PIM1

Lon protease homolog, mitochondrial

1177 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

129.478 kDa

MIDNKVSVCSVGKVVITEVATFASHPLYIDRKTALTMIRSTRAASRLRLGARYYASHAPYGVLSEHLKRTPRTNSQHYYPPPQGAHDLPKVSSMGDSIASIVRGRELWVQEKDKSDKPEKSDKPDKTDKTDKDKPEKQDKDKTDKPEKTKVSHTPSSTASTGAGEAAAPPSAPPSGSGSSSSSGGGSPPAKKKKSPAQTYPEILAVPISDRPLLPGFHRALVIRDPNVMKAIDEMITRGEPYLACFFLKEFSNADVIQDASEVHDIGVIAEIQIQSQDHKRSTVDASNEPVYVLILYPHKRVRLNSLKNPPSSGGAVSYASVSEDVAEDGELLLTSKDLEGYSEEFLEAREEAKKAKSGKTEDSKHDSKVTSKDGKETTEKYDSSTLQESPYSFLSTYDVSTAAISLIEDKPHDKNNRVITTLTNEILNVFKMLRAEDATLREQLSSVVGDILRTEPAVLQEPGRLADFAAALCAGEGKEIQAVLTALDLETRLNRALILLKREHTNAKLQQKIARDVENKLNSKHKKFLLTEQMKAIKKELGVDDGKEKLVEKFNERAEKLDMPENIQKVFEEEMTRLQSMEPSSSEYSVTRNYLDWITQIPWNKTTEDRFNLPQAKDVLDSEHYGMKEVKDRILEFIAVSRMKGGLTGKILLLQGPPGVGKTSIGKSIAKALNRQFYRFSVGGTNDASEVKGHRRTYVGAIPGRLVQALKQTQTENPLILIDEIDKLSSSRTQGDPGAALLEALDPEQNNAFLDHYLDVPIDLSKVLFVCTSNDLSTIPWPLLDRMEVIEMSGYVPDEKLNIANQYLVPQSKKETGLENVNVQVTDDAINALNRQYCRESGVRNLKKHIEKIFRKVVVKIVGEYGQDEVAAEKIIDVEPVEKDKESAEKKTTKSKSKEVNEEPAAKEEKDKATESAESSETKVGTKAPPVTVPEDYSLTIDEKDLYDYVNSPPYSSDRMFEDPPPGVVMGLAYSPLGGSALYIECILDGGLSADSSARLSSTGNLGNVMKESTNIAYSFAKSFMIRNFPANRFFERAGIHLHCPAGAISKDGPSAGCAVVTGLLSLALNHPIDSSISMTGEISLTGKVMKIGGLREKAVGAHSAGAKTIIIPKDNSGDWDELPDTVKEGLTPVFAGTYQDVYDVVFQGLDTKVAAEVWKKQFDLIDRKLDKRGSK

PIM1

Lon protease homolog, mitochondrial

1133 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner (PubMed:15870080, PubMed:16428434, PubMed:8146662, PubMed:8276800, PubMed:8354406, PubMed:8810243, PubMed:9405361, PubMed:9724747). Endogenous substrates include ABF2, ACO2, ILV1, ILV2, LSC1, LYS4, MGM101 and several oxidized proteins. The 2 nucleic acid-binding proteins ABF2 and MGM101 are protected from degradation by PIM1 when they are bound to DNA (PubMed:16428434, PubMed:20150421, PubMed:28377575).

Belongs to the peptidase S16 family.

127.112 kDa

MLRTRTTKTLSTVARTTRAIQYYRSIAKTAAVSQRRFASTLTVRDVENIKPSHIIKSPTWQEFQHQLKDPRYMEHFAQLDAQFARHFMATNSGKSILAKDDSTSQKKDEDVKIVPDEKDTDNDVEPTRDDEIVNKDQEGEASKNSRSSASGGGQSSSSRSDSGDGSSKQKPPKDVPEVYPQMLALPIARRPLFPGFYKAVVISDERVMKAIKEMLDRQQPYIGAFMLKNSEEDTDVITDKNDVYDVGVLAQITSAFPSKDEKTGTETMTALLYPHRRIKIDELFPPNEEKEKSKEQAKDTDTETTVVEDANNPEDQESTSPATPKLEDIVVERIPDSELQHHKRVEATEEESEELDDIQEGEDINPTEFLKNYNVSLVNVLNLEDEPFDRKSPVINALTSEILKVFKEISQLNTMFREQIATFSASIQSATTNIFEEPARLADFAAAVSAGEEDELQDILSSLNIEHRLEKSLLVLKKELMNAELQNKISKDVETKIQKRQREYYLMEQLKGIKRELGIDDGRDKLIDTYKERIKSLKLPDSVQKIFDDEITKLSTLETSMSEFGVIRNYLDWLTSIPWGKHSKEQYSIPRAKKILDEDHYGMVDVKDRILEFIAVGKLLGKVDGKIICFVGPPGVGKTSIGKSIARALNRKFFRFSVGGMTDVAEIKGHRRTYIGALPGRVVQALKKCQTQNPLILIDEIDKIGHGGIHGDPSAALLEVLDPEQNNSFLDNYLDIPIDLSKVLFVCTANSLETIPRPLLDRMEVIELTGYVAEDKVKIAEQYLVPSAKKSAGLENSHVDMTEDAITALMKYYCRESGVRNLKKHIEKIYRKAALQVVKKLSIEDSPTSSADSKPKESVSSEEKAENNAKSSSEKTKDNNSEKTSDDIEALKTSEKINVSISQKNLKDYVGPPVYTTDRLYETTPPGVVMGLAWTNMGGCSLYVESVLEQPLHNCKHPTFERTGQLGDVMKESSRLAYSFAKMYLAQKFPENRFFEKASIHLHCPEGATPKDGPSAGVTMATSFLSLALNKSIDPTVAMTGELTLTGKVLRIGGLREKAVAAKRSGAKTIIFPKDNLNDWEELPDNVKEGLEPLAADWYNDIFQKLFKDVNTKEGNSVWKAEFEILDAKKEKD

