ORF22

Large tegument protein deneddylase

2763 amino acids

Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.

Belongs to the herpesviridae large tegument protein family.

306.343 kDa

MDIIPPIAVTVAGVGSRNQFDGALGPASGLSCLRTSLSFLHMTYAHGINATLSSDMIDGCLQEGAAWTTDLSNMGRGVPDMCALVDLPNRISYIKLGDTTSTCCVLSRIYGDSHFFTVPDEGFMCTQIPARAFFDDVWMGREESYTIITVDSTGMAIYRQGNISFIFDPHGHGTIGQAVVVRVNTTDVYSYIASEYTHRPDNVESQWAAALVFFVTANDGPVSEEALSSAVTLIYGSCDTYFTDEQYCEKLVTAQHPLLLSPPNSTTIVLNKSSIVPLHQNVGESVSLEATLHSTLTNTVALDPRCSYSEVDPWHAVLETTSTGSGVLDCRRRRRPSWTPPSSEENLACIDDGLVNNTHSTDNLHKPAKKVLKFKPTVDVPDKTQVAHVLPRLREVANTPDVVLNVSNVDTPESSPTFSRNMNVGSSLKDRKPFLFEQSGDVNMVVEKLLQHGHEISNGYVQNAVGTLDTVITGHTNVPIWVTRPLVMPDEKDPLELFINLTILRLTGFVVENGTRTHHGATSVVSDFIGPLGEILTGFPSAAELIRVTSLILTNMPGAEYAIKTVLRKKCTIGMLIIAKFGLVAMRVQDTTGALHAELDVLEADLGGSSPIDLYSRLSTGLISILNSPIISHPGLFAELIPTRTGSLSERIRLLCELVSARETRYMREHTALVSSVKALENALRSTRNKIDAIQIPEVPQEPPEETDIPPEELIRRVYEIRSEVTMLLTSAVTEYFTRGVLYSTRALIAEQSPRRFRVATASTAPIQRLLDSLPEFDAKLTAIISSLSIHPPPETIQNLPVVSLLKELIKEGEDLNTDTALVSWLSVVGEAQTAGYLSRREFDELSRTIKTINTRATQRASAEAELSCFNTLSAAVDQAVKDYETYNNGEVKYPEITRDDLLATIVRATDDLVRQIKILSDPMIQSGLQPSIKRRLETRLKEVQTYANEARTTQDTIKSRKQAAYNKLGGLLRPVTGFVGLRAAVDLLPELASELDVQGALVNLRTKVLEAPVEIRSQLTGDFWALFNQYRDILEHPGNARTSVLGGLGACFTAIIEIVPIPTEYRPSLLAFFGDVADVLASDIATVSTNPESESAINAVVATLSKATLVSSTVPALSFVLSLYKKYQALQQEITNTHKLTELQKQLGDDFSTLAVSSGHLKFISSSNVDDYEINDAILSIQTNVHALMDTVKLVEVELQKLPPHCIAGTSTLSRVVKDLHKLVTMAHEKKEQAKVLITDCERAHKQQTTRVLYERWTRDIIACLEAMETRHIFNGTELARLRDMAAAGGFDIHAVYPQARQVVAACETTAVTALDTVFRHNPYTPENTNIPPPLALLRGLTWFDDFSITAPVFTVMFPGVSIEGLLLLMRIRAVVLLSADTSINGIPNYRDMILRTSGDLLQIPALAGYVDFYTRSYDQFITESVTLSELRADIRQAAGAKLTEANKALEEVTHVRAHETAKLALKEGVFITLPSEGLLIRAIEYFTTFDHKRFIGTAYERVLQTMVDRDLKEANAELAQFRMVCQATKNRAIQILQNIVDTANATEQQEDVDFTNLKTLLKLTPPPKTIALAIDRSTSVQDIVTQFALLLGRLEEETGTLDIQAVDWMYQARNIIDSHPLSVRIDGTGPLHTYKDRVDKLYALRTKLDLLRRRIETGEVTWDDAWTTFKRETGDMLASGDTYATSVDSIKALQASASVVDMLCSEPEFFLLPVETKNRLQKKQQERKTALDVVLQKQRQFEETASRLRALIERIPTESDHDVLRMLLRDFDQFTHLPIWIKTQYMTFRNLLMVRLGLYASYAEIFPPASPNGVFAPIPAMSGVCLEDQSRCIRARVAAFMGEASVVQTFREARSSIDALFGKNLTFYLDTDGVPLRYRVCYKSVGVKLGTMLCSQGGLSLRPALPDEGIVEETTLSALRVANEVNELRIEYESAIKSGFSAFSTFVRHRHAEWGKTNARRAIAEIYAGLITTTLTRQYGVHWDKLIYSFEKHHLTSVMGNGLTKPIQRRGDVRVLELTLSDIVTILVATTPVHLLNFARLDLIKQHEYMARTLRPVIEAAFRGRLLVRSLDGDPKGNARAFFNAAPSKHKLPLALGSNQDPTGGRIFAFRMADWKLVKMPQKITDPFAPWQLSPPPGVKANVDAVTRIMATDRLATITVLGRMCLPPISLVSMWNTLQPEEFAYRTQDDVDIIVDARLDLSSTLNARFDTAPSNTTLEWNTDRKVITDAYIQTGATTVFTVTGAAPTHVSNVTAFDIATTAILFGAPLVIAMELTSVFSQNSGLTLGLKLFDSRHMATDSGISSAVSPDIVSWGLRLLHMDPHPIENACLIVQLEKLSALIANKPLTNNPPCLLLLDEHMNPSYVLWERKDSIPAPDYVVFWGPESLIDLPYIDSDEDSFPSCPDDPFYSQIIAGYAPQGPPNLDTTDFYPTEPLFKSPVQVVRSSKCKKMPVRPAQPAQPAQPAQPAQTVQPAQPIEPGTQIVVQNFKKPQSVKTTLSQKDIPLYVETESETAVLIPKQLTTSIKTTVCKSITPPNNQLSDWKNNPQQNQTLNQAFSKPILEITSIPTDDSISYRTWIEKSNQTQKRHQNDPRMYNSKTVFHPVNNQLPSWVDTAADAPQTDLLTNYKTRQPSPNFPRDVHTWGVSSNPFNSPNRDLYQSDFSEPSDGYSSESENSIVLSLDEHRSCRVPRHVRVVNADVVTGRRYVRGTALGALALLSQACRRMIDNVRYTRKLLMDHTEDIFQGLGYVKLLLDGTYI

