Oas1b

Inactive 2'-5'-oligoadenylate synthase 1B

379 amino acids

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against west Nile virus (WNV) via an alternative antiviral pathway independent of RNase L (By similarity).

Belongs to the 2-5A synthase family.

44.122 kDa

MEQELRSIPASKLDQFIEVHLPDISFRDELREVIDVLCILLKNRCCRESSHPVRTSKVGKGGSSRKGTTLKGWSDADLVVFLDSFTCFGDQLNRRGEFTKEIKKLLFEVQRDRHIGVKIEVHSSWSPNHRALSFKLSAPDQQKEVKFDVLPAYDLLGHVCIPRKPNPQFYANLISERTSLGKEDEFSTCFTELQLYFLNWRPTKLKSLIRLVKHWYQLCKEKLGDPLPPQYALELLTIYAWERGGRLTKFNTAQGFRTVLELITKYKQLLIYWTVCYDFQHPEVSKYLRRQLKKPRPVILDPANPTGNIAGSNPKGWRRLAGEAAAWLRYPCFKYKDGFPVCPWDVPTEVDIPSQNYFFHIICLIFWLLLRLIFGKHSV

Oas1b

Inactive 2'-5'-oligoadenylate synthase 1B

376 amino acids

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA (PubMed:12396720, PubMed:27663720). The full-length protein displays antiviral activity against flaviviruses such as west Nile virus (WNV) via an alternative antiviral pathway independent of RNase L (PubMed:12080145, PubMed:16371364, PubMed:17904183, PubMed:27663720). The truncated form of the protein lacks antiviral activity (PubMed:12080145, PubMed:16371364, PubMed:17904183).

Belongs to the 2-5A synthase family.

43.62 kDa

MEQDLRSIPASKLDKFIENHLPDTSFCADLREVIDALCALLKDRSFRGPVRRMRASKGVKGKGTTLKGRSDADLVVFLNNLTSFEDQLNQQGVLIKEIKKQLCEVQHERRCGVKFEVHSLRSPNSRALSFKLSAPDLLKEVKFDVLPAYDLLDHLNILKKPNQQFYANLISGRTPPGKEGKLSICFMGLRKYFLNCRPTKLKRLIRLVTHWYQLCKEKLGDPLPPQYALELLTVYAWEYGSRVTKFNTAQGFRTVLELVTKYKQLQIYWTVYYDFRHQEVSEYLHQQLKKDRPVILDPADPTRNIAGLNPKDWRRLAGEAAAWLQYPCFKYRDGSSVCSWEVPTEVGVPMKYLLCRIFWLLFWSLFHFIFGKTSSG