Function
Receptor for octopamine (OA) which is a neurotransmitter, neurohormone and neuromodulator in invertebrates (PubMed:9570796, PubMed:15816867). Stimulates intracellular accumulation of cAMP and Ca(2+) following ligand binding (PubMed:9570796, PubMed:15816867). Required for ovulation (PubMed:14623240, PubMed:19262750). Following activation on mature follicle cells by OA, induces activity of the metalloprotease Mmp2 which leads to breakdown of the posterior follicle wall, resulting in ovulation (PubMed:26473732). Ligand binding probably also leads to activation of CamKII which is also required for ovulation (PubMed:19262750). Modulates sleep/wake behavior by acting in neurons of the pars intercerebralis to promote wakefulness (PubMed:20223202). Plays a role in courtship conditioning where the courtship behavior of males rejected by already mated females is inhibited with further females (PubMed:23055498). Required in the mushroom body for appetitive olfactory learning (PubMed:23103875, PubMed:23345239). Specifically conveys the short-term reinforcing effects of sweet taste (PubMed:23103875, PubMed:25728694). In insulin-producing cells of the brain, plays a role in inhibiting transcription of insulin-like peptide Ilp3 (PubMed:24923784). Also plays a role in social behavior by modulating male agression (PubMed:24923784).
Sequence
MNETECEDLIKSVKWTEPANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYIIRPFCQDCVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICRCFCSRQSVSLKSSRRGSDMSAIRIRARTPSITPSAAAHSFGDESELHHSEMSNDPR