PKD1L1

Polycystic kidney disease protein 1-like 1

2849 amino acids

Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.

Belongs to the polycystin family.

315.435 kDa

MAEEAAQNISDDQERCLQAACCLSFGGELSVSTDKSWGLHLCSCSPPGGGLWVEVYANHVLLMSDGKCGCPWCALNGKAEDRESQSPSSSASRQKNIWKTTSEAALSVVNEKTQAVVNEKTQAPLDCDNSADRIPHKPFIIIARAWSSGGPRFHHRRLCATGTADSTFSALLQLQGTTSAAAPCSLKMEASCCVLRLLCCAEDVATGLLPGTVTMETPTKVARPTQTSSQRVPLWPISHFPTSPRSSHGLPPGIPRTPSFTASQSGSEILYPPTQHPPVAILARNSDNFMNPVLNCSLEVEARAPPNLGFRVHMASGEALCLMMDFGDSSGVEMRLHNMSEAMAVTAYHQYSKGIFFHLLHFQLDMSTYKEAETQNTTLNVYLCQSENSCLEDSDPSNLGYELISAFVTKGVYMLKAVIYNEFHGTEVELGPYYVEIGHEAVSAFMNSSSVHEDEVLVFADSQVNQKSTVVIHHFPSIPSYNVSFISQTQVGDSQAWHSMTVWYKMQSVSVYTNGTVFATDTDITFTAVTKETIPLEFEWYFGEDPPVRTTSRSIKKRLSIPQWYRVMVKASNRMSSVVSEPHVIRVQKKIVANRLTSPSSALVNASVAFECWINFGTDVAYLWDFGDGTVSLGSSSSSHVYSREGEFTVEVLAFNNVSASTLRQQLFIVCEPCQPPLVKNMGPGKVQIWRSQPVRLGVTFEAAVFCDISQGLSYTWNLMDSEGLPVSLPAAVDTHRQTLILPSHTLEYGNYTALAKVQIEGSVVYSNYCVGLEVRAQAPVSVISEGTHLFFSRTTSSPIVLRGTQSFDPDDPGATLRYHWECATAGSPAHPCFDSSTAHQLDAAAPTVSFEAQWLSDSYDQFLVMLRVSSGGRNSSETRVFLSPYPDSAFRFVHISWVSFKDTFVNWNDELSLQAMCEDCSEIPNLSYSWDLFLVNATEKNRIEVPFCRVVGLLGSLGLGAISESSQLNLLPTEPGTADPDATTTPFSREPSPVTLGQPATSAPRGTPTEPMTGVYWIPPAGDSAVLGEAPEEGSLDLEPGPQSKGSLMTGRSERSQPTHSPDPHLSDFEAYYSDIQEAIPSGGRQPAKDTSFPGSGPSLSAEESPGDGDNLVDPSLSAGRAEPVLMIDWPKALLGRAVFQGYSSSGITEQTVTIKPYSLSSGETYVLQVSVASKHGLLGKAQLYLTVNPAPRDMACQVQPHHGLEAHTVFSVFCMSGKPDFHYEFSYQIGNTSKHTLYHGRDTQYYFVLPAGEHLDNYKVMVSTEITDGKGSKVQPCTVVVTVLPRYHGNDCLGEDLYNSSLKNLSTLQLMGSYTEIRNYITVITRILSRLSKEDKTASCNQWSRIQDALISSVCRLAFVDQEEMIGSVLMLRDLVSFSNKLGFMSAVLILKYTRALLAQGQFSGPFVIDKGVRLELIGLISRVWEVSEQENSKEEVYRHEEGITVISDLLLGCLSLNHVSTGQMEFRTLLHYNLQSSVQSLGSVQVHLPGDLAGHSPAGAETQSPCYISQLILFKKNPYPGSQAPGQIGGVVGLNLYTCSSRRPINRQWLRKPVMVEFGEEDGLDNRRNKTTFVLLRDKVNLHQFTELSENPQESLQIEIEFSKPVTRAFPVMLLVRFSEKPTPSDFLVKQIYFWDESIVQIYIPAASQKDASVGYLSLLDADYDRKPPNRYLAKAVNYTVHFQWIRCLFWDKREWKSERFSPQPGTSPEKVNCSYHRLAAFALLRRKLKASFEVSDISKLQSHPENLLPSIFIMGSVILYGFLVAKSRQVDHHEKKKAGYIFLQEASLPGHQLYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQLGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVERELTCLQGGLGFRKLFYCKFTEYLEDFHVWLSVYSRPSSSRYLHTPRLTVSFSLLCVYACLTALVAAGGQEQPHLDVSPTLGSFRVGLLCTLLASPGAQLLSLLFRLSKEAPGSARVEPHSPLRGGAQTEAPHGPNSWGRIPDAQEPRKQPASAILSGSGRAQRKAASDNGTACPAPKLQVHGADHSRTSLMGKSHCCPPHTQAPSSGLEGLMPQWSRALQPWWSSAVWAICGTASLACSLGTGFLAYRFGQEQCVQWLHLLSLSVVCCIFITQPLMVCLMALGFAWKRRADNHFFTESLCEATRDLDSELAERSWTRLPFSSSCSIPDCAGEVEKVLAARQQARHLRWAHPPSKAQLRGTRQRMRRESRTRAALRDISMDILMLLLLLCVIYGRFSQDEYSLNQAIRKEFTRNARNCLGGLRNIADWWDWSLTTLLDGLYPGGTPSARVPGAQPGALGGKCYLIGSSVIRQLKVFPRHLCKPPRPFSALIEDSIPTCSPEVGGPENPYLIDPENQNVTLNGPGGCGTREDCVLSLGRTRTEAHTALSRLRASMWIDRSTRAVSVHFTLYNPPTQLFTSVSLRVEILPTGSLVPSSLVESFSIFRSDSALQYHLMLPQLVFLALSLIHLCVQLYRMMDKGVLSYWRKPRNWLELSVVGVSLTYYAVSGHLVTLAGDVTNQFHRGLCRAFMDLTLMASWNQRARWLRGILLFLFTLKCVYLPGIQNTMASCSSMMRHSLPSIFVAGLVGALMLAALSHLHRFLLSMWVLPPGTFTDAFPGLLFHFPRRSQKDCLLGLSKSDQRAMACYFGILLIVSATLCFGMLRGFLMTLPQKRKSFQSKSFVRLKDVTAYMWEKVLTFLRLETPKLEEAEMVENHNYYLDEFANLLDELLMKINGLSDSLQLPLLEKTSNNTGEARTEESPLVDISSYQAAEPADIKDF