pim1

Lon protease homolog, mitochondrial

1113 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

122.528 kDa

MLRGQTLPWRAALQQVSRPFIPRPLLAPSRYNVTARSILNASRLHRSLPTSRAFSSSSIRRREKPPPGDEKDDPAQKEQKDANEEKDVERAPDARRKAADPSGKQGSSHEPGAPTSGFARRKEKAGADKEQRGLEEDSKKDGNAVEGKGNSSDTPSPIPVNGGSDSRPSGANNGGNEDGGKKGKKGSGEKALQKPSVPEVYPQVMAIPIAKRPLFPGFYKAITIRDPNVAAAIQDMMKRGQPYVGAFLFKDENADGDVIENLDDVYDVGVFAQITAAYPLRGEASGVTAVLYPHRRIKVSSLLPPSDAAKAGTTDEKTSERRGDVVASFEEGTAELAPKDHYEPTSFLRKYPVSLVNVENLAEEPYDKKSAIIRAVTSEIVNVCKEIASLNPLFRDQISAFYTDQFPGNLSDEPAKLADFAAAVSAGELNEMQEVLELMNIEERLPKALVVLKKELMNAQLQSKISKDVEAKIQKRQREYWLMEQMKGIKRELGIESDGKDKLVEKFKEKAEKLAMPDAVKKVFDEELNKLAHLEPAASEFNVTRNYLDWLTQIPWGQKSVENFGIQHAVKVLDEDHYGLKDVKDRILEFIAVGKLRGTVEGKILCLVGPPGVGKTSIGKSIARALNRQYYRFSVGGLTDVAEIKGHRRTYVGALPGRIIQALKKCQTENPLILIDEIDKIGRGHQGDPSSALLELLDPEQNSSFLDHYMDVPVDLSKVLFVCTANVTDTIPRPLLDRMELIELSGYVADEKMAIAQRYLAPAARELTGLKEVDVNLTEEAVEELIKSYCRESGVRNLKKQIEKVYRKAAYKIVRDLGEDVLAEEKALTDEGKAVQEESQKETESPDSKSPVDPEKSTTETPRVALKVPESVQLSIGKDSLTDYVGPPIFTADRLYDTFPPGVTMGLAWTSMGGAALYVESILENALTPQSRPGIDITGNLQNVMKESSQIAYSFAKSVMAKQFPENRFFEKAKLHMHCPEGAVPKDGPSAGITMATSLLSLALNHPLDPTIAMTGELTVTGKVLRIGGLREKTVAARRAGAKKIVFPADNMSDWLELPENIKEGIEGHAVGWYSEVFDLLFTDLDKGAANHVWQKQLAEKPEKKSNEVEEDE

PIM1

Lon protease homolog, mitochondrial

1111 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

124.188 kDa

MLRSSRSRLVTRNILLRQFKNGNNVRLMNATRFQHNGIVGNEKLASDSQKFVDESYHWMQYRKQMNDPVSRQRLEQLESQWVKSIQLKQDDKGKDIDQPESENRKKEEEQVPTEEKDNDTAKESETSQQRDSVAETQGPASTSGGASGNGESSGNGSGDDGNNGSGNGKPSKNAKQPFPEVYPQVMALPISRRPLFPGFYKAVVISDERVMKAIKDMSDRQQPYIGAFLLKDSTVDTDVIHKADEVYNVGVFAQVTSAFPSKDEKTGAETMTALLYPHRRIKLDELIPPTSEQNLKDESDVSKSEGVENNEQEVVKASLQKMENMKDVEEDDDENLTGFLKDYDVSLVNVSNLADKEFNPNSPVINALTSEILKVFKEISQLNTMFREQIATFSASIQSATTNIFEEPARLADFAAAVSAGEEEELQEILESLDIEQRLEKALTVLKKELMNAELQNKISKDVETKIQKRQREYYLMEQLKGIKRELGIDDGRDKLIESFKDRVSKLQLPETVQKVFDDEITKLATLETSQSEFGVIRNYLDWITSLPWGIISKEQYSIPKAKKILDEDHYGMKDVKDRILEFIAVGKLLGKVDGKIICFVGPPGVGKTSIGKSIARSLNRQFFRFSVGGMTDVAEIKGHRRTYIGALPGRVIQALKKCQTQNPLILIDEIDKIGHGGIHGDPAAALLELLDPEQNNSFLDNYMDIPIDLSKVLFVCTANSLETIPRPLLDRMEVIELTGYVAEEKVKIAENYLSPSAKKSAGLDNANVNITENAIVSLMKHYCRESGVRSLKKHIEKIYRKAALNVVKQLSIDDKPMENEEVKDQKDIKVKQSENKSSAEASTVESTTEENELIKTQKSHDNKGSLEVPETVSVTVDENNLKDYVGPPIFTTDRLYESTPPGVVMGLAWTSMGGCAMYVESVLEQPLTHSTQPTLERTGQLGDVMKESSRLAYSFSKMYLAKKFPENRFFEVAKIHLHCPEGATPKDGPSAGVTMASSFLSLALNKGLDPTVAMTGELTLTGKVLRIGGLREKAVAAKRSGAKTIIFPKDNLSDWAELPENVKEGLEPLAADWYEDVFQRLFGDVDTNKGNTVWSEDFKKIDEKRNKETK

