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PAE1327

Gene
PAE1327
Protein
Type-5 uracil-DNA glycosylase
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Length
226 amino acids
Function
DNA glycosylase with broad substrate specificity. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair. Can also process hydroxymethyluracil (mispaired with guanine or adenine), hypoxanthine and fluorouracil. Exhibits a clear preference for double-stranded DNA substrates, but can also process uracil in single-stranded DNA, with lower efficiency.
Similarity
Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.
Mass
24.915 kDa
Sequence
MDLARVHTPRGWYDDFVNRLVNCARCPRLVSYRSTVKPLRRYESWSYWGRPVPPWGDLNARVMVVGLAPAAHGGNRTGRMFTGDASAQNLFKALFLLGLSNKPYSVSRDDGVEVRCVYITSAVKCAPPKNRPTAEEVYNCSSWLREELEAVRPRAVVALGELAWRAVLKILGATTAAFKHGEVVNAAGVRVYASYHPSPLNVNTGRLTVETLAEVLRRAAADAGCL