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PE35

Gene
PE35
Protein
PE family immunomodulator PE35
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
99 amino acids
Function
Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M.tuberculosis infection. Together with PPE68, stimulates the secretion of IL-10 and MCP-1 from human macrophages, via the interaction with human Toll-like receptor 2 (TLR2).
Similarity
Belongs to the mycobacterial PE family.
Mass
9.928 kDa
Sequence
MEKMSHDPIAADIGTQVSDNALHGVTAGSTALTSVTGLVPAGADEVSAQAATAFTSEGIQLLASNASAQDQLHRAGEAVQDVARTYSQIDDGAAGVFAE

Gene
PE35
Protein
PE family immunomodulator PE35
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
98 amino acids
Function
Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M.tuberculosis infection. Together with PPE68, stimulates the secretion of IL-10 and MCP-1 from human macrophages, via the interaction with human Toll-like receptor 2 (TLR2).
Similarity
Belongs to the mycobacterial PE family.
Mass
9.799 kDa
Sequence
MEKMSHDPIAADIGTQVSDNALHGVTAGSTALTSVTGLVPAGADEVSAQAATAFTSEGIQLLASNASAQDQLHRAGEAVQDVARTYSQIDDGAAGVFA

Gene
PE35
Protein
Uncharacterized PE family protein PE35
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
97 amino acids
Function
Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain (PubMed:15314236).
Similarity
Belongs to the mycobacterial PE family.
Mass
9.285 kDa
Sequence
MQPMTHNPGAEAVAAQVIANAARGLAGGTTASAAVTALVPAGADEVSALAAVAFASEGVEALAANAFAQEELTRAGAAFAEIAGIYNAVDAANAATM