGIKGKINHKFPTDLDERNVHIAKTATQWNRRNELNNIRRAFVNNFSAAGGNTALLVEDYPLLIADSSQPDGRTAHVVTVSAKSIKSLKGNLENLKKFVQKQASTEGFLPKLSYTTTARRMHHPFRVAIPAANSEQLLSALNEELTHDSYTCCSESPVAFVFSGQGSQYSAMGQHLLHFTIFRDEVHAYDILAQRHGFPSIMPLIDGSVDIEDLEPLVVQLGTVCVQMALASLWMALGMRPAYVVGHSLGHYAALKVAGVLTASDTIYLVATRARLLQNKCSRGSHAMLAIRSSAAEIQAHLDEGIHDIACINGPQDTVVSGCIDDIDRLSQKLMDKGIKATRVNVPFAFHSAQVDPILDELEAVASQVEFHAPRVAIGCPLLSKTFKAGETPSLEAKHIRRHCRETVNFLDVLRSAKDDGLVSEKTAWIEIGPHTVCSNLVKANINQDITAVPSLMRNKDGWQVLASSVATLYRQGSSVAWDEYHHDFEACKQVLRLPAYSWDNKLYWIDYVHDWLLTRGDPPVQAAASLPAPPSSFSTASVHRIVHESVEKGKLTLTAECEFTNEQLHEVVYGHLVNGNRVCSSSLYTDFGVTLGSYILEKYRPDLQGHAVDVQDMVVNKALVHKEGPTMLLRIDVVLDTTDSKAASMSIYSVNSKGNKTADHAQSSLHFEQPKVWLKSWDSTQYYVERSIEWLKEKADQGLNSRMSSGVIYKLFSSLVDYSTAYKGMQEAIVNTEDFEATALVRFQVDEGNFRCNPMWVDSCGQLAGFLMNGHAKTPKDQVFINHGWQYFRTVRKFSRDKTYRTYVRMRCVEGTTYAGDVYIFDDDGIVGVCGSITFQGIPRKVLNTAMPPPKSQNEAPVRSGPAKPAVKPPRSASSEHSGHFARHANIEPLKLDAALKSATTARNPMLPVFKIVAEEIGIPSAGVDNGLVFADYGVDSLLSLSISGRLREELDLDVESSAFETCATLADLAAHLGMDTFSADQSSGQSSSSGGLSPRSDSIGEMTSSATTPPSMSPRGSVSGSQCKDVCAILAEEIGVSMGEITNDTDLGALGMDSLMSLAVLSRLREELELDLEGDFFVSHPNFSSFKHMFQQGHGDEAEPETSAELKQYRATSTLLQGSPKSALYTLFLLPDGSGSSFSYAPINAVRKDVCVFGLNCPWLKSAEKLVQFGLKGLATLYVEEIRRRAPHGPYNLGGWSAGGICAYEAAIQFTREGETVERLILLDSPNPIGLEKLPARLFDFVNGLGLFGDGKAPDWLLAHFLAFIDALDEWKPVPWDKALGGSSPPPMTYILWAEDGICKGTDARPEYRDDDPREMKWLLENRTNFGGNNWDVLLGQQSLSIERIQDANHFTMLRKGKNTERVAAFIRSIFG

Pks1

Polyketide synthase 1

2148 amino acids

Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:29958281). The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (By similarity). The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (By similarity).