pim1

Lon protease homolog, mitochondrial

1108 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

121.963 kDa

MLRGQSLPWRAALHQTPRPTVLRPLLPFARNNGPVRSNLSISRLSRSPSLSPRAFSTSSIRRKEKPPSDEKEDSNLQEQKDPNEQKDSDRSPEGRRRSPDSTGREPGAPTSASGRRRDKVAGEKEQRGVEEDAKKENVSIEGKSDPTEDPSPIPVNGGGSSDTKSSASNGGNEDGGRKGKKGSGDRALQKPSVPEVYPQVMAIPIAKRPLFPGFYKAITIRDPNVATAIQEMMKRGQPYVGAFLFKDENADGDVIENLDDVYDVGVFAQITAAYPLRGEASGVTAVLYPHRRIKISSLLPPGEQSKAGNTEDKAPEKKGDVVASFEEGVAEPAPKDLYEPTSFLRKYPVSLVNVENLAEEPFDKKSAIIRAVTSEIVNVCKEIASLNPLFRDQISAFYTDQFPGNLSDEPAKLADFAAAVSAGELHEMQEVLEIMNIEERLPKALVVLKKELMNAQLQSKISKDVEAKIQKRQREYWLMEQMKGIKRELGIESDGKDKLVEKFKEKASKLAMPDAVKKVFDEEINKLAHLEPAASEFNVTRNYLDWLTQIPWGQKSVENFGIKHAMTVLDEDHYGLKDVKDRILEFIAVGKLRGTVEGKILCLVGPPGVGKTSIGKSIARALNRQYYRFSVGGLTDVAEIKGHRRTYVGALPGRIIQALKKCQTENPLILIDEVDKIGRGHQGDPSSALLELLDPEQNSSFLDHYMDVPVDLSKVLFVCTANVTDTIPRPLLDRMELIELSGYVADEKMAIAERYLAPAARELTGLKDVDVNLQKDAIEELIKSYARESGVRNLKKQIEKVYRKAAFKIVQDLGEEVLGEDKALTDEGKAAQEESKKETEEGDPKDPPADPEKSTTETPRLALKVPESVHLSIGKDSLTDYLGPPVFTADRLYDTFPPGVTMGLAWTSMGGAALYVESILENALTPESRPGIDITGNLQPVMKESTQIAYSFAKSVLAKQFPENKFFEKAKLHMHCPEGAVPKDGPSAGITMATSLLSLALDHPLDPTIAMTGELTVTGKVLRIGGLREKTVAARRAGAKKIIFPADNMSDWLELPENIKDGIEGHAVSWYSEVFNILFAELDKDAANKLWQKQLAGKPKKGPLEEDD

pim1

Lon protease homolog, mitochondrial

1107 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

121.2 kDa

MLSRQRIPRILASRTSLAHSIRSFTSTTSSIRPVAAAGQHAVTRPRHERPTNLSSFSTYTALGKKNDKGFFDNSIEPLSEEERKANVEHAEAEAKEAESKQAKSKSSTSDAPPPAPEDGKAGAAGGSSAGSGSGADGGSGDGGKRGRKPGDKALAKPVVPEIYPQVMAIPIAKRPLFPGFYKAITIKDPNVAAAITEMIKRGQPYVGAFLFKDENADDDVIRNRDDVYDVGVFAQITSAFPMNNQNGEGASLTAILYPHRRIKLSELIPPGSPEAASIDGAKEGAAPEPVPEPIPKVTDESEQKGDVVASFEESAVTPRPEPSQKPYEPTSFLKKYPVSLVNVENLTEEPYDPKSQVIRAVTNEIVNVFKEVASMNSLFRDQISTFSMSQSTGNVMAEPAKLADFAAAVSAGEPAELQEVLSSLNVEERMHKALLVLKKEHVNAQLQSKITKDVEQKITKRQREYWLMEQMKGIRRELGIESDGKDKLVEKFKELADKLAMPEAVRKVFDDELNKLAHLEPAASEFNVTRNYLDWLTNIPWGQSSAENFDILNAVKVLDEDHYGLKDVKDRILEFIAVGKLRGTVEGKILCFVGPPGVGKTSIGKSIARALGRQYYRFSVGGLTDVAEIKGHRRTYVGALPGRVIQALKKCKTENPLILIDEIDKIGRGYQGDPSSALLELLDPEQNGSFLDHYLDVPVDLSKVLFVCTANLTDTIPRPLLDRMEVIRLSGYVADEKMAIAEKYLAPQAQEMAGLKGVDVQLTKDAIEELNKSYCRESGVRNLKKKIEQVYRKSALKIVQDLGEQALPESEALTEEGKAAQEETEKKKSEEAASGETSSPKAATEASEKETTEKPRVAMKIPEGVHVVINKDNLKDYVGPPIFTSDRLYDVTPPGVTMGLAWTSMGGAAMYVESILQSALTSKSAPSLEITGNLKTVMKESSAIAYSYAKAVMAKDFPKNRFFDKAKIHVHVPEGAVQKDGPSAGITMTTSLLSLALDTPIDPQIAMTGELTLTGKVLRIGGLREKTVAARRAGCKMVVFPEDNMSDWLELPENVKEGIEGRPVRWYSEVFDLIFPKLDREKANKSRIIEDDKSEKEESKKKNDDDE