ORF22

Large tegument protein deneddylase

2763 amino acids

Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.

Belongs to the herpesviridae large tegument protein family.

306.336 kDa

MDIIPPIAVTVAGVGSRNQFDGALGPASGLSCLRTSLSFLHMTYAHGINATLSSDMIDGCLQEGAAWTTDLSNMGRGVPDMCALVDLPNRISYIKLGDTTSTCCVLSRIYGDSHFFTVPDEGFMCTQIPARAFFDDVWMGREESYTIITVDSTGMAIYRQGNISFIFDPHGHGTIGQAVVVRVNTTDVYSYIASEYTHRPDNVESQWAAALVFFVTANDGPVSEEALSSAVTLIYGSCDTYFTDEQYCEKLVTAQHPLLLSPPNSTTIVLNKSSIVPLHQNVGESVSLEATLHSTLTNTVALDPRCSYSEVDPWHAVLETTSTGSGVLDCRRRRRPSWTPPSSEENLACIDDGLVNNTHSTDNLHKPAKKVLKFKPTVDVPDKTQVAHVLPRLREVANTPDVVLNVSNVDTPESSPTFSRNMNVGSSLKDRKPFLFEQSGDVNMVVEKLLQHGHEISNGYVQNAVGTLDTVITGHTNVPIWVTRPLVMPDEKDPLELFINLTILRLTGFVVENGTRTHHGATSVVSDFIGPLGEILTGFPSAAELIRVTSLILTNMPGAEYAIKTVLRKKCTIGMLIIAKFGLVAMRVQDTTGALHAELDVLEADLGGSSPIDLYSRLSTGLISILNSPIISHPGLFAELIPTRTGSLSERIRLLCELVSARETRYMREHTALVSSVKALENALRSTRNKIDAIQIPEVPQEPPEETDIPPEELIRRVYEIRSEVTMLLTSAVTEYFTRGVLYSTRALIAEQSPRRFRVATASTAPIQRLLDSLPEFDAKLTAIISSLSIHPPPETIQNLPVVSLLKELIKEGEDLNTDTALVSWLSVVGEAQTAGYLSRREFDELSRTIKTINTRATQRASAEAELSCFNTLSAAVDQAVKDYETYNNGEVKYPEITRDDLLATIVRATDDLVRQIKILSDPMIQSGLQPSIKRRLETRLKEVQTYANEARTTQDTIKSRKQAAYNKLGGLLRPVTGFVGLRAAVDLLPELASELDVQGALVNLRTKVLEAPVEIRSQLTGDFWALFNQYRDILEHPGNARTSVLGGLGACFTAIIEIVPIPTEYRPSLLAFFGDVADVLASDIATVSTNPESESAINAVVATLSKATLVSSTVPALSFVLSLYKKYQALQQEITNTHKLTELQKQLGDDFSTLAVSSGHLKFISSSNVDDYEINDAILSIQTNVHALMDTVKLVEVELQKLPPHCIAGTSTLSRVVKDLHKLVTMAHEKKEQAKVLITDCERAHKQQTTRVLYERWTRDIIACLEAMETRHVFNGTELARLRDMAAAGGFDIHAVYPQARQVVAACETTAVTALDTVFRHNPHTPENTNIPPPLALLRGLTWFDDFSITAPVFTVMFPGVSIEGLLLLMRIRAVVLLSADTSINGIPNYRDMILRTSGDLLQIPALAGYVDFYTRSYDQFITESVTLSELRADIRQAAGAKLTEANKALEEVTHVRAHETAKLALKEGVFITLPSEGLLIRAIEYFTTFDHKRFIGTAYERVLQTMVDRDLKEANAELAQFRMVCQATKNRAIQILQNIVDTANATEQQEDVDFTNLKTLLKLTPPPKTIALAIDRSTSVQDIVTQFALLLGRLEEETGTLDIQAVDWMYQARNIIDSHPLSVRIDGTGPLHTYKDRVDKLYALRTKLDLLRRRIETGEVTWDDAWTTFKRETGDMLASGDTYATSVDSIKALQASASVVDMLCSEPEFFLLPVETKNRLQKKQQERKTALDVVLQKQRQFEETASRLRALIERIPTESDHDVLRMLLHDFDQFTHLPIWIKTQYMTFRNLLMVRLGLYASYAEIFPPASPNGVFAPIPAMSGVCLEDQSRCIRARVAAFMGEASVVQTFREARSSIDALFGKNLTFYLDTDGVPLRYRVCYKSVGVKLGTMLCSQGGLSLRPALPDEGIVEETTLSALRVANEVNELRIEYESAIKSGFSAFSTFVRHRHAEWGKTNARRAIAEIYAGLITTTLTRQYGVHWDKLIYSFEKHHLTSVMGNGLTKPIQRRGDVRVLELTLSDIVTILVATTPVHLLNFARLDLIKQHEYMARTLRPVIEAAFRGRLLVRSLDGDPKGNARAFFNAAPSKHKLPLALGSNQDPTGGRIFAFRMADWKLVKMPQKITDPFAPWQLSPPPGVKANVDAVTRIMATDRLATITVLGRMCLPPISLVSMWNTLQPEEFAYRTQDDVDIIVDARLDLSSTLNARFDTAPSNTTLEWNTDRKVITDAYIQTGATTVFTVTGAAPTHVSNVTAFDIATTAILFGAPLVIAMELTSVFSQNSGLTLGLKLFDSRHMATDSGISSAVSPDIVSWGLRLLHMDPHPIENACLIVQLEKLSALIANKPLTNNPPCLLLLDEHMNPSYVLWERKDSIPAPDYVVFWGPESLIDLPYIDSDEDSFPSCPDDPFYSQIIAGYAPQGPPNLDTTDFYPTEPLFKSPVQVVRSSKCKKMPVQPVQPAQPVQPAQPAQPVQPAQPIEPGTQIVVQNFKKPQSVKTTLSQKDIPLYVETESETAVLIPKQLTTSIKTTVCKSITPPNNQLSDWKNNPQQNQTLNQAFNKPILEITSIPTDDSISYRTWIEKSNQTQKRHQNDPRMYNSKTVFHPVNNQLPSWVDTAADAPQTDLLTNYKTRQPSPNFPRDVHTWGVSSNPFNSPNRDLYESDFSEPSDGYSSESENSIVLSLDEHRSCRVPRHVRVVNADVVTGRRYVRGTALGALALLSQACRRMIDNVRYTRKLLMDHTEDIFQGLGYVKLLLDGTYI

