Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function
Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
Similarity
Belongs to the archease family.
Sequence
MRQWEHYEHTADIGIRGYGDTLEEAFEAVALALFDVIVNVRKIEKKVEIDIEVEGEDLESLLYSFLEELLYLHDIEGLVFGDFKVKIEQKDGKYILRGKAYGEKFDPEKHEPKEEVKAITYHDMKIERLPDGRWMAQLVPDI