PCBAB

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

3791 amino acids

Each of the constituent amino acids of the tripeptide acv are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates.

Belongs to the ATP-dependent AMP-binding enzyme family.

425.922 kDa

MTQLKPPNGTTPIGFSATTSLNASGSSSVKNGTIKPSNGIFKPSTRDTMDPCSGNAADGSIRVRFRGGIERWKECVNQVPERCDLSGLTTDSTRYQLASTGFGDASAAYQERLMTVPVDVHAALQELCLERRVSVGSVINFSVHQMLKGFGNGTHTITASLHREQNLQNSSPSWVVSPTIVTHENRDGWSVAQAVESIEAGRGSEKESVTAIDSGSSLVKMGLFDLLVSFVDADDARIPCFDFPLAVIVRECDANLSLTLRFSDCLFNEETICNFTDALNILLAEAVIGRVTPVADIELLSAEQKQQLEEWNNTDGEYPSSKRLHHLIEEVVERHEDKIAVVCDERELTYGELNAQGNSLARYLRSIGILPEQLVALFLDKSEKLIVTILGVWKSGAAYVPIDPTYPDERVRFVLDDTKARAIIASNQHVERLQREVIGDRNLCIIRLEPLLASLAQDSSKFPAHNLDDLPLTSQQLAYVTYTSGTTGFPKGIFKQHTNVVNSITDLSARYGVAGQHHEAILLFSACVFEPFVRQTLMALVNGHLLAVINDVEKYDADTLLPFIRRHSITYLNGTASVLQEYDFSDCPSLNRIILVGENLTEARYLALRQRFKNRILNEYGFTESAFVTALKIFDPESTRKDTSLGRPVRNVKCYILNPSLKRVPIGATGELHIGGLGISKGYLNRPELTPHRFIPNPFQTDCEKQLGINSLMYKTGDLARWLPNGEVEYLGRADFQIKLRGIRIEPGEIETMLAMYPRVRTSLVVSKKLRNGPEETTNEHLVGYYVCDSASVSEADLLSFLEKKLPRYMIPTRLVQLSQIPVNVNGKADLRALPAVDISNSTEVRSDLRGDTEIALGEIWADVLGARQRSVSRNDNFFRLGGHSITCIQLIARIRQRQRLSVSISVEDVFATRTLERMADLLQNKQQEKCDKPHEAPTELLEENAATDNIYLANSLQQGFVYHYLKSMEQSDAYVMQSVLRYNTTLSPDLFQRAWKHAQQSFPALRLRFSWEKEVFQLLDQDPPLDWRFLYFTDVAAGAVEDRKLEDLRRQDLTERFKLDVGRLFRVYLIKHSENRFTCLFSCHHAILDGWSLPLLFEKVHETYLQLLHGDNLTSSMDDPYTRTQRYLHAHREDHLDFWAGVVQKINERCDMNALLNERSRYKVQLADYDQVQEQRQLTIALSGDAWLADLRQTCSAQGITLHSILQFVWHAVLHAYGGGTHTITGTTISGRNLPILGIERAVGPYINTLPLVLDHSTFKDKTIMEAIEDVQAKVNVMNSRGNVELGRLHKTDLKHGLFDSLFVLENYPNLDKSRTLEHQTELGYSIEGGTEKLNYPLAVIAREVETTGGFTVSICYASELFEEVMISELLHMVQDTLMQVARGLNEPVGSLEYLSSIQLEQLAAWNATEAEFPDTTLHEMFENEASQKPDKIAVVYEETSLTYRELNERANRMAHQLRSDVSPNPNEVIALVMDKSEHMIVNILAVWKSGGAYVPIDPGYPNDRIQYILEDTQALAVIADSCYLPRIKGMAASGTLLYPSVLPANPDSKWSVSNPSPLSRSTDLAYIIYTSGTTGRPKGVTVEHHGVVNLQVSLSKVFGLRDTDDEVILSFSNYVFDHFVEQMTDAILNGQTLLVLNDGMRGDKERLYRYIEKNRVTYLSGTPSVVSMYEFSRFKDHLRRVDCVGEAFSEPVFDKIRETFHGLVINGYGPTEVSITTHKRLYPFPERRMDKSIGQQVHNSTSYVLNEDMKRTPIGAVGELYLGGEGVVRGYHNRADVTAERFIPNPFQSEEDKREGRNSRLYKTGDLVRWIPGSSGEVEYLGRNDFQVKIRGLRIELGEIEAILSSYHGIKQSVVIAKDCREGAQKFLVGYYVADAALPSAAIRRFMQSRLPGYMVPSRLILVSKFPVTPSGKLDTKALPPAEEESEIDVVPPRSEIERSLCDIWAELLEMHPEEIGIYSDFFSLGGDSLKSTKLSFMIHESFNRAVSVSALFCHRTVEAQTHLILNDAADVHEITPIDCNDTQMIPVSRAQERLLFIHEFENGSNAYNIDAAFELPGSVDASLLEQALRGNLARHEALRTLLVKDHATGIYLQKVLSPDEAQGMFSVNVDTAKQVERLDQEIASLSQHVFRLDDELPWEARILKLESGGLYLILAFHHTCFDAWSLKVFEQELRALYAALQKTKSAANLPALKAQYKEYALYHRRQLSGDRMRNLSDFWLRKLIGLEPLQLITDRPRPVQFKYDGDDLSIELSKKETENLRGVAKRCKSSLYVVLVSVYCVMLASYANQSDVSVGIPVSHRTHPQFQSVIGFFVNLVVLRVDISQSAICGLIRRVMKELVDAQLHQDMPFQEVTKLLQVDNDPSRHPLVQNVFNFESRANGEHDARSEDEGSLAFNQYRPVQPVDSVAKFDLNATVTELESGLRVNFNYATSLFNKSTIQGFLHTYEYLLRQLSELSAEGINEDTQLSLVRPTENGDLHLPLAQSPLATTAEEQKVASLNQAFEREAFLAAEKIAVVQGDRALSYADLNGQANQLARYIQSVSCIGADDGIALMLEKSIDTIICILAIWKAGAAYVPLDPTYPPGRVQLILEEIKAKAVLVHSSHASKCERHGAKVIAVDSPAIETAVSQQSAADLPTIASLGNLAYIIFTSGTSGKPKGVLVEQKAVLLLRDALRERYFGRDCTKHHGVLFLSNYVFDFSVEQLVLSVLSGHKLIVPPAEFVADDEFYRMASTHGLSYLSGTPSLLQKIDLARLDHLQVVTAAGEELHATQYEKMRRRFNGPIYNAYGVTETTVYNIIAEFTTNSIFENALREVLPGTRAYVLNAALQPVPFDAVGELYLAGDSVTRGYLNQPLLTDQRFIPNPFCKEEDIAMGRFARLYKTGDLVRSRFNRQQQPQLEYLGRGDLQIKMRGYRIEISEVQNVLTSSPGVREGAVVAKYENNDTYSRTAHSLVGYYTTDNETVSEADILTFMKARLPTYMVPSHLCCLEGALPVTINGKLDVRRLPEIINDSAQSSYSPPRNIIEAKMCRLWESALGMERCGIDDDLFKLGGDSITSLHLVAQIHNQVGCKITVRDIFEHRTARALHDHVFMKDSDRSNVTQFRTEQGPVIGEAPLLPIQDWFLSKALQHPMYWNHTFYVRTPELDVDSLSAAVRDLQQYHDVFRMRLKREEVGFVQSFAEDFSPAQLRVLNVKDVDGSAAVNEILDGWQSGFNLENGPIGSIGYLHGYEDRSARVWFSVHHMAIDTVSWQILVRDLQTLYRNGSLGSKGSSFRQWAEAIQNYKASDSERNHWNKLVMETASSISALPTSTGSRVRLSRSLSPEKTASLIQGGIDRQDVSVYDSLLTSVGLALQHIAPTGPSMVTIEGHGREEVDQTLDVSRTMGWFTTMYPFEIPRLSTENIVQGVVAVSERFRQVPARGVGYGTLYGYTQHPLPQVTVNYLGQLARKQSKPKEWVLAVGDNEFEYGLMTSPEDKDRSSSAVDVTAVCIDGTMIIDVDSAWSLEESEQFISSIEEGLNKILDGRASQQTSRFPDVPQPAETYTPYFEYLEPPRQGPTLFLLPPGEGGAESYFNNIVKRLRQTNMVVFNNYYLHSKRLRTFEELAEMYLDQVRGIQPHGPYHFIGWSFGGILAMEMSRRLVASDEKIGFLGIIDTYFNVRGATRTIGLGDTEILDPIHHIYNPDPANFQRLPSATDRIVLFKAMRPNNKYESENQRRLYEYYDALDSTDWTACYQAIPTSSWSRLRTIHTFPGSEIHNRWSRCVRLSRNTSLAIDPSLAAQYIGRWK

