ORF1

Genome polyprotein

2344 amino acids

Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

256.908 kDa

MAAMSRLTGMTTAILPEKKPLSFFLDLRDKTPPCCIRATGRLAWPVFPGQNGKEGPLETCNMCGKWLNGFGNFGLEDLGDVCLRSIAQQKHKFGPVCLCNRVYLHDCGRWRRRSRFLKHYKALNKVIPCAYQFVESFPTPIFEGEVDDLFVELGAPTSMGFMDKKLLKKGKKLMDKFVDVDEPCLTSRDASLLDSIASDNTIRAKLEEEYGVEMVQAARDRKDFMKNLRLALDNWPANPVTWYRKLGNITKKGKQWAKKVVYGARKVTDPLKTLASILLVGLHNVIAVDTTVMLSTFNPVNLLAILMDWNNDLTGFFATLVRLLELYGVVQATVNLIIEGVKSFWDKVVCATDRCFDLLKRLFDTFEDSVPTGPTAGCLIFMAFVFSTVVGYLPNNSVITTFMKGAGKLTTFAGVVGAIRTLWITINQHMVAKDLTSVQQKVMTVVKMANEAATLDQLEIVSCLCSDLETTLTNRCTLPSYNQHLGILNASQKVISDLHTMVLGKINTSKQRPQPVAVIFKGAPGIGKTYLVHRIARDLGCQHPSTINFGLDHFDSYTGEEVAIADESNTCGDGESWVELFIQMVNTNPCPLNCDKAENKNKVFNSKYLLCTTNSNMILNATHPRAGAFYRRVMIVEARNKAVESWQATRHGSKPGKSCYNKDMSHLTFQVYPHNMPAPGFVFVGDKLVKSQVTPREYKYSELLDLIKSEHPDVASFEGANKFNFVYPDAQYDQALLMWKQYFVMYGCVARLAKNFVDDIPYNQVHISRASDPKIEGCVEYQCKFQHLWRMVPQFVLGCVNMTNQLGTPLTQQQLDRITNGVEGVTVTTVNNILPFHSQTTLINPSFIKLIWAVRKHLKGLSGVTKVAQFIWRVMTNPVDAYGTLVRTLTGAATFSDDPVSTTIICSNCTIQLHSCGGLLVRYSRDPVPVASDNVDRGDQGVDVFTDPNLISGFSWRQIAHLFVEVISHLCANHLVNLATMAALGAVATKAFQGVKGKTKRGRGARVNLGNDEYDEWQAARREFVNAHDMTAEEYLAMKNKAAMGSDDQDSIMFRSWWTRRQLRPDEDQVTIVGRSGVRNEVIRTRVRQTPRGPKTLDDGGFYDNDYEGLPGFMRHNGSGRMIHIGNGLYISNTHTARSSCSEIVTCSPTTDLCLVKGEAIRSVAQIAEGTPVCDWKKSPISTYGIKKTLSDSTKIDVLAYDGCTQTTHGDCGLPLYDSSGKIVAIHTGKLLGFSKMCTLIDLTITKGVYETSNFFCGEPIDYRGITAHRLVGAEPRPPVSGTRYAKVPGVPDEYKTGYRPANLGRSDPDSDKSLMNIAVKNLQVYQQEPKLDKVDEFIERAAADVLGYLRFLTKGERQANLNFKAAFNTLDLSTSCGPFAPGKKIDHVKDGVMDQVLAKHLYKCWSVANSGKALHHIYACGLKDELRPLDKVKEGKKRLLWGCDVGVAVCAAAVFHNICYELKMVARFGPIAVGVDMTSRDVDVIINNLTSKASDFLCLDYSKWDSTMSPCVVRLAIDILADCCEQTELTKSVVLTLKSHPMTILDAMIVQTKRGLPSGMPFTSVINSICHWLLWSAAVYKSCAEIGLHCSNLYEDAPFYTYGDDGVYAMTPMMVSLLPAIIENLRDYGLSPTAADKTEFIDVCPLNKISFLKRTFELTDIGWVSKLDKSSILRQLEWSKTTSRHMVIEETYDLAKEERGVQLEELQVAAAAHGQEFFNFVCGELVRQQAYTQFSVYSYDAARKILADRKRVVSVVPDDEFVNVMEGKARAAPQGEAARTATTASVPGTTTDGMDPGVVATTSVITAENSSASIATAGIGGPPQQVDQQETWRTNFYYNDVFTWSVADAPGSILYTVQHSPQNNPFTAVLSQMYAGWAGGMQFRFIVAGSGVFGGRLVRAVIPPGIEIGPGLEVRQFPHVVIDARSLEPVTITMPDLRPNMYHPTGDPGLVPTLVLSVYNNLINPFGGSTSAIQVTVETRPSEDFEFVMIRAPSSKTVDSISPAGLLTTPDLTGVGNDNRWNGQIVGLQPVPGGFSTCNRHWNLNGSTYGWSSPRFADIDHRKGSASYPGSNATNVLQFWYANAGSAIDNPISQVAPDGLPDMSFVPFNGPGIPAAGWVGFGAIWNSNSGAPNVTTVQAYELGFATGAPGNLQPTTNTSGAQTVAKSIYAVVTGTAQNPAGLFVMASGIISTPNASAITYTPQPDRIVTTPGTPAAAPVGKNTPIMFASVVRRTGDVNATAGSANGTQYGTGSQPLPVTIGLSLNNYSSALMPGQFFVWQLTFASGFMEIGLSVDGYFYAGTGASTTLIDLTELIDVRPVGPRPSKSTLVFNLGGTANGFSYV

ORF1

Genome polyprotein

2344 amino acids

Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

256.817 kDa

MAAMSRLTGMTTAILPEKKPLNFFLDLRDKTPPCCIRATGKLAWPVFLGQNGKEGPLETCNKCGKWLNGFGCFGLEDLGDVCLCSIAQQKHKFGPVCLCNRAYIHDCGRWRRRSRFLKHYKALNKVIPCAYQFDESFSTPVFEGEVDDLFVELGAPTSMGFMDKKLLKKGKKLMDKFVDVDEPCLTSRDASLLDSIASDNTIRAKLEEEYGVEMVQAARDRKDFMKNLRLALDNRPANPVTWYTKLGNITEKGKQWAKKVVYGACKVTDPLKTLASILLVGLHNVIAVDTTVMLSTFKPVNLLAILMDWTNDLTGFVTTLVRLLELYGVVQATVNLIVEGVKSFWDKVVCATDRCFDLLKRLFDTFEDSVPTGPTAGCLIFMAFVFSTVVGYLPNNSVITTFMKGAGKLTTFAGVIGAIRTLWITINQHMVAKDLTSIQQKVMTVVKMANEAATLDQLEIVSCLCSDLENTLTNRCTLPSYNQHLGILNASQKVISDLHTMVLGKINMTKQRPQPVAVIFKGAPGIGKTYLVHRIARDLGCQHPSTINFGLDHFDSYTGEEVAIADEFNTCGDGESWVELFIQMVNTNPCPLNCDKAENKNKVFNSKYLLCTTNSNMILNATHPRAGAFYRRVMIVEARNKAVESWQATRHGSKPGRSCYSKDMSHLTFQVYPHNMPAPGFVFVGDKLVKSQVAPREYKYSELLDLIKSEHPDVASFEGANRFNFVYPDAQYDQALLMWKQYFVMYGCVARLAKNFVDDIPYNQVHISRASDPKIEGCVEYQCKFQHLWRMVPQFVLGCVNMTNQLGTPLTQQQLDRITNGVEGVTVTTVNNILPFHSQTTLINPSFIKLIWAVRKHLKGLSGVTKVAQFIWRVMTNPVDAYGSLVRTLTGAATFSDDPVSTTIICSNCTIQIHSCGGLLVRYSRDPVPVASDNVDRGDQGVDVFTDPNLISGFSWRQIAHLFVEVISHLCANHLVNLATMAALGAVATKAFQGVKGKTKRGRGARVNLGNDEYDEWQAARREFVNAHDMTAEEYLAMKNKAAMGSDDQDSVMFRSWWTRRQLRPDEDQVTVVGRGGVRNEVIRTRVRQTPKGPKTLDDGGFYDNDYEGLPGFMRHNGSGWMIHIGNGLYISNTHTARSSCSEVVTCSPTTDLCLVKGEAIRSVAQIAEGTPVCDWKKSPISTYGIKKTLSDSTKIDVLAYDGCTQTTHGDCGLPLYDSSGKIVAIHTGKLLGFSKMCTLIDLTITKGVYETSNFFCGEPIDYRGITAHRLVGAEPRPPVSGTRYAKVPGVPEEYKTGYRPANLGRSDPDSDKSLMNIAVKNLQVYQQEPKLDKVDEFIERAAADVLGYLRFLTKGERQANLNFKAAFNTLDLSTSCGPFVPGKKIDHVKDGVMDQVHAKHLYKCWSVANSGKALHHIYACGLKDELRPLDKVKEGKKRLLWGCDVGVAVCAAAVFHNICYKLKMVARFGPIAVGVDMTSRDVDVIINNLTSKASDFLCLDYSKWDSTMSPCVVRLAIDILADCCEQTELTKSVVLTLKSHPMTILDAMIVQTKRGLPSGMPFTSVINSICHWLLWSAAVYKSCAEIGLHCSNLYEDAPFYTYGDDGVYAMTPMMVSLLPAIIENLRDYGLSPTAADKTEFIDVCPLNKISFLKRTFELTDIGWVSKLDKSSILRQLEWSKTTSRHMMIEETYDLAKEERGVQLEELQVAAAAHGQEFFNFVCKELERQQAYTQFSVYSYDAARKILADRKRVVSVVPDDEFVNVMEGKARTAPQGEAAGTATTASVPGTTTDGMDPGVVATTSVVTAENSSASIATAGIGGPPQQVDQQETWRTNFYYNDVFTWSVADAPGSILYTVQHSPQNNPFTAVLSQMYAGWAGGMQFRFIVAGSGVFGGRLVAAVIPPGIEIGPGLEVRQFPHVVIDARSLEPVTITMPDLRPNMYHPTGDPGLVPTLVLSVYNNLINPFGGSTSAIQVTVETRPSEDFEFVMIRAPSSKTVDSISPAGLLTTPVLTGVGNDNRWNGQIVGLQPVPGGFSTCNRHWNLNGSTYGWSSPRFADIDHRRGSASYPGNNATNVLQFWYANAGSAIDNPISQVAPDGFPDMSFVPFNGPGIPAAGWVGFGAIWNSNSGAPNVTTVQAYELGFATGAPGNLQPTTNTSGSQTVAKSIYAVVTGTAQNPAGLFVMASGVISTPSANAITYTPQPDRIVTTPGTPAAAPVGKNTPIMFASVVRRTGDVNATAGSANGTQYGTGSQPLPVTIGLSLNNYSSALMPGQFFVWQLTFASGFMEIGLSVDGYFYAGTGASTTLIDLTELIDVRPVGPRPSKSTLVFNLGGTANGFSYV

ORF1

Genome polyprotein

2344 amino acids

Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

256.898 kDa

MAAMSRLTGMTTAILPEKKPLNFFLDLRDKTPPCCIRATGKLAWPVFPGQNGKEGPLKTCNKCGKWLNGFGYFGLEDLGDVCLCSIAQQKHKFGPVCLCNRAYIHDCGRWRRRSRFLKHYKALNKVIPCAYQFDESFSTPVFEGEVDDLFVELGAPTSMGFMDKKLLKKGKKLMDKFVDVDEPCLTSRDASLLDSIASDTTIRAKLEEEYGVEMVQAARDRKDFMKNLRLALDNRPANPVTWYTKLGNITEKGKQWAKKVVYGACKVTDPLKTLASILLVGLHNVIAVDTTVMLSTFKPVNLLAILMDWTNDLAGFVTTLVRLLELYGVVQATVNLIIEGVKSFWDKVVCATERCFDLLKRLFDTFEDSVPTGPTAGCLIFMAFVFSTVVGYLPNNSVITTFMKGAGKLTTFAGVIGAIRTLWITINQHMVAKDLTSIQQKVMTVVKMANEAATLDQLEIVSCLCSDLENTLTNRCTLPSYNQHLGILNASQKVISDLHTMVLGKINMTKQRPQPVAVIFKGAPGIGKTYLVHRIARDLGCQHPSTINFGLDHFDSYTGEEVAIADEFNTCGDGESWVELFIQMVNTNPCPLNCDKAENKNKVFNSKYLLCTTNSNMILNATHPRAGAFYRRVMIVEARNKAVESWQATRHGSKPGKSCYSKDMSHLTFQVYPHNMPAPGFVFVGDKLVKSQVAPREYKYSELLDLIKSEHPDVASFDGANRFNFVYPDAQYDQALLMWKQYFVMYGCVARLAKNFVDDIPYNQVHISRASDPKIEGCVEYQCKFQHLWRMVPQFVLGCVNMTNQLGTPLTQQQLDRITNGVEGVTVTTVNNILAFHSQTTLINPSFLKLIWAVRKHLKGLSGVTKVAQFIWRVMTNPVDAYGSLVRTLTGAATFSDEPVSTTIICSNCTIQIHSCGGLLVRYSRDPVPVASDNVDRGDQGVDVFTDPNLISGFSWRQIAHLFVEVISHLCANHLVNLATMAALGPVATKAFQGVKGKTKRGRGARVNLGNDEYDEWQAARREFVNAHDMTAEEYLAMKNKAAMGSDDQDSVMFRSWWTRRQLRPDEDQVTIVGRGGVRNEVIRTRVRQTPKGPKTLDDGGFYDNDYEGLPGFMRHNGSGWMIHIGNGLYISNTHTARSSCSEIVTCSPTTDLCLVKGEAIRSVAQIAEGTPVCDWKKSPISTYGIKKTLSDSTKIDVLAYDGCTQTTHGDCGLPLYDSSGKIVAIHTGKLLGFSKMCTLIDLTITKGVYETSNFFCGEPIDYRGITAHRLVGAEPRPPVSGTRYAKVPGVPDEYKTGYRPANLGRSDPDSDKSLMNIAVKNLQVYQQEPKLDKVDEFIERAAADVLGYLRFLTKGERQANLNFKAAFNTLDLSTSCGPFVPGKKIDHVKDGVMDQVLAKHLYKCWSVANSGKALHHIYACGLKDELRPLDKVREGKKRLLWGCDVGVAVCRAAVFHNICYKLKMVARFGPIAVGVDMTSRDVDVIINNLTSKASDFLCLDYSKWDSTMSPCVVRLAIDILADCCEQTELTKSVVLTLKSHPMTILDAMIVQTKRGLPSGMPFTSVINSICHWLLWSAAVYKSCAEIGLHCSNLYEDAPFYTYGDDGVYAMTPMMVSLLPAIIENLRDYGLSPTAADKTEFIDVCPLNKISFLKRTFELTDIGWVSKLDKSSILRQLEWSKTTSRHMMIEETYDLAKEERGVQLEELQVPAAAHGQEFFNFVCKELERQQAYTQFSVYSYDAARKILADRKRVVSVVPDDEFVNVMEGKARTAPQGEAAGTATTASVPGTTTDGLDPGVVATTSVVTAENSSASIATAGIGGPPQQVDQQETWRTNFYYNDVFTWSVADAPGSILYTVQHSPQNNPFTAVLSQMYAGWAGGMQFRFIVAGSGVFGGRLVAAVIPPGIEIGPGLEVRQFPHVVIDARSLEPVTITMPDLRPNMYHPTGDPGLVPTLVLSVYNNLINPFGGSTSAIQVTVETRPSEDFEFVMIRAPSSKTVDSISPAGLLTTPVLTGVGNDNRWNGQIVGLQPVPGGFSTCNRHWNLNGSTYGWSSPRFADIDHRRGSASYPGSNATNVLQFWYANAGSAVDNPISQVAPDGFPDMSFVPFNGPGIPAAGWVGFGAIWNSNSGAPNVTTVQAYELGFATGAPGNLQPTTNTSGAQTVAKSIYAVVTGTAQNPAGLFVMASGVISTPNANAITYTPQPDRIVTTPGTPAAAPVGKNTPIMFASVVRRTGDVNATAGSANGTQYGTGSQPLPVTIGLSLNNYSSALMPGQFFVWQLTFASGFMEIGLSVDGYFYAGTGASTTLIDLTELIDVRPVGPRPSKSTLVFNLGGTANGFSYV

