Ost48

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

449 amino acids

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).

Belongs to the DDOST 48 kDa subunit family.

49.981 kDa

MMWKALLIAVLAIAHCQAVLETDANTLVLLDNLAIRETHSIFFKSLQDRGFKLTYKLADDSSLLLSKYGEYLYKNVIIFAPSVEEFGGDVSVERLAQFVDDGGNVLVAGSEKSGDALREFASECGFELDEENAAVIDHLHYDVSDAGEHTTILTSAKNLIQADTIVGKANRQADAAPLLYRGTGLIADKENPLVLKLLTAESTAYSYNPEASVSDYPHAVGRGTLLIAALQARNNARVVFSGSLLFFSDESFTTAVQYAQSGVFHKLAGNRDVAESISKWVFGETGRLRVASVQHHKEGELLPPDQAYTITDPVVYTIGIEELVQGEWRAFKASDIQLEFVRIDPFVRTYLKQTNTGAYQAKFKIPDVYGVYQFKVDYNRVGYTHLYSTTQVSVRPLEHTQYERFIPSAFPYYTSAFSMMIGVFVFSFVFLHFKDEPVGRAAKEDKKSQ

OST48

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

439 amino acids

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

Belongs to the DDOST 48 kDa subunit family.

48.39 kDa

MAAPRHHHLALAVALALLVVTAAAADEGGPRGRRVLVLVDDLAVRSSHSAFFASLQGRGFDLDFRLADDPKLSLHRYGQYLYDGLVLFAPSTPRFGGSVDQNSILEFIDAGHDMILAADSSASDLIRGIATECGVDFDEDPEAMVIDHINYAATDAEGDHTLIAGDDLIQSDVILGSKKIEAPVLFRGIGHAVNPSNSLVLKVLSASPSAYSANPKSKLASPPSLTGSAISLVSVMQARNNARVLISGSLDLFSNRFLKSGVQKAGSKIRHEKAGNEQFVTETSKWVFHERGHLKAVNVKHNKVGETNEPGMYRINDDLEYSVEIYEWSGTSWKPYVADDVQVQFYMMSPYVLKTLSTDKKGVFSTSFKVPDVYGVFQFKVEYQRLGYTGLSLSKQIPVRPYRHNEYERFITSAYPYYAASFSTMGAFFIFSFVYLYHK

OST48

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

437 amino acids

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:15860005). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity).

Belongs to the DDOST 48 kDa subunit family.

48.744 kDa

MVNLSRSVALISVFLLPLLSFSFSVDNPTDRRVLVLLDDLSLKSSHSIFFNTLKSRGFDLDFKLAEDSKLALQRYGQYLYDGLIIFAPSTERFGGSLDSKSIADFVDSGRDLILSADTAASDLIRGIATECGVDFDEDSSAMVIDHTSFSVSDVDGDHTLIAADDLVKSDVILGKTKIEAPVLFRGVAHSLNPTNNLVLKVLSASPSAYSANPSSKLSSPPQLTGSSISLVSVMQARNNARVVISGSVQLFSDRLIRSGVQKAGSPNQYEKSGNEQFVTELSKWVFHERGHLKAGNLVHHRVGETDEPAIYRIKDDLEFSVEIYEWSGKSWEPYVANDVQVQFYMMSPYVLKTLSTDKKGLFHTSFKVPDVYGVFQFKVEYEKLGYTTLSLSKQIPVRPYRHNEYERFIPTAYPYYGACFTTMAGFFVFSFVYLYHK