PCBAB

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

3746 amino acids

Each of the constituent amino acids of the tripeptide acv are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates.

Belongs to the ATP-dependent AMP-binding enzyme family.

421.076 kDa

MGPSNPAMAYFKPSTRDTMDPCSGNAADGSIRVRFRGGIERWKECVNQVPERCDLSGLTTDSTRYQLASTGFGDASAAYQERLMTVPVDVHAALQELCLERRVSVGSVINFSVHQMLKGFGNGTHTITASLHREQNLQNSSPSWVVSPTIVTHENRDGWSVAQAVESIEAGRGSEKESVTAIDSGSSLVKMGLFDLLVSFVDADDARIPCFDFPLAVIVRECDANLSLTLRFSDCLFNEETICNFTDALNILLAEAVIGRVTPVADIELLSAEQKQQLEEWNNTDGEYPSSKRLHHLIEEVVERHEDKIAVVCDERELTYGELNAQGNSLARYLRSIGILPEQLVALFLDKSEKLIVTILGVWKSGAAYVPIDPTYPDERVRFVLDDTKARAIIASNQHVERLQREVIGDRNLCIIRLEPLLASLAQDSSKFPAHNLDDLPLTSQQLAYVTYTSGTTGFPKGIFKQHTNVVNSITDLSARYGVAGQHHEAILLFSACVFEPFVRQTLMALVNGHLLAVINDVEKYDADTLLPFIRRHSITYLNGTASVLQEYDFSDCPSLNRIILVGENLTEARYLALRQRFKNRILNEYGFTESAFVTALKIFDPESTRKDTSLGRPVRNVKCYILNPSLKRVPIGATGELHIGGLGISKGYLNRPELTPHRFIPNPFQTDCEKQLGINSLMYKTGDLARWLPNGEVEYLGRADFQIKLRGIRIEPGEIETMLAMYPRVRTSLVVSKKLRNGPEETTNEHLVGYYVCDSASVSEADLLSFLEKKLPRYMIPTRLVQLSQIPVNVNGKADLRALPAVDISNSTEVRSDLRGDTEIALGEIWADVLGARQRSVSRNDNFFRLGGHSITCIQLIARIRQRLSVSISVEDVFATRTLERMADLLQNKQQEKCDKPHEAPTELLEENAATDNIYLANSLQQGFVYHYLKSMEQSDAYVMQSVLRYNTTLSPDLFQRAWKHAQQSFPALRLRFSWEKEVFQLLDQDPPLDWRFLYFTDVAAGAVEDRKLEDLRRQDLTERFKLDVGRLFRVYLIKHSENRFTCLFSCHHAILDGWSLPLLFEKVHETYLQLLHGDNLTSSMDDPYTRTQRYLHAHREDHLDFWAGVVQKINERCDMNALLNERSRYKVQLADYDQVQEQRQLTIALSGDAWLADLRQTCSAQGITLHSILQFVWHAVLHAYGGGTHTITGTTISGRNLPILGIERAVGPYINTLPLVLDHSTFKDKTIMEAIEDVQAKVNVMNSRGNVELGRLHKTDLKHGLFDSLFVLENYPNLDKSRTLEHQTELGYSIEGGTEKLNYPLAVIAREVETTGGFTVSICYASELFEEVMISELLHMVQDTLMQVARGLNEPVGSLEYLSSIQLEQLAAWNATEAEFPDTTLHEMFENEASQKPDKIAVVYEETSLTYRELNERANRMAHQLRSDVSPNPNEVIALVMDKSEHMIVNILAVWKSGGAYVPIDPGYPNDRIQYILEDTQALAVIADSCYLPRIKGMAASGTLLYPSVLPANPDSKWSVSNPSPLSRSTDLAYIIYTSGTTGRPKGVTVEHHGVVNLQVSLSKVFGLRDTDDEVILSFSNYVFDHFVEQMTDAILNGQTLLVLNDGMRGDKERLYRYIEKNRVTYLSGTPSVVSMYEFSRFKDHLRRVDCVGEAFSEPVFDKIRETFHGLVINGYGPTEVSITTHKRLYPFPERRMDKSIGQQVHNSTSYVLNEDMKRTPIGSVGELYLGGEGVVRGYHNRADVTAERFIPNPFQSEEDKREGRNSRLYKTGDLVRWIPGSSGEVEYLGRNDFQVKIRGLRIELGEIEAILSSYHGIKQSVVIAKDCREGAQKFLVGYYVADAALPSAAIRRFMQSRLPGYMVPSRLILVSKFPVTPSGKLDTKALPPAEEESEIDVVPPRSEIERSLCDIWAELLEMHPEEIGIYSDFFSLGGDSLKSTKLSFMIHESFNRAVSVSALFCHRTVEAQTHLILNDAADVHEITPIDCNDTQMIPVSRAQERLLFIHEFENGSNAYNIDAAFELPGSVDASLLEQALRGNLARHEALRTLLVKDHATGIYLQKVLSPDEAQGMFSVNVDTAKQVERLDQEIASLSQHVFRLDDELPWEARILKLESGGLYLILAFHHTCFDAWSLKVFEQELRALYAALQKTKSAANLPALKAQYKEYALYHRRQLSGDRMRNLSDFWLRKLIGLEPLQLITDRPRPVQFKYDGDDLSIELSKKETENLRGVAKRCKSSLYVVLVSVYCVMLASYANQSDVSVGIPVSHRTHPQFQSVIGFFVNLVVLRVDISQSAICGLIRRVMKELVDAQLHQDMPFQEVTKLLQVDNDPSRHPLVQNVFNFESRANGEHDARSEDEGSLAFNQYRPVQPVDSVAKFDLNATVTELESGLRVNFNYATSLFNKSTIQGFLHTYEYLLRQLSELSAEGINEDTQLSLVRPTENGDLHLPLAQSPLATTAEEQKVASLNQAFEREAFLAAEKIAVVQGDRALSYADLNGQANQLARYIQSVSCIGADDGIALMLEKSIDTIICILAIWKAGAAYVPLDPTYPPGRVQLILEEIKAKAVLVHSSHASKCERHGAKVIAVDSPAIETAVSQQSAADLPTIASLGNLAYIIFTSGTSGKPKGVLVEQKAVLLLRDALRERYFGRDCTKHHGVLFLSNYVFDFSVEQLVLSVLSGHKLIVPPAEFVADDEFYRMASTHGLSYLSGTPSLLQKIDLARLDHLQVVTAAGEELHATQYEKMRRRFNGPIYNAYGVTETTVYNIIAEFTTNSIFENALREVLPGTRAYVLNAALQPVPFDAVGELYLAGDSVTRGYLNQPLLTDQRFIPNPFCKEEDIAMGRFARLYKTGDLVRSRFNRQQQPQLEYLGRGDLQIKMRGYRIEISEVQNVLTSSPGVREGAVVAKYENNDTYSRTAHSLVGYYTTDNETVSEADILTFMKARLPTYMVPSHLCCLEGALPVTINGKLDVRRLPEIINDSAQSSYSPPRNIIEAKMCRLWESALGMERCGIDDDLFKLGGDSITSLHLVAQIHNQVGCKITVRDIFEHRTARALHDHVFMKDSDRSNVTQFRTEQGPVIGEAPLLPIQDWFLSKALQHPMYWNHTFYVRTPELDVDSLSAAVRDLQQYHDVFRMRLKREEVGFVQSFAEDFSPAQLRVLNVKDVDGSAAVNEILDGWQSGFNLENGPIGSIGYLHGYEDRSARVWFSVHHMAIDTVSWQILVRDLQTLYRNGSLGSKGSSFRQWAEAIQNYKASDSERNHWNKLVMETASSISALPTSTGSRVRLSRSLSPEKTASLIQGGIDRQDVSVYDSLLTSVGLALQHIAPTGPSMVTIEGHGREEVDQTLDVSRTMGWFTTMYPFEIPRLSTENIVQGVVAVSERFRQVPARGVGYGTLYGYTQHPLPQVTVNYLGQLARKQSKPKEWVLAVGDNEFEYGLMTSPEDKDRSSSAVDVTAVCIDGTMIIDVDSAWSLEESEQFISSIEEGLNKILDGRASQQTSRFPDVPQPAETYTPYFEYLEPPRQGPTLFLLPPGEGGAESYFNNIVKRLRQTNMVVFNNYYLHSKRLRTFEELAEMYLDQVRGIQPHGPYHFIGWSFGGILAMEMSRRLVASDEKIGFLGIIDTYFNVRGATRTIGLGDTEILDPIHHIYNPDPANFQRLPSATDRIVLFKAMRPNNKYESENQRRLYEYYDGTRLNGLDSLLPSDSDVQLVPLTDDTHFSWVGNPQQVEQMCATIKEHLARY

