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P35

Gene
P35
Protein
Early 35 kDa protein
Organism
Bombyx mori nuclear polyhedrosis virus
Length
299 amino acids
Function
Blocks the insect or worm host cells apoptotic response initiated by the viral infection. Confers protection from cell death in mammalian cells. Acts by blocking the activity of members of the caspase family of proteases.
Similarity
Belongs to the protease inhibitor I50 (p35) family.
Mass
34.912 kDa
Sequence
MCVIFPVEIDVSQTVIRDCHVDEQTRELVYINKIMNTQLTKPVLMMFNISGPIRSVTRKNNDLRDRIKSKVDEQFDQLEREYSDKIDGFHDNIQYFKDEHYSVSCQNGSVLKSKFAKILKSHDYTDKKSIETYEKYCLPQLVDKHNDCYVAVCVLKPGFENGSNQVLSFEYNPIGNKVIVPFAHEINDTGLYEYDVLAYVDSVEFDGKQFEEFVQKLILPSSFNDSEKVLYYNEASKNKNMIYKALEFTTESSWVKSNKFNWKIFCNGFIYDKKSKALYVKLHNVTSTLNKNVILDMIK

Gene
P35
Protein
Early 35 kDa protein
Organism
Autographa californica nuclear polyhedrosis virus
Length
299 amino acids
Function
Functions as an inhibitor of the host RNA interference antiviral response. Inhibits the insect host cell apoptotic response initiated by the viral infection. Blocks as well the activity of members of the caspase family of proteases. Required for late and very late gene expression.
Similarity
Belongs to the protease inhibitor I50 (p35) family.
Mass
34.829 kDa
Sequence
MCVIFPVEIDVSQTIIRDCQVDKQTRELVYINKIMNTQLTKPVLMMFNISGPIRSVTRKNNNLRDRIKSKVDEQFDQLERDYSDQMDGFHDSIKYFKDEHYSVSCQNGSVLKSKFAKILKSHDYTDKKSIEAYEKYCLPKLVDERNDYYVAVCVLKPGFENGSNQVLSFEYNPIGNKVIVPFAHEINDTGLYEYDVVAYVDSVQFDGEQFEEFVQSLILPSSFKNSEKVLYYNEASKNKSMIYKALEFTTESSWGKSEKYNWKIFCNGFIYDKKSKVLYVKLHNVTSALNKNVILNTIK