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PARL

Gene
parl
Protein
Presenilins-associated rhomboid-like protein, mitochondrial
Organism
Danio rerio
Length
383 amino acids
Function
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of opa1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity).
Similarity
Belongs to the peptidase S54 family.
Mass
42.409 kDa
Sequence
MAWRSCFMKWTQINSINASSLCPKSTRLNIHPQQRCGFRKTERPSESKKGVQETEAEAGGHNRAVPPKPVPPLPPRRPHQLFRPLVFTVGFTGCSFGAAAILQYESVKSRVQLAIEEAKEEKRDTLLEGHDTTYWHNWWNQLSNFQKQVILLISAVDDFWSGLSEGQKTVTGIIALNTVVLCCWRVPAMQRFLVKYFTSNPASKTRCLPMVLSSFSHYSVIHMVVNMYVLWTFSSSIVSLLGREQFLALYLSGGVISTFVSYVFKTATGRLGPSLGASGSIMTVLAAVCTKIPEAKLGIVLLPVISFSAGNALKALVALDIAGLVLGWRFFDHAAHLGGALFGVWYIGYGHELIWRKREPLIKFWHELRNMSPGRPGPGGGGG

Gene
PARL
Protein
Presenilins-associated rhomboid-like protein, mitochondrial
Organism
Homo sapiens
Length
379 amino acids
Function
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
Similarity
Belongs to the peptidase S54 family.
Mass
42.19 kDa
Sequence
MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKVEPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK

Gene
PARL
Protein
Presenilins-associated rhomboid-like protein, mitochondrial
Organism
Pongo abelii
Length
379 amino acids
Function
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity).
Similarity
Belongs to the peptidase S54 family.
Mass
42.208 kDa
Sequence
MAWRGWAQRGWGCGQAWAASVGGRSCEELTAALTPPRLLGRRFNFFIQQKCGFRKAPRKVEPRRSDTGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK

Gene
PARL
Protein
Presenilins-associated rhomboid-like protein, mitochondrial
Organism
Bos taurus
Length
377 amino acids
Function
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity).
Similarity
Belongs to the peptidase S54 family.
Mass
42.301 kDa
Sequence
MAWRGWAQRGWGCGQAWTLPVCGGSYEELTAALAPSRLLRRRFNFFIQQKCGFRKAPRKVEPRRSDTSSEAYKRSALIPPVEETAFYPSPYPIRTLVKPLFFTVGFTGCAFGSAAIWQYESLKSKVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVFVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISTFVSYVCKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYITYGHELIWKNREPLVKIWHEMRTNSPKKGGGSK

Gene
Parl
Protein
Presenilins-associated rhomboid-like protein, mitochondrial
Organism
Mus musculus
Length
377 amino acids
Function
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity).
Similarity
Belongs to the peptidase S54 family.
Mass
41.964 kDa
Sequence
MALQGWVQRGWRCGPAWAPPLGGGYRELSATQAPRLLGRRFNLFVQQKCGFRKAPRKVEPRRSDTGSSGEAYKRSALIPPLEETVFYPSPYPIRTLVKPFFFTIGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGNLRKEINKWWNSLSDGQRTVTGIIAANALVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFVAVYLSAGVISNFVSYVCKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPVFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYITYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK

Gene
Parl
Protein
Presenilins-associated rhomboid-like protein, mitochondrial
Organism
Rattus norvegicus
Length
377 amino acids
Function
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity).
Similarity
Belongs to the peptidase S54 family.
Mass
42.126 kDa
Sequence
MALYSWVQRGWRCGQTWAPLLGGGYRELSATQARQLLGRRFNLLLQQKCGFRKAPRKVEPRRSDTGSSGEAYKRSALIPPLEETVFYPSPYPVRTLLKPFFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGNLRKEINKWWNSLSDGQRTVTGIIAANALVFCLWRVPSLHRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSTSIVNILGQEQFVAVYLSAGVISNFVSYVCKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPVFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYITYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK