Protein
Probable threonylcarbamoyladenosine tRNA methylthiotransferase
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Function
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Similarity
Belongs to the methylthiotransferase family. CDKAL1 subfamily.
Sequence
MVKVYIENYGCARNRADGEIMAALLYLSGHEIVESPEESEIVVVNSCAVKDPTERKIARRIRELLDNGKKVIVTGCLPHVNPDVIDERVSAILGVKSIDRIVQAVEYAMRGEKLISVPDWKKRNLDKLDFPRLSPRNVYFILPIAEGCLNACTYCATRLARGVLKSYSPEKIIGWVKWAIKQGYKEIWLSAEDTGCYGFDIGTNLAKLIDEITAIEGEFRIRVGMMNPNHVLKFLDELIDAYKDEKVYKFLHLPVQSGDNEILRKMGRMYTVEEFEEIVKAFRREFPELNLHTDIIVGFPGESEEAFQRSVELIKRIRPDKVNVSRYSPRPGTIAAKWKQLPGWVVKERSRLLHRIRLQISYEINRKYIGKKVKVLIHGEGKKGNVDAVTMNYKHIILPEGRKGEFREARVKNAASTYLLGEIIT