PIM1

Lon protease homolog, mitochondrial

1104 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

120.467 kDa

MLPLRAFARLAQRPRLSRPTQLARSSLPRPSPSRPAAHYLALAPAPSTRFLHSSPPVLKEKRWLNNTPPEDDGEDGQNPKQDDQVEKPLPDAESSKSAEERAKSQSSKPDIKASSSDSVSSSAPAPGSADGGSPPGAGGPKEVAKPVIPEIYPQVLAIPITHRPLFPGFYKAVTVRSPPVIKAIRELQAHGQPYVGAFLLKDSTVDSDVVTDINQVQPVGVFCQITSCFTSQEGEGKPEALTAVLFPHRRIKINELVKSSGTKGDGTVGVGGLVEGSQDSAKGEGEVKSFESEVPGVEEVREELGTVSIDSEQPDVHKENRDLETKEVTQIDFLHSLLPQVSLTNVSNLSTEPYEKDSQVIRAIMSELISVFKEIAQLQPMFREQVTSFAISNTSSQVFDEPDKLADLAAVVSTADVSDLQAVLSSTSIEDRLQRALVLLKKELINAQLQFKISRDVDTKIQKRQREYYLMEQLKGIKKELGMESDGKDKLVEGFKEKASKLAMPEGVRKVFDEELNKLVHLEPAASEFNVTRNYIDWLTQVPWGVHTPENYNISHAIKILDEDHYGLKDVKDRILEFMAIGKLRGSVEGKILCLVGPPGVGKTSIGKSIAKALGRQFFRFSVGGLTDVAEIKGHRRTYIGAMPGKPIQALKKVATENPLILIDEVDKISKAYNGDPASALLEMLDPEQNKSFLDHYLDVPIDLSKVLFVCTANVLETIPGPLLDRMEVLEVSGYVSAEKMNIAERYLSPQAKVAAGLEDVNIELEPGAIEALIRYYCRESGVRNLKKHIDKIYRKAAFKIVTDLGESGLPEPATPPAENQVEAQYPDIKPASELTSNVIPGTEVSGVDTKTDVTTVPREPMKVPAGIHVKVTQENLKDYVGPPLYHKDRLYTHSPPAGVSTGLGYLGNGSGAVMPVEINSMPGKGNLQLTGKLGEVIRESAQIAMSWVKSNAYLLGITKSEAEATLNDRDVHLHMPEGGIGKEGPSAGTAILTAFVSLFTKTRVDPDIAMTGEISLLGQVLPVGGLKEKILAAHRAGIKKLIVPAGCKPDIDENVPESVKGGIEFVFVEDVRQVLHEAFRGTEVEKRWQETLPMEEEPQRERH

PIM1

Lon protease homolog, mitochondrial

1104 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

120.556 kDa

MLPLRAFARLAQRPRLSRPTQLARSSLPRPSPSRPAAHYLALAPAPSTRFLHSSPPVLKEKRWLNNTPPEDDGEDGQNPKQDDQVEKPLPDAESSKSAEERAKSQSSKPDIKASSSDSVSSSAPAPGSADGGSPPGAGGPKEVAKPVIPEIYPQVLAIPITHRPLFPGFYKAVTVRSPPVIKAIRELQAHGQPYVGAFLLKDSTVDSDVVTDINQVQPVGVFCQITSCFTSQEGEGKPEALTAVLFPHRRIKINELVKSSGTKGDGTVGVGGLVEGSQDSAKGEGEVKSFESEVPGVEEVREELGTVSIDSEQPDVHKENRDLETKEVTQIDFLHSLLPQVSLTNVSNLSIEPYEKDSQVIRAIMSELISVFKEIAQLQPMFREQVTSFAISNTSSQVFDEPDKLADLAAVVSTADVSDLQAVLSSTSIEDRLQRALVLLKKELINAQLQFKISRDVDTKIQKRQREYYLMEQLKGIKKELGMESDGKDKLVEGFKEKASKLAMPEGVRKVFDEELNKLVHLEPAASEFNVTRNYIDWLTQVPWGVHTPENYNISHAIKILDEDHYGLKDVKDRILEFMAIGKLRGSVEGKILCLVGPPGVGKTSIGKSIAKALGRQFFRFSVGGLTDVAEIKGHRRTYIGAMPGKPIQALKKVATENPLILIDEVDKISKAYNGDPASALLEMLDPEQNKSFLDHYLDVPIDLSKVLFVCTANVLETIPGPLLDRMEVLEVSGYVSAEKMNIAERYLSPQAKVAAGLEDVNIELEPGAIEALIRYYCRESGVRNLKKHIDKIYRKAAFKIVTDLGESGLPEPATPPAENQVEAQYPDIKPASELTYNVIPGTEVSGVDTKTDVTTVPREPMKVPAGIHVKVTQENLKDYVGPPLYHKDRLYTHSPPAGVSTGLGYLGNGSGAVMPVEINSMPGKGNLQLTGKLGEVIRESAQIAMSWVKSNAYLLGITKSEAEATLNDRDVHLHMPEGGIGKEGPSAGTAILTAFVSLFTKTRVDPDIAMTGEISLLGQVLPVGGLKEKILAAHRAGIKKLIVPAGCKPDIDENVPESVKGGIEFVFVEDVRQVLHEAFRGTEVEKRWQETLPMEEEPQRERH

pim1

Lon protease homolog, mitochondrial

1104 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

121.838 kDa

MLRGQTLRWRAALQTPRSLILRPLFAPGGYNVGPRSVLETSRRFRSLPPSLRTFSSSTARRKEKPPPGDEKEDSNKKENKDNDDGTEDKEVERDPRRKQADSSGKHGSSVDPGAPTSGFARRREKAADRDQRSVTEDAKREAEAKGNSSDTPSAIPVSDSSSESKPSGSHNGGDDGGKKGKKNDKALQKPSVPDVYPQVMAIPIAKRPLFPGFYKAITIRDPNVATAIQEMMKRGQPYVGAFLFKDENADGDVIESTDDVYDTGVFAQVTAAYPLRGEQSGVTAVLYPHRRIKISSLIPPGDSTKSGNSEDKTTEKRGDVVASFEENAAELVTKDHYEPTSFLRKYPVSLVNVENLTEEPFDKKSAIIRAVTSEIVNVCKEIATLNPLFRDQISAFYTDQFPGNLSDEPAKLADFAAAVSGGELHELQEVLESMNIEERLPKGLVVLKKELMNAQLQTKISKDVEAKIQKRQREYWLMEQMKGIKRELGIESDGKDKLVEKFKEKAEKLAMPEAVKKVFDEELNKLAHLEPAASEFNVTRNYLDWLTQIPWGQKSVENFGISHATDVLNEDHYGLKDVKDRILEFIAVGKLRGTVEGKILCLVGPPGVGKTSIGKSIARALNRQYYRFSVGGLTDVAEIKGHRRTYVGALPGRIIQALKKCQTENPLILIDEVDKIGRGHQGDPSSALLELLDPEQNSSFLDHYMDVPVDLSKVLFVCTANVTDTIPRPLLDRMELIELSGYVADEKMAIAQKYLAPAARELTGLKNVDVTLTEEAIEELIKSYCRESGVRNLKKQIEKVYRKAAFKIVSDLGEDVLAEDKALTAEGKAAQEESEKETGPIESTSEQEKATTENPRVALNVPDSVHLSIGKDSLTDYVGPPIFTTDRLYDTFPPGVTMGLAWTSMGGAALYVESILENALTPESQPGLDITGNLQNVMKESTQIAYSFVKSVMAKQFPENRFFEKAKLHMHCPEGAVPKDGPSAGITMATSLLSLALNHPLDPTIAMTGELTVTGKVLRIGGLREKTVAARRAGAKTIIFPADNMSDWLELPENIKSGIEGHAVSWYSEVFDILFADLDKQAANRVWQKQLSKEPKKSNDKDDH

PIM1

Lon protease homolog, mitochondrial

1086 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

120.08 kDa

single

MLRTSCTSSLRRVVGKYVVSPLVASQIRFATSSVRSQPYLLNSELTELPAQFKRYSSILLTEKPEGDVPESGPEPSGESGISEKSNVENDKHDGNDEIKPEAEKNEKDEIEKPEIDKDAIVETDGVSESSVENVSGSSSAAGGASAPPSGNSNNNNNNNNNNNDNDEPNEIVTNAGTGLYPPLLAIPMKDRPPLPGRPFAINITDPEVIRSIYTIIDKREPYFVLFHVKDPNEGDTDVINSKDSVYNIGVHCQIIRHTTPRPGVFNVLGYPLERCSLADLSTPSEKKGETETRKEGENFPTSYLKGLKVSYATVKPVKDEPFDKTSTDIKSLVESLKALLSKMGAKNPLEKLQIKEGTELVNDPPRFADFVGSTIHGDPKKIQEILESLNIQTRLSKALELLKVELKASLIKENTIHNLSTKADEYQTRLFIKEFIKELQKRAGIVESDDKKTSKFDERLKHLKMTEEALEAYNAEKAKMESQNEHSSELGVSERYLDWLTSIPWGIYSKDRFNIKQAREILDRDHYGLKDVKDRILEFISMGRVSGKVDGKILCLTGPPGTGKTSIAKSIAESLNRKYVRIAMGGIQDVHEVKGHRRTYVGSIPGRIISALKQAKTSNPLMLIDEIDKLDLSRSGGASSAFLEILDPEQNNAFVDNYIDVKVDLSKVLFVCTANYLGNISPPLRDRMEIIEVNGYTNNEKIEIAKRHLIPDAAKKAGLEGGHVVIETKTISRLIEKYCRESGLRNIKKLITRIFSKASLKIVEEVEAREGESKSKSEEAKSEAITGSVTEISVEDATVKAQSIEEPSVESASQKVDEAKPVESEELKSDEEEEEVVKLEIPDDIKLEITSANLKDYVGPEIYTRDRVYDIPPPGVATGLSYSTSGNGDALYIESILTHSIGSGSGHASIHVTGSLKDVMKESASIAYSFAKSYMVKNYPENRFFEAAEIHVHCPDGAIPKDGPSAGISFTSSLISLALQKPLPPTIAMTGEITVTGRVLAVGGLREKILGAKRYGCNTIIFPKDIENELEEIPEEVKEGVKFIPVEWYQDVFDEIFPNLSSDEGNEVWKEEFNKLDKKKASNKKK

