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ORM1

Gene
ORM1
Protein
Protein ORM1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
222 amino acids
Function
Component of the SPOTS complex that acts as a negative regulator of sphingolipid synthesis. Acts by inhibiting serine palmitoyltransferases (LCB1 and LCB2) activity.
Similarity
Belongs to the ORM family.
Mass
25.245 kDa
Sequence
MTELDYQGTAEAASTSYSRNQTDLKPFPSAGSASSSIKTTEPVKDHRRRRSSSIISHVEPETFEDENDQQLLPNMNATWVDQRGAWIIHVVIIILLKLFYNLFPGVTTEWSWTLTNMTYVIGSYVMFHLIKGTPFDFNGGAYDNLTMWEQIDDETLYTPSRKFLISVPIALFLVSTHYAHYDLKLFSWNCFLTTFGAVVPKLPVTHRLRISIPGITGRAQIS

Gene
Orm1
Protein
Alpha-1-acid glycoprotein 1
Organism
Mus musculus
Length
207 amino acids
Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Similarity
Belongs to the calycin superfamily. Lipocalin family.
Mass
23.895 kDa
Sequence
MALHTVLIILSLLPMLEAQNPEHANFTIGEPITNETLSWLSDKWFFMGAAFRKLEYRQAIQTMQSEFFYLTTNLINDTIELRESQTIGDQCVYNSTHLGFQRENGTFSKYEGGVETFAHLIVLRKHGAFMLAFDLKDEKKRGLSLYAKRPDITPELREVFQKAVTHVGMDESEIIFVDWKKDRCGQQEKKQLELGKETKKDPEEGQA

Gene
Orm1
Protein
Alpha-1-acid glycoprotein 1
Organism
Mus caroli
Length
207 amino acids
Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Similarity
Belongs to the calycin superfamily. Lipocalin family.
Mass
23.896 kDa
Sequence
MALHMILVMLSLLPLLEAQNPEHVNITIGEPITNETLSWLSDKWFFIGAAVLNPDYRQEIQKMQMVFFNITPNLINDTMELREYHTIDDHCVYNSTHLGIQRENGTLSKYVGGVKIFADLIVLRKHGAFMLAFDLKDEKKRGLSLNAKRPDITPELREVFQKAVKHVGMDESEIIFVDWKKDKCGQQEKKQLELEKETKKDPEEGQA

Gene
Orm1
Protein
Alpha-1-acid glycoprotein
Organism
Rattus norvegicus
Length
205 amino acids
Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Similarity
Belongs to the calycin superfamily. Lipocalin family.
Mass
23.575 kDa
Sequence
MALHMVLVVLSLLPLLEAQNPEPANITLGIPITNETLKWLSDKWFYMGAAFRDPVFKQAVQTIQTEYFYLTPNLINDTIELREFQTTDDQCVYNFTHLGVQRENGTLSKCAGAVKIFAHLIVLKKHGTFMLAFNLTDENRGLSFYAKKPDLSPELRKIFQQAVKDVGMDESEIVFVDWTKDKCSEQQKQQLELEKETKKETKKDP

Gene
ORM1
Protein
Alpha-1-acid glycoprotein
Organism
Bos taurus
Length
202 amino acids
Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction (By similarity).
Similarity
Belongs to the calycin superfamily. Lipocalin family.
Mass
23.182 kDa
Sequence
MALLWALAVLSHLPLLDAQSPECANLMTVAPITNATMDLLSGKWFYIGSAFRNPEYNKSARAIQAAFFYLEPRHAEDKLITREYQTIEDKCVYNCSFIKIYRQNGTLSKVESDREHFVDLLLSKHFRTFMLAASWNGTKNVGVSFYADKPEVTQEQKKEFLDVIKCIGIQESEIIYTDEKKDACGPLEKQHEEERKKETEAS

Gene
ORM1
Protein
Alpha-1-acid glycoprotein 1
Organism
Homo sapiens
Length
201 amino acids
Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Similarity
Belongs to the calycin superfamily. Lipocalin family.
Mass
23.512 kDa
Sequence
MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDQITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQDQCIYNTTYLNVQRENGTISRYVGGQEHFAHLLILRDTKTYMLAFDVNDEKNWGLSVYADKPETTKEQLGEFYEALDCLRIPKSDVVYTDWKKDKCEPLEKQHEKERKQEEGES

Gene
ORM1
Protein
Alpha-1-acid glycoprotein
Organism
Oryctolagus cuniculus
Length
201 amino acids
Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Similarity
Belongs to the calycin superfamily. Lipocalin family.
Mass
23.028 kDa
Sequence
MALPWALAVLSLLPLLHAQDPACANFSTSPITNATLDQLSHKWFFTASAFRNPKYKQLVQHTQAAFFYFTAIKEEDTLLLREYITTNNTCFYNSSIVRVQRENGTLSKHDGIRNSVADLLLLRDPGSFLLVFFAGKEQDKGMSFYTDKPKASPEQLEEFYEALTCLGMNKTEVVYTDWTKDLCEPLEKQHEEERKKEKAES

Gene
ORM1
Protein
Protein ORM1
Organism
Saccharomyces pastorianus (strain ATCC 76670 / Carlsberg bottom yeast no.2 / CBS 1503 / CLIB 180 / NBRC 10610 / NRRL Y-1525)
Length
148 amino acids
Similarity
To yeast YLR350W C-terminus.
Mass
17.005 kDa
Sequence
MNATWVDQRGAWIIHVVVITLLKLFFNLFPGVTAEWSWTLTNMTYVVGSYVMFHLIKGTPFDFNGGAYDNLTMWEQIDDETLFTPSRKFLIIVPIALFLVSTHYAHYDLKMFSWNCFLTTFVAVVPKLPVTHRLRISIPGITGRAQIS