ORF1

Genome polyprotein

2344 amino acids

Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

257.068 kDa

MAAMSRLTGMTTAILPEKKPLDFFLDLRDKTPPCCIRATGRLAWPVFPGQNGKEGPLETCNKCGKWLNGFGNFGLEDLGDVCLCSIAQQKHKFGPVCLCNRVYIHDCGRWRRRSRFLKHYKALNKVIPCAYQFDESFPTPIFEGEVDDLFVELGAPTSMGFMDKKLLKKGKKLMDKFVDVDEPCLTSRDTSLLDSIASDNTIRAKLEEEYGVEMVQAARDRKDFMKNLRLALDNRPANPVTWYTKLGNITEKGKQWAKKVVYGARKVTDPLKTLASILLVGLHNVIAVDTTVMLSTFKPVNLLAILMDWNNDLTGFITTLVRLLELYGVVQATVNLIIEGVKSFWDKVVCATDRCFDLLKRLFDTFEDSVPTGPTAGCLIFMAFVFSTVVGYLPNNSVITTFMKGAGKLTTFAGVVGAIRTLWITINQHMVAKDLTSVQQKVMTVVKMANEAATLDQLEIVSCLCSDLETTLTNRCTLPSYNQHLGILNASQKVISDLHTMVLGKINMTKQRPQPVAVIFKGAPGIGKTYLVHRIARDLGCQHPSTINFGLDHFDSYTGEEVAIADEFNTCGDGESWVELFIQMVNTNPCPLNCDKAENKNKVFNSKYLLCTTNSNMILNATHPRAGAFYRRVMIVEARNKAVESWQATRHGSKPGKSCYSKDMSHLTFQVYPHNMPAPGFVFVGDKLVKSQVTPREYKYSELLDLIKSEHPDVASFEGANKFNFVYPDAQYDQALLMWKQYFVMYGCVARLAKNFVDDIPYNQVHISRASDPKIEGCVEYQCKFQHLWRMVPQFVLGCVNMTNQLGTPLTQQQLDRITNGVEGVTVTTVNNILPFHSQTTLINPSFIKLIWAVRKHLKGLSGVTKVAQFIWRVMTNPVDAYGTLVRTLTGAATFSDDPVSTTIICSNCTIQLHSCGGLLVRYSRDPVPVASDNVDRGDQGVDVFTDPNLISGFSWRQIAHLFVEVISHLCANHLVNLATMAALGAVATKAFQGVKGKTKRGRGARVNLGNDEYDEWQAARREFVNAHDMTAEEYLAMKNKAAMGSDDQDSIMFRSWWTRRQLRPEEDQVTIVGRSGVRNEVIRTRVRQTPRGPKTLDDGGFYDNDYEGLPGFMRHNGSGWMIHIGNGLYISNTHTARSSCSEIVTCSPTTDLCLVKGESIRSVAQIAEGTPVCDWKKSPISTYGIKKTLSDSTKIDVLAYDGCTQTTHGDCGLPLYDSSGKIVAIHTGKLLGFSKMCTLIDLTITKGVYETSNFFCGEPIDYRGITAHRLVGAEPRPPVSGTRYAKVPGVPDEYKTGYRPANLGRSDPDSDKSLMNIAVKNLQVYQQEPKLDKVDEFIERAAADVLGYLRFLTKGERQANLNFKAAFNTLDLSTSCGPFVPGKKIDHVKDGVMDQVLAKHLYKCWSVANSGKALHHIYACGLKDELRPLDKVKEGKKRLLWGCDVGVAVCAAAVFHNICYKLKMVARFGPIAVGVDMTSRDVDVIINNLTSKASDFLCLDYSKWDSTMSPCVVRLAIDILADCCEQTELTKSVVLTLKSHPMTILDAMIVQTKRGLPSGMPFTSVINSICHWLLWSAAVYKSCAEIGLHCSNLYEDAPFYTYGDDGVYAMTPMMVSLLPAIIENLRDYGLSPTAADKTEFIDVCPLNKISFLKRTFELTDIGWVSKLDKSSILRQLEWSKTTSRHMVIEETYDLAKEERGVQLEELQVAAAAHGQEFFNFVCRELERQQAYTQFSVYSYDAARKILADRKRVVSVVPDDEFVNVMEGKARAAPQGEAAGTATTASVPGTTTDGMDPGVVATTSVITAENSSASIATAGIGGPPQQVDQQETWRTNFYYNDVFTWSVADAPGSILYTVQHSPQNNPFTAVLSQMYAGWAGGMQFRFIVAGSGVFGGRLVRAVIPPGIEIGPGLEVRQFPHVVIDARSLEPVTITMPDLRPNMYHPTGDPGLVPTLVLSVYNNLINPFGGSTSAIQVTVETRPSEDFEFVMIRAPSSKTVDSISPAGLLTTPVLTGVGNDNRWNGQIVGLQPVPGGFSTCNRHWNLNGSTYGWSSPRFGDIDHRRGSASYSGSNATNVLQFWYANAGSAIDNPISQVAPDGFPDMSFVPFNGPGIPAAGWVGFGAIWNSNSGAPNVTTVQAYELGFATGAPGNLQPTTNTSGAQTVAKSIYAVVTGTAQNPAGLFVMASGIISTPNASAITYTPQPDRIVTTPGTPAAAPVGKNTPIMFASVVRRTGDVNATAGSANGTQYGTGSQPLPVTIGLSLNNYSSALMPGQFFVWQLTFASGFMEIGLSVDGYFYAGTGASTTLIDLTELIDVRPVGPRPSKSTLVFNLGGTANGFSYV

ORF1

Genome polyprotein

2344 amino acids

Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

257.122 kDa

MAAMSRLTGMTTAILPEKKPLNFFLDLRDKTPPCCIRATGKLAWPVFLGQYGKEGPLETCNKCGKWLNGFGCFGLEDLGDVCLCSIAQQKHKFGPVCLCNRAYIHDCGRWRRRSRFLKHYKALNKVIPCAYQFDESFSTPVFEGEVDDLFVELGAPTSMGFMDKKLLKKGKKLMDKFVDVDEPCLTSRDASLLDSIASDNTIRAKWEEEYGVEMVQAARDRKDFMKNLRLALDNRPANPVTWYTKLGNITEKGKQWAKKVVYGACKVTDPLKTLASILLVGLHNVIAVDTTVMLSTFKPVNLLAILMDWTNDLTGFVTTLVRLLELYGVVQATVNLIVEGVKSFWDKVVCATDRCFDLLKRLFDTFEDSVPTGPTAGCLIFMAFVFSTVVGYLPNNSVITTFMKGAGKLTTFAGVIGAIRTLWITINQHMVAKDLTSIQQKVMTVVKMANEAATLDQLEIVSCLCSDLENTLTNRCTLPSYNQHLGILNASQKVISDLHTMVLGKINMTKQRPQPVAVIFKGAPGIGKTYLVHRIARDLGCQHPSTINFGLDHFDSYTGEEVAIADEFNTCGDGESWVELFIQMVNTNPCPLNCDKAENKNKVFNSKYLLCTTNSNMILNATHPRAGAFYRRVMIVEARNKAVESWQATRHGSKPGRSCYSKDMSHLTFQVYPHNMPAPGFVFVGDKLVKSQVAPREYKYSELLDLIKSEHPDVASFEGANRFNFVYPDAQYDQALLMWKQYFVMYGCVARLAKNFVDDIPYNQVHISRASDPKIEGCVEYQCKFQHLWRMVPQFVLGCVNMTNQLGTPLTQQQLDRVTNGVEGVTVTTVNNILPFHSQTTLINPSFIKLIWAVRKHLKGLSGVTKVAQFIWRVMTNPVDAYGSLVRTLTGAATFSDDPVSTTIICSNCTIQIHSCGGLLVRYSRDPVPVASDNVDRGDQGVDVFTDPNLISGFSWRQIAHLFVEVISRLCANHLVNLATMAALGAVATKAFQGVKGKTKRGRGARVNLGNDEYDEWQAARREFVNAHDMTAEEYLAMKNKAAMGSDDQDSVMFRSWWTRRQLRPDEDQVTIVGRGGVRNEVIRTRVRQTPKGPKTLDDGGFYDNDYEGLPGFMRHNGSGWMIHIGNGLYISNTHTARSSCSEVVTCSPTTDLCLVKGEAIRSVAQIAEGTPVCDWKKSPISTYGIKKTLSDSTKIDVLAYDGCTQTTHGDCGLPLYDSSGKIVAIHTGKLLGFSKMCTLIDLTITKGVYETSNFFCGEPIDYRGITAHRLVGAEPRPPVSGTRYAKVPGVPEEYKTGYRPANLGRSDPDSDKSLMNIAVKNLQVYQQEPKLDKVDEFIERAAADVLGYLRFLTKGERQVNLNFKAAFNTLDLSTSCGPFVPGKKIDHVKDGVMDQVLAKHLYKCWSVANSGKALHHIYACGLKDELRPLDKVKEGKKRLLWGCDVGVAVCAAAVFHNICYKLKMVARFGPIAVGVDMTSRDVDVIINNLTSKASDFLCLDYSKWDSTMSPCVVRLAIDILADCCEQTELTKSVVLTLKSHPMTILDAMIVQTKRGLPSGMPFTSVINSICHWLLWSAAVYKSCAEIGLHCSNLYEDAPFYTYGDDGVYAMTPMMVSLLPAIIENLRDYGLLPTAADKTEFIDVCPLNKISFLKRTFELTDIGWISKLDKSSILRQLEWSKTTSRHMMIEETYDLAKEERGVQLEELQVAAAAHGQEFFNFVRKELERQQAYTQFSVYSYDAARKILADRKRVVSVVPDDEFVNVMEGKARTAPQGEAAGTATTASVPGTTTDGMDPGVVATTSVVTAENSSASIATAGIGGPPQQVDQQETWRTNFYYNDVFTWSVADAPGSILYTVQHSPQNNPFTAVLSQMYAGWAGGMQFRFIVAGSGVFGGRLVAAVIPPGIEIGPGLEVRQFPHVVIDARSLEPVTITMPDLRPNMYHPTGDPGLVPTLVLSVYNNLINPFGGSTSAIQVTVETRPSEDFEFVMIRAPSSKTVDSISPAGLLTTPVLTGVGNDNRWNGQIVGLQPVPGGFSTCNRHWNLNGSTYGWSSPRFADIDHRRGSASYPGNNATNVLQFWYANAGSAIDNPISQVAPDGFPDMSFVPFNGPGIPAAGWVGFGAIWNSNSGAPNVTTVQAYELGFATGAPGNLQPTTNTSGSQTVAKSIYAVVTGTAQNPAGLFVMASGVISTPSANAITYTPQPDRIVTTPGTPAAAPVGKNTPIMFASVVRRTGDVNATAGSANGTQYGRGSQPLPVTIGLSLNNYSSALMPGQFFVWQLTFASGFMEIGLSVDGYFYAGTGASTTLIDLIELIDVRPVGPRPSKSTLVFNLGGTANGFSYV

ORF1

Genome polyprotein

2334 amino acids

Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

255.925 kDa

MAVASRPCGVATSVLPAKKPLSFFTDLVGKTPPRCIRAPHTLAWPVFADLDNEEESPEICRKCGKYANGFGVFDLTDLGDVCLCSIRPQRHVGGPCCLCNKQYIRACGRYCARVLKHYKAFNKVIPCLHSRQVKPVFEGEVEDLFVELGAPTRMNFTEAELASQGASIMDRFVDLVEPCLSTEDSNFLDNICSDASIRKRLEDEYDVDMIAAARARKDFAKTLKLALQDRERKPDKWYSKLGCITTKGRQWAKKVVHGAKKLSDPLKTLAAILLVALHNCVAVDTTTMLSHFKPVNLLAILLDWTNDLPGFLTTLIRFMELYGVVQSTVNLVVDAIKSFWDRVMCATERCCDLLKRLFDKFEDSVPTGPTAGCLIFMSFVFSVIVGYLPNNSVISTFMKGAGKLTTFAGVIGAIRTLWITINQHMVAKDITSIQEKVMAVVKMANEAATLNQLEIVSVLCSELESTLTNRCTLPSYNQHMGVLNAAQKVVADIHTLVLGKINMTKQRPQPVAVVFKGAPGIGKTYLVHRLAKDLGCPHPSNINFGLDHFDSYTGEDVAIADEFNTSGDERWVELFIQMVNTNPCPLNCDKVENKNKVFSSKYLLCTTNSSMVLNATHPRATAFYRRVIIVDVRNKAVEGWQSTRHGSKPGKHCYTKDMSHLTFQVYPHNMPAPGFVFVGEKLVKSQVAPRELKYNELLDMIKNEHPDANFEGATKHEFVYPDVQYEQALLMWKQYFLMYGCTARLAKVFVDDIPYNQVHVARKSDPRSPGAVHHECELKYIWRMVPHFALGCVNMTNQLGTDLTQSQLDRITCGVEGITVTTVDNILPFHSQNTLINPSFLKLIWALRRHLRGLRGITQVATFIWKVMCNPVCAYDTLIRTLTGAATFSEDPVTTTIVCPNCTIQIHTCGGLLVRYSGDPAPVASDNVDRGNQGIDCLTNPNLIAGFSWRQIADLFSTVMTSLCNNHLVNLATMAAIGAVATKALQGVKGKTKRGRGARINLGNDEYDEWQQMRREFNNAHDMTAEEFLELRNRAAMGSDDADAIKFRSWWTNRQLRQDEAHVTVVGKGGVRNEVIRTRVRNAPKGPRTLDDGGFYDNDYEGLPGYLRFNGSGWMIHIGNGMYLSNTHTARSSCSEIVTCSPTTDLCLVKAEPIRSVAQIAEGTPVRDWKRASITTYGLKKTFSDSTKIDVLAYDGPTQTTHGDCGLPLFDEAGKVVAIHTGKLLGFSKMCTLIDCTITKGVYENTDLFCGDPIDYRGLVAFRVAGVEPRPPVSGTRYAKVPGVPEEYHTGYRPANLGRGDPDSHCTLMNIAVKNLQVYQQEPKLTKVDTFIERAAADVLGFLRFLTKGERQMNLNFSAAFNVLDLSTSCGPFVPGKKIDHVKDGKLDEVLSKHLYKCWSVANSGKALHHVYACGLKDELRPLDKVKEGKKRLLWGCNVGVALCAAAVFHNLCFKLKTVARFGPIAVGIDMTSRDVDVMITQLTSKAGDFLCLDYSKWDSTMSPCVVRLAIDILADCCEQTELTKSVVLTLKSLPMTVLDAMIVPTKRGLPSGMPFTSVINSICHWLLWSAAVYKACDEIGLFCSNLYEDAPFFVYGDDGVYAMTPMMVSLLPAILDNLRDYGLSPTAADKTEFIDVCPLKDISFLKRKFVMSELGWLSQLDRSSILRQLEWTKTAKRHMCIEECSELDKDERGVQLEELQIHAAAHGEEFFELVKKELRRQQAFTRFSVFDYQTARKTLGDRKRIVSVVPDDSFVNVMEGKPRADAPGTATTASVPGTTTDGMDPGVVASTDVVTADNVAASVATAGIGGPPQQASPQESWRVNFFYNDVFTWSVTDAPGSILYTVQHSPQNNPFTQVLSQMYAGWAGGMQFRFIVAGSGIFGGRLVCAIIPPGIQIQPGLEVRQFPHVVIDARSLEPVTITMPDLRPEMYHPTGNPGLVPTLVVSVYNNLINPFGGTTSAIQVTVETRPSEDFEFVLIRAPSSKTVDSVNPSWLLTTPVLTGAGSDNRWGAPIVGLQPVPGGFSTSNRHWNMNGETYGWSSPRFDDIDHPSGNVSYPSGSATNTIETWYANAGTATTNPISNIAPDGFPDMGAIPFSGTTIPTGAWVGFGQVWNASNGTPYVGTVQAYELGFANGAPSSIRPVTTTTGAQLVAKSIYGVAIAQNQTSAGIIFLSKGMVSTPGVAATTYTPQPSAIVTTPGTPVAAPIGKNTPIMFSAVVRRTGDVNAGPGSANGTQYGVGSQPLSVTLGLSLTNYSSALQPGQFFVWQLNFASGFMEVGMNTDGYFYAGTGAYSGMIDLTDLIDVRPVGVRPNTSTLVFNLAGVATTGYSYV