234.867 kDa

MNHVTIKQSDTRADPFRVFIFGDQSSCNLSNLQLLLFKKSNVYLASFIDQVNLTLRHEIARLTAAERQSFPAFSSIQNLVARALKKDTSVALESTLATIYHLCCFLNYFGDGQEAYPTGPTTHVSGLCIGALAAAAVSSSKSLAELVQAGIDAVRVSLKVGLLVARTAALFSHQESNGASSSPWSYAVPDSQLPLALAEEAIESYQAKTNIPPLSLPYISAKGQNSWTVSGPPAIVQHFLQTSQFEKTLRLTPLAVHAPYHAPHIFSAVDVQHIMHAVGTVSNFSSKLSFISSSSSRNLPTGLKFQDLLYRAVEDILILPLDLREAAENIRLVLEATDNVQQCALFPISTGVCPSLKQSFSPAMASRVSIVDCIMERATADAGPKSTSGPKPSESKIAIIGMSGRFPESADVEAFWDLLHQGLDVHRPVPPDRYNGELYYDVTGKRKNTCKVMHGCWINDPGLFDAKFFNISPKEAEQSDPGQRLALATAYEALEAAGVVADRTPSTQRDRVGVFYGMTSDDYREVSCGQNVDTYFIPGGNRAFTPGKINYFFKYCGPSVSVDTACSSSLAAIHLACNSIWRNECDTAIAGGTNVMSNPDSFVGLDRGYFLSRTGNCHTFDDEADGYCRADAVGTVILKRLEDAIADHDPILGVISGALTNHSADAVSITRPHSGAQEEIFSKLLTESGVHPHQVSYIEMHGTGTQAGDATEMTSVLNCFAPSTSPRRLPHESLHLGSTKANVGHSESASGVSALIKVLLMMEKNIIPPHCGIKGKINHKFPTDLDQRNVHIAKTATQWNRRNEFNNIRRAFVNNFSAAGGNTALLVEDYPLLIADSSQQDARTAHVVTVSAKCIKSLKGNLENLKKFVQKQASTDGFLPKLSYTTTARRMHHPFRVAIPAANSEQLLSALDEELKHDSYTCSSESPVAFVFSGQGSQYSAMGQHLLHFTIFRDEVHAYDILAQRHGFPSIMPLIDGSVDIEDLEPLVVQLGTVCVQMALASLWMALGMRPAYVVGHSLGHYAALKVAGVLTASDTIYLVAMRARLLQNKCSRGSHAMLAIRSSAAAIQAHLDEGIHDIACINGPQDTVVSGCIDDIDRLSQKLMDKGIKATRVNVPFAFHSAQVDPILDELEAIASQVEFHTPRVAIGCPLLGRTFKAGETPSIEANHIRRHCRETVNFFDVLRSAKDEGFVSEKTAWIEIGPHTVCSNLVKANINQDIVAVPSLMRNKDGWQVLASSVATLYRHGSSVAWDEYHHDFEACKEVLRLPAYSWDNKLYWIDYVHDWLLTRGDPPVQAAASLPAPPSSFSTASVHRIVHESVDKGKLTLTAECEFTNEQLREVVYGHVVNGNRVCSSSLYTDFGVTLGSYILEKYRPDLQDHAVDVQDMVVNKALVHKEGPTMLLRIDVVLDMTDSKAASMSIYSVNSKGNKTADHAQSSLHFEQPKVWLKSWDSTQYYVERSIEWLKEKADQGLNSRMSSGVIYKLFSSLVDYSTAYKGMQEAIVNTEDFEATALVRFQVDEGNFRCNPMWVDSCGQLAGFLMNGHAKTPKDQVFINHGWQSFRTVRKFSKDKTYRTYVRMRCIEGTTYAGDVYIFDDEGIVGVCGSITFQGIPRKVLNTAMPPPKSQNEAPVRSAPAKPAAKPPKSASSEHSGHFARHSNIEPLKLDAALKSATTARNPMLAVFKIVSEEIGIPSASVDNGLVFADYGVDSLLSLSISGRLREELDLDVESSAFETCATLADLATHLGLDTFSSDQSSGQSSSSGGLSPRSDSIGEITSSATTPPSLSPRGSVSGSQCKDVCAILAEEIGVSMSEITNDTDLGALGMDSLMSLAVLSRLREELELDLEGDFFVSHPNFSSFKHMFQQGHGDEVEPEPSAELKQYRATSTLLQGNPKSALYTLFLLPDGSGSSFSYAPINAVRKDVCVFGLNCPWLKSAEKLVQFGLKGLATLYVEEIRRRAPHGPYNLGGWSAGGICAYEAAIQFTREGETVERLILLDSPNPIGLEKLPARLFDFVNGLGLFGDGKAPDWLLAHFLAFIDALDEWKPVPWDKALGGNSPPPRTYILWAEDGICKGTDARPEYRDDDPREMKWLLENRTNFGGNNWDVLLGQQSLSIERIQDANHFTMLRKGKNSERVAAFIRSTFG

Pks1

Polyketide synthase 1

2148 amino acids

Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:25445307, PubMed:28447400, PubMed:29958281). The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (PubMed:29958281). The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (PubMed:20382249, PubMed:25445307, PubMed:28447400).

