Protein
Sphingolipid C9-methyltransferase
Organism
Komagataella phaffii (strain GS115 / ATCC 20864)
Function
Catalyzes methylation of the sphingoid base component of glucosylceramides (GluCers) at the C9-position. Sphingolipid C9-methylation requires 4,8-desaturated ceramides as substrates. Glucosylceramides play important roles in growth, differentiation and pathogenicity. The methyl group at the C9-position distinguishes fungal glucosylceramides from those of plants and animals, and may thus play a role in host-pathogen interactions enabling the host to recognize the fungal attack and initiate specific defense responses.
Similarity
Belongs to the CFA/CMAS family.
Sequence
MSQTESTKGVKITNYAAIKNAPLPADGPGAKNFSNWLLLGLLTGVPLFVTRKFHGGLKTFIFFFILFAIPILMAYWTVLSSYSPRLNEKVQFPNRGVEHYLKFHDDQLAARYQGQNKIPMETFHELYFEGKVSFKGDALDALEYRHDWASFRFTLSLFRFFLLGMIPEVIMHSRSQDEEQVRDHYDRGDDFYSWFLGDRMVYTSGLISDVNKDESLEELQDNKLKTVCEKIQLKEGEYLLDLGCGWGTLAAFASSQYGAKVTGITLGKNQTKYGNDKIASFGVDEKQSRILCHDYRDTPLPKDENGNTTKYDKITCLEMAEHVGVRKFRSFLQQVYDMLDDDGVFFLQYAGLRKSWQYEDLIWGLFMNKYIFPGADASTPLDFVVSALEATGFETVSIDNIGVHYSATLYRWYKNWLSNRDNVVNKYGIKWFKIWEYFLASSTIISRQGSATCYQIVLRKNLNSYDRAGYISTQEGLQGPISRKTDWVK