ORF22

Uncharacterized protein ORF22

1632 amino acids

184.431 kDa

MSNNKQTAAPAATSNEKAENGAEKEAIEKFVEVVRNTPELQGEMFFDGCIIAMTKDAFKGKYRVFYGNGLHTSIMFGAGTAALDLMTPGSFLPPFPQRLIKSREGSAPTMEATDPMMSRVIILMNGECLDVNSELINRPKTMGDDAISNLTDDLNNITPKEGEATVKEWDSLPGGELRYLSKANKPDETYMKDLIEKYFEKAICHNGKKVEDYVFFLVANPIAMVSLARKGFMSNVNMHNYESFENNIVIPADDDELYFGDHTFKVAVNNERLNTSSVANCNAYVRPFFHGCNGFYQGRNKRIYPESHDLYRRDYIKDYNTDYKSLCYSRKTENVMPVCDFISSTAATLVLQKFPLNYVIEHKFTTEDDDYKTKMAMSVKLDLIKEIAIKNRYRPNVFDDNFHVSQDRIYATKYQGHLERNTISPNALHTYKTGGKLGIAGELMEGEKMSQWVHTDIASKFTSMENFNKNGGDEAALCDDEEKELGFGKMYVTSRLSSVFDFKSIFNANRMTTQHELSSQLGDTDTKKEQKEKRSKQGGSKLFNYKIKSAFNPVFNSLKSPAQKILFNMCGDRTLFKSVMEDALFLLRDEIFLEDKLVMTHPAFAESENPNHCQYCKCSFNNGMAGVENKDFCFCYLILRTMCALSAREPTQFNITNLWDKTAFPSELPPTTTETFDYNFNMNVRTIERKNKCSAYGNAVLTDSERENGFADPNLKEENGSKKKLQSYMKEVKLEALIKAVLTAEPTLLHPDQRINMDKITEGDEFYHKLEANRFAKSMGYKQDFTMGSIGPDETPNGSYQLSSIKSIRDVLLKDSKSSVDYELNKFIVVPGKMTHTIKGTKKSDDGDSKTDGSGDMEDDFTSLAKMTNRKRKAGGKDGPSKKKKKDGADKSLEKLARAMLLDLLEISIPNSDASLSLEEQNQEIRKFWREKQIHPDYIFLFPNAEEKRKLTPETTKQLCQKFMKVVGICRDMIRPEPTSSENIRLKLVTTYMAGVRDYIKRLAEFLAKKLNYSSVEEMRGYAMSSIRMKNESVKKTQSSWMDPQSTSDPVQKMMERKITSAYATHRIESANTKVLPYTDSKLIPVCSEIPIPARMILCSVGETESDGCKRLGYNIEGYKRNEKDIKMAGEKQQPHSYLTPLEMKIKMDTFQKEAENIEKEKYVDGNKPETAAREEIFKQVREKEINCGVYIPWEIMAKDLCENAGYKDSDVLDPAVLAHILKRADVKFEKLGNGGFASALNCKTIAKLLAGYLDTMEDVNVTRPSLITNIFSDMDTICSMVNKIGMNMKSFFGSYDYATFDMATFNLKDTLLKMISQEPELGSVLHLLITMATIYGVNTSTNGKLFYKSYERDSQAAVVGIGGILNIFLGMDACKSSNAAREIKQAQRKINPMITTHMDYNMKRGGGIDRWSTLDTAKCQGMSRYLGCYSFSTYPGQQGSNDIYTKLKLSGGFFYNSIPAHICAQSKSHNTNKVTMCLKNSGVLYSSFKRGGRNVDIAELLNRGDLDDINNTILSTNGLAQKIAAYFLSSIGIEPKTNGFPDMGNMSKSMFVRKIVKIHFSEFAEEDGEIMVERKVLKHILGFVYPDDSVVEKPDMFMVYDPSAMDVDEDEDEDMDDESDDESDGEEMSGE