ORF1

Genome polyprotein

2278 amino acids

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

250.097 kDa

MASKPFYPIEFNPSVELQVLRSAHLRVGGREQMFETINDLNDHVRGVVAKLWCKHLHRSLAAAPTFTEEGLLDSFLSKPPVDINPDTTFRELFGINPHEQFPLSIHDLAKLQGELVDAARNPGHVLRRHYSTDSLTALINKITKFVPVHATLQEMQARRAFERERAELFRELPHADLDVSRQQKSYFYAMWRQVVKKSKEFFIPLVKCTSWRKKFTEPAEIVRQVLVHFCEGMRSQFSTNANYINLSLIAKLRPTVLTMILQQHKNTYRGWLATVTALVEVYSNLFQDMRDTAVSAVSAITLVFETIKDFVVNVIDLVKSTFQSQGPTSCGWAAIIAGALLILMKLSGCSNTTSYWHRLLKVCGGVTTIAAAARAVVWVRDIIAEADGKARLKKYMARTAALLELAASRDVTGTDELKRLLDCFTQLIEEGTELIQEFGTSPLAGLTRSYVSELESTANSIRSTILLDTPRKTPVAIILTGPPGIGKTRLAQHLAAGFGKVSNFSVTLDHHDSYTGNEVAIWDEFDVDTQGKFVETMIGVVNTAPYPLNCDRVENKGKVFTSDYIICTSNYPTSVLPDNPRAGAFYRRVTTIDVSSPTIEDWKKKNPGKKPPPDLYKNDFTHLRLSVRPFLGYNPEGDTLDGVRVKPVLTSVDGLSRLMETKFKEQGNEHRNLWITCPRDLVAPAASGLKAYMAANRALAQVFQEPSSQDIGETCTSRVYVSCNNPPPTYSGRVVKITAINPWDASLANSMLSMFETTSHIPASIQREIMYRVWDPLVHLQTREPNTQMLPYINRVVPVSSAFDFIRGLRHHLGLCSVKGMWRAYQGWNSSSSILEFLSKHMADVAFPHNPECTVFRAPDGDVIFYTFGSYACFVSPARVPFVGEPPKNVHSNITRNMTWAETLRLLAETITESLVHFGPFLLMMHNVSYLATRSGREEEAKGKTKHGRGAKHARRGGVSLSDDEYDEWRDLVRDWRQDMTVGEFVELRERYALGMDSEDVQRYRAWLELRAMRMGAGAYQHATIIGRGGVQDTIIRTQPMRAPRAPRNQGYDEEAPTPIVTFTSGGDHIGYGCHMGNGVVVTVTHVASASDQVEGQDFAIRKTEGETTWVNTNLGHLPHYQIGDGAPVYYSARLHPVTTLAEGTYETPNITVQGYHLRIINGYPTKRGDCGTPYFDSCRRLVGLHAATSTNGETKLAQRVTKTSKVENAFAWKGLPVVRGPDCGGMPTGTRYHRSPAWPNPVEGETHAPAPFGSGDERYKFSQVEMLVNGLKPYSEPTPGIPPALLQRAATHTRTYLETIIGTHRSPNLSFSEACSLLEKSTSCGPFVAGQKGDYWDEDKQCYTGVLAEHLAKAWDAANRGVAPQNAYKLALKDELRPIEKNAQGKRRLLWGCDAGATLVATAAFKGVATRLQAVAPMTPVSVGINMDSYQVEVLNESLKGGVLYCLDYSKWDSTQHPAVTAASLGILERLSEATPITTSAVELLSSPARGHLNDIVFITKSGLPSGMPFTSVINSLNHMTYFAAAVLKAYEQHGAPYTGNVFQVETVHTYGDDCLYSVCPATASIFQTVLANLTSFGLKPTAADKSETIAPTHTPVFLKRTLTCTPRGVRGLLDITSIKRQFLWIKANRTVDINSPPAYDRDARGIQLENALAYASQHGHAVFEEVAELARHTAKAEGLVLTNVNYDQALATYESWFIGGTGLVQGSPSEETTKLVFEMEGLGQPQPQGGEKTSPQPVTPQDTIGPTAALLLPTQIETPNASAQRLELAMATGAVTSNVPNCIRECFASVTTIPWTTRQAANTFLGAIHLGPRINPYTAHLSAMFAGWGGGFQVRVTISGSGLFAGRAVTAILPPGVNPASVQNPGVFPHAFIDARTTEPILINLPDIRPVDFHRVDGDDATASVGLWVAQPLINPFQTGPVSTCWLSFETRPGPDFDFCLLKAPEQQMDNGISPASLLPRRLGRSRGNRMGGRIVGLVVVAAAEQVNHHFDARSTTLGWSTLPVEPIAGDISWYGDAGNKSIRGLVSAQGKGIIFPNIVNHWTDVALSSKTSNTTTIPTDTSTLGNLPGASGPLVTFADNGDVNESSAQNAILTAANQNFTSFSPTFDAAGIWVWMPWATDRPGASDSNIYISPTWVNGNPSHPIHEKCTNMIGTNFQFGGTGTNNIMLWQEQHFTSWPGAAEVYCSQLESTAEIFQNNIVNIPMNQMAVFNVETAGNSFQIAILPNGYCVTNAPVGTHQLLDYETSFKFVGLFPQSTSLQGPHGNSGRAVRFLE

ORF1

Genome polyprotein

2254 amino acids

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

247.17 kDa

MANCRPLPIGQLPNRIFDTPRLTPGWVWACTSEATFKLEWLQDPVVIRPPDVFVAQGVVDDFFRPKRVLQGDPQLIAQVLLGDANGPLVGPVSMQQLTSLLHEVSQALSDHKHPLANRYTRASLQRYADTLSNYIPLVDILTGPKDLTPRDVLEQLAAGREWECVPDSALKKVFRDMWQYICEGCDSVYIKLQDVKRKMPHIDTTVLKQFIITLTDTISMATALDTKTWLAHILGWLKPTCLVMIMQQHVNSPQGWAATLTALAELYYGIMPLTETLGSVASWVTDKFADMATSTWGKFKSWWDSLYTPQAGNDLIILGGVVGLVYFMVFGDAPTQMFTKKLMRVCGFITSTVAAIKAAMWIVDYFKQREHEHQVRITLARWAALQEVIKQNRCAGLSEVTKLKECCEVLLNEVTELMYKLGASPLAGLIRSTSDVIQTTINELAQLMAYDTQRKPPAMVVFGGPPGIGKTRLVEALAKQLGEVSHFTMTVDHYDTYTGNTVAIWDEFDVDSKQAFIEATIGIVNCAPYPLNCDRPEAKGRVFTSKYVLATTNCPTPVMPDHPRAMAFWRRITFIDVTAPTIEQWLVDNPGRKAPTSLFKDDFSHLQCSVRGYTAYDEKGNTLSGKVARARYVSVNNLLDLIKEKYNSEAADVKHLWFTVPQAIHKQARDIILGWLRFHSYPNTVADNIPLSEVRDPTCFGYVVISDVDPPRHVAEHVAHIEVESILRTDIVGLLREGGGGLFRALKVKSAPRNCIINKVMMQAHHTTLQVLTSQEPHPPNLPRPRRLVFVESPIDIISALRHHVGFCTIPGIVKLITSGVGLGVENLGNFLQSIAGNVRFPLQSECSLLRTPSGDVLFYTSGQAAVWATPARFPIVTPGEASVGKEVCSESSWWDILKALFSTLVVAFGPIATLVLTAHNLAYLNTRENTLSEAKGKNKRGRGARRAIALRDDEYDEWQDIIRDWRKEMTVQQFLDLKERALSGASDPDSQRYNAWLELRAKRLSAGAYQHAVVDIIGKSGHRREVIRTQVMRAPREPKGDTYDSEGRGYVVPMTAQEKHTGWAVHIGNGRLVTCTHVANMCDRVAEVEFKVAETDRDTCIITAPLGHLPSVALGNGPPAFYTTNFHPIRVLDEGSWDTTTTRVTGWRVVINNGTTTAPGDCGQPYLNARRQLVGVHAATSTCGVKKLVSRVQTKKTAKATFPWKGLPVTTMPDAGGLPTGTRYHRSIAWPKLLPEETHAPAPYGVNDPRHPFSQHQMIANNLQPYINTPVALDQTLLQRAVKHTKGYLDQIIGTHRSPNLTYAAAVESMAHDTACGPNLPGRKKDYMTDQGEPIGPLKQMLEEAWDMAHRGVPRRHEYKLALKDELRPIEKNDQGKKRLLWGCDAGVSMIANAVFKPVTERLVDTVPMHPVAVGICMDSPQIEQMNQALTGRVLYCLDYSKWDSTQNPAVTCASVDILASYAEDTPLSSAAIATLCSPAVGRLDDIGLTVTSGLPSGMPFTSVINSVNHMIYFAMAVLEAYEEFKVPYMGNIFDNETIYTYGDDCVYGLTPATASIMPVVVKNLTSYGLVPTAADKSQSIEPTDTPVFLKRTFSQTPFGLRALLDETSLARQCYWVKANRTTDLFEPAAVDVDIRKNQLEVMLAYASQHPRSVFDKLAGMAEVTASAEGYQLVNVNWANAVATYNAWYGGTDGGRAPTNEDEEPEVFVMEAPAPTRSVASNPEGTQNSNESRPVQPAGPMPVAAAQALEMAVATGQINDTIPSVVRETFSTYTNVTWTTRQPTGTLLARMSLGPGLNPYTLHLSAMWAGWGGSFEIKVIISGSGMYAGKLLCALIPPGVDPSAVDQPGAFPHALVDARITDGVTFTLGDVRAVDYHETGVGGAIASLALYVYQPLINPFETAVSAAMVTIETRPGPDFGFTLLKPPNQAMEVGFDPRSLLPRTARTLRGNRFGRPITAVVIVGVAQQINRHFSAEGTTLGWSTAPIGPCVARVNGKHTDNTGRAVFQLGPLSNGPLYPNIINHYPDVAASTIFNTGTAVNDNTTGGGGPMVIFNDVGDVVEDVAYQMRFIASHATSQSPTLIDQINATSMAVCSFGNSRADLNQNQLNVGIELTYTCGNTAINGIVTSFMDRQYTFGPQGPNNIMLWVESVLGTHTGNNTVYSSQPDTVSAALQGQPFNIPDGYMAVWNVNADSADFQIGLRRDGYFVTNGAIGTRMVISEDTTFSFNGMYTLTTPLIGPSGTSGRSIHSSR

ORF1

Genome polyprotein

2210 amino acids

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

239.021 kDa

MAPVVSRDRHRHKIPKPHQPAPPHRCTVWCPEDCGWYVGRCSCPKSCQREGWDDFFVADKVKPPSYVASKTSVADVVDWLLEEDPATDGPSEFDLTQFFQAYTDKSHQIHRDYAPDQLAQALDMAYILSVDPPDIKLPEYEATRFTHDTSYKGKLPRWLRVYGFKSRELAKKAITNIKGGAHWAKGLFKQAWDTLPGWSEVEAYFKAFFAGIITGVEDALSKSPSSVWTSLKLTPLLYIWRNINECSDIPVILGAFWATLELYNIPSKVYDLVSTALGPMVQDLARRVINIIKGDGNGPKQEGGRPSFSIPGVLLATFLSAIILGSMPSDGIIKKVLRGCATAAGLVGGFNAVKSIITTVQGASACKDVKKLASQLMCVTTMAATVSTRGERQVLASMLNDLNESVRERLVDPAFAALVPQLSAMSSKIMELSTINAAALSAARKRVPAKIVVLCGPPGHGKSVAAHKLAKMLNPNEPSIWNPFSDHHDEYTAEDVVIIDETPAEPGQWVEDLIAMGSNSPFVPNYDRVENKTRCFDSKYVLITTNHNPLINPTHSRAAALARRLTWVYVNSPDVADFLRQHPGVAPPATLFKADCSHLNFDIHPYNSIGTTAVVGHNGTTPLPRAKRTSLEGLCKHIKDLPDREGPPDGVPERMVLVAPDKGTARFVEAVINTYHNSGLVAQPAAWDTTPQKYQLAVTWQGSTSSVVGQRWDCNPQTPFVAPHFTRNMFKRVLGTEVPEYHLLAYACRITSSSLGDKSLPVPNPTVVINDPSPTRLALALMRHLKNPIASGLRVVWDLFRGCATGPKRLFTWALSQEWNPMPVTTAFTFPAGTVILHTAGGVRVVVLPPGPQFGLTEVTHLADHSGQDDPVVPDMFGQTWTELLWRLLKVIGTFLANYGVAIAGLTLSIAAFKTANKSTRNDRQGWLSGSGVALSDEEYDEWMKYSKKKGKKINADEFLQLRHRAAMGNDDDDARDYRSFYTAYQLGREGNNCEDLPLHPAVGPTTGGGYYVHIGNGVGITLKHVASGEDVIKELGNDLVKIRARHHKMGDPAMVVGEGAPVKFVTGHLVVDARNESVVFDQTRLSVVRVKVPGLETQRGYCGLPYVNSAGHVVGLHQGSYGVGDKVFTPITDAPAASPDTIMWRGLECTRSDIVTHLPHGTKYSISPGMREEAHKCTHQPASLGRNDPRCNQTQVAMVVKALTPYTSAPAIEKLDPCMVAAITEVRTAIQSLTPKGGFRPLTFAAAWQSLDLSTSAGALAPGKTKRDLCDPDTGMPAGKYREMLLAAWSRAGTGTPLDHTYIVALKDELRPVEKVAEGKRRLIWGADARVALIASAALTPVANALKTVTNLLPIQVGVDPSSANCVSSWVGRLQRHDHCLELDYSKWDSTMSPVIINIAIDILCNTCGSDSLRMAVAQTLKSRPTALVEGVSVPTKSGLPSGMPFTSQINSIVHWILWSATVRKCSLPLHIGSVNELAPFLTYGDDGLYTIPSHLTKSIDEIISTLKGYGLSPTAPDKGANVEIKRTSFTYLSGPVFLKRRIVLTPGGHRALLDLTSLARQPVWVNGPRRSVWNHEAQPIEIDAETRTIQLQNVLIELAWHQPQDFDHVLALVVKSAEASGLTIPRYSQEEARAIYDGRYYGIQHVSLPNNSDLIREGNMSDNKSTPEQQHESSRAMDAGATGAAAAAPAPPVAAAPASGLVGALVAEPQSGPSAEQWRTAYTLFGTVSWNANAGPGTILTVGRLGPGMNPYTQHIAAMYGGWAGGMDIRITIAGSGFIGGTLAVAAIPPGVDPESVNVLRMPHVLIDARGGVPLEVTLEDIRTSLYHPMGDTNTASLVIAVMTGLINPLGTDTLSVTVQLETRPGRDWVFFSLLPPTAGVASADPSQLLTRVALATSPEVRFGTGVLGILGLPSNPSVNRVYDVQSRTRGWSFPIPSSSVFMGDARNVEHNRRVMVQSSAPNNPLSDVFPDGFPDFVPQSDTEPDGGAVIAGQVLPHPGDNDNFWRLTPVVRGNTTAAINTIPERFNQVYFINLADEEAVSAATEELRFNGIQGIFGQRTNARAVQVMQGYVPRAEHIIRPAGFAGVGPQGPNVPIGFAGTMPNFNATASGADDLVPVWGPTLVHTASLLAGTTYELAENSMYVFSVSTSTSTFELGMLANGTWLGPAQLAGTGITWTEVLSVTYMGMRFAYNPLSGQGIGGESRRL

