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PGTG_06409

Gene
PGTG_06409
Protein
S-methyl-5'-thioadenosine phosphorylase 1
Organism
Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL)
Length
303 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
32.896 kDa
Sequence
MTGHAPLVGVIGGSGLYKLEGIEPVESLNIDTPWGRPSSPITLFKLPSGPVVAFLARHGVSHQFTPSEVPSRANIAALKKIGCQVIIAFSAVGSLREEIKPRDIVVPSQIIDRTKSVRPCTFFEGLGVVGHAMFGEPFDTELTGLVTKSIKEAVTGFEMNDRIGVHAEKVAICMEGPAFSTRAESNMYRMFGGDIINMSVLPEAKLAREAELSYALIAQITDYDAWRESEEPVTVAEVMATIAANVSVSNRLTLTILDEVHNAVAKGQLKTCKGTMEYSVMTKKEMISEESKKTLSFILPYFS