PIM1

Lon protease homolog, mitochondrial

1079 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

119.97 kDa

MLRPRTYVRKLAWRCPRKSQLGLRLATSVSSHKSLPLPMNFDISHSQSAFRAYQDIIHRNKSVGDDEPSQRSENENNPSESDKDSNQDPETPKKDKESENDKEPEKEKDIENDNKVSSESNENVTLASSNTGGAAPPNGNNNGDDPDDSNPSLPVDPVTGLYPPLLAIPMKDRPPLPGRPFAINVTDPEVIRSIYTIIDKREPYFVLFHVKDSNEPDTDVINKKDSVYDIGVHCQIIRHTTPRPGVFNVLGYPLERCKLEELTTPSSEKEAKSEEPSKEDAESFPTSYLKGLNVSYATVKPVEDEPYDKSSAEIRSLVESLKTLLSKMGGKNPLEKLQIKEGTDLISDPSKFADFVGSTIHGDPKKIQEILETLNIETRLSRALELLKVELKASLIKESTIHNLSTKADEYQTRLFIKEFIKELQKRAGISESEDKKTSKFDERLKHLKLTEEAMEAYNAEKAKMENQNEHSSELGVSERYLDWLTSIPWGVYSKDHFNIKQAREVLERDHYGLKDVKDRILEFISLGKVSGKVDGKILCLAGPPGTGKTSIAKSIAESLNRKYVRIAMGGIQDVHEVKGHRRTYVGSIPGRIISALKQAKTSNPLMLIDEIDKLDLSRGGGAASAFLEILDPEQNNSFVDNYIDVKVDLSKVLFVCTANYLGNIPAPLRDRMEIIDVSGYTNNEKIEIAKRHLIPEASKKAGLETNHVSITNETISRLIEKYCRESGLRNVKKLITRIFSKASLKIVEEIEAKEALDSSKEKEGVTASSEEANVNSESTKSNTSQAEPVAESSTDISTKSKVASEKIETKEKKETNKENGQSEEDQQPEPKFVIPEDIKLEITPANLKDYVGPEIYTRDRVYEFPPPGVATGLSYSTSGNGDALYIESILTHSIGSGSGVPGMHVTGSLKDVMKESASIAYSFTKSFMAKNYPDNRFFEAADIHVHCPDGAIPKDGPSAGISFTSSLVSLAINESLPPTVAMTGEITVTGRVLPVGGLREKILGAKRYGCDTIIFPKDIENELEEIPDEVKDGVTFIPVEWYQEVFDKIFPNATAQKCNEVWKEEFAKLDSKKKNKKK

PIM1

Lon protease homolog, mitochondrial

1078 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

120.913 kDa

MIKASKCNKPRALFLVRVSIPRTFIRNATSAVPTTIKLNDLASLPPITKSLPTNLPFLMPDTLQSLLRFDSEKEKQPSTDKSNDKDKPSRKEKGKDKEKENEEKKDINMDEKYEINEETDTKPTIDPNNPVSSKSNISSSSGGDNNNNNNNNNNNNDSDGKNDDGSPKDKEFLSPSDSGLHPPFLAIAMKDRPFLPGATRHLHVSDPEVIKCVNHMINSNIKSPYFVLFHVRDTNSEDAALDVIKDRDFVHEVGTLCQIIKTTGSEILVYPHYRVKLVDISTPNSRSESIEKEQDNSQTSYLKKFEVSYAVTQQLKDEPYDEQSITINAWTRRIKELYEKLAPKYDQPENKEEIMSNPSMLADFIASKVHAKPEQIQEILESSNVETKLELSLQLLQVEADADEMRQTALKNIRERTEKAYAQSLIKEYTKELLKAAGIGENSKVHKFDERIKHLKMPEEAMKAYKTEKERLGTQSDMEQNVVERYLDWLTQIPFGVYTKDSFNVKKAREILDRDHYGLKDVKDRILEFISVGKISGNVDGKILCLAGPPGTGKTSIAKSIAEALNRKYTRIAVGGVQDVHDVKGHRRTYVASIPGRIVTALTQAKTSNPLMLIDEIDKLDTTSHGGAARAFLEILDPEQNNSFVDNFIEVKVDLSKVLFVCTANYLGSIPGPLRDRMEIIEVNGYTKNDKIEITKRHLIPAAAKKVGLDEGRVVIPDETISRLIDKYCRESGLRHIKSLINRIFSKASRKIVEELEETDVDSHNKDTVEGTLVAKESEKVISDKAKIDTENSPIEYIQSNTEVKAETTTESQQEQEKEKEKDEEIKKLDLPADLKIEVKPETLKDFVGPEIYIKDRLYETLNPGVATGLAYNTSGDGDALYIESILTDSISSDLGNAGLHVTGSLKDVMKESASIAYSFAKQFMVRQFPDNRFFEAAHIHVHCPGGAIPKDGPSAGIAFTSSLVSLALNKSLPNDTAMTGEITLTGKVLAIGGLREKSLGAKRAGYTKIIFPKDCEYQLDEIPDEVKEGLTYIPVEWYSEVFEHLFQGISKEEGNSVWKEEFAKLEDKKKSKKTNTK

