Protein
viral cyclin homolog
Organism
Human herpesvirus 8 type P (isolate GK18)
Function
Modulates host cell cycle progression and apoptotic signaling pathways by acting as a cyclin. Forms an active kinase complex with cellular CDK6 kinase. Promotes host S-phase entry of quiescent cells and activates host cyclin A. Triggers host apoptosis by inactivating host BCL2.
Similarity
Belongs to the cyclin family.
Sequence
MATANNPPSGLLDPTLCEDRIFYNILEIEPRFLTSDSVFGTFQQSLTSHMRKLLGTWMFSVCQEYNLEPNVVALALNLLDRLLLIKQVSKEHFQKTGSACLLVASKLRSLTPISTSSLCYAAADSFSRQELIDQEKELLEKLAWRTEAVLATDVTSFLLLKLLGGSQHLDFWHHEVNTLITKALVDPKTGSLPASIISAAGCALLVPANVIPQDTHSGGVVPQLASILGCDVSVLQAAVEQILTSVSDFDLRILDSY