pkd1l1

Polycystic kidney disease 1 like 1

2742 amino acids

Component of a ciliary calcium channel that controls calcium concentration within cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with pkd2l1 in cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and gli2 transcription. Does not constitute the pore-forming subunit (By similarity). Also involved in left/right axis specification downstream of nodal flow: forms a complex with pkd2 in cilia to facilitate flow detection in left/right patterning.

Belongs to the polycystin family.

308.537 kDa

MFCLWIFSLAFLHLHLCSVSSSSLEGSGFFVGWINASSLQLFASIGGCDLSPCMDEGQEGMEALYRSEEPFQCSIRASASPGRRQAGRTCVRKVPGNLAVHCHLLSENEGLEEEDLLRITVMTPRGQSSLQVNVSHGGLLTACSDWIWNTSEKHKNNVPASGLHLGISLEVPCCTSCTRFGSDSELVEEQCSALHVSVSDVLVKDYICCLTPRDKDKTLNRTETPCLYSSNSLKDSLVRGRVYQMSFEECFRWHLLVVLLMLEAQYNHSQEVHEDPSSTVKLCDYAVRIHAEKQAYSTNTDIPLLAVVDILDPVEFLWDFGDFTSARANSRTITKRYTNPGIYKLVVVASWGQMSVRSHVLSLVVQRAVKLNRLVHEPSVLQNHTVTVSCRVNVGTNLTFLWNFGDGTVRTGLSTEQHVFTRTGEFRVMVIASNLVSSASLSSYLFVVDRPCQPPPVKNLGPPNIQVRRNEVVFLGVTFESELNCNVSRELHYSWTVYDSAGLTFPLPLTNTHRQSLVLQSYTLPYGIYKAIARVQIVGSVVYSNYSVRLQVVPNSVVVVIQGGTNIYVNTKSSNEVTLDGQASYDPDFPLNPLRYSWTCQPVSTISSSCFSQSIPTSYPVLKFPTSLLKSNFDQFKFTLTVHSGERSASSEIFLTLTSHLAGKLFVHCPECQGDQVSWDQSFSVRAECEDCNVSAEFIQYSWSLFRVNASSKPVAEIPFCYTVDLNAPSAVLENASTPTPAPEMSPSHHFNADWTRFTEDSLASSSPSRIYKSKNRNSELTDSPVSSVTVGFSGSESFNGPPGVDRGSSQFSNFPGQRDMFSEFQSDPESSAEWEFTFPYLESEDLRGQRGDSRVPFPRPEEGDPGISAGRPKETDMESFPSDSDSFSHSSSNKGEGSNLVDPRPSVRLQKPGLLDLHRDSVDKSLFESYTYTGISSCFLSFRSFSLKPSSTYMLELTAKSQRRFYGQTQLFLKVKPVPKGVACQVQPVRGIELYTHFSIFCTSGREDLIYTYSFSVGGRMPRILYQGRDFLYYFSLPSGDPTDDYKVIIYTEIRSSMYGSAKKLCPVTVRVEPSFVRNASSSYSHHEPDLMISDSGLRNVSVLVQLGNIAEIYNYISLLSTILNRLSLDSQANTHALKHLRNVLICIVCKLEYSAQASPADGIFILNELLRVTSQVTVQSARWVTAHVGALSVQFSESNRSILSALVSLLSSSLQVVTSSPETSDSADSPQPLESHLVTGKSRNAFVDDADHCITDLSETTYNKQSEPVPKRLMMRLVNDLLQTTSDLMLRNFDLQKTKELQVQSDLITLCAGFLNKTSTAINCGLITFFLPASLIKMLLLHDGISAKRGFSQREQPSCVQRIGMELLHNPYEWGRYPIQLKGPVADLSLYSCKTRRKIPVHSFLQPITVELRHPQKTSSMSEYTLLRSQINYHNFSITQEHLQQAVQVTVVFTAPPHMAFPVKILFRMFERPTPSMHHLHRLLNWRNNTILLTLPPSYLSAAGVGHLALLDANFGKTPTRRHLAEQISYSLTVESSLCLSWEDQQGSWTQNGCRAQTNDKTSAVNCSCHHLKPLKVLQQQIQSSHFRADLDQFLSVSRDLTVVFVLLLCVSLNIPVLVWCKKTDATSEENNRAHFLPDNSATDQHFYAVTVHTGLCSAARMSARVYVVLHGEDGCSQTKELHVPGCTLFRRNSQNTFILSVADSLGSVQGVHIWHNNSGPSPEWYLKQVQVSELMPGHMEGRSWQFISQCWLAVNKGDGQVERMLRVSTHGLTFSKMLFLKLFEYMPDYHIWMSVYTCPSPHLFTRAQRLCVCLLLFLGYACVNIIITHQRDDQLPFDLGVIDVTSVSIATGLVSVVAVLPVAMVISFLFRVKSGRMTLENYDNVFSKRPSGKTKYQDTDFLSVSTTNLENKDADDKEAVTPQRNKRRKDSVSFESIHELLFQEVLQVSRRRSLFLKKSKGNDSELSPQSSEFCGALKATKNEAQSVRVKRRYRLASLLYHCVAWTLCLLFCLSCLILSAVLGTRLNSGKILHWIHSLFVSLTFCFFVIHPATILVLAAVVSWRFKRSQDFHCFFNKMNSHLEDLKHQDPDQLRPSAFTRTRAPNAEKILEARQRARYLRRVHPPTRAELRKTRTKRKKQAVIHKMLRDLCLCGSMFFLMVCITYGSPVDEHYPLNAAFRRHFIRAHGDDFMSIKKYEDWWKWAQTSLLSSLYYNESENPQMSFISIGAPLVQKTEVCGTFHSQVSMVTPPRPRYHTGSSSKQEVTVGLGYTRSEGASKLRLLHLSGWLSEQTVALKVQFSLYSPAPNLFSSVTLLSEQSSTGLLQSSATVQSVRLYHSPSMLDYTVMVWQLLFLLLSLVNLYHQTSTAAQHGLMGYWKTTSISVEVSLVIVSLVYYVHYVYHPTMVMEVAEQLRRNHREHVDVSTLANSEQFSRTLRGIILFLLAVKCVTVVRLNRILAPSMPLLSLSSLLWPAISGLLLLSIFSCMGRLLYIERTFHSIQTVLWHFWSLRKSRDLISLWRDFYYFGLLYASSAMLTTMVFAVMIRKAKRSPSTKNDPTIREVLGCISQKFTGMKTQIPDCHTQKTYFLEECESLVDELLFKLNALSNSLHHTLPPKLHTYTDKDSPDASSTTELCKERLQDLVRSLSVGQGEAALTFPHDRSLLELQEEEEVKHQEGRCSVGCKESRLPETLWTADYRESMDEHWTEKKSSNGLGGATYSHVVVVEALVHHEQGTKN