PIM1

Lon protease homolog, mitochondrial

1073 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

120.378 kDa

MIKASKCNKARALFLVRTSIPRTFIRNATSAIPTTVKLKDLSSLPPLTKSLPTNLPFLMPDTLHNLLRFDSKKEKQPSTDKSNDKDKPSRKEKGKDKEKENEERKDINEDEKYDIKEETDSKPTIDPNNPVSSKSSISSSSGGANNNNNNDDSDGRDDDGSPKDKEFLSPSDAGLHPPFLAIAMKDRPFLPGATRHLHVTDPEVIKCVNHMINSNIKSPYFVLFHVRDTNSEDAALDVIKDRDFVHEVGTLCQIIKTTGSEILVYPHYRVKLVDISTPNSRSERIEMEQDNSQTSYLKKFEVSYAVTQQLKDEPYDEQSITINAWTRRIKELYEKLAPKYEQPENKEEIMNNPSMLADFIASKVHAKPEQIQQILESSNVETKLELSLQLLQVEADADEMRQTALKNIRERTEKAYAQSLIKEYTKELLKAAGIGENSKVHKFDERIKHLKMPEEAMKAYKTEKERLGTQSDMEQNVVERYLDWLTQIPFGVYTKDSFNVKKAREILDRDHYGLKDVKDRILEFISVGKISGNVDGRILCLAGPPGTGKTSIAKSIAEALNRKYTRIAVGGVQDVHDVKGHRRTYVASIPGRIVTALTQAKTSNPLMLIDEIDKLDTTSHGGAARAFLEILDPEQNNSFVDNFIEVKVDLSKVLFVCTANYLGSIPAPLRDRMEIIEVNGYTKNDKIEITKRHLIPAAAKKVGLEEGRVVIPDETILRLIDKYCRESGLRHIKSLINRIFSKASRKIVEELEDTDADPHSREIVEESLVAKENESVISDKAKKDAGSSSIESNDSNTEAKVSTTTENEKKQEQKQKQDEEIKKLDLPADLKIEVKPETLKDFVGPEIYIKDRLYETLNPGVATGLAYNTSGDGDALYIESILTDSISSDLGNAGLHVTGSLKEVMKESASIAYSFAKQFMVRQFPDNRFFEAAHIHVHCPGGAIPKDGPSAGIAFTSSLVSLALNKSLPNDTAMTGEITLTGKVLAIGGLREKSLGAKRAGYTKIIFPKDCEYQLDEIPDEVKEGLTYIPVEWYSEVFEHLFKGISKEEGNSVWKEEFAKLEEKKKSKKTHTV

pim1

Lon protease homolog, mitochondrial

1067 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

118.642 kDa

MITRLSGACLRRSGAKRNWPREHLVHRSLLASFSTTQRVLKCSVGPFRTSNVVFKSKEPKDNKPLDNKNDPKKTHNEDESHTNESLPSTDKKKKKDNDDFKQNLKSSSNKTEEKYSATQASKSKNDEFELGGEENEDEMPLNGEFNKNVPAKYSVPDVYPQLLALPIARRPLFPGFYKAIVTKNPSVSEAIKELIKKRQPYIGAFLLKDENTDTDVITNIDQVYPVGVFAQITSIFPAKSGSEPALTAVLYPHRRIRITELIPPKEDADSAASSDAAELETDKSSNLSSNGEVKSDLKQDNGKEEPEKEVESTPSILQNFKVSLVNVENVPNEPFKRQDPVIKAVTSEIMNVFKDIANVSPLFREQIANFSISQTSGNVFDEPAKLADFAAAVSAADHRELQEVLEATNIGDRLQKALYVLKKELLNAQLQHKINKEIEQKITQRHKEYLLTEQLKQIKRELGQELDSKEALVTEFKKRTESLSMPDHVKKVFNDELSKFQHLEPMAAEFNITRNYLDWITQLPWGKRSVENFDLDHAKEVLDRDHYGLKDVKDRVLELVAVGKLRGTMQGKIMCLVGPPGVGKTSVGKSIASALNREFFRFSVGGLTDVAEIKGHRRTYIGAMPGKIVQALKKVQTENPLILIDEIDKVGKSHQGDPASALLELLDSEQNSAFLDYYMDIPLDVSSVLFVCTANTIDTIPPPLLDRMEVIELSGYVSAEKVNIAKGYLIPQAKAACGLKDANVNISDDAIKGLISYYAHESGVRNLKKSIEKIFRKTSFSIVKEIDDELNSKEKSTGKSGKKTSPQSSEDAANKEASSVPLKVPDKVNIEIEEKDLTKYLGPPIYTSQRLYDTTPPGVVMGLGWTPMGGVSMYVETIVKNILSSNSTPSLERTGQLGDVMKESSEISYSFSKSFLSKHFPNNKFFEHARLHMHCPEGSISKDGPSAGITMATSLLSLALDTPVPATTAMTGELTLTGKILRIGGLREKTVAAKLSGMKEILFPKSNLADWEQLPDYVKEGLTGVPVAWYDDVFKRVFSNIDAEKCNNLWPNLIKSSSKQHQISPSH

PIM1

Lon protease homolog, mitochondrial

1058 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

116.15 kDa

MLTRIRNAGVGGNAARRVRLLAGYTGARMAHAAALNSTTGAGGAARAAGAGRRAHSDVHVWALRQQSGIHRGGQCILKQDREPDQSDDKKVPPRAEEGRDEEAVRDEEAERQPREEQANRSSEASSSRGSGGSASSAGGGGRSNPPSEGEVPRKYEELMVLPMSNRPLFPGYYKSVTVYDPAVIEAICGLLRRNIPYLGAFLLKDRSMDKDSIDSIEEVHRVGVFAQITSVHHGVDVDGRKAMSMVLYPHRRVQLDELVSTPKLVAEAKEKATDDGLVQAKKEKFRDMSEGGEEEENPTEFLLETGVTVGNFSDHLDLPVDHSSVMLNALTSETLNTFKHLSSINATVKQQLIALSSITTSLKPNIFESPSLLADFAAAISVGDPNELQDVLETRDVEQRLEKALVFIKKEVYVAELQQKIEKETDAKVQKRYKDQVLTEQMRGIKKEMGVEDAKDKAIATFRERAEKLKFPEHVKKIFDEELARLSGLESAMSEYSVTKNYLDWITSLPWGIASTDQYSILSARKVLDNDHYGMQDVKDRILEFIAVGKLKGQIDGKIICLVGPPGVGKTSIGQSISRALNRTFFRFSVGGMSDVSEIKGHRRTYIGALPGRLIHALKRCQTENPLILIDEIDKLGRTGHQGDPASALLELLDPEQNKTFLDTYLDFPVDMSKVLFVCTANTLDTIPRPLLDRMEVIELSGYVADEKVKIAERHLIPAAKKSTGLGSANINLTSDSIVALLKNYCRESGVRSLKKHIEKIYRKAALKIVQQLSIDDTPKSAPAETNIEPENGKPDASAKPLTNNLPAPEPLNIPDSVKIDITPETLVEYLGPPVFTADRIYEKTPAGVVMGLAYTYLGGCTMYVESVLGQPLSKDSNPSLEHTGQLGDVMKESSRLAYSFSKMFMSRRFPNNRFFEKAAIHLHCPEGATPKDGPSAGITMASSLLSLAMNKPLDPTIAMTGELTLTGKVLRIGGIKEKTVAAKRSGAKTIIFPKDNMADWEDLPAHVKEGLIPVAAEWYDDVFNVLFGSVTEEEGNNVWKDQFDLIERSKATASSSN

