Protein
N-glycosylase/DNA lyase
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Function
DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
Similarity
Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
Sequence
MIAELIREIGIEGARFIEENIDEQFKALSYLSEGMDRVNFVRLVIANALVSYQLTGKGEMWWWEFAKYFKGKEVKTIYSAYKEFLPNSKFNRRLIQQKLLRIKKIEPFLSTLTEESIERYYEDMTLLWKAIAKVLKVDRESKTVVFSVKMFGYAARIVLSKFNPYPMEIPIPEDVRIIKLTRKLTNERPRDFWMKIAKESNVPPLHIDSILWPLLGGARVEEAPPELKEKLEKLIRVIR