Protein
Phosphatidylinositol 4-kinase gamma 2
Organism
Arabidopsis thaliana
Function
The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
Similarity
Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
Sequence
MSVADVALSPIHRGSAFAVGGFGQSTTTHYSVKSVLVFLSVSGSTMPMLILESDSIAEVKLRIQTCNGFRVRRQKLVFSGRELARNASRVKDYGVTGGSVLHLVLKLYDPLLVTVITTCGKVFQFHVDRRRNVGYLKKRISKEGKGFPEVDDQEILFKGEKLDDNRIIDGICKDGNSVIHLLVKKSVEDTVKREEDTATGKDSLLEPVVLNPDVKLPEVLEDMIDRTVDGLNKGSPPVRSAEGTGGTYLMQDSSGLNYVSVFKPMDEEPMAVNNPQQLPVSSDGQGLKRGTRVGEGATREVAAYLLDHPKSGLRSVSKEVMGFAGVPPTAMVRSSHKVYNYPNGFSSCATKDAKVGSLQMFMKNNGSCEDIGPGAFPVEEVHKICVFDIRMANADRHAGNILTGKSEEGKTLLIPIDHGYCLPENFEDCTFEWLYWPQAKLPFSADTIDYINSLDSEQDIALLQLHGWNVPEAVSRTLRISTMLLKKGVERNLTPYQIGSVMCRETVNKDSAIEEIVREAHNSVLPASSEATFLEAVSVAMDRRLDELTK