234.854 kDa

MNHVTIKQSDTRADPFRVFIFGDQSSCNLSNLQLLLFKKSNVYLASFIDQVNLTLRHEIARLTAAERQSFPAFSSVQNLVARALKKDTSVALESTLATIYHLCCFINYFGDGQEAYPTGPTTHVSGLCIGALAAAAVSSSKSLAELVQAGIDAVRVSLKVGLLVARTAALFSHQESNGTSSSPWSYALPDSQLPLALAEEAIESYQAKTNIPPLSLPYISAKGQNSWTVSGPPAIVQHFLETSQFEKTLRLTPLAVHAPYHAPHIFSAIDVQHIIRAVGPVSSFSSKLSFISSSSSRNLPTGLKFQDLLYRAVEDILILPLDLREAAENIRLVLEATDNVQQCALFPISTGVGPSLKQSFSPAMASRVSIVDCIMERVAADAGPKSTSGPKPSESKIAIIGMSGRFPESADVEAFWDLLHQGLDVHRPVPPDRFNGELYYDVTGKRKNTCKVMHGCWINDPGLFDAKFFNISPKEAEQSDPGQRLALATAYEALEAAGVVADRTPSTQRDRVGVFYGMTSDDYREVSCGQNVDTYFIPGGNRAFTPGKINYFFKYCGPSVSVDTACSSSLAAIHLACNSIWRNECDTAIAGGTNVMSNPDSFVGLDRGYFLSRTGNCHTFDDDADGYCRADAVGTVILKRLEDAIADHDPILGVISGALTNHSADAVSITRPHSGAQEEIFSKLLTESGVHPHQVSYIEMHGTGTQAGDATEMTSVLNCFAPSTSPRRLPHESLHLGSTKANVGHSESASGVSALIKVLLMMEKNIIPPHCGIKGKINHKFPTDLDERNVHIAKTATQWNRRNELNNIRRAFVNNFSAAGGNTALLVEDYPLRIADSAQQDARTAHVVTVSAKSIKSLKGNLENLKKFVQKQAFTEGFLPKLSYTTTSRRMHHPFRVAIPAANSEQLLCALDEELKHDSYTCSSESPVAFVFSGQGSQYSAMGQHLLHFTIFRDEVHAYDILAQRHGFPSIMPLIDGSVDIEDLEPLVVQLGTVCVQMALASLWMALGMRPAYVVGHSLGHYAALKVAGVLTASDTIYLVAMRARLLQNKCSRGSHAMLAIRSSAAEIQAHLDEGIHDIACINGPQDTVVSGCIDDIDRLSQKLMDKGIKATRVNVPFAFHSAQVDPILDELEAIASQVEFHAPRVAIGCPLLGKTFTAGETPSLEAKHIRRHCRETVNFLDVLRSAKDDGFVSEKTAWIEIGPHTVCSNLVKANINQDITAVPSLMRNKDGWQVLASSVATLYRHGLSVAWDEYHHDFEACKQVLRLPAYSWDNKLYWIDYVHDWLLTRGDPPVQAAAPLPAPPSSFSTASVHRMVHESVEKGKLTLTAECEFTNEQLREVVYGHVVNGNRVCSSSLYTDFGVTLGSYILEKYRPDLQGHAVDVQDMVVNKALVHKEGPTMLLRIDVVLDTTDSKAASMSIYSVNSKGNKTADHAQSSLHFEQPKVWLKSWDSTQYYVERSIEWLKEKADQGLNSRMSSGVIYKLFSSLVDYSTAYKGMQEAIVNTEDFEATALVRFQVDEGNFRCNPMWVDSCGQLAGFLMNGHAKTPKDQVFINHGWQYFRTVRKFSRDKTYRTYVRMRCVEGTTYAGDVYIFDDEGIVGVCGSITFQGIPRKVLNTAMPPPKSQNEAPVRSGPAKPAAKPPRSASSEHSGHFARHANIEPLKLDAALKSATTARNPMLPVFKIVAEEIGIPSASVDNGLVFADYGVDSLLSLSISGRLREELDLDVESSAFETCATLADLAAQLGLDTFSSDQSSGQSSSSGGLSPRSDSIGEITSSVTTPPSLSPRGSVSGSQCKDVCAILAEEIGVSMGEITNDTDLGALGMDSLMSLAVLSRLREELELDLEGDFFVSHPNFSSFKHMFQQGHGDEVEPEPSAELKQYRATSTLLQGNPKSALYTLFLLPDGSGSSFSYAPINAVRKDVCVFGLNCPWLKSAEKLVQFGLKGLATLYVEEIRRRAPHGPYNLGGWSAGGICAYEAAIQFTREGETVERLILLDSPNPIGLEKLPARLFDFVNGLGLFGDGKAPDWLLAHFLAFIDALDEWKPVPWDKALGGNSPPPMTYILWAEDGICKGTDARPEYRDDDPREMKWLLENRTNFGGNNWDVLLGQQSLSIERIQDANHFTMLRKGKNTERVAAFIRSTFG

