PI4KG4

Phosphatidylinositol 4-kinase gamma 4

566 amino acids

The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). Undergoes autophosphorylation and phosphorylates serine/threonine residues of protein substrates. Phosphorylates RPN10 and UFD1 in vitro.

Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.

62.625 kDa

MSSAGVALSPVRSEPLIMPLVRANSCLDSYPDDTIMIYLTLPGSVIPMRVLESDSIESVKLRIQSYRGFVVRNQKLVFGGRELARSNSNMRDYGVSEGNILHLVLKLSDLQVLDVKTTCGKHCRFHVERGRNIGYVKKQISKKRGDFVDPDEQEILYEGEKLEDQSLINDICRNDDSVLHLLVRRSAKVRVKPVEKNFELSIVAPQAKDKKGREAKSIVPPKKLSLEPVVVNSKAKVPLVVKDMIQSASDGLKSGNSPVRSSEGTGGAYFMQGPSGNKFVGVFKPIDEEPMAENNPQGLPLSPNGEGLKKGTKVGEGALREVAAYILDHPKSGNKSMFGEEIGFAGVPPTAMIECLHPGFNHPKGIKTKIGSLQMFTENDGSCEDMGPLSFPVEEVHKISVLDIRLANADRHGGNILMTKDESGKLVLVPIDHGYCLPESFEDCTFEWLYWPQARKPYSAETQEYIRSLDAEEDIDLLKFHGWKMPAETAQTLRISTMLLKKGVERGLTAFEIGTIMCRETLSKKSLVEEMVEEAQEAVLPGTSEAAFLEALSDVMDYHLDHSQEH

PI4KG4

Phosphatidylinositol 4-kinase gamma 4

565 amino acids

The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). Involved in the control of flowering under long day conditions by promoting degradation of FTIP1 (PubMed:28254780). Recruits FTIP1 for degradation by the 26S proteasome in leaves, which affects RFT1 transport to the shoot apical meristem (SAM) (PubMed:28254780).

Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.

61.806 kDa

MSSAGIATLSPLLDQFCFAPHGEPRLQQLDSIVIFLAMPGVAPMPMRVLHSDSVASVKLRIQQFKGFVTTKQRLVFSGHELSLNNSHVRDYGLTDGNVLHLVVRLADLRAISIETANGKKFQFQVESCCNVGYLKDKLSAESGQQLGSLKDQRLVFDGEELEDNQLIADISKKGAAVIHLFIRRPAKVQTQQGDKETVVTVVTPKDNDNLQTDALNLAKPAKGKPAPVEPIIANGKVKLSPAVMEMIYSTISGIENGYLPVMSTEGSGGVYFMKDSSGESNVAVFKPIDEEPMAKNNPRGLPLSTDGEGLKRGTRVGEGALREVAAYILDHPVYGCKSCDVPGFSGVPPTALVRCFHMGKGSNKVGSLQLFVDNNGSCEDMGPRAFPVKEVQKIAILDIRLANADRHAGNILVCQDGEDHLKLIPIDHGYCLPEKFEDCTFEWLYWPQAREPFGPETAAYIGSLDADKDIALLKFHGWALSPQCARVLRISTMLLKKGAERGLTPYDIGSILCRQTVKKESEIEAIIEEAEDAILPGTSEETFLETISEIMDFHLDKLAVKLKKF