Protein
Serine/threonine-protein kinase ATR
Organism
Oryza sativa subsp. japonica
Function
Probable serine/threonine kinase. Seems to play a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism (By similarity).
Similarity
Belongs to the PI3/PI4-kinase family. ATM subfamily.
Sequence
MANFSSHIQELRELIAASSTTTSTSAPASVHFEVKLREVLPNLLRDYVVPSSPTADGREATAVLKLLSYTAGKFPGVFFHGRAADVIRVIGRVLPFFAEPNFRSRHEIIFDTVWSLLSLLRTGDREAYRQFFLDVMVAVQDVLYVVASMHGDRPSGVLTERYLVKCLCGSFSDILDSPGIFSDLPDSCQPKNGPGVLVDLTGETRWRPFATMLIKLVNKCLADGTLYVEGLVNMPFVSAACSIICYGDESLHKVCFDFARIVATVITVEILPVENIIRSIMCILSQDVNGLSDIRDADYDFSMGACLHALHSSCPGYIVAITASDIVNVFQRAVHTSRSSELQVAMCNAYKRIVELCSPRVWKPEILLKLLCLPKPCAKLIECIRLVVDKSGQSFLSSDDRDDGSSLLAKSEGLDLPKVGQKRIALDEENSFPKRLKMTEPRFSSGSFMVDELSAGVGQELEKDHGCDFRVQLYSLINCLSPDNHMAYPLEPAISIQVLSLLCLSLSVYPKTNLFSRISKQVLSWIPWICKQTTKICMFSFDVSLYFEAVQTVMLLQSFLPGHTKLFEDEPLLIGNGCTDFEYPRYADLINLLKLVSDDGYLTSQTCSEKLKCLAVQIIAKIGSRQNAECDLQVLELAIQSETGELQNEALMSLPIIVLYSGPRMLGAMFRKLETIGTLGCKKLWKSIAISLGFLSCLNGTTDCTDKVGNHCKLFLAKHCEQPILTLNLLRGFWCPQCDVRTVHIEDQVPIVDIALSEDKNIDFKINMFKAHSLFFKFLYAETSEECIVSIVEVLPRILKHSSRDVLLDMKFQWVQCVDFLLLHEMKAVRDAFSSVVSCFLETNAMDILFSDGTGMSGGTSRVKFMDKIKSAFTEAEDPQILLTLLESTAAIVKASDIHGEVFFCSFVLLIGQLGNHDYIVRVTALRLLQRCCTYCFKGGLELFLSKYFHVRDNLYDYLSSRLLTHPVVISEFAESVLGVKTEELIRRMVPSIIPKLIVSHQNNDQAVVTLNELASHLNSELVPLIVNSLPKVLSFALFYEDGQHLSSVLQFYHTETGTDSKEIFSAALPTLLDEIICFPGESDQIETDRRMAKISPTIQNIARILTGNDNLPEFLKNDFVRLLNSIDKKMLHSSDVNLQKQALQRIRKLVEMMGPYLSTHAPKIMVLLIFAIDKETLQMDGLDVLHFFIKRLAEVSCTSIKYVMSQVVAAFIPSLERCRERPLVHLGKIVEILEELVVKNIILLKQHIRELPLLPSLPSLSGVNKVIQEARGLMTLQDHLKDAVNGLNHESLNVRYMVACELNKLFNDRRGDITSLIIGEDIADLDIISSLIMSLLKGCAEESRTVVGQRLKLVCADCLGALGAVDPAKFKVMSCERFKIECSDDDLIFELIHKHLARAFRAASDTTVQDSAALAIQELLKLSGCQSLPNESSSCKMSKRGQKLWGRFSSYVKEIIAPCLTSRFHLPSVNDATLAGPIYRPTMSFRRWIYYWIRKLTSHATGSRSGIFGACRGIVRHDMPTAIYLLPYLVLNVVCYGTPEARQSITEEILSVLNAAASESSGAIVHGITGGQSEVCIQAVFTLLDNLGQWVDDLKQEIALSQSNYAMAGRQGGKLRDESNSMYDQDQLLVQCSNVAELLAAIPKVTLAKASFRCQAHARALMYFESHVREKSGSSNPAADCSGAFSDDDISFLMEIYGGLDEPDGLLGLANLRKSSTLQDQLIINEKAGNWAEVLTLCEQSLQMEPDSVHRHCDVLNCLLNMCHLQAMIAHVDGLVYRIPQSKKTWCMQGVQAAWRLGRWDLMDEYLAEADKGLVCRSSENNASFDMGLAKIFNAMMKKDQFMVAEKIAQSKQALLVPLAAAGMDSYMRAYPYIVKLHMLRELEDFNSLLGDESFLEKPFAADDPKFLKLTKDWENRLRCTQPSLWAREPLLAFRRMVYNLSHMNAQAGNCWLQYARLCRLAGHYETAHRAILEADASGAPNAHMEKAKYLWNIRKSDSAIAELQQTLLNMPADVLGPTVLSSLSSLSLALPNAPLSVTQASKENPDVSKTLLLYTRWIHYTGQKQSNDIKSLYSRVADLRPKWEKGFFCIAKFYDDLLVDARRRQEDKKIASGVGPVPPSSTGSLTTATEEKPWWDMLPVVLIQYARGLHRGHKNLFQALPRLLTLWFEFGSIYIQDGSSFNKPMKEVHIRLLGIMRGCLKDLPPYQWLTVLSQLISRICHQNIEVVKLVKCIVTSILREYPQQALWMMAAVSKSTVAARRDAAAEILQSAKKGSRRGSDSNALFMQFPSLIDHLIKLCFHPGQPKARAINISTEFSSLKRMMPLGIILPIQQALTVTLPSYDTNMTDQSTFRPFSVSEHPTIAGIADDAEILNSLQKPKKVVFIGSDGISRPFLCKPKDDLRKDSRMMEFNAMINRLLSKVPESRRRKLYIRTFAVVPLTEDCGMVEWVPNTRGLRQILQDIYITCGKFDRMKTNPQIKKIYDQLQGKMPEEMLKAKILPMFPPVFHKWFLTTFSEPAAWIRARAAYAHTTAVWSMVGHIVGLGDRHGENILLDSTTGDCIHVDFSCLFDKGLLLEKPEVVPFRFTQNMVDGLGITGYEGVFVKVCEITLSVLRTHKEALMTVLETFIHDPLVEWTKSHKSSGVEVRNPHAQRAISNITERLQGVVVGVNAAPSLPLSVEGQARRLIAEAVSHSNLGKMYVWWMAWF