ORF1

Genome polyprotein

2210 amino acids

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

238.639 kDa

MAPVVSRDQCKPKTPKPHRPAPPHRCTTRCPEDCGWYVGRCSCPNVCQREGWDDFFVADKVKPPSYVASKTSVADVVDWLLEEDPATDGPSEFDLTQFFQAYTDKSHQIHRDYAPDQLAQALDMAYILSVDPPDIKLPEYEATRFTHDTSYKGKLPKWLRVYGIKSRELAKKAVTNIRGGAHWAKGLFKQMWDSLPGWSEVEAYFKAFFAGIITGVEDALSKSPSSVWTSLKLTPLLYIWRNINECSDIAVILGAFWATLELYNIPSKVYDLVSTALGPMVQELARKVINVVKGDGSGPKQEGGRPSFSIPGVLLATFLSAIILGSMPSDGLIKKILRGCATAAGLVGGFNAVKSIITTVQGASACKDVKKLASQLMCVTTMAATVSTRGERQVLASMLNDLNESVRERLVDPAYASLVPQLSAMSNKIVELSTMNASALSAARKRTPAKIIVLCGPPGHGKSVAAHKLAKMLNPNEPSIWNPFSDHHDEYTAEEVMVIDETPAEPGQWIEDLIAMGSNSPFVPNYDRVENKTRCFDSKYVIITTNHNPLINPTHTRAAALARRLTLVYVNSPDVADFLRQHPGVPPPATLFKADCSHLHFDIHPYNSIGTTAIVGHNGTTPVPRAKRVSLEGLCKHVKEMPDREGPPDGVPERMVLVAPDKGTARFVEAVINTYHNSGLVAQPAAWDTTPQPYQLAVTWQGSNSTVTGQRWDCNPQTPFVAPHFTRNMFKRVLGTEVPEYHLLAYACRITSSSLGDKSLPVPNPTVVINDPSPTRLALALMRHLKNPIASGLRVVWDLFRGCATGPKRLFTWALSQEWNPMPVTTAFTFPAGTVILHTAGGVRVVVLPPGPQFGLTEVARLADHSGQDDPVVPDMFGATWTELLWRLLKVIGTFLANYGVAIAGLTLSIAAFKTANKSAKNDRQGWLSGSGVALSDEEYDEWMKYSKKKGKKINADEFLQLRHRAAMGNDDDDARDYRSFYTAYQLGREGNNCDDIPLHPAVGPTTGGGYYVHIGNGVGVTLKHVASGEDVIKELGNDLVKIRTKHHKVGDPAMVVGDGMPVKFVTGHLVVDTRSESVVFDQTRLNVIRVKVPGLETRRGYCGLPYVNSAGQVVGLHQGSYGVGDKVITPITPEPTAPPDTIMWRGLECARSDIVTHLPHGTKYSVSPGMKEEATKCSHQPAPLGRNDPRCGQTQVAMVVKALSPYTGSPAVEKLDGCLVAAISEVRTAIQSLTPKGGFRPLTFAAAWQSLDLSTSAGALAPGKTKRDLCDPDTGMPTGKYKEELLRAWSRAGTGTALDHTYIVALKDELRPVEKVAEGKRRLIWGADARVALIASAALSPIANALKTVTNLLPVQVGVDPSSASCVSAWVNRLNRHDHCLELDYSKWDSTMSPVLINIAIDILCNTCASDGLRVAVCQTLKTRPTALVEGVAVPTKSGLPSGMPFTSQINSIVHWILWSATVRKCSLPLNIGSVNELAPFLTYGDDGLYTIPSHLTKSIDEIVSTLKGYGLSPTAPDKGMNIEIKKTSFTYMSGPVFLKRRIVLTPGGHRALLDLTSLARQPVWVNGPRRSVWDHEAQPIEIDSEVRTIQLQNVLIESAWHQPQDFNQVAALVYKSAEASGITIPRYSLEEARAIYDGRFYGIQHVSMPCNSDLIREGNMSDNKSIPEQQHESSRAMDAGATGAAAAAPAPPVAAAPASGLVGALVAEPQSGPSTEQWRTAYTLFGTVSWNANAGPGTILTVGRLGPGMNPYTQHIAAMYGGWAGGMDIRITIAGSGFIGGTLAVAAIPPGVDPESVNVLRMPHVLIDARGGVPLEVTLEDIRTSLYHPMGDANTASLVIAVMTGLINPLGTDTLSVTVQLETRPGRDWVFFSLLPPTAGVASADPSQLLTRVALATSPEVRFGTGVLGILGLPSNPSVNRVYDVQSRTRGWSFPIPSSSVFMGDARNVEHTRRVMVQSSAPNNPLSDVFPDGFPDFIPQSDTEPDGGAVIAGQVLPHPGDNDNFWRLTPVVRGNTTAAINTIPERFNQVYFINLADEEAVSAATEELRFNGIQGIFGQRTTARAVQVMQGYVPRAEHIIRPAGFAGVGPQGPNVPIGFAGTMPNFNATASGADDLVPVWGPTLVHTASLLAGTTYELAENSMYVFSVSTSTSTFELGMLANGTWLGPAQLAGTGITWTEVLSVTYMGMRFAYNPLSGQGIGGESRRL

ORF1

Genome polyprotein

2208 amino acids

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

242.737 kDa

single

MFGTKAPDSVQEGTLFRELFGVDQTEQFPLSLADLARLQGELVDATRTPGHALRQKYTMTTIQDLINKITKVVPVQATLNEMHARRQFERERADLFHELPLVDEDAVAQPKTYFYTMWRQVVKKGKAYFCPLVKTSAWRTKISAITEPIKDFLIAFWQAVQQEMGVNPQYLQLAWLQKLKPTTLTIILQQHKHTVSGWLATMTALVEVYSNLFDDLRKSSVTIVSSIGAFFDICKDFVSQVVELVKTTFTAQGPTDLGWAAVLAGAAMILLKMSGCPGVIGMWTKVLKICGGITTITAAARGVRWLKDLYEEAEGRRLPKMYMARGAALIELAASREVTGVDELKGLLDCFTILIEEGTELIHKFGTSPLAGLVRTYVSELETQANNIRSTIKLDTPRRVPVVIILTGAPGIGKTRLAQYIGQRFGKTSNFSVAVDHHDGYTGNTVCIWDEFDVDSKGAFVETMIGIANTAPFPLNCDRVENKGRVFTSDYVICTSNYPTSVIPDNPRAAAFYRRVLTVDVSAPDLEEWKKRNPGKRPTPDLYQDDFSHLKLMLRPYLGYNPDGDTLEGPRVAPTQISIAGLITLMERRFKEQAGPLQNLWLQVPKTLVEQSTNMVKAFMYANRAVCDVIPNPATRDITETALSKVFVCGTAPPPEFVGKHIVITGIEVGDASIANSLLSMFTTTTRLSAAAQREYMYRVWSPLIHIQDRSMNTQNLPYINRVIPVTSHWDFLRGLRHHLGFTSIPGMWKAFQGWRTSQGIVDFVAHHMADVTFPSNPECTIFRTPDADVVFYTFGSYVCFATPARVPYVGTPPTTIHSNTPRCMTWGETLALLCEVVAEFVLHFGPVILSAANIAYLMTRGSRTEEAKGKTKHGRGMRHGHRAGVSLSDDEYDEWRDLMRDWRRDMSVNDFLMLRERSALGMDDEDVARYRAWLEIRAMRMAGGAYTHATIIGRGGVRDEIIRTSPRRAPTRPQQHYEEEGPTAIVEFTQGGDHIGYGVHIGNGNVITVTHVASTSDEVNGSAFKITRTVGETTWVQGPFSQLPHMQIGSGSPVYFTTRLHPVFTISEGTFETPNITVNGFHVRIMNGYPTKKGDCGLPYFNSNRQLVALHAGTDTQGETKVAQRVVKEVTTQDEFQWKGLPVVKSGLDVGGMPTGTRYHRSPAWPEEQPGETHAPAPFGSGDKRYTFSQTEMLVNGLKPYTEPTAGVPPQLLSRAVTHVRSYIETIIGTHRSPVLTYHQACELLERTTSCGPFVQGLKGDYWDEEQQQYTGVLANHLEQAWDKANKGIAPRNAYKLALKDELRPIEKNKAGKRRLLWGCDAATTLIATAAFKAVATRLQVVTPMTPVAVGINMDSVQMQVMNDSLKGGVLYCLDYSKWDSTQNPAVTAASLAILERFAEPHPIVSCAIEALSSPAEGYVNDIKFVTRGGLPSGMPFTSVVNSINHMIYVAAAILQAYESHNVPYTGNVFQVETIHTYGDDCMYSVCPATASIFHTVLANLTSYGLKPTAADKSDAIKPTNTPVFLKRTFTQTPHGIRALLDITSITRQFYWLKANRTSDPSSPPAFDRQARSAQLENALAYASQHGPVMFDTVRQIAIKTAQGEGLVLVNTNYDQALATYNAWFIGGTVPDPVGHTEGTHKIVFEMEGNGSNPEPKQSNNPMVVDPPGTTGPTTSHVVVANPEQPNGAAQRLELAVATGAIQSNVPEAIRNCFAVFRTFAWNDRMPTGTFLGSISLHPNINPYTSHLSGMWAGWGGSFEVRLSISGSGVFAGRIIASVIPPGVDPSSIRDPGVLPHAFVDARITEPVSFMIPDVRAVDYHRMDGAEPTCSLGFWVYQPLLNPFSTTAVSTCWVSVETKPGGDFDFCLLRPPGQQMENGVSPEGLLPRRLGYSRGNRVGGLVVGMILVAEHKQVNRHFNSNSVTFGWSTAPVNPMAAEIVTNQAHSTSRHAWLSIGAQNKGPLFPGIPNHFPDSCASTVVGAMDTSLGGRPSTGVCGPAISFQNNGDVYENDTPSVMFATYDPLTSGTGVALTNSINPASLALVRISNNDFDTSGFANDKNVVVQMSWEMYTGTNQIRGQVTPMSGTNYTFTSTGANTLVLWQERMLSYDGHQAILYSSQLERTAEYFQNDIVNIPENSMAVFNVETNSASFQIGIRPDGYMVTGGSIGVNVPLEPETRFQYVGILPLSAALSGPSGNMGRARRVFQ

ORF1

RNA replication polyprotein

2183 amino acids

Protease: Thiol protease that cleaves the polyprotein.

Belongs to the potexviruses/carlaviruses RNA replication protein family.

247.262 kDa

MALLSRTAAEEVIASFTSEEQSRISTQAVLALTNVEKDKHDLFNYALPELAKMRLFNSGIYLSPHSYRPHSHPVCKTLENNILFNILPSYLDNSFYLVSIKKNKVDFLKRRHPDLQMVETINRYISSIDKTRYGGFFHVSPSKISAKFKCDRRTGFEDDASLIDLIPGCMEGARKRFFFHDELHYWTKEALITFLDHVKPEVMLASIVFPPEILAGAKESLNPWCYTFRIVGKDLVFFPDGEQSEAYIQPVAGSYLLRTGKITTPSGDIFQLDLLKSSFSHHLISITKGEAIGQKMRFFNGFEAVAMKGLNPLRRKVESCLPISKNTILKIYRYLRTLKKPDLQSAMAKLSQVCKDPNGYEIKFFEEFSKLCLKCDTLNTNMIPDMKRIVQGFFLKLFPNPISRNFKVVQQLHLDNFIETLEEFNFSINTESLSLNWKDDLEFVNLTFGDTDFNVEDSFAEAWGTKKDVVNITTVHHSPYLVSKFESYDHQFHSILSVKSISALTRIAKIVLSLYDPCVVEAFSESRVTNLAVNVIIAANLRACFAVTDLWRIFEGILLKECKRAQGKMRKRFHFELGIRWFLFVDVSNQWFLPPCRDGLIARSVSFDQFIKGCQRDNSLHNGRMSLRQVLKGPKLQALFDVSELSIIHNVEMENAPEAGSTLDAGIKPTSSPLEVVPIENARCNLAPCKCDLNCFIQPADVNSLHGNLVFLDFIGGSKGRGASFYSRDLKGYSYTGFSHVSRGWPAFLDKFLSDNKIPLNFYNQCLVQEYSTGHGLSMHKDDESIYDINHQVLTVNYSGDAIFCIECLGSGFEIPLSGPQMLLMPFGFQKEHRHGIKSPSKGRISLTFRLTKEGDSQVPIQEVVTICDHGDSDDRAALKALERRSHQSGGRPAVELEGHEREKVNSDSSDSAPVQEFLIQIDSSLLEYALKSLSGLSKNVVNCDMCLCNSPWLKNEELRFSEALRDLAFAQGLIQLIDFLCLKVLRCAEVNRIISELPTHVFPLRGTMHIVDLDDESIRGDVKEGSFSGFRRWKVMSCSTDLIMLAFLKPKMTLGGELRSHEDECELSDLTEKLHGCSVILSRKFEPDLFHSFDVEADGNCFWHSVGPLIGVDGEYLKRILHDQAKKDGVKCPRLSKQLEGNTWAEREAVAYFCSHYGIRLNVLYTREECTWIFKPHEVLKAATLICQDNHFKPCMPVNGCVIRAISSALNRREVDVLAVLGKPAHEDLFEEVAEGRGFSIFDLTRLFEIFSICGSVDTGGELIMVNENGRIPAEFSLEKEHLAHIPTLSRRKFSPIVSDLNRVSNSAMRFLAINGAEVDYRPSIDRASTLLDSFEIGATGVLCQGIKEAQKDLASKLIPELVHERKLIMILGTFGCGKSSLFKKFIEKSPGKAITFVSPRRSLAESINHDLGLARVGGKKTGKSKDLKNVRVKTFELFILHLDSIKEGHTVVIDEIQLFPPGYIDLIILGLKPNVNIIIAGDPCQSDYDCSSDRHIFAGSESDIMRILSGRSYKFNILSQRFRNPVFYGRLPCNLNKTRLTLDEEEYTLWDSIQEFSMMGRKDCPVVLVSSFEEKKIVAAHLGLKMKCITYGESTGLNFQKGAILVTYESALTSDRRWWTALSRFSHDIHFINGMGVTWDNAITHFVGKPLHKFFTKRACNDDIIDLLPGRPELIEGFQSQVGADEGVREAKLVGDPWLKTKIFLGQNPDFEIEIADEVEAAEDWFKTHIPIMSLEAVRAQWVHKLISREDREFRIGDITTEQFTDDHSKNRGQELTNAAERYEAIYPRHKGTDTATFLMAVKKRLSFSSPAAEHAKLRRAKPFGKFLLDTFLKRVPLNSSHDEKMMQEAVHAFEEKKLSKSMATIENHSGRSCEDWPVDKALIFMKSQLCTKFDNRFRSAKAGQTLACFQHSVLCRFAPYMRYIESKVTEVLPKNLYIHSGKNIDDLAAWVTTSKFNGVCTESDYEAFDASQDHFILAFELEVMKFLGLPSDLIADYTFIKTHLGSKLGSFAIMRFTGEASTFLFNTMANMLFTFLRYDLNGREAICFAGDDMCANSRLKVTNRFSNFLDKIKLKAKVQFTATPTFCGWGLCEHGVFKKPDLVLERLQIARETRNLENCIDNYAIEVSCAYKMGENLNLYLTPQEVDAHYNCVRFIVQHNHLLKSNIRDLFKGESLPASS

ORF1

Replicase

2109 amino acids

Replicase large subunit: is a methyltransferase active in RNA capping and an RNA helicase. Methyltransferase displays a cytoplasmic capping enzyme activity. This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus. Helicase region probably exhibits NTPase and RNA unwinding activities. Contains a cysteine protease activity responsible for autocatalytic processing of the 237 kDa protein (Potential).

Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.

