Protein
Geranylgeranylglyceryl phosphate synthase
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Function
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
Similarity
Belongs to the GGGP/HepGP synthase family. Group II subfamily.
Sequence
MGELRIGKVEKYIHEKLEKKKLHFVLIDPDDTSPEVAGKLARVCEELGVDAIMVGGSTGAEGEVLDNVVRSIKDNSSLPVILFPGSHGGISRYADAIFFMSLLNSRNPFFITGAQALGAFTVKKFGIEPIPMAYIVVEPGETVGWVGDARPIPRHKPKLAAAYALAGQYLGMRLVYLEAGSGAPEPVPEEMVRVVKSVIDVPLIVGGGIKSGEQAKKLIKSGADIIVTGTAIEKAKSLEEARKRLEAIRNGVFV