PCBAB

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

3712 amino acids

Each of the constituent amino acids of the tripeptide acv are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates.

Belongs to the ATP-dependent AMP-binding enzyme family.

414.775 kDa

MALEQWKTTVQSVSERCDLSGLSQHPTDYQLASTGVKGAGGSSIEERSAIVSDELFSSLRDVCSQRQLDPRSLMLFSVHQMLKRFGNGSHTVVASLVTSSEGCPSTSAWRAIPSVIHHIEGGDNNNTVASAVEQAANLLNSEGSGQDLLIPIGLTELVKSELIDLLVIFDDETNNIRLPQDFPLILRIHQRQDHWQLSVRYPSPLFDTMVIDSFLSALHNLLSAVTKPSQLVRDIELLPEYQVAQLEKWNNTDGDYPTEKRLHHLFEEAAVRRPQHVALICGDKRITYEELNAMANRLAHHLVSSGIQTEQLVGLFLDKTELMIATILGIWKSGAAHVPIDPGYPDERVKFVLNDTKAQVVIASQRHVDRLRAEAVGGQHLRIIGLESLFDNLAQQTQHSPETSGNLTHLPLNSKQLAYVTYTSGTTGFPKGIYKEHTSVVNSITDLSARYGVAGEDDEVILVFSAYVFEPFVRQMLMALTTGNSLAIISDEDKFDPDTLIPFIQKHKVTYIHATSSVLQEYDFGSCPSLKRMILVGENLTEPRYEALRQRFKSRILNEYGFTESAFVTALNIFEPTSQRKDMSLGRPVRNVKCYILDANLKRVPIGVTGELHIGGLGISRGYMNREELTRQKFLPNPYQTDKERQRGVNSTMYKTGDLARWLPSGEVEYLGRADFQIKLRGIRIEPGEIESTLAMYPGIRASIVVSKKLLSQGQETIQDHLVGYYVCDEGHIPEGDLLSFLEKKLPRYMVPTRLVQLAQIPTNINGKADLRALPAVEVAVAPTHKQDGERGNQLESDLAAIWGNILSVPAQDIGSESNFFRLGGHSIACIQLIARVRQQLGQGITLEEVFQTKTLRAMAALLSEKYTKASNGTNGVTNGTAHVNGHAANGHVSDSYVASSLQQGFVYHSLKNELSEAYTMQSMIHYGVPLKRDIYQAAWQRVQGEHPALRLRFTWEAEVMQIVDPKSELDWRVVDWTDVSSREKQLVALEQLQTEDLAKVYHLDKGPLMRLYLILLPDSKYSCLFSCHHAILDGWSLPLLFNNVHQAYLDLVEGTASPVEQDATYLLGQQYLQSHRDDHLDFWAEQIGRIEERCDMNALLNEASRYKVPLADYDQVREQRQQTISLPWNNSMDAGVREELSSRGITLHSILQTVWHLVLHSYGGGTHTITGTTISGRHLPVPGIERSVGLFINTLPMIFDHTVCQDMTALEAIEHVQGQVNAMNSRGNVELGRMSKNDLKHGLFDTLFVLENYPNLDTEQREKHEEKLKFTIKGGTEKLSYPLAVIAQEDGDSGCSFTLCYAGELFTDESIQALLDTVRDTLSDILGNIHAPIRNMEYLSSNQTAQLDKWNATAFEYPNTTLHAMFESEAQQKPDKVAVVYEDIRLTYRELNSRANALAFYLLSQAAIQPNKLVGLIMDKSEHMITSILAVWKTGGAYVPIDPRYPDQRIQYILEDTAALAVITDSPHIDRLRSITNNRLPVIQSDFALQLPPSPVHPVSNCKPSDLAYIMYTSGTTGNPKGVMVEHHGVVNLCVSLCRLFGLRNTDDEVILSFSNYVFDHFVEQMTDALLNGQTLVVLNDEMRGDKERLYRYIETNRVTYLSGTPSVISMYEFDRFRDHLRRVDCVGEAFSEPVFDKIRETFPGLIINGYGPTEVSITTHKRPYPFPERRTDKSIGCQLDNSTSYVLNDDMKRVPIGAVGELYLGGDGVARGYHNRPDLTADRFPANPFQTEQERLEGRNARLYKTGDLVRWIHNANGDGEIEYLGRNDFQVKIRGQRIELGEIEAVLSSYPGIKQSVVLAKDRKNDGQKYLVGYFVSSAGSLSAQAIRRFMLTSLPDYMVPAQLVPIAKFPVTVSGKLDAKALPVPDDTVEDDIVPPRTEVERILAGIWSELLEIPVDRISIYSDFFSLGGDSLKSTKLSFAATRALGVAVSVRNLFSHPTIEALSQWIIRGSNEVKDVAVVKGGASLDIPLSPAQERLMFIHEFGHSGEDTGAYNVPLQLQLHHDVCLESLEKALRDVVSRHEALRTLITRTQKSSVHCQKILDAEEAQKLFSVDVLRLTSETEMQGRMAESTAHAFKLDEELPIHVRLYQVVRDGRTLSFASIVCHHLAFDAWSWDVFQRDLDAFYAVHTKHKAAANLPTLRVQYKEYAIEHRRALRAEQHRVLADYWLRKLSDMEASYLVPDRPRPAQFDYTGNDLQFSTTPETTAQLKELAKREGSSLYTVVAAAYFLLLYVYTNQRDITIGIPVAHRNHPDFESVVGFFVNLLPLRVNVSQSDIHGLIQAVQKELVDAQIHQDLPFQEITKLLHVQHDPSRHPLLQAVFNWENVPANVHEEQLLQEYKPPSPLPSAAKFDLNVTVKESVNSLNVNFNYPTSLFEEETVQGFMETFHLLLRQLAHNKASTSLSKLSVEDGVLNPEPTNLQPSSRDSGNSLHGLFEDIVASTPDRIAIADGTRSLSYSELNERANQLVHLIISSASIVADDRIALLLDKSIDMVIALLAVWKAGAAYVPLDPTYPSQRTELILEESSARTLITTRKHTPRGGTVANVPSVVLDSPETLACLNQQSKENPTTSTQKPSDLAYVIFTSGTTGKPKGVLVEHQSVVQLRNSLIERYFGETNGSHAVLFLSNYVFDFSLEQLCLSVLGGNKLIIPPEEGLTHEAFYDIGRREKLSYLSGTPSVLQQIELSRLPHLHMVTAAGEEFHASQFEKMRSQFAGQINNAYGITETTVYNIITTFKGDAPFTKALCHGIPGSHVYVLNDRLQRVPFNAVGELYLGGDCLARGYLNQDALTNERFIPNPFYEPKQASDSRPQRLYKTGDLVRFRGPHHLEYLGRKDQQVKLRGFRIELSEVRDAVLAISAVKEAAVIPKYDEDGSDSRRVSAIVCYYTLNAGTVCEASSIRDHLHANLPPYMVPSQIHQLEGSLPVTVNGKLDLNRLSTTQVSQPELYTAPRNSTEETLCQLWASLLGVDHCGIDDDLFARGGDSISSLRLVGDIYRALGRKVTVKDIYLHRSVRALSENVLTDQKDKGTLPASPPLQRAEQGQVEGDAPLLPIQDWFLSKPLDNPAYWNHCFTIRTGALSVEGLRGALKLLQERHDVLRLRLQRRDEGRHVQTFARDCAQPRLTVLDRRSFEDAEDVQEALCEIQSHFDLENGPLYTVAYIHGYEDGSARVWFACHHVMVDTVSWNIILQDLQALYHGDSLGPKSSSVQQWSLAVSDYKMPLSERAHWNVLRKTVAQSFETLPICMGGVLQCQEKFSRETTTALLSKACPALDSGMHEILLMAVGSALQKAAGDVPQVVTIEGHGREDTIDATLDVSRTVGWFTSMYPFEIPKVTDPAQGVVDVKEAMRRVPNRGVGYGPAYGYGGSCLPAVSFNYLGRLDQASSGAQRDWTLVMDEDEYPVGLCTSAEDSGRSSSMVDFTFSISGGQLVMDMSSSWGHGARNEFVRTVRNTLDDLIKTTSSRDFSAPLPPSDQESSFTPYFVFEEGERHGAPLFLLPPGEGGAESYFHNIVKGLPNRNLVVFNNHYREEKTLRTIEALAEYYLSHIRSIQPEGPYHILGWSFGGILGLEAAKRLTGEGHKIATLALIDPYFDIPSASKAIGQPDDACVLDPIYHVYHPSPESFRTVSSLTNHIALFKATETNDQHGNATQQALYEWFATCPLNNLDKFLAADTIKVVPLEGTHFTWVHHPEQVRSMCTMLDEWLG