237.518 kDa

MADSFGFTPMEVLLFGGESVQLLTSDMPIDVQWGFVHSTRCYALWKDDLIHLNPLLKYSQRIAKRWERLVSGFVGPVPLDKLLSLLAKLMRYCVNMGVSVQEIYLSDAIVSSSYMLHVSRSAGCVSFSWLYAKLSMFASCGKFWVGSSHHTAANMIEGSRAVNGPDVAISEMVEAFHLEVKSSLVVTVSLTPREKKILERELGFVPLYKQKSRAPRNHPVLAALREVMRQEYSASCNILNTKLKTLVVGAASREVNCYSSNPSVHYYFANKDSKDLVRTTLELLHSALATKYRNMESGERELMNNLKGCGYIVKRSVENAVYEVVSDKDVAEVLRYAQTVASTKKEAKKKPNTGKRKMVMSEATRRTIELHELSRIVAEEKKIPNHFHFDESDFASVGNFTQLVCEDVGYNFSVDAWLHLFEATGAQTAVGYMALPNELLFEHYPISDYYDYWEGVEKHGSLGGITISPLRNGQVVGMPTGVFQPVHFDKTSAGLGIPGSKMGAAERVICHMSDGLGNGYNHVKSDWQTLLKHPILSSSKYNFAVEVDLTGRYGCLATFRLTRVTGVKYVARTIKLRPEDRYVRVLDLLHIVRSIRLKGHAGLKEPYQYFPVYKREVDTPVSYCFSIAEKSLTVQNIANFIRHHIGGVSLVNKELVSAWRLNPQLVPSFAYAVYFYVVNLRGELDGMLQKLMKKGITWADRLKANVSAFLRDMVDPISFLWTWLFERRLVDQIFQDGTDVFYQMDRACVDEKALRLNDHIKITRDFLPADTLLPEGWSLDDWEKAPDSLKTLSAAASLPVECGAVNCVGKSFKSVRTLLPPSVVTSPVEQFFKSGGKFRDDAEFAELLSAHYRWQMDNSFCACQVCAALTGKTGSQVVECRWKAESMYTFSMSQTEVDDFRNEIKAQSIEKGNRFGEMLIGVHQKIPTQAFEVSVRLEYVKGGPGTGKSFLIRSLADPIRDLVVAPFIKLRSDYQNQRVGDELLSWDFHTPHKALDVTGKQIIFVDEFTAYDWRLLAVLAYRNHAHTIYLVGDEQQTGIQEGRGEGISILNKVDLSKVSTHVPIMNFRNPVRDVKVLNYLFGSRMVPMSSVEKGFSFGDVKEFSSLSNIPDTKIIHYSDETGEHMMPDYVRGVSKTTVRANQGSTYDNVVLPVLPSDLNLINSAELNLVALSRHRNKLTILLDNDGMNIGAVLKGMLEGVPEELERRDYIVGMYLGLHLPIKKEFFFPESEFAKSFRLMVAKYEAFVPYDSNLPTLVLQGDVVVLDIARVENDINDAFNCPDFYNLVSRPNNCLVVAISECLGVTLEKLDNLMQANAVTLDKYHAWLSKKSPSTWQDCRMFADALKVSMYVKVLSDKPYDLTYEVDGAGSSVTLHLVGKESDGHFIAAPLSPSLSTNERESGHDSKKPADDSDTFDAANLFADKGVSSADIEAFCAYLEKTLMATIMEYDLRLQSWANVVDDTDDFYQINISEFRQSTCFGKLLSALEVLKVDVSRKRFISDWLCKNLENKQFRWRWSSSVASTSSAGSNVDDDFVNMAGGKTDANVDPADVLRQSFMDYASEFVPILIAESPILMPLVEPEPILSKCMVPEFDAFLLIKEFDLDNGADEYQCAYLNESVANRVGDKFVSGVLDTDIISPLNLRGHPIAENVKYHSMCVAPAQIYFKRNQWQELQVQQARYLFRKVRNSPSSTQDSVARMVAQLFVSDCLVPNVADTFSASNLWRIMDKAMHDMVTKNYQGQMEEEFTRNAKLYRFQLKDIEKPLKDPETDLAKAGQGILAWSKEAHVKFMVAFRVLNDLLLKSLNSNVVYDNTMSETEFVGKINAAMNIVPDSAINGVIDAAACDSGQGVFTQLIERHIYAALGISDFFLDWYFSFREKYVMQSRYVRAHMSYVKTSGEPGTLLGNTILMGAMLNAMLRGTGPFCMAMKGDDGFKRQANLKINDQMLKLIKKETVLDFKLDLNVPITFCGYALSNGHLFPSVSRKLTKIAAHRFREYKHFCEYQESLRDWIKNLPKDPAVYADFLECNASLSCRNVDDVQRWLDAIISVSRIGREQFMMMFPIREVFMSLPPVEDSLGELSSTKVAVSIGDNVSNVVRKVARVDMKKF

ORF1

Genome polyprotein

2027 amino acids

Capsid protein CP1 and CP2 assemble to form an icosahedral capsid, about 30 nm in diameter, and consisting of capsid proteins CP1 and CP2 in a 1:3 ratio. The capsid encapsulates the single-stranded RNA genome. While CP1 is produced as a C-terminal fusion of the replication protein, CP2 may be expressed from a 3'-co-terminal subgenomic RNA.

223.738 kDa

MSSFLRGGHLLSGVESLTPTTHRDTITAPIVESLATPLRRSLERYPWSIPKEFHSFLHTCGVDISGFGHAAHPHPVHKTIETHLLLDVWPNYARGPSDVMFIKPEKFAKLQSRQPNFAHLINYRLVPKDTTRYPSTSTNLPDCETVFMHDALMYYTPGQIADLFFLCPQLQKIYASVVVPAESSFTHLSLHPEIYRFRFQGSDLVYEPEGNPAANYTQPRSALDWLQTTGFTVGHEFFSVTLLDSFGPVHSLLIQRGRPPVFQAEDIASFRVPDAVALPAPASLHQDLRHRLVPRKVYDALFNYVRAVRLRVTDPAGFVRTQVGKPEYSWVTSSAWDNLQHFALQTAAVRPNTSHPLFQSPFARLSHWLRTHTWALWCLASPSASVSAWATASALGRLLPLHTDRLRLFGFDIIGRRFWPRLPFHGPEPRFLWETHPACRPPVLFADSAFECQILAGLANRCSPSPFWSRLFPTASPPSWVAYSALALAAVPLAALALRWFYGPDSPQALHDQYHATFHPDPWTLDLPRRLRRFERESFMRTGSAPLPQSLPPPEGSLLPVEPPPVPSDPEPALEPSPPAASVPAPAPALASEPPPSPESVAPSRRRRRARRAAARAPSPSPALLGADLRFGDLPPVSAWDSDPEISKLGESTQGTVFAVTPGPRAPEPDTARLDADPSASGPVMEFRELQKGAYIEPTGAFLTRARNSVSSSIPYPTRAACLLVAVSQATGLPTRTLWAALCANLPDSVLDDGSLATLGLTTDHFAVLARIFSLRCRFVSEHGDVELGLHDATSRFTIRHTPGHFELVADNFSLPALVGASSVPGADLAEACKRFVAPDRTVLPFRDVHIHRTDVRRAKNLISNMKNGFDGVMAQANPLDPKSARERFLMLDSCLDIAAPRRVRLIHIAGFAGCGKSWPISHLLRTPAFRVFKLAVPTTELRDEWKALMDPRDQDKWRFGTWESSLLKTARVLVIDEVYKMPRGYLDLAIHADAAIQFVILLGDPIQGEYHSTHPSSSNARLSPEHRYLRPYVDFYCFWSRRIPQNVARVLDVPTTSTEMGFARYSQQFPFSGKILISARDSAKSLADCGYHAVTIASSQGSTIAGPAYVHLDNHSRRLSHQHSLVAITRSKSGIVFTGDKAAADGTSSANLLFSAVLLDRRLSVRSLFSALLPCCPFVTEPPTSRAVLLRGAGYGIARPLRARDAPPLGPDYVGDVILDSSAPILGDGSANAPQVSTHFLPETRRPLHFDIPSARHQVADHPLAPDHSACAIEPVYPGESFESLASLFLPPTDAESKETYFRGEMSNQFPHLDKPFELGAQTSSLLAPLHNSKHDPTLLPASIGKRLRFRHSEAPYVIAPRDEILGSLLYEAWCRAYHRSPRDVEPFDPDLYAECINLNEFAQLSSKTQATIMANANRSDPDWRWSAVRIFAKTQHKVNEGSLFGSWKACQTLALMHDAVVLLLGPVKKYQRFFDQRDRPSTLYVHAGHTPFEMADWCRAHLTPAVKLANDYTAFDQSQHGEAVVFERYKMNRLSIPAELVDLHVYLKTNVSTQFGPLTCMRLTGEPGTYDDNTDYNIAVLHLEYAVGSTPLMVSGDDSLLDSEPPVRDQWSAIAPMLALTFKKERGRYATFCGYYVGFTGAVRSPPALFAKLMIAVDDGSISDKLIAYLTEFTVGHSSGDAFWTILPVEAVPYQSACFDFFCRRAPAQAKVMLRLGEAPESLLSLAFEGLKWASHSVYALMNSSHRRQLLHSSRRPRSLPEDPEVSQLQGELLHQFQSLHLPLRGGHMPNPLAAPFRLLQQSSSLGPTYAVAPIARAPQVPPPSMADNATQVGPVPPRDDRVDRQPPLPDPPRVLETAPSHFLDLPFQWKVTDFTGYAAYHGTDDLVASAVLTTLCAPYRHAELLYVEISVAPCPPSFSKPIMFTVVWTPATLSPRDGKETDYYGGRQITVGGPVMLSSTTAVPADLARMNPFIKSSVSYNDTPRWTMSVPAVTGGDTKIPLATAFVRGIVRVRAPSGAATPSA

ORF1

RNA replication polyprotein

1968 amino acids

Protease: Thiol protease that cleaves the polyprotein.

Belongs to the potexviruses/carlaviruses RNA replication protein family.

223.386 kDa

MAVTYRTPMEDIVNCFEPATQAVIANSAATLYKNFEEQHCQYFNYYLSPLAKRKLSMAGIYLSPYSAVVHSHPVCKTLENYILYSVLPSYINSSFYFVGIKERKLQLLKSKCKNLDSVQVVNRYVTSADRMRYTNDFVPYGSYEHECLVHKGVGLDNEALRGLVGPLRRHKAKNLFFHDELHYWSSKVLIDFLDVMRPDKLLGTVVYPPELLFKPTRSLNEWCYTYDIVGDTLMFFPDGVQSEGYQQPLKGGYLLGARSLKLPDGTVYMVDVLCSKFPHHLISITKGEAAAPTHRAFGPFEAVASEALKATLSPDYPCAFPVSYEVVNKIYRYLRTLKKPDEQSAIAKLSQIIAEPSGREIDFVECFARLVIHNSSMCATIMPEQLKEFMGNWLGKMPSVLARRFSSVRAVCVNKFIRGLKPYSFTLRLNEITWWNIWENSYAWFFDTDAEVDVPEKLDSLFMGEGAGLVAHITSRPYVGTVPLADREWNALLCMDSQKLLHAMRRMFMRGAWGAHMCVISREFLLKYVEARLKSSCLIAKARRRGQHKEKLEAWEVLGLKSSDALFRAMTYLCNARLEPMFSESGLRFFLTRGRNNLYGLTNYTEGKRAVTGVQNLWSNVVHEVSTKRHKGMIRLEKARVTEQPRSEFASCVLEPEVWRDVEAALDIELGEVACACNARFVQGVVLSNQAGLNVREQVAGASVGLYTKDRSNLKWGNSELLSNGWGRSLSVWMEINSVSQKFDVAVRLSYSKETQMNVLLPSLDGIERGAGATVVNLRKCGAFIVRCARGWRLALAWMDHICLEVMANVAYGHECYMRSWGTMDVVVFLKRATVSEQVTFESAQEVGPIEGKSDSGAPGVGVNLDLGGVVGSEYPANGAERYKRVSGPGDGCCCWHSFAYLVGMHHMELKRLCTSHVFENAALNVELEQCKASGAFVTHAAILATALRLRAEIRVHNAGTGRVHRFAPKQKNMALDLWLESEHYEPQVLRNGCVIESVAQALGTRNADILAVVEERCCEEVVESVQAGLGLNLHHVEIVLQCFDIVGHCNLGDKEITLNAGGKMPFCFDISDEHMSFCGRRKDPICKLVSGALHGKMFAESALLDLENCGLKIDFEPNWNRAGMLADSMYQGATGVLGSALFNNKRNMREKFVRNVSLSLHAIVGTFGSGKSTLFKNLLKYGAGKSLDFVSPRRALAEDFKRTVGMNERGGRAKAGQENWRVTTLETFLARVEFLTEGQVVILDEMQLYPPGYFDLVVSMLKVDVRLFLVGDPAQSDYDSEKDRLVLGAMEENMSVVLGAREYNYKVRSHRFLNCNFIGRLPCEINKDDCTIDEPHIMRMHLENLLDVAEEYKSVVLVSSFDEKMVVCAHLPEAKVLTFGESTGLTFMHGTIYISAVSERTNERRWITALRRFRFNLCFVNCSGMDYQQLAGRYKGRVRSKFLCKTAIPDDLNSMLPGQALFKSEYPRLIGKDEGVREEKLAGDPWLKTMINLYQAPEVEIAEEPEVVMQEEWFRTHLPRDELESVRAQWVHKILAKEYREVRMGDMVSEQFTHDHTKQLGAKQLTNAAERFETIYPRHRASDTVTFLMAVKKRLSFSNPGKEKGNLFHAASYGKALLSEFLKRVPLKPNHNVRFMEEALWNFEEKKLSKSAATIENHSGRSCRDWPTDVAQIFSKSQLCTKFDNRFRVAKAAQSIVCFQHAVLCRFAPYMRYIEMKVHEVLPKNYYIHSGKGLEELDAWVKKGKFDRICTESDYEAFDASQDEFIMAFELELMKYLRLPSDLIEDYKFIKTSLGSKLGNFAIMRFSGEASTFLFNTLANMLFTFMRYNIRGDEFICFAGDDMCASRRLQPTKKFAHFLDKLKLKAKVQFVQFVNKPTFCGWHLCPDGIYKKPQLVLERMCIAKEMNNLSNCIDNYAIEVAYAYKLGEKAVNRMDEEEVAAFYNCVRIIVRNKHLIRSDVKQVFEVL

ORF1

RNA replication polyprotein

1967 amino acids

Protease: Thiol protease that cleaves the polyprotein.

Belongs to the potexviruses/carlaviruses RNA replication protein family.

223.431 kDa

MALTYRSPVEEVLTLFEPTAQSLIASAAVSAFQRHEKDNFEWFRYSVPAFAKEHLSKAGIYLSPYAGFPHSHPVCKTLENYILYVVVPSIVNSTFFFVGIKDFKINFLKSRFDKLNMISALNRYVSSADKIRYGNDFVIRAGVEHRALKRHRGLVDSPTLKALMPNVKSGSKLFLHDELHYWSKEELIGFLEICEPEVLLGTVIYPPELLIGSDCSLNPWCYEYEVKKKKLLFYPDGVRSEGYEQPLSGGYLLQTSRIKLPNAGIYCVDLLCSRFAHHLFSITRGDLITPDNRSFGPFEAVHSGALAGISRGKPNFYPVSQHTILRVYRYLRSLKKPDKQSAMAKFSQIVHEPCGRAVKFMEEFSDLIINTGTLRTVINPEQVKLFFGNLGRCMPPCFASKLKGTRTVCLDEFISMLRPLSVDVTLETISMHSMTMVVTTWSQEAEEGVDLPKIFEEKWEGKQSLDRTEAPYLGLAPFVDYKIQWRLQFNIPKFLNQLAELFVNSCSVNGGVRSMSIPAYLRRLATCRSCVGRAMLCCLTEVDIASLRVVVRNRYPYTEDFYRCRRRWFLRIGAQRRPSFYIEDAKHLERLGQFEEEQFQRPMSRRSLYTLASVSMNGTDDPFCSDCFYDPVPVARAKIVPTPTVIVERALEPLAIDTGTTSDAPCDAPGATCLRGAQAVVCACGLSMAVSAVPYAELKMDFYPDALKGRDAAWYSKEDREYKYNGGSHLCRGWPKWLQLWMQANGVDETYDCMLAQRYGAQGKIGFHADNEEIFMRGAPVHTVSMDGNADFGTECAAGRQYTTLRGNVQFTMPSGFQETHKHAVRNTTAGRVSYTFRRLAKKDESRVIEEVVEVETKDMGFSSSLFGVQIIVDEPCDGVEETFNVQCVPGDGNCFWHSLGSFTGLTVECMKAGIKNFACGPEGAEKLSRQLEPNVWAEDEALCAACAHLGVDLVIFDEDQGFKMLYRYPGNKREALLRLKGSHFEPLEPKEMCVVKAIAQAVKRSPMDVLRVALKKMGEDFKEQICRGKGVMLDVFMVLAKIFDVSACVLQGTEQIMINPKGRIKGLFRMTTDHLSYDGVPDKVKHSEVNVYKHDVALQIEDLIELRELSSLVEYTPSFSRAKLLADCLHDGSTGVMCSELYNDKGHLCPEGRETTRVTIGVLLGTFGCGKSRLFKEILFKLCGKSVCYISPRKALCDSFDDEIRKARGNMGERGIKHYKSLTFEKAILQASKLHKGSLVIIDEIQLYPPGYLDLLLLLAGPTMKYFALGDPCQSDYDSEKDRTILGSVRSDVFELLDGIEYKFNILSRRFQSSLFRGRLPCLMYEEDLEAGAPLRLIDGLESIDTSAAYSRCCLVSSFEEKKIVNAYFGERTKCLTFGESTGMTFDVGCVLITSISAHTSEQRWITALSRFRKDIVFVNAASVAWDTLQSVYANRWLGRFLNRSARQEDLRRMLPGTPLFVEGFQKNLLGADEGKRECKLEGDPWLKTMVDLLQVEDMEDIEIAKEVLQDEWCKTHLPQCELESVRARWVHKILAKEFREKRMGCLVSEQFTDQHSKQMGKHLTNSAERFETIYPRHRAADTVTFIMAVRKRLSFSCPIKESAKLNQALPYGPFLLKEFLKRVPLKPMHDRKMMEQAKFDFEEKKTSKSAATIENHSNRSCRDWLIDVGLVFSKSQLCTKFDNRFRDAKRAQTIVCFQHAVLCRFAPYMRYIEKKLNEVLPSKYYIHSGKGLEELNRWVIEGRFEGVCTESDYEAFDASQDHYIVAFEICLMRYLGLPNDLIEDYKFIKTHLGSKLGNFAIMRFSGEASTFLFNTMANMLFTFLQYDLKGNERICFAGDDMCANGRLHVSSKHKNFMSKLKLKAKVSNTMNPTFCGWNLSSDGIFKKPQLVLERLCIAKETNNLANCIDNYAIEVSFAYLMGERAKQRMDEEEVEAFYNCVRIIVKSKHLLKSDVATIYQTARVD

ORF1

RNA replication polyprotein

1962 amino acids

Protease: Thiol protease that cleaves the polyprotein.