ORF22

Uncharacterized protein ORF22

1403 amino acids

153.309 kDa

MGPIRKPVNQWELSENVKRNLGTFGEMYVQYSTSPSQTAAAAVFKMFGQYLRTLFQTHLEILQSDGAGDPSVRMDVLQRIEELLGTTVSDDSVFEVIEAHLSKVKDIFGNCSVTWIADVKAADRAVTAAVTGTVHAVTGGMGAMWGTLDRAMIDLKLDLVLPPTTGPSTNFVGVALPATPLVPYTAGSAQGSPLDPTLDRFGALFGLFGLTIPTATKKVFLEQNDILNKAVQAISVSYTAMNSNFQAGLAKYKPPRVPTADGALTARGIAPDRPRQAKYETVKTYATNMGFDVLIGGKVPGSKGDIESLVSGILLAGKSLDELGALVGGIGSDGAIVSRDQMDQVRSLIDSLVKIIYDTDRDRFIAMTGVHVITEYANDLLRVLDLIAQKYGEFQRTISGLEPSWATIVSNTEGLIPLYAERAAYAAERAVIIDEFQKMAMDHANNVKEVEHIRERAAATQKQTEERRAVDIQKLAVETTAKMTDMKNGYEKTIADLRAQLSVANLSLESLKGTLKGETTLGTTVMDLSKANRQLESRVAELQGKLGIQENEAKLRDEQHKAQAEQIANLHRDLRVATERLHKKDTKILETGINTGVSTARVRELEQRVKELVAEKKSIRHENRMARRKMDPTEAAAKGGPRQSERPRSQTAVHAHCALIRKNLHDTNKRLLTRNTRLEKSISSKEELISSLTIKGNALSSQLADAREQHAVLKREYDALRAERGGTARTKKDALEALQSKLTQSESQLAIEKLKVMELEAAAKRLGKSSVTKSEVETVEVRVNLLTEELARTKKTVDELRKLNNAYLTAKDRLQARVEALTTDNQSMKLLVGNGGTLDEANKRITTLTQRLATVSGELVTATETLAFVRGSLKRVNHQRDELAKESAATKKSCEAQIRALTDRHATEMRTAAGARDGLEAELGRVKRTLVDTETKLAGVERDRVVLRDELTRMQKASHIGADRQLTHAEKVAHDMGVLNAGLTLARTELREIQRELVHEKNKSRDAEQRHVASEAALREQIRTLTDERDRLLATGVADLQRENAELHAAITEAANTCADTKIQLENITADYNGLLAEYERRLGRRPPGPVDPPATTEEPIAGYGGGNWDTGSGAARAPIDHHDMFGISSLLGESQGGLSDYHGSYAGGRELSSEESGDDESVDPVPDSNGTRGDGVCREEDEEDRQGGETESGGEEEESEEESEESEDEDPPSAGGPLELIGVPAGGIGADPEPARVPSRRPVTLLERRGAHVAEPKPTPRVRGKRPAARHSHKRVHLSITRETLRLALAAGPEMSAEEIFQRLNTDMETSSLINSLTVTAADIPRGQLAVLNRDTAVEYATPGTPVSDRDHQRVELSMKAILLIMICAKHGIMNHEEFTDGDLSWFKSYDNNLSVTGSDSE

ORF22

Uncharacterized 24.3 kDa protein

209 amino acids

24.254 kDa

MRNSAGLFMIMEPDRAVLLCARRAYHGGAVSDTFLEKISIPRGHRDCTDAKIYETAVREFVEETGRFFHSAYIYKFPFTLHWTDEGVTYKYSIYVGVVRGALADVKFKPNTYTVKLLPGANNDYRIVLRPRRFNCEISRSLTIVPLNQYFDYMTSKQLNTYASSNYGEFFDFVRQVKRLFDNKQLHDFFHASLQRVDPNDALACPGPQR

ORF22

Uncharacterized protein ORF22

32 amino acids

3.557 kDa

MAVTIAVDFCACVCNIDLWLPKAMVFKLALAW