Pkd1l1

Polycystic kidney disease protein 1-like 1

2615 amino acids

Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.

Belongs to the polycystin family.

290.844 kDa

MDVDEDQHAVAVLHHKIQANPELCVSDEQDSCPSDAPKGTARDPESQKPSSPAPWDKNVLNTGSEERLSFINGEPQAPPNWDEGTNSFSNPPPGISHTCNLSASWYHPESSSPLTQHPPRATLVTQPENVEHFAICCFPETDAQALPALGIRVHVASGTALCLLLDFGDNCGAQMRLCTLAGATTVTGYHQYRKEGVYELKAVVHDFHRAEELGPYYVDISHGNVSVFMNSSSIHDSEALSFADSLPQQRGTVVVHCFSSISSYNVSFISQTQVASGQAWCGVTVGYKMQSVSVYTNGTVFAANTNITFVAITEETIPLEFAWYFGENPPVMTTSRSIRRRLSVPQWYRVKVKATSRIGSVVSEPHLIRVQKRIMANRLVSTASALVNANVSFECRLNFGTDVAYLWNFGDDTIELGSSSSSHVYSREGEFTVEVLAFNNVSSTTLRKQLFIVREPCQPPPVKNMGPAKVQIWRSQPLRLGVTFEAAILCNISQGLSYTWSFVSAEMTTVTLPTAVNTRRQTIMLPSYTLECGNYTAIAKVQIKGSMVYSNYCVGVEVRARAPVSVISEGTHIFISTATSTFIILRGAQSYDPDNPGAALRYHWTCTAASSPRWPCFDNSTSYQVDTQAPAISFPAKWLSECCDQFLVTLTVSSRGQNSSQALMFLSTRPDLAFRFVHISWVNFRDISVNWNEEVSLRAVCEDCGDVPDLTYSWDLFLVNATEKSAVEVPFCSTVGLLGALALGTSLKSSKSDLPSNLRAPLTPHSPEPSPTPLGWTALSNLGSISAESTAGGHHVPASGAVAGSGEPMEEYSSLSSLAEEALMTNSSEGSWPSPSSSTDFDDFEAYYSDIQEAVLSLGRQPGTSTNFQEAGPSLSAEESASYGDNLLGPFLHTGRAKPTLMIDWPKALVSQAAFHGYTTSGIMGPAVTIKPFSLSSGKTYVLQASVASKHVLLGKAQLYLTVNQAPQDMSCQVRPHHGMEAYTIFSVFCMSGKPDFHYEFRYRIGNTSSHTLYRGQDTQHYFLLPAGDSSDNYKVIVSTEITDGHGSKVQPCTVAVTVLPRYHGNDCCDKELYNSTLESLSTLRLAGSYMETRNYITMITGILSRLYVESRNTSSCGQWSQIQDVLISSACKVPYTDQEGMMDSIHILRDLISFPNKLSLTSAMCIFKYTKMFLAQGQFSRRLLVDKKLRVEFVLLISGVWEAAKEDARDGDYLQEEGMKIISDMLLACLSDEHQIHVSTGQMEFQTLLHRSPQSSIQNLGFVQVHFPSDLASLHSTTQEATQSSCYISQLMFFMKSPYLGGQVPGQVGGVMIPRLYSCESRRPILRGQLETPVTMEFGEEDYLHKRNPAMFVLLRDEVNVHRFTGLSENSQESLQIHIKFSKPVTRPFPIILLVRFSEKATPSDFLVKRVYFWDEQTVQMYVPAAPWKGANVGYLSLLDADYDRKPPNKYLAGAVNYTVHFQWIQCVFWDKTEWRSEGPYPQPGSSPEKVNCSYHHLAPVSVLRRKLNATLEVSSISEFQSHPHNLLPGIFSAFLLVLYGILVSKSRYVDCHEKKNPGFIFLEEDTLPGYQLYAVVIDTGFRSPVRFTSKVFIVLCGENGCSETKELCCPEKPLFGRNSRHTFILSIPNQLGPLQKIRLWHDSSGSSPCWFISHVMVKELCSGQAWFFSAQCWLAVSKLGGHVLREFFCLSHGLGFWKLFYSKFTEYLEDFHIWLSLYSQPPSRSYLHTQRLAVSFCLLCVYSCLTALVTVRDHQQRPLDVGPTAITLEPFCMALLCTLLACPVAQLLSLLFRCSKEARGDMQASTQWPLRGVKTETPQGHDSSGRPDSRQPSPHPTSDLLPWNDQAWRIAASSSAVVCSPFPMEACSHKHHDLREKSHYSPPSSQAPGSGFEELGSQKSRVCLLWSSSVAWAISGSASLACGLGTGFLGYWFVPAQCMWWLYLLLLSLVCCAFITQPLMICLAALVFAWKRKHDSKFFTESLQDATKGLDLELEEHSRTRVPLSPISYSPDTAEEAERVLATRQRERHLRWAQTPSKAKLRVTGERLRRESIMQAALRDMTTHSIMLLLLLFIAYGRFCPGEISLNHAIRKAFTRKANHSLGDLSSTEDWWDWTLSTLLDELYPERTSARAWGAQPGALGGQCHLIGPPVVKLLKISAGTACTPPRPFSELVEDVLPMHSNDLDLENQNVSPGGPETCGVKKESYMHSLGKTRHEAHAALTALRASKWIDHSTRAMSVHFTLYNPPTQLFTSVILGTECLPSGGLVPSFLVESFRIFYSDSALKYLLMLSELLFLVLNVIHLCFQLWGMTTKGILSYWRKPRHWLELSMVGVAIAYYAASGHLTTLAVNITDQFHKGLYQRLVDIGLMVSWHQRARCLQGILLFLWMLKYVHLLSSLSTMTPFSAVTCFPLFRVLLVGALLLAAHYHSRWFLLFTGTLSHGTSAEAFPGLLLQFPGRSKKDSWHNCLKSDHGVMRCYYGTLFLLLATLGFRMLRATFLTVFQNRKSSHRKPLVTLKDIAVYTWHKVLTLLGLETTLEETEVATDHIYYLDEFSSLLDELLMKIDGLSDSLELSILENQWKRALESRAGDSPPVGSSEYQATGVSGPLAAESE