227.379 kDa

MALMSNKTAIESILGNFEKKHVDAIYNAAAQTILSHSEFRNKHFAYSLNSYQKKIASKVGIELYPNGYLPHSHPLSKIFENHLLFDVLPGVVNTSRLVMCSIKESKVLVFKGIRDKSRRQVSDLNALNSLNNSHTSFINRLVASKDVSRYTEEADAFFQSKKGSPELFSRNFIKSLENKEAVFFHDEVHHWTKAQMFSFLKSTKVKRFIFTVVYPPEILKKFANSQNPKVYDFKVDKGRLFFFPDGVKTEAYEQKLNMEWLFSASHLRSGDCVWTVTRHKSIYAHHLFEISIGELVTDSKLFFSDYNSIDMSKIFLDRFRSYEVFPISIEHLYKVYSYLLCLKKPDLESGLAKLRQIIGDDVEIKEFLFFEQFCKRLIERQTSWGLFGHSFFEKLTDMALSSLPNSIARIFPQWKKKNTFEFLFSLGTLVVDVERKVCFEHVLEEWGFEVVITDENAYLDPLSIFAINENFNEDRVDDGYLERIRLPFWNLNDYDLKRKRVNAYNILSYRFEEERKIESAQKGPNKMLQIEWYGIKEFKVDPFISNSITEFTLLEALLGKRIDPKKYSYSKQACTLSNYLTFLCAEGLDGFNLEEHLERRLKAAGHDVSDDEEEELTSAEQAGPIKILADPLGFMKECLEEIPIETEPSLEERGQFSTDYHSEKFEINYNDIFNPHNCMNTHGDEIPTPSDGNCFFSAFTETFEVERPDTLRSDFSDWLMEFNGGSYASLAEMIRPNGVFMEAELIYLFCVFRGVTLIIHDRTHEKENVYAVHRGFEEGHMVHRGNHFVGIETYNISTLTSDPLLGDIPCGFSEEITKFHFRPDHFNCAQFRGRKAAFITKVDADYGHNGMVYPHNSWVPSLEEIIQICGQGDDFNCALINFYEANSSLGFHRDNERVYNDDPILTVCTFGEGRFTIEFKDQVTSFLMTAGSFFLMPKGFQKKARHSVSNEMSRVSITFRKHVRRLNGSPIAIREENYKNTCLINAFSKAMKRSKQAIIAKLKTVNSPFWSRYLSEGNGGSIEDCQSACEALDVTVDLNVNGKCVVLGKGALRISMALRNNHFSVINAAQLMERTFVSHLLEKGNVNVLEGFDAMLSGDVGAAGVNKIQFAANFEFARILANSFLNMTTGICLGKALDNGEKYFLHILKDRVKQIGIDVTMVCGFAGSGKSRKLQSWLHSRKKGNFCVVSPRTNLAADWAFKLELEPNEQRKVSTFEKFIKTDKSKLDLIVIDELTLFPNGYLDLLVYELADVNRHCQIILLFDPLQARYHNKMDESILTFEHDVDRLIGGQNIEYIYSTHRMSRYFNRFFDVPCFNQADRTEEQRLWIFDDVYSIPSICSDRQEPCDVLLVESDLEKKAFSPIINVMTFGESQGLTFNHVCILLSESSAASNEFRWMVALTRARTRFSLCSTFLGGIEEFKVKRKESLITSILQGEKITFNRLNLMLKCNLIRREKENGCRDEVDREERLEGDPFLKPFIFLGQRVEKDEDEVEEVKIREPTCQTHLYITEPNFGLCYNFDFIREKEQREYREDMLVTNQFCDSYDKVHINGKRETPGPLRFKAIYPKHSADDDMTFWMAVRKRLVFREEEENYQRLSRAHLVGGLLYTNFKKKMGLEFTFDQGLLEESINAFEKKKLEKSCGTIKSHSIRSDIDWALNDVFLFMKSQLCTKYEKQFVDAKAGQTLACFQHLILVQFAPWCRYLETQIRNQLPEEIYIHSNKNFDDLNAWVKKFFQRDICVESDYEAFDASQDEYILSFEIHLMKDAHFPQKIIDAYIDLKCKLGCKLGHFSIMRFTGEFCTFLFNTLANMAFTMCRYEWRRGQPIAFAGDDMCALNNLAVCHDFDDLFELISLKAKVERTETPMFCGWRLTPYGIVKEPELVYNRFQVAIEEGKVLECLENYAIEVSYAYSLSERLYEVLKSERQVQYHQAVVRFIVTHIDKLKTKVRDLFLEQSSDEDI

ORF1

Genome polyprotein

1929 amino acids

Protease-polymerase processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).

214.806 kDa

MASAIALSSSTAQNKITLKSVASRLQQTDDPDIRVWSQSVGFHLQFSNWKCANAFCRFVTDAYNLTPYKECARSITRQLTSLSNYLSAQTGVSVSGTQFLLSPSDVEVPVAKTGESVSDIMVPSYSVNGTSMEFDSMAQLAQALTTGFTFSVNDAQIGNAPAQTGESVSGTGFIAEACPSCALYDKCPNCTSELINDDGSSQSPGDIPHWTHHKIASGIVNILSSDMSSMEDDDFANIAAHVKKALGTNSHPANNDMSKDQLNWLLNIAEASLIRKADRTALPMNAARIAARRGWREKLFNEPADKLYTLLRKSKDSFQKSAIWGILFEKASNAKHYTEIVFQDIVKLIKEECNPSNNFYFKVMAQSFLDHFRMLVIDNPDPVANLPKFILKLKPLNLKMIIENHENTAEGWIVTLTAVAELYGWLEFAVDLVPKIVSELYDLLTSATQKCFSMVRELLTNLNILKAESFDFTNPFWYALAALLSYFVTGFLPNNAKCSAIKQTLNGATTLVAGITAIQKLAAMFSAWSNESVVDDLSTKVIGLTEADNPTVTQDIDAVTNLQIMAEQLKDQIKLKTLDPTFQPYLPVLRNLMSTTDSVISHCAKRKALATQRTAPVCIILTGPAGCGKTTLAYAIANRLSAQKPSVLNLNIDHHDAYTGNEVCIIDEFDSNPDSKFVEFVVEMVNTNPMLLNCDLIENKGKTFSSKYVIMTSNNETPVKPNSTRAPPFYRRVRIIDVTNPGVMSFKYENPGQEVPSYLFSNDFNHLSMSMRGFGAFSKTRVIDPEGRKTCGLEGPPGQRVDVDDIVRYMQRMYRENQMNFKSEAGNNRLKTPRFAFVTQRKHVDTVYKILAAAKTTYNGYYSLTKDSFDVNEGHNIGSSVFVVGDDKEIPHNCKIFRCNHLAMFRHPELAHIEGDNFRAALGVTMSDQDVTLMFYHIRGKHIQDEVRLDELPANHHIVTVHSVYDMAWALNRHLSLTGKWQALKAVYDLYMTPDILPAALRHWMDNTKFSSDHVVTQFIVPGGTIILETCNGARMWATSRRLIRAGGISNNNGPEGGFRFGSIAPRDIPWSEILREFLNLISLIWSRVKGATIVLTALLLYMKRYKPRSEAKGKTKGGRGAIRHGGKGIVLSDDEYDEWREFNMEKRMDMSVDEFLMLKHRAALGSDDTGAIQFRSWWTARQMRESTGLDHDDVTVIGKGGVRHEVHRTEIMKAPKQKKKSFAWGEDMYAEGDGKIVNHVNAIVPVTGLCGEHIGYAVHIGHGKCISLKHVLKTGSYVFNQKPIDVTFDGELAHFQIQQPPSSAAPVTFSSKPTRDPWGRSVSTEWKHDTYNTTAGKMYGSICWTATRTQPGDCGLPYVDRAGQVVGLHAGSGGDSAPGRKIVIPVTKFKLPSNTVLSNRFWKEEAPTISYKGLTVQETGVNKAVLKGTNYHVSPAHVDDYQDCTHQPANLGAQDERYPVSLTSIVINNLEPYKQPTQGPPTEVLNKAYNMLVQHYEPLIPKATTHLEMGDAFAALNVKTSCGPYITGRKKDHIDPETGKWDETLRNHINARWSLATQGVPIPHEYQLGLKDELRPKDKIAVGKRRLIWGCDVGVAVVAASAFKEVSSAIMAMSEFDFIQVGINMDGTAVETLYKRLYTPGTHRYCVDYSKWDSTQPPNVTRMSLELLRHFTDKSPVVDSAVATLSSPSIAVFGGVSFKTNGGLPSGMPLTSILNSLNHCLLVGSAIIQVLESKGVDVNWNIYDTIDLFTYGDDGVYIVPNFVHSVMPEVFSCLSSYGLKPTRTDKSSAPITEIPLSEPIEFLKRQFVRNQFGVRALLDRSSLIRQFYYIKGKNTMEWTKPPEQIDLTSRTAQLQVVMLYASQHGREFYKKCLDYYQLAMEYEGIKLDAPTYDEALAKYNANFNGVEDCDLLPAGYDEHRLDKIVFEN

ORF1

Replicase polyprotein

1906 amino acids

VPg is covalently linked to the 5'-end of genomic RNA.

219.43 kDa

MNFTKQPASLKYLSSMKLITSQDQDFFNFGEVSREFILEQAYVNGYDFHMLHQDMNCIGFVLSIFDEDARDEYEYKDLNCEYHENLFDAVVDSEFDKIWPHLVLKYITYYPCSLNWRGMPTIPIVYVSKHFWYELYRTGFLNKLYHCGSWTDILLLLSGDVETNPGPVETYKDLCRRKNIRKRKSRIREEIKMQQHIDKIIGQENEEYKIINVNMQGIFSFNEEKEIIKSTAWKFNSTLDKTNSIIDNLIPQLEETLAGFRKTYSKCESKIFGTISVVDVCVDLISALLQVSFAKPAMKIASLAVEVFRLIKKYVSNININIDKIKELLSYGKVALNNNNPIIHVTMQSNSPILEVLLQPNIIVSAIFIALSVVFHKKFTYKKLGIEAMIKRLGDLGRAAKGCSDLNVVLNQAITNHMLEHFGKNVLGLKQEDELKVLVEGYRNWCDEVRDLVGHKINSDGELDSKSIVENIMKDVYEIQRIENMYKKGLEISRNIAELKLPTKLTISFNTHMRYLTEVFKSVDTSGAFGNKPRTQPIVIWLFGESGRGKSGMTWPLAIDLNNSLLDNVDEMRNFSKNIYMRNVEQEFWDNYQGQNIVCXDDFGQMRDSSSNPNPEFMELIRTANIAPYPLHMAHLEDKRKTKFTSKVIIMTSNVFEQDVNSLTFPDAFRRRVDLCAEVKNKDEFTKMCWSKSAGKMVQRLDKGKVKKITGDIHSTVPYIVDLIDPESGEVYKTGLEYEEFLDMCLEKTSQCRDDSAKLNDFLMDYAEKRANRSREIDEVCARTMDEAFVDAYDDVIDVNMQIETVDEMELIEPNKLREMIEQCSNKIVYTYEGIAVKITSLAFKLATLNYEEQWEQIKEMKYYVKVSSGVNYLKRVLSQGMKVCEEWMKEMINYVKEHPWMTVSLILGTLIGILTVVGFWKWLCSGDKKKNPIKRHFINTGNVLILPDRELNTFWKNQESLDLRDMYINRVEEHIISLLKLQHKVVLVPKVTKYILTTVENHAKISDKIILITRNRYLNYQGKFVELICGEINQFFIDPETLDTNVEAFASADLKTFVQRKPIVIEGPEFVEAQTSGDQITLRKQTQKVIEAFASSDAITMARKTPKFVESDDVVEVSMQMWKDQVAQKLITNRVLTNLYKICLVKENGDMVPLLNGLFVRSNIMLAPGHLVGFLSDSDTIEIRNLFDVVFRVPWKDVKKVDVVNAFGESKEAVLLCFPKFVCQHTDLVKHFQDSESMSKFKRCEVTLPVLRYSDKMNRFLATLIECDKVEAYDRPYTLNDSSKGQYILRQGLEYTMPTTNGDCGAPLVINETQVIRKIAGIHVAGDARGKAYAESISQKDLIRAFSKIDVSMQIQLDLDQTLNFNQQQXIIPPNAEFGPEDLDFCDLPSLKMIPVGRLSEPLFEPGKTDIRPSLVYGKISEIKTKPAILRNVIVDGKIVNIKHKNLKKCAMDTPYVSKEMTEEAFQLVKSVWLKGMRNELKKVLTYEEAICGNDSSEFISAINRSSSPGFPWIRDRIKGTKGKQGWFGAEGEYILDEDVFEAVKTRIQNAKNGVRTPVMWVDTLKDERRPIEKVDQLKTRVFSNGPMDFSITFRMYYLGFIAHLMENRITNEVSIGTNVYSQDWNKTVRKLKTMGPKVIAGDFSTFDGSLNVCIMEKFADLANEFYDDGSENALIRHVLLMDVYNSTHICGDSVYMMTHSQPSGNPATTPLNCFINSMGLRMVFELCSKKYSALNGTKCYVMKDFSKHVSIVSYGDDNVINFSDEVSEWFNMETITEAFEKLGFTYTDELKGKNGEVPKWRTIEDVQYLKRKFRYDSKRKVWEAPLCMDTILEMPNWCRGSLDIQEGTKVNCENAIMELSMHEEYVFDKWSKVISKAYQKATGDCLDISTYNGYAQERFLNYYL

ORF1

RNA replication protein

1896 amino acids

RNA replication protein replicates the viral genomic RNA. The central part of this protein possibly functions as an ATP-binding helicase and/or methyltransferase (Probable).

