Protein
Non-structural protein ORF4a
Organism
Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)
Function
DsRNA-binding protein that plays a role in the inhibition of host innate response. Suppresses host PACT-induced activation of DDX58 and MDA5 and thereby circumvents the production of type I inteferons. Prevents also the activation of host NF-kappaB.
Sequence
MDYVSLLNQIWQKYLNSPYTTCLYIPKPTAKYTPLVGTSLHPVLWNCQLSFAGYTESAVNSTKALAKQDAAQRIAWLLHKDGGIPDGCSLYLRHSSLFAQSEEEESFSN