PIKA

Gene

pikA

Protein

Phosphatidylinositol 3-kinase 1

Organism

Dictyostelium discoideum

Length

1571 amino acids

Similarity

Belongs to the PI3/PI4-kinase family.

Mass

178.472 kDa

Sequence

MNSIESSSNDSNEINKNSNKNNTHLNSNYNNIYKNNSTSSNNNNNHNNIEIIGIDNNKNNNKNNNDNNNNNNNIDKKRKDSKNKQNQEINQEMSENKKIYNSNDSNCSSGSSSGGHVNNGHHILIEENERLEHENQEIQEIYKQKGMEFQKKDLRFGYDVNSNNNNNNGGGSSSGSSSGGSDESASNQPIIRTRNREGSILNLKKQGLVKEISQRFQTPDTASYTRPNANNISIKDKISILKKEQERRKQDSEVQQREKVIVLSADSSNIQIYHPSVLIEKMNSKLDTEEKPATTTTTTTTTSTSISTSTPTTTTTTTTNTSTTNDITIKPKTSPTKNNEERSQSPITTPKQPVEEIVKKVSTPKSNNTSKKTSSDTTPTGKTTKKDKKDKKDKSRDSGNLVIVNNTNNTSSNNNNNNNNNNNNETIIKRRGRVLVTPSSDLKKNIQIYFTIPINPPVNKTNKPNQLLSNTSQQFLKTLISNEIPIDCKINDINDTDAFSDLSASASSSSFITKSSQSLLNVQSLRVKAIKTSFNILFLMPNQSKKILQVKGSDTIENLKERIISDYLFNNNSNNNNNNCKYGADSYLILDFNDNPMERSLVLNKSDYILDKRAQGLIPKLKVIEKSTILDSDPSDELSPSEYEIIRKLIPGTDTWRGEEVEYFRRVTSRLRYEALPLIKGSIQSTLLVRLSPLPIPIVGNKILISIFLPITQVTKTLDLELNETADQFTNRLFTKNYSKHLPNVNSNDFILKVVGSSDFIHGPHDIRTFESIRNHIIQGTKPQLTLIQRPKPELDPQPFKPRFDYPPELIIDHSCSNAINCNNNNTNSTNNNNINFDNWDQITHISIREIKKPFRVKVMGSTRIPLSCIKDIDSSSVIVSISLYHGIECFSKAFTQPIIPPPFAFLAETLSVDWCEWLVFTNIDYSNLPVDARLSISVYSANETVDDVEEIKNLDEATKKLTPIGWINVMITDFKYQLRQGMVELSLWPSDFSNPLGTCSNNPSSSQSVGLTLEFEEFNLPVLFPRKTKFSTSVSVIEQPPTNINSNEMREFFEQITALDPLSDLKQEKYNQLWTLRHYSILFPQVLPRLMLSVPWTQATAVDEAISLLDRWPKLKPYESLELLDAKHANRKVREFAVTCLEDLSEDELLDILLQLVQVLKYEPFHDSKLSRFLLRKAILNRNIGHSFFWYLKSDLHDSNLSERFGILLESYLYACGAHRIELLKQMEVINNLTEVAKKIKPLKDQDRREFMIKEFESLEWPKRFHLTLNPRFESNGLIINKSKYMDSKKLPLRLSFTNTDMNADPIEVIFKAGDDLRQDMLTLQMIRLMDKLWQKEGLDLKLSPYGCISTGDMIGMIEVVLNSETTAKIQKSEGGGAASAFKLDPLANWILQHNKSDMEYQKAVDTFILSCAGYCVATYVLGIGDRHNDNLMVTKGGRLFHIDFGHFLGNYKKKFGFKRERAPFVFTPDFCYVMGGKESFKFSQFVNYCCTAYNIVRKNAKLFMNLFAMMVSTGIPELQSMEDLNYLKESFSIELSDEKAREKFVALIHESLATKTTQLNNFFHHLAHA

Protein

Phosphatidylinositol 3-kinase 1: pikA

Gene

PIKA

Protein

Phosphatidylinositol 4-kinase PIK1a

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876)

Length

956 amino acids

Function

Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate.

Similarity

Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

Mass

109.252 kDa

Sequence

MPVAPHELRDTIKSRDLGLFQCIDLLKQHNDNIGVHHQLVQKLYSYSYDELEFFIPQFIQLLVNFETDSMALEDFLLHYCNQFPHFSLIVFWYLQAFLFELRNEPKSYSFQTVRKFINKLQNILFNVETSFHIRGPEFRENMQPALILCGSVASAFSSPLVNEYALPIVRSQGKQQKSFVFKLASFQKSLTRNLTMKNQRLSADAITPVISDDDSKVSNRIQESQRLKTKYSKKKISAALQLDDSENYTTDEEELGYVQTLSRPKIREMKYTEVEENLKINTIIRSKKNRSKTTVNSISFFSDTDQSASMEEYNRSAQSLPELVRTRSRLDLYSSESEAALGTSRNSAELIISKKKFMGSEVKTRPYKELLKILQVNYSKKETSFIMSLQNISLRLSSVPKVARLSALRAELSIINESILPSEIDIPQLLPVTSNKNKKFHKILKLNINEACVLNSAERVPYLLLIEYLSDEIDFNPFSDQNQKIINDCVRKPEVKPNDQISGDDDTSVVSSIQEEMFLDNNASENYNEDGDLGEISLLHSRSSSRDWAKSTPGSPVARSSQEDEKFYGNVSSTTGGTIESSVLADQMRIASLMLQQLESSGQSNTQQFVSIRNRIIESMISLQDQFDFIDYETLKELKTDEQDAGKRKLENDFKLAEDWNEKKHRIRKSSIYGHLENWDLCSVIVKNGDDLPQEAFACQLISLISNIWKKHKVDFWTKRMKILITSANAGLVETITNAMSIHSIKKSLTELSIENGENAKGRIFTLKDYFQKLYGSVDSSKYVKAQENFAISLASYSIICYVLQIKDRHNGNIMLDHEGHIIHIDFGFLLSNSPGSVGFEAAPFKLTSEYVEVLGGLESKAYLKFVDTCKNCFKALRKEWGQIVSIVELMQKGSSLPCFNNGDNTSVLLQQRLQLHLSDEEIDSFIEVYLIEKSVGSMYTRLYDQFQMITQGIYS

Protein

Phosphatidylinositol 4-kinase PIK1a: PIKA