212.378 kDa

MAVPLERAFASVTQSFHKDATQGPTTNEYLVARAETQRYAPYAVRKGPAALLAQVGINTIHDSPLSHSHPACYALNAFHFLKVIPRYLHGKAEVWGTKDNWFRKLQAQIDSQTTTLTHRNYAITARDHVRYPGTVVDHPGSCTAGTLFMHDALQYMTPLDVYTLFATSPEMHSLVATAVIPPESVDRLPAFWPELYQLAYYEDHLCYAPDGNFADAYNQPLAAHQWMTMKSLHGPDFTLSVDVPASRYSHHIFVISKRPGLPDTHRDFMCPDLVELPKDFFPGANKADKLLPRTLVNQMVEYAASVKRATIKDATSRTRAYVKDQKYAAVTPVQQMYLSWFGSGLSQMQFPDRPVTPLDNFATALWYRLLPSRLYRLPATIRNFQLKAFVDQLRTPQYLLHFKLDEYHLSSNDKYSDFYRNESRQASSKDMLSAFEAICFGGAPELEKKILGNNNPAPFATVPNPPSQTALGLATITAAIAFILPNRAARLTRLVARYAIRAVKEIVNPSFLTIPRFGLLSHSIASWLQTDGAVITYGLAPKIASWSAPIWYNAALLAPTDMRSCQVLVDIANDLRFDYRYGTMRLAVTLGLTLLNPFLRRLVLLPFKVLWHSYLPSIKNKLDSMVLMSISTLPDNISVPLLTLRGNLNRQRCPDNKDPTPIHESDDNSTADDKCLHCPIHCLKSKLSEPAASPDTVPEDNPLQEGDLTEEVYAAALAKKDTPPPYPTRNDCLLVALADGLLTKRILWFSCIKMFGNTACWVIHDTGKAFDWMHLKMLAEQLKLNVSIEVAAEHDHHWTGLAKRVGPIDGRKIALRWYPYHWELSDRGREDYGPPPPPPPPSTTEPPPPPNPPAASPYHSPTVEDEPLEEIPLANSNGEFSTFAFDDMAADDLNPAQPLSSLDLDEEPSAKQEPLEPAAIKTSEPEPLVPESEEVFFRPSPTPTPSDATPTPAARAPSSVSNENAQRPRHPLPPVPTGGASAPSNDKLNSAAKQYARLVAGKTRQMTVAQPRSKAYLRDLKRGNIGTIPTAEAEQLDAYIDSWAVNGFNRSVHVIYFCGLPGTGKSRRCMKMTERLLKENKYLAQTVRIVTPTDNLRNSVARQLKPPTESSYSVQTYETPIRQPSLGPVLIVDEYGKMPAGWLETVLFLNPRVQMVIFTADPTQGIFRTRIPDAYCCRIPSSTEAIASYAHEYRRVSDRPAPGVARALGLPTTSRRPGQIETSTELNVDWITVRPEGERAAWHNTWGGKVYTYATCQGETFHRAYQMVINGNTRFWDDRDLFAALTRGSGTLRLIYETQSSKPLPRSTSKLYNALLDFRTDPHKLPLAIEEHVNRYIPSHLRNVNQAVPRRNAASNPDALPSQRILPGGQSTTAEPXQSQASALPTGGEAIDVPALDRQDPQRFPQLKVLPHLCGYIGDYSEASYPEPEHPKTQMLDATFPTYLARNRGWNDPALTDAVTANYKAPEHRDIWVEAVGETTRQVHGSGDDRDVFLEHRGDDKATANITYAKRLRFSQRAANERSIAATKVAGSELFEAFTRAIPLPQETFNDSLLEECRTENDTVHLTSKPLATLINNAERSDPSWSLNMIKLFIKGQTVKKLEKMGSDATAGQSIASFRAEVLLAWGPYARYIDRRIRALLPPHVYIHSRRTNEDFEKFVAAHWDHTRESTDGDYTAYDASQDATFVNFETLLMRRLDFPLDIIEAYVEMKASITSHFGPLAIMRFSGEVWTYLFNTLGNIAFTYAKYEVPSVAQVYGGDDKSINSPITVRTGWSQLVGKFNLVEKPVVGYEPTFCGWRIVPGGIVKDPQLLFWRTRYARIRYDAALWAPGYYDELVLSLKTSDRLMDHMSPNDLAYLQALVRFYTKLSRRLPSLADRRRCNPLPADSPSVVLSRD

ORF1

Genome polyprotein

1881 amino acids

Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).

208.813 kDa

MAQTLSKISNKENASSGLRPKRFKPHQPIPTWMVRCEPLDHDSRRGRDPVRASPQAKRVRTPTPYPRHLKPAASAVVRSGNNPSHLKPASTDVVRSGPQPLCCEAKDGGVVRSCKTYNLKPAHESKAVAFSLPKTDGPTGNEPEFIAEACPSCALYDTCPNCTSKVINDDGSTDGTIPSWDQIETTPAFLSLLSNTDEEMSADELTNLAAHLRKAFETGSHPANVDYSKDQLQGLLEMAEAAVPPARRQTLPFYQQRLEARRTWREKIFNQPLEEINKILTTSKDRFQRCAAWKVILEKAVLAKEYGEEAYAYAQQALKNINSFDVNLVLKMAAATFIDHIRMMTVDNPDLVSYIPKLIVKLKPLTLKMIIDNHENTKEGWLVTLTSLAELYGMVEVAIDFVPTVVGKLFDLLMKTTSKMYSMFKSVVLATFTSESLDFTNPFWYAIAAILCFLITGAIPHNGKMKIHKNILSNATGIVAGIKAIQALAAMFSTWSNERLVNDLSSRTIALTELNNPTITADIDAVINLQRLAEVLRDEVKSHTLNPLMQPYNPILRNLMSALDKVISCCTRRKAIATKRTAPVAVILTGPPGCGKTTAAFALAKRLSQQKPSIISLDVDHHDTYTGNEVCIIDEFDSSDKVDYANFVVNMVNTNPMVLNCDLIENKGKTFTSKYVIMTSNTETPVKPTSRRAGAFYRRVMIVDVTNNAVDKWKSDNPGKAVPKWCFNKDFSHLSLSLRGTEPYSKEYVLDPTGRNHQSRRAPPPQQITLEQLAQKMVVQHTTNTSEFVTQAGDVPVFGFVCQNNEIDTVYNLLAAVKARYGANFNLYKGMVRTAHENSGCGAHVHVISREDNFRGKAFTVNRSRLESVPHLEGDSFRRSLGVVMSDKDVTTMFYYIKGKVINDQVSLTELPANQHVVTVHTVYDMAWALRRHLKWSGQWQLIKAAYEIMCYPDTAACALRNWMDSTDFSEEHVVTQFIAPGGTIILESCYGARMWATGQRLIRAGGLTEAGGPQGGVRFAGLGARNVPWSEILREFMTLISHIWSQIKGATVVLTALTFYLKRFRPRVEAKGKNKNKGPRKNTGVALTDDEYNDWKQSKAEKNLDLTVKDFLQLRHRAAMGADNTDAVKFRYWYSKKQKIYHDLENFPIIGRGGLKRELIRKGPLRPRGNDFYDEPDDWYSEGVIDGVTHKNAIVSVDDVDGMHKGYAIHIGHGVYISLKHVLTGNARILSEEPKGITISGELATFRLNNILPTAVPVGTNKPIKDPWGNPVSTDWQFKNYNTTSGNIYGACGSSCSLTRQGDCGLPYVDDHGVVVGLHAGSGGDKCPSRKLIVPYVKVDMRIRDTCTKESPTKTHKPTFSYRGLLGKETGEPRTIMKGTRLHVSPAHVDDYEECTHQPASLGAGDPRCPISLTGIMVNNLQPYTEASPGPDTATLNRVSKMLTSHMEGYVPKVHKTEEDSISAFYMLNHDTLCGPYIGARKKDHVKDGVLDKNLLDLLSSKWNRAKLGLALPHEYALGLKDELRPKDKVAVGKRRLIWGCDVGVSTVCAAAFKRVSESIMANHALGFIQVGINMDGPAVEDLFKRLERPKHDRYCVDYSKWDSTQPPKVTSQSIDILRHFTDKSPIVDSACATLKSNPIGIFNGVAFKVAGGLPSGMPLTSIINSLNHCLMVGSAVVKALEDSGVRVTWNIFDSMDLFTYGDDGVYIVPPLISSVMPKVFANLRQFGLKPTRTDKSDAEITPIPADEPVEFLKRTIVRTENGVRALLDRSSIIRQFYYIKAENTENWTVPPKRIDTPSRGQQLYNACLYASQHGEEFYTSKIVPLIERAVKLEGLHIEVPEFHQAVAAYNGYFNGTEGQPNQIAHASGGLGLSGEVFEN

ORF1

Genome polyprotein

1879 amino acids

Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).

209.295 kDa

MAQTLSKISNKENASVGLWPKRFKPHQPTPTWMVRCGPLDHDSRHGRDPVRASPQAKRVRTPNPYPRHLKPAASAVVRSGTNPSHLKPTSTDVVRSGPETPCCEAKDGGVVRSCKTCNLKPAHDSKAVSFFPAQTDGLTGDEPEFIAEACPSCVLYDTCPNCTSRAINDDGSTDGTIPSWDQIETTPAFLSLLSNTDEEMSADELTNLAAHLRKAFETGSHPPNVDYSKDQLQGLLEMAEAALPPARRQTLPFYQQRLEARRTWREKIFNLPLDELSKILTTSKDRFQRCAAWKVVLEKAVLAKEYGEEAYAYAQEALKNINSFDVNLVLKMAAGTFIGHLRMMTVDNPDMVSYLPKLIVKLKPLTLKMIIDNHENTKEGWLVTLTSLAELYGMVEVAIDFVPTVIGNLFDLLMKTTSKVYSMFKSVILATFTSESLDFTNPFWYAIAAILCFLITGAIPHNGKMKIIKNILSNATGIVAGVKAIQTLGAMFSTWSNERLVNDLSSRTIAITELNNPTITADIDAVINLQRLAETLREEVKSHTLNPLMQPYTPILRNLMSALDNVISCCTRRKAIATKRTAPVAVILTGPPGCGKTTAAFALAKRLSQQKPSIISLDVDHHDTYTGNEVCIIDEFDSSDKVDYANFVVNMVNTNPMVLNCDLVENKGKTFRSKYVIMKSNSETPVKPTSRRAGAFYRRVMIVDVKNTAVENWKRENPGKPVPKWCFNKDFSHLHLSMRGTEAYWREYVLDPTGRNHQSQKAPPDQHVTLEQLDQKMVVQHTTNTSEFVTQAGEVPVFGFVCQNNEIDTVYNLLAAVKARYGANFNLYKGMTRTAHENSGCGAHVHVISREDNFRGKAFTVNRSRLESVPHLEGDSFRRSLGVVMSDKDVTTMFYYIKGKVINDQVNLTELPANQHVVTVHTVYDMAWALRRHLKWTGQWQLIKAAYEIMCYPDTAACALRNWMDSTDFSEEHVVTQFIAPGGTIILESCYGARMWATGQRLIRAGGLTEAGGPQGGVRFAGLGARNVPWSEILREFMTLISHIWSQIKGATVVLTALTFYLKRFRPRVEAKGKNKNKGPRKNTGVALTDDEYDEWRQYKAEKKLDLTVEDFLQLRHRAAMGADDTDAVKFRCWYSERQRNYHDLEDVTIIGRGGVKRELIRKGPLRPRGNDFYDEPDDWYSEGVIDGVTHKNAIVSVDDVDGMHKGYALHIGHGVYMSLKHVVSGNAKILSEEPKNLTFNGELATFRLNTTLPTAAPVGTSKPIKDPWGNPVSTDWQFKNYNTTSGNIYGACGSSCSLTRQGDCGLPYVDDHGVVVGLHAGSGGDKCPSRKLIVPYVKVDMRIRDTCTKEYYKDNVPMISYKGLLVKETGEPRTIMKGTRLHVSPAHTDDYEECTHQPASLGAGDPRCPMSLTGIMVNNLQPYTEAPRTDTATLNRVTKMLISHMEGYVPKIHKTEEDMISAFYMLNHDTSCGPYIGGRKKDHVKDGVLDKNLLDLLSSKWNRAKCGLALPHEYALGLKDELRPKDKVAVGKRRLIWGCDVGVSTVCRAAFKRVSESIMANHALGFIQVGINMDGPAVEDPFKRLERPKHDRYCVDYSKWDSTQPPKVTSQSIDILRHFTDKSPIVDSACATLKSNPIGIFNGVAFKVAGGLPSGMPLTSIINSLNHCLMVGSAVVKALEDSGVQVTWNIFDSMDLFTYGDDGVYIVPPLISSVMPKVFSNLRQFGLKPTRTDKTDAEITPIPADEPVEFLKRTIVRTENGVRALLDKSSIIRQFYYIKAENTENWTVPPKKIDTSSRGQQLYNAGLYASQHGEEFYTNKIIPLVQRAIEFEGLHIEVPEFHQAVQAYNGYFNGTEDQPSQIALASGGTGFGGEVFEN

ORF1

Genome polyprotein

1789 amino acids

RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).

198.694 kDa

MMMASKDVVPTAASSENANNNSSIKSRLLARLKGSGGATSPPNSIKITNQDMALGLIGQVPAPKATSVDVPKQQRDRPPRTVAEVQQNLRWTERPQDQNVKTWDELDHTTKQQILDEHAEWFDAGGLGPSTLPTSHERYTHENDEGHQVKWSAREGVDLGISGLTTVSGPEWNMCPLPPVDQRSTTPATEPTIGDMIEFYEGHIYHYAIYIGQGKTVGVHSPQAAFSITRITIQPISAWWRVCYVPQPKQRLTYDQLKELENEPWPYAAVTNNCFEFCCQVMCLEDTWLQRKLISSGRFYHPTQDWSRDTPEFQQDSKLEMVRDAVLAAINGLVSRPFKDLLGKLKPLNVLNLLSNCDWTFMGVVEMVVLLLELFGIFWNPPDVSNFIASLLPDFHLQGPEDLARDLVPIVLGGIGLAIGFTRDKVSKMMKNAVDGLRAATQLGQYGLEIFSLLKKYFFGGDQTEKTLKDIESAVIDMEVLSSTSVTQLVRDKQSARAYMAILDNEEEKARKLSVRNADPHVVSSTNALISRISMARAALAKAQAEMTSRMRPVVIMMCGPPGIGKTKAAEHLAKRLANEIRPGGKVGLVPREAVDHWDGYHGEEVMLWDDYGMTKIQEDCNKLQAIADSAPLTLNCDRIENKGMQFVSDAIVITTNAPGPAPVDFVNLGPVCRRVDFLVYCTAPEVEHTRKVSPGDTTALKDCFKPDFSHLKMELAPQGGFDNQGNTPFGKGVMKPTTINRLLIQAVALTMERQDEFQLQGPTYDFDTDRVAAFTRMARANGLGLISMASLGKKLRSVTTIEGLKNALSGYKISKCSIQWQSRVYIIESDGASVQIKEDKQALTPLQQTINTASLAITRLKAARAVAYASCFQSAITTILQMAGSALVINRAVKRMFGTRTAAMALEGPGKEHNCRVHKAKEAGKGPIGHDDMVERFGLCETEEEESEDQIQMVPSDAVPEGKNKGKTKKGRGRKNNYNAFSRRGLSDEEYEEYKKIREEKNGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGETEMEIRHRVFYKSKSKKHQQEQRRQLGLVTGSDIRKRKPIDWTPPKNEWADDDREVDYNEKINFEAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIAIHQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAVRMGAIASMRIQGRLVHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDWVVCGVHAAATKSGNTVVCAVQAGEGETALEGGDKGHYAGHEIVRYGSGPALSTKTKFWRSSPEPLPPGVYEPAYLGGKDPRVQNGPSLQQVLRDQLKPFADPRGRMPEPGLLEAAVETVTSMLEQTMDTPSPWSYADACQSLDKTTSSGYPHHKRKNDDWNGTTFVGELGEQAAHANNMYENAKHMKPIYTAALKDELVKPEKIYQKVKKRLLWGADLGTVVRAARAFGPFCDAIKSHVIKLPIKVGMNTIEDGPLIYAEHAKYKNHFDADYTAWDSTQNRQIMTESFSIMSRLTASPELAEVVAQDLLAPSEMDVGDYVIRVKEGLPSGFPCTSQVNSINHWIITLCALSEATGLSPDVVQSMSYFSFYGDDEIVSTDIDFDPARLTQILKEYGLKPTRPDKTEGPIQVRKNVDGLVFLRRTISRDAAGFQGRLDRASIERQIFWTRGPNHSDPSETLVPHTQRKIQLISLLGEASLHGEKFYRKISSKVIHEIKTGGLEMYVPGWQAMFRWMRFHDLGLWTGDRDLLPEFVNDDGV

ORF1

Genome polyprotein

1788 amino acids

RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).