PIM1

Lon protease homolog, mitochondrial

1026 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

114.998 kDa

MLGTRVTRAVYTRAPLKLQLRALGLHRRYVHNGSKNDEGSSTSTTTNKEENDKKLPDVYPQMLALPISRRPLFPGFYKAVVISEPRVMKAITDMVERQQPYIGAFMLKDSNNDTDIIHDISEVHELGVLAQVTSAFPSKDEKTGKETMTALLYPHKRIKIDQLIPPKDVKIEDIVVEKVVDNEVASEETKDEETVDKTESATDKVSEEITEEIAKAPSTEVTEDPDNYENPTDFLKDYNVTLVNVSNLEDEPFDIKSPIINALTSEILKVFKEISQLNSMFREQIATFSASIQSATTNIFEEPAKLADFAAAVSAGEEEELQEVLESLNIEQRLEKSLLVLKKELMNAELQNKISKDVETKIQKRQKEYYLMEQLKGIKRELGIDDGRDKLVDTYKKRVEKLNLPENVQKTFDEEITKLATLETSMSEFGVIRNYLDWLTSLPWGINSKEQYSIPRARKILDEDHYGMKDVKDRILEFIAVGKLLGKVDGKIICFVGPPGVGKTSIGKSISRALNRQFFRFSVGGMTDVAEIKGHRRTYIGALPGRIIQALKKCQTQNPLILIDEIDKIGHGGIHGDPSAALLEVLDPEQNNSFLDNYLDIPIDLSKVLFVCTANSLDTIPRPLLDRMEVIELTGYVAEDKIKIAEQYLVPSAKKTAGLQNATVSMDEEAINALMKYYCRESGVRNLKKHIEKIYRKAALEVVKKMSIEDTEPLVSTSEEPQLSQTNQNISSSSAEDSTTDLEDSVNPDTAKEASKPNNSQEGASVEETKKAVKTEEEEDTSMIVPEDIKVEITPEDLKKYVGPPIYTTDRLYETTPPGVIMGLAWTNMGGCSLYVESVLEQPLHNCKHANLERTGQLGDVMKESSRLAYSFSKMYLSKKFPENRFFEKAAIHLHCPEGATPKDGPSAGVTMATSFLSLALNKPVDPTVAMTGELTLTGKVLRIGGLREKVVAAKRSGAKTVIFPKDNLNDWEELPENVKEGMEPLAADWYDDIYKRLFSGVKKSEGNNVWKSEFELIDKKKKEND

pim1

Protein pim1

539 amino acids

Promotes the exchange of Ran(spi1)-bound GDP by GTP. Involved in the control of mitosis. Regulates a variety of nuclear events, including mitotic check-point, chromosome decondensation and mRNA processing/transport.

58.349 kDa

MTSNRSTRSSTKREEVSKNGVEKRELDESDVMKNGKKPVKRAKVSSLPKPVRVPGSAKRINKIPELPTERLNVYVFGSGSMNELGMGEEEMDVVYRPRLNPILSTDKVGVVDLAVGGMHSAALSHDGRVYTWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALSHLRVTKVICSDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMRLPEICQLATGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISVGAGSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEHHTLALLEDGRVLAWGRDDRHQLGIPDNALPETVVKDEKGNNYYLSTPTIIPGLTNVIQVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLVRSKAIKEVAIRVAGAGGQFSIIAGIPNASEEPVANGIKSEPENEKKLKTEETSKTDDSPVTDAKPDVTSNGEPSTATSESKDSVLEPSSTTA

PIM1

Serine/threonine-protein kinase pim-1

313 amino acids

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3 protein binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis (By similarity).

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

35.63 kDa

MLLSKINSLAHLRAAPCSDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHDCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIVRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK

PIM1

Serine/threonine-protein kinase pim-1

313 amino acids

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3 binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis (By similarity).

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

35.686 kDa

MLLSKINSLAHLRTAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPSFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK

PIM1

Serine/threonine-protein kinase pim-1

313 amino acids

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

35.686 kDa

MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK

Pim1

Serine/threonine-protein kinase pim-1

313 amino acids

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3 binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis (By similarity).

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

35.451 kDa

MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSDFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEDLARGFFWQVLEAVRHCHNCGVLHRDIKDENILIDLSRGEIKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQVFFRQTVSSECQHLIKWCLSLRPSDRPSFEEIRNHPWMQGDLLPQAASEIHLHSLSPGSSK

Pim1

Serine/threonine-protein kinase pim-1

313 amino acids

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-protein binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis (By similarity).

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

35.631 kDa

MLLSKINSLAHLRAAPCNDLHANKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIVKGQVYFRQRVSSECQHLIRWCLSLRPSDRPSFEEIQNHPWMQDVLLPQATAEIHLHSLSPSPSK