pcbAB

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

3649 amino acids

Each of the constituent amino acids of the tripeptide acv are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates.

Belongs to the ATP-dependent AMP-binding enzyme family.

404.088 kDa

MTSARHLKSAADWCARIDAIAGQRCDLEMLLKDEWRHRVAVRDSDTAVRATQEKELTISGQDYTALKQALGAMPLEAFALATLHSVLHAYGHGHQTVVAFLRDGKVLPVVVDHLEQAGLTCAEAAEQLEDAVAREDMYLPPEELLQRGLFDALLVLADGHLGFTELPPAPLVTIVRDDPAAGCLHWRIAYAGEFFEDKIIAGVLDVAREVLGQFIGRPEQLVADIDLVSAEQELQLHQWNGTDGEFDEDKRLNELFEDVVRRAPDREAVVCGDVRLTYREVNERANQFAHWLIQGPVRVRPGALIGLYLDKSDLGVVATFGIWKSGAAYVPIDPAYPAERIRFLVGDTGLSGIVTNRRHAERLREVLGDEHASVHVIEVEAVVAGPHPEQARENPGLALSSRDRAYVTYTSGTTGVPKGVPKYHYSVVNSITDLSERYDMRRPGTERVALFASYVFEPHLRQTLIALINEQTLVIVPDDVRLDPDLFPEYIERHGVTYLNATGSVLQHFDLRRCASLKRLLLVGEELTASGLRQLREKFAGRVVNEYAFTEAAFVTAVKEFGPGVTERRDRSIGRPLRNVKWYVLSQGLKQLPIGAIGELYIGGCGVAPGYLNRDDLTAERFTANPFQTEEEKARGRNGRLYRTGDLARVLLNGEVEFMGRADFQLKLNGVRVEPGEIEAQATEFPGVKKCVVVAKENATGDRHLVGYYLVEDGAEVAEADLIAFLEQRLIRIMVPARMVRLTSIPVNVNGKVDWRALPDVSLHPAPANAMNGALLAIDGSNAPLLAITEQLRAIWSEVLGVPQNRIGERDDFFRLGGQSISCILLIARVRQRLSLSLGVEDVFALRTLDALAGHLESQGHAEPEVVAEEVTTGSEPVRVLANGLQQGLLYHHLKTAGGDDAYVVQSVHRYHAPIRPELMKDAWQAARQTYPALRLRFDWAEEPVQIVDNDDKPFDWRFVDLSATADDAEQEARVRELQERDRTEPYDLAGGRLFRVYLIKQREDLFSLIFSCHHIILDGWSLPVLHDEVHRNYLALRAGQPIESDVDNAYVAAQRYWEAHRNDHAAYWVEQLGRIDERGDFAGLLNEKSRYRVSLGDYDHVQRHRTRKLYLGADLTGALKAGCAADQVTLHSVLQFVWHKVLHAIGGGNTTVVGTIVSGRNLPVDGIENSAGLFINTLPLIVDHDQQAGQNVAEAVRDIQAAVNTMNSKSIVELGRLQSGEMKRRLFDTLLVLENYPRLLDEEEELAHQEALRFEKAYDADKVDYPIAVVAREEGDELTVTLWYAGELFDEDTIDTLLDVARTLFRQVTEDIARPVRELDLISPSMRARFDSWNETAEEFPADKTLHAVFEEMAERWPDEIAVVYRENRLTYRELNERANRLAHYLRSVVELRPDDLVALVLDKSELMITAIIAAWKTGAAYVPIDSGYPDDRISFMLSDTAARVVVTNEIHSDRLRSLAETGTPVLEIELLHLDDQPAVNPVTETTSTDLAYAIYTSGTTGKPKAVLVEHRGVVNLQVSLAKLFGLDKAHRDEALLSFSNYIFDHFVEQMTDALLNGQKLVVLDDSMRTDPGRLCRYMNDEQVTYLSGTPSVLSLYDYSSATSLTRIDAIGEDFTEPVFAKIRGTFPGLIINGYGPTEISITSHKRPYPPDVHRVNKSIGFPVANTKCHVLNKAMKPVPVGGIGELYIGGIGVTRGYLNREDLTADRFVENPFQTAEERRLGENGRLYKTGDLVRWLPNGEVEYLGRTDLQVKIRGQRVELGEVEAALSSYPGVVRSLVVAREHAVGQKYLVGFYVGEQEFDEQDLKQWMRKKLPESVVPARVLRITDIPVTPSGKLDARRLPETDFGAGEGAEYVAPVSEFELKLCGIWAQVLEIAPDRIGVHDDFFALGGDSIRAMALAQAITTGFGQGLGVATVLQHTTLAAQAEHIQAAALEHTAWTPPPTAVEHPPVSLAQERLLFIDDFEGGTAAYNIPFVLRLPAHTRAALPGALGTLVRRHPALRTLLKTDDQGVRRQYPIPADDVRLEVPSTTVDSRAELDEVLTERAGYVFRLHEELPIRAEAFDHGDEIYLSVVVHHSCFDGWSWDIFRRELAALLDGVPEADLGALRGTYGEFAVWQRQYLTGKRLAALTEFWTGALGGFETIALPLDHPRPPRFDYRGRELEFELDERTTEALRELARTARVSLYSVLLGAWCLMLNMYTGQHDLVVGTPSANRGRPEFDRAVGFFANLLALRVRVDPAATLPAYVRSVGEAVVAAQVHGELPFEQLVKELKVEKDPSRHPILQLNFTLQNVSDHTSALTGYQPDSGGWTTTKFDLSATMTETATGLAGNLTYAASLFDDTSASGFIATFKHVLAEFASAAAQTPIAQLTALDEPGQAALPDATRRARRPGGPGRCTRLFEEVAATWPDRVAVVHGDVRLTYRELNERANRLAHHLRSVAEPRADELIALVLDKSELTLVAILAVWKAGAAYMPIDPSYPDDRIAFMLSDTGAKLVLAGEAHGSRVRGLTSGDVLDLEQLDLTGEPAENPVTETTSTELAYAIYTSGTTGKPKAVLVSHGSVDSFRAQLSGRYFGSPDESAEAVLFLANYVFDFSVEQLALSVLGGHKLLVPPPSAADDPAFYELANREGLSYLSGTPTQVERFDLARLSHLRCVLVAGEAFQPQHFEKMRGEFAGPILNAYGTTETTVYNTVHRFEPGDAYRNTLGAPLGNTRLYVLGDGMKLLPTGAVGELYLAGDCVTEGYLHRPELTRERFLPNPFAAESGRFPMIYRTGDVVRRGPDGELQYLGRNDAQVKINGLRIEPGEVEAALAGCSGVRQCAVVAGADPQAPERKRLVGYYLPEPGAAVDEADLFAALRAQLMPSMVPSLLVRLDRPLPMTITGKLDVDALPSADFSPKRAAYAAPRDRVEARLCHLWSAQLPGGTVGIDDDFFRCGGDSISALHLASQVQREIERKVSVKYLFDHPTVRSFVDNVLSGLAESSGDDEPEQGRLTGECPMLPIQEWFFAKPLADRHRWNHNFAIRTPPLDPGELRTALDRLVEHHDAFRLRFPESGGEVYAEDAAPITLHELDVRGLADADLRQRLVDWQRTFDLANGPTACAAYLHGFDDGTARVWFALHHLVVDTVSWHILAQDLEILYNGGDLGAKTGSYRQWAQAVRDYTPAEGEREFWAETTRDMESAELLAQTEGTTRRREEFALTAPDTRTLLAESPWAYDTEVNDLLLTATGFALRSITRQATNHLTVEGHGRELFEGAPDVRDTVGWFTTMHPFAVEVDPGDLGRSVLATRANRRRVPHHGIGYGALFGGEAPLPAVSFNYLGRLGEGDGQPTEAWQLDPALSGSHTVDGNRLANRSSIDVTMSCTGGRLVAVVDSLLGEAATRLFASELKVWLERLVSHTATVARNEPAREATTELFDPYILVNEDAERTLFVLPPGEGGAESYLSNLARQLPDLRLVLFNNVHLHTPMGSFEELGRYYVEHIRRLQPSGPYHLLGWSFGGVLSLEISRQLARAGERIDDLLLIDPYFGMRQASANIGLPGVEDILDPINYHYRPDEADLARLAGRLGNLVLFKAGEPNDVVNGPHQPRLFEYYHGTRFNHLDLLLPAAAIEVCDLAGETHHSWVRNEKLVRLMCERISTSLGSD