pks1

Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks1

1616 amino acids

May play a role in phthiocerol biosynthesis.

166.672 kDa

MISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELDRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA

PKS1

Protein PHYTOCHROME KINASE SUBSTRATE 1

439 amino acids

May be responsible for light-regulated cytoplasmic sequestration of phytochromes or may be a negative regulator of phytochrome B signaling. Component of the network that modulates the very low-fluence response (VLFR) branch of phyA signaling. Acts positively in PHOT1 signaling. Regulates phytochrome-mediated photomorphogenesis and hypocotyl phototropism. Involved in the control of leaf flattening and leaf positioning. Promotes negative root phototropism and negatively regulates root gravitropism. May act by controlling auxin homeostasis.

Belongs to the PKS family.

48.085 kDa

MVTLTPSSASTPKTSFDFMKNNNSHSSLYVSSSSYLSSKEDALVTTKKLMEPSKTLNMSINPKQEEFGDEKKMVKKAPEDPEIGVFGAEKYFNGDMDSDQGSSVLSLTNPEVERTVVDSKQSAKKSTGTPSVRSESSWNSQSVLLQNKLVNSCNSSFKEKKNSNGQIQKVTNNKKSFLANLGCKCACSDGDSVDVEEKTSVKRSADPNISVITMRSSADMNTELIKIQKQEELSQRKSLEVFGSPVAIEKKSSVVQKKLPLPPWKSRTEEDDTKSEGSDSSSDLFEIEGLTGNPKPFLTRQGSDPASPTCYAPSEVSVEWSIVTASAADFSVMSECATSPVRRNRPTQIPRIPITAKSAPQRRKSSSSSGGNGFLMSCKSHKSVMVSGDLDRRSSMNKTQPSYVPRFPMETTKPKSFETRRRISNSSISHTQSSLLYSQ

PKS1

Polyketide synthase 1

391 amino acids

Polyketide synthase producing naringenin chalcone and slightly p-coumaryltriacetic acid lactone (CTAL). Can use p-coumaryl-CoA as substrate.

Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

42.781 kDa

MVTVDEVRKAQRAEGPATILAIGTATPPNCVDQSTYPDYYFRITKSEHKTELKEKFQRMCDKSMIKKRYMYLTEEILKENPSMCEYMAPSLDARQDMVVVEIPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAIIVGSDPLPDIERPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPLDITDWNSLFWIAHPGGPAILDQVEAKLGLKPEKLEATRNILSEYGNMSSACVLFILDEVRRKSVANGHKTTGEGLEWGVLFGFGPGLTVETVVLHSVAAST