Protein
Probable inosine/xanthosine triphosphatase
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Function
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Similarity
Belongs to the YjjX NTPase family.
Sequence
MIVAVGTKNPNKIRAVEDAYRLFGIPARIVPAPRPLTTPPQPVGLEAVLKGAVERAKAALQAVEKAEHGVGIEAGVVEAGGVHLDITIAAIVDAGGRTTIGFGPAFQIPPPFLSQVLSGVEMGAVAEQYFKRPSIGYREGLIGVLTKRRVTRYHLNLAAVAMALTPRLPHNSQLYLKP