PEP3

Vacuolar membrane protein PEP3

918 amino acids

Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.

Belongs to the VPS18 family.

107.398 kDa

MIKTRIEEVQLQFLTGNTELTHLKVSNDQLIVTTQRTIYRINLQDPAIVNHFDCPLSKELETIMNVHVSPMGSVILIRTNFGRYMLLKDGEFTQLNKIKNLDLSSLHWINETTFLMGIKKTPKLYRVELTGKDITTKLWYENKKLSGGIDGIAYWEGSLLLTIKDNILYWRDVTNMKFPLVLPDESEQFERLKHHAIKKFDSYNGLFAWVTSNGIVFGDLKEKQMEKDPASNNFGKFLSSSKVLLNFELPDYQNDKDHLIKDIVLTAFHILLLRKNTVTMVSQLNNDVVFHETIPRHQLTGSNTDSNEKFLGLVRDSVKETFWCFSNINVFEIIIENEPNSVWNLLVRDNKFDKALSLKGLTVREIESVKLSKAMYLFHTAKDFHSAAQTLGSMKDLSHFGEIALNFLQIKDYNDLNVILIKQLDNVPWKSTQVVLSSWIIWNFMKQLNDIELKINTTKPASTDEDNLLNWNLNLKEKSNELTKFLESHLEKLDNETVYQIMSKQNRQNELLIFASLINDMKFLLSFWIDQGNWYESLKILLTINNHDLVYKYSLILLLNSPEATVSTWMKIKDLDPNKLIPTILKFFTNWQNNSKLITNISEYPENYSLTYLKWCVREVPKMCNPIVYNSILYMMITDPRNDMILENDIIKFMKSNENKYDLNFQLRLSLKFKKTKTSIFLLTRLNLFEDAIDLALKNNLIDDCKVIVNDEILIEDYKLRKRLWLKIAKHLLLSMKDIDIKQLIRTILNDSNEILTIKDLLPFFNEYTTIANLKEELIKFLENHNMKMNEISEDIINSKNLKVEINTEISKFNEIYRILEPGKSCDECGKFLQIKKFIVFPCGHCFHWNCIIRVILNSNDYNLRQKTENFLKAKSKHNLNDLENIIVEKCGLCSDININKIDQPISIDETELAKWNE

pep3

Vacuolar membrane protein pep3

900 amino acids

Required for vacuolar biogenesis.

Belongs to the VPS18 family.

103.72 kDa

MSLAEDWIDPNSSEDSDIQEDAELEYTADNPEKEQRGVFSLEKVQLQFPVSIRCLAVENNILVMALTSDKLMIVDLERPEDIIDIELPKKVLALGLTYKIFLDPSGHYIFVTTTAGDNCLFTPSHQGRVLTKLKGHTVEAVQWNLNGGNILELLIASKSGVLLELVLTLDSANLKRIEKSINTLYSFPFMESPMGILKNIQDDSMTIVTNKRILRFEPKTSRGKDQLYFSPAFQGSMKEILSFSEEETAQCFSYSPFPKNLAEPYTLALKTSKRIIYLDIMNPVNPDIQDYEFNESPKLSVPTVEMNMILTSFHLAFLDLDTLYIVNRVNGKESYQQRVNLSPHEEILGLCCDHEKNTYWLYTTDSLHELVVNNETREASLVFLEKGDFEKALECANTAKVRNTVLVGYAEFLMEHEEYERAATLYAETLKSVEEVALKFIELNQKDVLRLYLWKKLRSYKSTMKIQKSLLVNWLLELMLAKLNSLDEKERLELFPENVMQQRQQVQREFSTLLNQYKDEINREAAYNLANNYGKEEQLLQIATVMKDQSYIMHYWVQRENYEKALETLNEGVSQETLIQHATALLTHRPNETVSIWERQTDLDVHALIPSLLSYNQRSHVPVEENAAIRYLRYVTGVLGCVDPSIHNTLFCIYACHSSSNESYLMNYIEQQGNHPLYDMDLGIRLCLQFNCRRSAVKILVLMKLYSQGVELALEADDCELAATIANIPEEDVVLKKTLWQTIAKYMFSKKSGIKETLRFLENSEVLQLPELIRLLPEDIKLDDLSDNVCDELDHCMKRIEQLDFEIGQASEVAHEIQTNAENMRNRYIVLEPNESCWHCNQPLFSEPFVLFPCQHAFHRSCMLEKTYKLASEKNILKECQLCGPSYAVRLINEPFSTDF

PEP3

Aspartic protease PEP3

443 amino acids

Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions.

Belongs to the peptidase A1 family.

47.804 kDa

MQNRPRVFDSAMNLSPNMHFLSLMPGLLLLSLQVHTSPTPLKKTIRSVRIERIRQPNYVPDGPGALKKAYAKFGIIPSGISFDSFEDFTPFSSDNVRNTVSKAMQANETGIVTNTPTNNDVEYLSPVTIGGQKFVMNLDTGSSDTWVFNTQLSEDAKRGHSIFDPAKSKAFSDLEDATFNITYGDASFAFGRVGIDTVDIGGATVQKQAVGLPTDVSGSFILDQASDGLIGLGFDELNTVEPQQQKSFFTNLAANLDEPVLAAQLKKGAPGSYEFGSIDETKFKGDLVTIPVNNSRGFWEVKSTMFKVGKDEQLHRITKGVGSAIADTGTTLMLVNEEIVNSYYDQVDNARSVYAAGGFIFPCNATLPDLYVSLGDTHLARIPGDLMNFSKVGLSTETGEELCFGGVQSNSGSGLQVFGDVLFKAIFVVFDLRGPSLHVAGHA

PEP3

Elicitor peptide 3

96 amino acids

Elicitor of plant defense.

Belongs to the brassicaceae elicitor peptide family.

10.399 kDa

MENLRNGEDNGSLIPFTFFDQSSVTIPLLKCSGLESSSSSSSSCDLSSSHSEEDESIDIKEEEEEEEEDGMTIEIKARGKNKTKPTPSSGKGGKHN