OXP1

5-oxoprolinase

1286 amino acids

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.

Belongs to the oxoprolinase family.

140.428 kDa

MQKGNIRIAIDKGGTFTDCVGNIGTGKQEHDTVIKLLSVDPKNYPDAPLEGIRRLLEVLEHKTIPRGIPLDISNVRSLRMGTTLATNCALERNGERCAFITTKGFKDSLLIGDQTRPDIFNLNIKKVVPLYDTVVEIDERVTLEDFSEDPYFTKSSPNEQEGILEGNSGEMVRVIKKPDESSVRSILKVLYASGIKSIAIAFLHSYTFPDHERIVGNIAREIGFSHVSLSSEVSPMIKFLPRAHSSVADAYLTPVIKKYLNSISAGLSHAEDTHIQFMQSDGGLVDGGKFSGLKSILSGPAGGVIGYSSTCYDKNNNIPLIGFDMGGTSTDVSRYGDGRLEHVFETVTAGIIIQSPQLDIHTVAAGGSSILSWKNGLFRVGPDSAAADPGPAAYRKGGPLTITDANLFLGRLVPEFFPKIFGPNEDESLDLETTTLKFRELTDVINKDLNSNLTMEEVAYGFIKVANECMARPVRAITEAKGHVVSQHRLVSFGGAGGQHAIAVADSLGIDTVLIHRYSSILSAYGIFLADVIEENQEPCSFILGEPETILKVKKRFLELSKNSIKNLLSQSFSREDIVLERYLNLRYEGTETSLMILQKYDDQWNFREWFSEAHKKEFGFSFDDKRIIIDDIRIRAIGKSGVRKEKTVDEQLIEISHFKKADVSKDASFTQKAYFDNKWVDTAVFKIDDLPAGTIIEGPAILADGTQTNIILPNSQATILNSHIFIKINQKAAKTLSKSGYELDIDPILLSIFSHRFMDIALQMGTQLRKTSVSTNVKERLDFSCALFDSKGNLVANAPHVPVHLGSMSTCISAQAKLWEGKLKPGDVLITNHPDIGGTHLPDITVITPSFSSTGELIFYVASRAHHADIGGILPGSVPPNSKELYEEGTAIYSELVVKEGIFQEELIYKLFVEDPGKYPGCSGSRRFSDNISDLKAQVAANTKGIQLIGSLTKEYDLATILKYMAAIQTNASESIKKMLAKMVEHFGTTKFSGEDRLDDGSLIKLQVIIRPEKEEYIFNFDGTSPQVYGNLNAPEAITNSAILYCLRCLVGEDIPLNQGCLKPLTIKIPAGSLLSPRSGAAVVGGNVLTSQRVTDVILKTFNVMADSQGDCNNFTFGTGGNSGNKTDKQIKGFGYYETICGGSGAGADSWRGSGWNGSDAVHTNMTNTRMTDTEVFERRYPVLLKEFSIRRGSGGKGKYTGGNGVVRDVQFRKAVTASILSERRVIGPHGIKGGQDGSRGENLWVRHSTGALINVGGKNTIYAQPGDRFIIKTPGGGGFGQYKD

OXP1

5-oxoprolinase

1266 amino acids

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Acts in the glutathione degradation pathway.

Belongs to the oxoprolinase family.

137.531 kDa

MGTVIEGKLRFCIDRGGTFTDVYAEIPGHSDGHVLKLLSVDPSNYDDAPVEGIRRILEEYTGKKIPRTSKIPTDKIQWIRMGTTVATNALLERKGERIALCVTKGFKDLLQIGNQARPDIFDLTVAKPSNLYEEVIEVDERVVLALEDDDDDEGSLIKGVSGEFLRVVKPFDGEGLKPLLKGLLDKGISCLAVVLMHSYTYPKHEMDVEKLALEMGFRHVSLSSALTPMVRAVPRGLTATVDAYLTPVIKEYLSGFISKFDDDLGKVNVLFMQSDGGLAPESRFSGHKAVLSGPAGGVVGYSQTLFGLETEKPLIGFDMGGTSTDVSRYDGSYEQVIETQIAGTIIQAPQLDINTVAAGGGSKLKFQFGAFRVGPDSVGAHPGPVCYRKGGELAVTDANLVLGFVIPDYFPSIFGPNEDQPLDVAATREAFEKLAGQINIYRKSQDPSAKDMSVEEIAMGFVSVANETMCRPIRQLTEMKGHETKNHALACFGGAGPQHACAIARSLGMKEVLVHRYCGILSAYGMGLADVIEDAQEPYSAVYGPESLSEVFRRETVLLREVREKLQEQGFGDGNISTETYLNLRYDGTDTAIMVKGKKTGDGSAFDYAAEFLKLFEQEYGFKLQNRNLLICDVRVRGIGVTSILKPRAVEAAPVTPKVERHYKVYFEGGWHDTPLFKLENLGFGHEILGPAIIMNGNSTVIVEPQCKAIITKYGNIKIEVEPATSSVKLAENVADVVQLSIFNHRFMGIAEQMGRTLQRTSISTNIKERLDFSCALFSPDGGLVANAPHVPVHLGAMSSTVRWQLKHWGENLNEGDVLVTNHPCAGGSHLPDITVITPVFDKGKLVFFVASRGHHAEVGGITPGSMPPFSKAIWEEGAAIKAFKVVEKGVFQEEGIVKLLQFPSSDETTTKIPGTRRIQDNLSDLQAQIAANQRGISLIKELIEQYGLGTVQAYMKYVQLNAEEAVREMLKSVANRVSSETPNSRVGNSVTIEEEDYMDDGSIIHLKLTIDADKGEASFDFTGTSPEVYGNWNAPEAVTSAAVIYCLRCLVNVDIPLNQGCLAPVEIRIPAGSFLSPSEKAAVVGGNVLTSQRVTDVVLTAFQACACSQGCMNNLTFGDDTFGYYETIGGGCGAGPTWNGTSGVQCHMTNTRMTDPEIFEQRYPVLLHRFGLRENSGGNGLHKGGDGLVREIEFRKPVVVSILSERRVHSPRGLNGGQNGLRGANYLITKDKRRIYLGGKNTVHVEAGEILQILTPGGGGFGSNI