pcbAB

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

805 amino acids

Each of the constituent amino acids of ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates.

Belongs to the ATP-dependent AMP-binding enzyme family.

88.718 kDa

single

MMSARYPRTAAEWTTRIQGVSSERCDLEMLLKDEWRNRIAVRDDDPGVRATRQRDIVVDGREYTALKDALRAADGVSAGALALASLHSVMRAYGHGEQTVAAFVDATATAELKTAAVLPVIVDHIEHTRLTCAEAIRELDETLRRKDSYTRADEVLQRGLFDALLVLAEREVALSELPSAPLVMVVRDDAARGRLCWTMAYAGELFEDTTVAGVLEVVREVLGQYAGRPGDRVAEIELASREQRERLQRWNATDGDFPADQRLNDLVEAAVRRSPDREAVVFGTQRLTYREVDARANRFAHWLLGPGLGVRSQQLVGIFLDKSDLGVVATLGIWKAGAAYVPIDPAYPAERVRFAVGDTGLRGIVTNRHHAGRLREILGAEHADVTVVEIESVLDEQAAADTDGLLSVKPELALGVRDLAYLTYTSGTTGVPKGVPKYHDSVVNSITDLSERYDMRRPGTERVALFASYVFEPHLRQTLIALINGQTLVVVPEEVRLDPDRFPAYIEEHGVTYLNATGSVLQHFDLRRRTSLKRLLLVGEELTAAGLRQLRERFSGRIVNEYAFTEAAFVTAVKKFAPGVTERADRSIGRPVRNVKWYVLSQDLKRLPVGAIGELYIGGCGVAPGYLNRDDLTAERFLTNPYASEQDRARGTNARIYRTGDLARMLPSGEVEFMGRSDFQLKLNGVRVEPGEIEAQATEYAGVRKCVVIAREGAGGGSDRHLVGYYLTEPGAGVTEAELLSFLERRLIRIMVPARMVRLESIPVNVNGKVDWRALPEVDLARPDTGGGAVGSTTTGGVRGELREI