Protein
Phosphatidate phosphatase PAH2
Organism
Arabidopsis thaliana
Function
Magnesium-dependent phosphatidate phosphatase which catalyzes the dephosphorylation of phosphatidate to yield diacylglycerol. Acts redundantly with PAH1 to repress phospholipid biosynthesis at the endoplasmic reticulum (ER). May function indirectly as repressor of multiple enzymes involved in phospholipid biosynthesis. Is involved in the pathway of galactolipid synthesis in the ER, which is required for the membrane lipid remodeling, an essential adaptation mechanism to cope with phosphate starvation.
Similarity
Belongs to the lipin family.
Sequence
MNAVGRIGSYIYRGVGTVSGPFHPFGGAIDIIVVEQPDGTFKSSPWYVRFGKFQGVLKNGRNLIRIDVNGVDSGFNMYLAHTGQAYFLREVEDVVGESESGEVYTLSSGDEAETTSRDDVVDKVKIPLKSRSCNYDSPSPRTGNGKIVGKPGILGYVFGGRSVRESQDCGVERAEIAADLLEVKWSTNIDTRKRGKGMSSESLDGKDYGESTSTSGKSCVEGSSEMLVDSDSILETPLVASPTLRFLDEKEQDFRESTNVEDYCEEDGSSGVVVENGLCEASSMVFSVTSEGSGNVEIFVEPRTEALAEDAVSGSDLDSKQELLRAPESVEIATLGSADQADMGSIGTSQEGSSTGSPVQDENKITIKDMHISAGDFEKSQSASGESILQPEIEEEQFSFSDLDECKPGGNSSVGSSSSDTVKVDGKESYDETKTSPEKGVENTMALSEPINIERKKDIFTDEMERLVGSLPIMRLQNNDDMDASPSQPLSQSFDPCFNTSKLDLREDESSSGGLDAESVAESSPKLKAFKHVIANPEVVELSLCKHLLSEGMGAEAASQAFNSEKLDMEKFASLGPSILENDKLVVKIGGCYFPWDAAAPIILGVVSFGTAQVFEPKGMIAVDRNEKPGDVLAQGSGSWKLWPFSLRRSTKEAEASPSGDTAEPEEKQEKSSPRPMKKTVRALTPTSEQLASLDLKDGMNSVTFTFSTNIVGTQQVDARIYLWKWNSRIVVSDVDGTITRSDVLGQFMPLVGIDWSQTGVTHLFSAVKENGYQLIFLSARAISQASVTRQFLVNLKQDGKALPDGPVVISPDGLFPSLFREVIRRAPHEFKIACLEEIRGLFPPEHNPFYAGFGNRDTDEISYLKVGIPRGKIFIINPKGEVAVNRRIDTRSYTNLHTLVNRMFPATSSSEPEDFNTWNFWKLPPPSLM