Protein
Mitochondrial glycine transporter
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Function
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
Similarity
Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
Sequence
MTNAATDKSVASVARDVSTGKPGKSPDAAVHLLSGGLAGLTSAVTLQPFDLLKTRLQQQHSETSKLTIAGEIRKLSQLKELWRGAVPSALRTSVGAGLYFTTLSKMRAAVAQYNHRDSSVTSVLPKLLPMENLATGFVARAIVGYITMPITMVKTRFESNIYSYRTMGESIVGIYKDIGPDGVVHRSSLLNFFKGSVATLARDCPYAGLYVLFYEGFKNDVLVKVIPESVTGSDSRSSVINSSSAILAASVSTTITAPFDAIKTRLQLTKETSILKTTGILLREDGGVFNLFRGLSLRFGRKALSAGISWCIYEELIKSDFSQCRLFNKERLA