Protein
Lon protease homolog 2, peroxisomal
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Function
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
Similarity
Belongs to the peptidase S16 family.
Sequence
MARYKNPKSPAKLKQQIVLPTCKLDSNLVLLPGIIYNVTFSRFKAAALLYRYKDLVSQVSIINNLLNEYEFNPSKDSDSVEEDDMVTSPITISKVAVEGIEQFFKYEAAFKNSQGLVSEKDIAEVAPSNEFDWLTLAIKPNLEKIKEPSNAQIDPTEHNSVVTIARIVGIVDDTTNIKLTLQAITRGLKIAPKKKTRPNEQLLEVDWSSDIPELRRHFKSLKDSSLDLFKVIDKFIVDYRQALSINSANGNKSNLQITKPGSRYKGANGSSQKPGDLLTLNPLANALYLQLAGSKDFSKAFLSLQKLYGQFASDENLKVDTKSYLRLLDLTCGILPFPNHEKLKLLHKISIDDRGNELINMINQLIKIFDTLDGNNSFVNHWFYNEATNIQKANVVANQLKSIRLLLEGMTNKTRPISNRGNIKSFNNSENGNNNKTNGSGITSRRPKSNEDGGEVYDEEDDDEEDDELRAITNFIKYKLPNITTLSPDSKRLIIKDFKRIRASSQSPGGGGNSDFHVIRNYLEIVMDIPWDKYVTKFKSNKDIDLNFAKKQLDDDHYGLEHVKKRLIQYLVVLKLLGINAEKQISDFRKENQVPSPSSSGSNLATQNSLVPASSIVIANNDETSFAHKQAQNKVKTSIKESNIENQTNQSIQVTKYNKSPIIMLAGPPGTGKTSLAKSIASSLGRNFQRISLGGVKDESEIRGHRRTYVGAMPGLIIQALRKSRSMNPVILLDEIDKVIGGSSGVNKFNGDPSAALLEVLDPEQNTSFIDHYLGFPVDLSQVIFICTANEPHNLTRPLLDRLEMIEVSAYDYNEKLIIGRKYLLPRQVKRNGFPASDRIEEFVNIDDASMKKIIVDYTREAGVRNLERKLGTICRFKAVEYCEGLSGKSFYNPNVEEADLPKYLGIPYSSGDFSSIETTISNNSRVGIVNGLSYNSDGSGSVLVFETIGFDKRVGNPNSSNTGCSLVMTGRLGEVLMESGKIGLTFIKSLIYKNLIQAKEQPDDKYLIEKFNNLELNLHVPMGSISKDGPSAGITMATSFLSVILDKPVPADVAMTGEITLRGLVLPIGGVKEKMMGAHLNGNIRRMIVPRENRKDLIEEFSRSVEEAGDVVDSNLMNELLKDNEEADFKMDKVEKFYLKRYGIQIFYAREFYDVMKILWGEDDLLTKPKSNRILEYHL