Protein
Lipoyl synthase, mitochondrial
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Similarity
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Sequence
MVPVRGQITAFRCSQNPTKTIWRTLATAEPPKPKRKRTMFTDKLNQGPSFADFVSGKASNMTIDPLEAARQDPDQRLPSWLKVPIPKGKSFHTLKKDVRELKLATVCEEAKCPNIGECWGGKKSEATATIMLMGDTCTRGCRFCSVKTSRKPAPPDPMEPENTAEAISRWGLGYVVLTTVDRDDLVDGGAHHLAETVRKIKEKAPQILVEVLGGDFRGDLDMASVLARSGLDVYAHNIETVEDLTPHVRDRRATYRQSLSILQRAKETKPSLVTKTSMMLGFGETDEQIMQTLRDLREIKCDVVTFGQYMRPTKRHMKVVEYVTPEKFDYWRDTALKMGFLYVASGPLVRSSYKAGEAFIENVIRKRNHNVGETPRLESASAAQL