Protein
tRNA (uracil(54)-C(5))-methyltransferase
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Function
Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in tRNA.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Sequence
MRGVVKELNDDGFGVLGNVLVPFSAPGDEVEILKIEKVKKAKIASKWKLIKSSPLRVGARCKVFGRCGGCSLQHLSYDYQLEFKGERIRRLLGVDVEVIPSPRIFGHRNRIDLAVTVEGIGFRERGKWWKIVDIQECPVFGKTSRKAIERLREFIEEERISVWNVKKDEGFLRYMVLREGKFTGEVMVNLVTKEGKLPDPSKYFDFATSIYWSVNRTKSDVSYGEVESVWGREFITEKLDDVIYLIHPNSFFQTNSYQAVNLVKKVSELVEGERVLDMYSGVGTFGIYLAKRGFKVVGFDSNEFAIEMARKNAKINKVDAVFDVATDREVEVNGFDTVIVDPPRVGLHPKLIKKLNREKPEVIVYVSCNPKTFARDIEKLEYKIDEIVALDMFPHTPHLELVAKLIV