pcid2

PCI domain-containing protein 2 homolog

430 amino acids

Belongs to the CSN12 family.

49.476 kDa

MAELTNHFNKVNELLNDWDGVGLSHELSMTELITSILNSINHNSHSGMSNQKKQQIQAKVNQIKKTDLVVKRQQDIDTLCANKIQHNYNEIVAYRLRSISSLLDSKYYDAFRYLIEAINSFVKVFELWSQNILWRLSLDLRLMAELATLNVGSNDSNNSNNNVTIDYFEEASRTLLSKCFQAANADRTPNLAESKKNAALGVVNQLFQIYFKINNLKLCKNLIKTMESPGFPTLESYPLNQVITYRFFNGRLSVFNGQYKKAQEELLYAFNKCPNDSIKNKRLILLFLVPMQLEQCKFPKKSLLEKFKLTQFIDIVQSIKSGNIKQFNECLSTHQNFFISKGIYLILEKLKIIVYRNLFKKVHLITTGQRIPIGNFVSALKWMENDAIDIDETECILSNLIYNGYLKGYISHKVALVVSPTNPFPKLPLN

PCID2

PCI domain-containing protein 2

408 amino acids

Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells (By similarity).

Belongs to the CSN12 family.

46.814 kDa

MAHITINQYLQQVCEAIDTRDGASLAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRIFANNADQQLVKKGKSKVGDMLEKAAELLMGCFRVCASDTRAGIEDSKKRGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYRYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMVLIYLLPVKMLLGHMPTIELLRKYHLMQFAEVTRAVSEGNLLLLNEALAAHETFFIRCGIFLILEKLKIITYRNLFKKVNSLSSASSRYLLLKTHQLSLDAFLVALKFMQVEDVDIAEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPLSTVC

pcid2

PCI domain-containing protein 2

399 amino acids

Belongs to the CSN12 family.

46.065 kDa

MAHITLNQYLQQVLEAIDSRDGSFCAEMMSFKHPHVANPRLQLSSPEEKCQQLLEPPYDEMVAAHLRCTFAVSNHDFVEAYKCQTVVVQSFLKAFQAHKEENWALPIMFAVTLDLRIFANNAEQHLQQKGKGKVGDMLEKAAEQLMSCFRVCASDNRAGIDDSKKWGMLFLINQLFKIYFKINKLHLCKPLIRAIDSSNLKDEYTMAQRVTYKYYVGRKAMFDSDFKPAEECLSFSFTHCHRSCQRNKRLILIYLLPVKMLLGHMPTHQLLKKYDLMQFADVTRAVSEGNLLLLNAALVKHETFFIRCGIFLILEKLKIITYRNLFKKVYHLLRTHQLPLAAFLVSLQMTKVEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPLSSIS

PCID2

PCI domain-containing protein 2

399 amino acids

Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:22307388) (Probable). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells (PubMed:24896180).

Belongs to the CSN12 family.

46.03 kDa

MAHITINQYLQQVYEAIDSRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFANNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTVELLKKYHLMQFAEVTRAVSEGNLLLLHEALAKHEAFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMQVEDVDIDEVQCILANLIYMGHVKGYISHQHQKLVVSKQNPFPPLSTVC

Pcid2

PCI domain-containing protein 2

399 amino acids

Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (PubMed:20870947). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells (By similarity).

Belongs to the CSN12 family.

46.132 kDa

MAHITINQYLQQVYEAIDTRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRIFANNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRITYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTIELLRKYHLMQFSEVTKAVSEGNLLLLNEALAKHETFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMHVEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPLSTVC

pcid2

PCI domain-containing protein 2

399 amino acids

Belongs to the CSN12 family.

46.163 kDa

MAHITINQYLQQVQEAIDSKDGFNCADLVSFKHPHVANARLQLLSPEEKCQQVLEPPYDEMFAAHLRCINAASNHDFVEAYKYQTLVVQSFLKSFQAHKEENWALPIMYSITLDLRIFANNADQQLVKKGKGKVGDMLEKAAEILMSCFRVCASDTRAAFEDSKKWGMLFLVNQLFKIYFKISKLHLCKPLIRAIDSSNFKEEYTMAQRVTFKYYVGRKSMFDSDFKKAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTIHLLKKYDLMQFAEVTKAVSEGNLLLLTEALTKHETFFIRCGIFLILEKLKIISYRNLFKKVYLLLKTHQLSLDAFLVALKFMEVGDVDIDEVQCIIANLIYMGHIKGYISHQHQKLVVSKQNPFPPLSTVC

PCID2

PCI domain-containing protein 2 homolog

395 amino acids

Required for mRNA export together with Moe (PubMed:18086857, PubMed:28554770). Associates with translationally active polysomes (PubMed:18086857).

Belongs to the CSN12 family.

45.18 kDa

MFGTVNNYLSGVLHAAQDLDGESLATYLSLRDVHVQNHNLYIAQPEKLVDRFLKPPLDEVVSAHLKVLYHLAQEPPGYMEAYTQQSAACGAVVRLLQQLKDENWCLPLMYRVCLDLRYLAQACEKHCQGFTPGHVLEKAADCIMACFRVCAADGRASEEDTKRLGMMNLVNQLFKIYFRINKLHLCKPLIRAIDNCIFKDSFPLPEQITYKYFVGRRAMFDSNYQAAVQYLSYAFSNCPDRFASNKRLILIYLVPVKMLLGYLPSKSLLQRYDLLLFLDLAMAMKAGNVNRFDEIVRDQELVLIRSGIYLLVEKLKFLVYRNLFKKVFVIRKSHQLDMGDFLSALHFVGLTDVSLDETHCIVANLIYDGKIKGYISHAHNKLVVSKQNPFPSVSL