Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Function
Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
Similarity
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Sequence
MRAKVKILKIKTGSFNVFISPRDAEEWKLHPNDLVKIESGKRSIYASVAIGDFIEDGEVGLSQDILSSYQFSEGEVVSITPSGTPESVKYIKKKMKGEKLRKVEIETIIRDIVDRKLRNTEISAFITAIEINGLSMDEIAALTIAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNILVVPIVAAAGLTIPKTSSRAITSAAGTADVVEVLTNVKLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHVERRLSLDPRGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMDEARTLAKDFIELGKKLGQYVEVAITYGGQPIGYAIGPALEAKEALETLMTGKGPGSLVEKATGLAGILLEMGGVAPKGMGKKVAKEILESGKAYEKMKEIIEEQGGDPNIKPEDIPIGDKTYTIHAQTGGYVTGIDNRAITAIAREAGAPEDKGAGVRLHVKVGEKVKEGDPLITIHAESESRLEKAIVLARRLEPIKIEGMVLQVIGNI