198.582 kDa

MMMASKDVVATNVASNNNANNTSATSRFLSRFKGLGGGASPPSPIKIKSTEMALGLIGRTTPEPTGTAGPPPKQQRDRPPRTQEEVQYGMGWSDRPIDQNVKSWEELDTTVKEEILDNHKEWFDAGGLGPCTMPPTYERVKDDSPPGEQVKWSARDGVNIGVERLTTVSGPEWNLCPLPPIDLRNMEPASEPTIGDMIEFYEGHIYHYSIYIGQGKTVGVHSPQAAFSVARVTIQPIAAWWRVCYIPQPKHRLSYDQLKELENEPWPYAAITNNCFEFCCQVMNLEDTWLQRRLVTSGRFHHPTQSWSQQTPEFQQDSKLELVRDAILAAVNGLVSQPFKNFLGKLKPLNVLNILSNCDWTFMGVVEMVILLLELFGVFWNPPDVSNFIASLLPDFHLQGPEDLARDLVPVILGGIGLAIGFTRDKVTKVMKSAVDGLRAATQLGQYGLEIFSLLKKYFFGGDQTERTLKGIEAAVIDMEVLSSTSVTQLVRDKQAAKAYMNILDNEEEKARKLSAKNADPHVISSTNALISRISMARSALAKAQAEMTSRMRPVVIMMCGPPGIGKTKAAEHLAKRLANEIRPGGKVGLVPREAVDHWDGYHGEEVMLWDDYGMTKILDDCNKLQAIADSAPLTLNCDRIENKGMQFVSDAIVITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPEVEQIRRVSPGDTSALKDCFKLDFSHLKMELAPQGGFDNQGNTPFGKGTMKPTTINRLLIQAVALTMERQDEFQLQGKMYDFDDDRVSAFTTMARDNGLGILSMAGLGKKLRGVTTMEGLKNALKGYKISACTIKWQAKVYSLESDGNSVNIKEERNILTQQQQSVCTASVALTRLRAARAVAYASCIQSAITSILQIAGSALVVNRAVKRMFGTRTATLSLEGPPREHKCRVHMAKAAGKGPIGHDDVVEKYGLCETEEDEEVAHTEIPSATMEGKNKGKNKKGRGRRNNYNAFSRRGLNDEEYEEYKKIREEKGGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGETEMEIRHRVFYKSKSRKHHQEERRQLGLVTGSDIRKRKPIDWTPPKSAWADDEREVDYNEKISFEAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVIPTSAKEFFGEPLTSIAIHRAGEFTLFRFSKKIRPDLTGMILEEGCPEGTVCSVLIKRDSGELLPLAVRMGAIASMRIQGRLVHGQSGMLLTGANAKGMDLGTIPGDCGAPYVYKRANDWVVCGVHAAATKSGNTVVCAVQASEGETTLEGGDKGHYAGHEIIKHGCGPALSTKTKFWKSSPEPLPPGVYEPAYLGGRDPRVTVGPSLQQVLRDQLKPFAEPRGRMPEPGLLEAAVETVTSSLEQVMDTPVPWSYSDACQSLDKTTSSGFPYHRRKNDDWNGTTFVRELGEQAAHANNMYEQAKSMKPMYTGALKDELVKPEKVYQKVKKRLLWGADLGTVVRAARAFGPFCDAIKSHTIKLPIKVGMNSIEDGPLIYAEHSKYKYHFDADYTAWDSTQNRQIMTESFSIMCRLTASPELASVVAQDLLAPSEMDVGDYVIRVKEGLPSGFPCTSQVNSINHWLITLCALSEVTGLSPDVIQSMSYFSFYGDDEIVSTDIEFDPAKLTQVLREYGLRPTRPDKSEGPIIVRKSVDGLVFLRRTISRDAAGFQGRLDRASIERQIYWTRGPNHSDPFETLVPHQQRKVQLISLLGEASLHGEKFYRKISSKVIQEIKTGGLEMYVPGWQAMFRWMRFHDLGLWTGDRNLLPEFVNDDGV

ORF1

Replicase polyprotein

1771 amino acids

RNA-directed RNA polymerase replicates genomic and antigenomic RNA.

203.83 kDa

MSFQQTNNNATNNINSLEELAAQELIAAQFEGNLDGFFCTFYVQSKPQLLDLESECYCMDDFDCGCDRIKREEELRKLIFLTSDVYGYNFEEWKGLVWKFVQNYCPEHRYGSTFGNGLLIVSPRFFMDHLDWFQQWKLVSSNDECRAFLRKRTQLLMSGDVESNPGPVQSRPVYACDNDPRAIRLEKALQRRDEKISTLIKKLRQEIKNNRIYTQGFFDDLKGAKGEVGQLNGNLTRICDFLENSLPTLTAQIQTTVLTTTDKYVNLKEDLLKVAILLVLVRLLMVWKKYRAALIVIILFVMHFYGFDKQILDIVLDLKDKILQTTTQAGTETLEEVVYHPWFDTCGKLIFAVLAFFAIKKIPGKQDWDNYISRLDRIPKAIEGSKKIVDYCSEYFNLSVDEVKKVVLGKELKGTQGLYDEIHVWAKEIRHYLDLDERNKITLDTETAAKVEDLYKRGLKYSEEKIPDRDIARFITTMLFPAKSLYEQVLLSPVKGGGPKMRPITVWLTGESGIGKTQMIYPLCIDILREMGIVKPDAYKHQAYARQVETEYWDGYNGQKIVIYDDAFQLKDDKTKPNPEIFEVIRTCNTFPQHLHMAALQDKNMYSQAEVLLYTTNQFQVQLESITFPDAFYNRMKTHAYRVQIKQEKSIWVRNARGEEYNALDVTKLNKDEAIDLSVYEFQKMRFDDESATKWIDDGEPISYDEFARTICKAWKEEKEKTFHQLQWLEAYASRTVAQGGSETSEYYDVWDETYFSNLLSQGFMAGKSLIEMEAEFASDAETFNAYIEYKKNIPKETKWSKWMTILDEQISALSTKIRELKNKAYKFISEHPYLTALGFIGVMISAFAMYSFFERTLTDDTITSEVGSSGDNKTQKISKRVVEVGGSGDVKTTKPAKTAVEVGSSGDSKTMKNKITKVEVGSSGDSKTQKQRNTKVEVGKELEKEAETQGCSDPAAHALVLDVLQKNTYCLYYERMVKGEMKRYRLATATFLRGWVCMMPYHFIETLYARKVAPSTNIYFSQPNCDDVIVVPVSHFIAPNAERVELTTACTRIHYKDETPRDCVLVNLHRRMCHPHRDILKHFVKKSDQGNLRGVFQGTLATFHQSANELCRAYQWLQAIRPLDQEITIYHEDTDMFDYESESYTQRDCYEYNAPTQTGNCGSIVGLYNKRMERKLIGMHIPGNVSECHGYACPLTQEAIMDGLNRLEKLDPVNNITVQCCFEPPSDIKDTMSGETPEGKFCAIGKSNIKVGQAVKTTLLKSCIYGMLSKPITKPAHLTRTRLPNGEIVDPLMKGLKKCGVDTAVLDAEIVESAALDVKQVVLTQYNSMLDVNKYRRFLTYEEATQGTGDDDFMKGIARQTSPGYRYFQMPRKLPGKQDWMGSGEQYDFTSQRAQELRRDVEELIDNCAKGIIKDVVFVDTLKDERRPIEKVDAGKTRVFSAGPQHFVVAFRKYFLPFAAYLMNNRIDNEIAVGTNVYSTDWERIAKRLKKHGNKVIAGDFGNFDGSLVAQFFGQSCGKSFYPWFKTFNDVNTEDGKRNLMICIGLWTHIVHSVHSYGDNVYMWTHSQPSGNPFTVIINCLYNSMIMRIVWILLARKLAPEMQSMKKFRENVSMISYGDDNCLNISDRVVEWFNQITISEQMKEIKHEYTDEGKTGDMVKFPSLSEIHFLKKRFVFSHQLQRTVAPLQKDVIYEMLNWTRNTIDPNEILMMNINTAFREIVYHGKSEYQKLRSGIEDLAMKGILPQQPQILTFKAYLWDATMLADEVYDF

ORF1

Genome polyprotein

1763 amino acids

Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1, eIF4G2 and PABP1 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).

194.988 kDa

MSQTLSFVLKTHSVRKDFVHSVKVTLARRRDLQYLYNKLARTMRAEACPSCSSYDVCPNCTSSDIPDNGSSTTSIPSWEDVTKTSTYSLLLSEDTSDELCPDDLVNVAAHIRKALSTQAHPANTEMCKEQLTSLLVMAEAMLPQRSRASIPLHQQHQAARLEWREKFFSKPLDFLLERIGVSKDILQITAIWKIILEKACYCKSYGEQWFCAAKQKLREMRTFESDTLKPLVGAFIDGLRFMTVDNPNPMGFLPKLIGLVKPLNLAMIIDNHENTLSGWVVTLTAIMELYNITECTIDVITSLVTGFYDKISKATKFFSQVKALFTGFRSEDVANSFWYMAAAILCYLITGLIPNNGRFSKIKACLSGATTLVSGIIATQKLAAMFATWNSESIVNELSARTVAISELNNPTTTSDTDSVERLLELAKILHEEIKVHTLNPIMQSYNPILRNLMSTLDGVITSCNKRKAIARKRQVPVCYILTGPPGCGKTTAAQALAKKLSDQEPSVINLDVDHHDTYTGNEVCIIDEFDSSDKVDYANFVIGMVNSAPMVLNCDMLENKGKLFTSKYIIMTSNSETPVKPSSKRAGAFYRRVTIIDVTNPLVESHKRARPGTSVPRSCYKKNFSHLSLAKRGAECWCKEYVLDPKGLQHQTIKAPPPTFLNIDSLAQTMKQDFVLKNMAFEAEDGCSEHRYGFICQQSEVETVRRLLNAIRARLNATFTVCVGPEASHSIGCTAHVLTPDEPFNGRRFIVSRCNEASLAALEGNCVQSALGVCMSNKDLTHLCHFIRGKIVNDSVRLDELPANQHVVTVNSVFDLAWALRRHLTLTGQFQAIRAAYDVLTVPDKVPAMLRHWMDETSFSDEHVVTQFVTPGGVVILESCGGARIWALGHNVIRAGGVTATPTGGCVRLVGLSAQTLPWSEIFRELFTLLGRIWSSIKVSTLVLTALGMYASRFRPKSEAKGKTKSKIGPYRGRGVALTDDEYDEWREHNANRKLDLSVEDFLMLRHRAALGADDADAVKFRSWWNSRTRPGDGFEDVTVIGKGGVKHEKIRTSTLRAVDRGYDVSFAEESGPGTKFHKNAIGSVTDVCGEHKGYCVHMGHGVYASVAHVVKGDSYFLGERIFDVKTNGEFCCFRSTKILPSAAPFFSGKPTRDPWGSPVATEWKPKAYTTTSGKIVGCFATTSTETHPGDCGLPYIDDNGRVTGLHTGSGGPKTPSAKLVVPYIHIDMKNKSVTPQKYDETKPNISYKGLVCKQLDEIRIIPKGTRLHVSPAHVDDFEECSHQPASLGSGDPRCPKSLTAIVVDSLKPYCDRVEGPPHDVLHRVQKMLIDHLSGFVPMNISSETSMLSAFHKLNHDTSCGPYLGGRKKDHMVNGEPDKQLLDLLSSKWKLATQGIALPHEYTIGLKDELRPIEKVQEGKRRMIWGCDVGVATVCAAAFKGVSDAITANHQYGPIQVGINMDSPSVEVLYQRIKSAAKVFAVDYSKWDSTQSPRVSAASIDILRYFSDRSPIVDSAANTLKSPPIAIFNGVAVKVASGLPSGMPLTSVINSLNHCMYVGCAILQSLEARQIPVTWNLFSSFDMMTYGDDGVYMFPTMFASVSDQIFGNLSAYGLKPTRVDKSVGAIESIDPESVVFLKRTITRTPNGIRGLLDRSSIIRQFFYIKGENSDDWKTPPKTIDPTSRGQQLWNACLYASQHGVEFYNKVLKLAMRAVEYEGLHLKPPSYSSALEHYNSQFNGVEARSDQINMSDVTALHCDVFEV

ORF1

Genome polyprotein

1763 amino acids

Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1, eIF4G2 and PABP1 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).

195.029 kDa

MSQTLSFVLKTHSVRKDFVHSVKLTLARRRDLQYIYNKLSRTIRAEACPSCASYDVCPNCTSGDVPDDGSSTMSIPSWEDVTKSSTYSLLLSEDTSDELCPEDLVNVAAHIRKALSTQSHPANAEMCKEQLTFLLVMAEAMLPQRSRASIPLHQQHTAARLEWREKFFSKPLDFLLERVGVSKDILQTTAIWKIILEKACYCKSYGEQWFTAAKQKLREMKNFESDTLKPLIGGFIDGLRFLTVDNPNPMGFLPKLIGLVKPLNLAMIIDNHENTISGWIITLTAIMELYNITECTIDIITSVITAFYDKIGKATKFYSCVKALFTGFRSEDVANSFWYMAAAILCYLITGLIPNNGRFSKIKACLAGATTLVSGIVATQKLAAMFATWNSESIVNELSARTVALSELNNPTTTSDTDSVERLLELAKILHEEIKIHTLNPIMQSYNPILRNLMSTLDGVITSCNKRKAIARKRQVPVCYILTGPPGCGKTTAAQALAKKLSDQEPSVINLDVDHHDTYTGNEVCIIDEFDSSDKVDYANFVIGMVNSAPMVLNCDMLENKGKLFTSKYIIMTSNSETPVKPSSKRAGAFYRRVTIIDVTNPFVESHKRARPGTSVPRSCYKKNFSHLSLAKRGAECWCKEYVLDPKGLQHQSMKAPPPTFLNIDSLAQTMKQDFLLKNMAFEAEDGCAEHRYGFVCQQEEVETVRRLLNAVRARMNATFTVCVGPETSHSIGCTAHVLTPNETFNGKKFVVSRCNEASLSALEGNCVKSALGVCMSDKDLTHLCHFIKGKIVNDSVRLDELPANQHVVTVNSVFDLAWAVRRHLTLAGQFQAIRAAYDVLTVPDKIPAMLRHWMDETSFSDDHVVTQFVTPGGIVILESCGGARIWALGRNVIRAGGVTATPTGGCVRLMGLSAPTMPWSEIFRELFSLLGRIWSSVKVSALVLTALGMYASRFRPKSEAKGKTKLKIGTYRGRGVALTDDEYDEWREHNASRKLDLSVEDFLMLRHRAALGADDNDAVKFRSWWNSRTKMANDYEDVTVIGKGGVKHEKIRTNTLKAVDRGYDVSFAEESGPGTKFHKNAIGSVTDVCGEHKGYCIHMGHGVYASVAHVVKGDSFFLGERIFDLKTNGEFCCFRSTKILPSAAPFFSGKPTRDPWGSPVATEWKPKMYTTTSGKILGCFATTSTETHPGDCGLPYIDDNGRVTGLHTGSGGPKTPSAKLVVPYVHIDMKTKSVTAQKYDVTKPDISYKGLICKQLDEIRIIPKGTRLHVSPAHTEDYQECSHQPASLGSGDPRCPKSLTAIVVDSLKPYCENVEGPPHDVLHRVQKMLIDHLSGFVPMNISSETSMLSAFHKLNHDTSCGPYLGGRKKDHMANGEPDKQLLDLLSAKWKLATQGIALPHEYTIGLKDELRPVEKVSEGKRRMIWGCDVGVATVCAAAFKGVSDAITANHQYGPIQVGINMDSPSVEALFQRIKSAAKVFAVDYSKWDSTQSPRVSAASIDILRYFSDRSPIVDSASNTLKSPPVAIFNGVAVKVSSGLPSGMPLTSVINSLNHCLYVGCAILQSLEAKAIPVTWNLFSTFDIMTYGDDGVYMFPIMYASISDQIFGNLSSYGLKPTRVDKSVGAIEPIDPDSVVFLKRTITRTPQGIRGLLDRSSIIRQFYYIKGENSDDWKSPPKHIDPTSRGQQLWNACLYASQHGLEFFNKVYRLAERAVEYEELHFEPPTYASALDHYNSQFNGVEARSDQIDSSGMTALHCDVFEV

ORF1

Genome polyprotein

1763 amino acids

Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1, eIF4G2 and PABP1 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs.

194.911 kDa

MSQTLSFVLKTHSVRKDFVHSVKRTLQRRRDLQYLYNKLSRPIRAEACPSCASYDVCPNCTSGSIPDDGSSKGQIPSWEDVTKTSTYSLLLSEDTSDELHPDDLVNVAAHIRKALSTQSHPANVDMCKEQLTSLLVMAEAMLPQRSRSTLPLHQKYVAARLEWREKFFSKPLDFLLEKIGTSRDILQITAVWKIIIEKACYCKSYGEHWFEAAKQKLREIKSYEHNTLKPLIGAFIDGLRLMTIDNPNPMGFLPKLIGLIKPLNLAMIIDNHENTLSGWVITLTAIMELYNITECTIDVITSIITGFYDKIGKATKFYSQIKALFTGFRSEDVANSFWYMAAAILCYLITGLIPNNGRLSKIKACLAGATTLVSGIVATQKLAAMFATWNSESIVNELSARTVAISELNNPTTTSDTDSVERLLELAKILHEEIKIHTLNPIMQSYNPILRNLMSTLDGVITSCNKRKAIAKKRPVPVCYILTGPPGCGKTTAALALAKKLSDQEPSVINLDVDHHDTYTGNEVCIVDEFDSSDKVDYANFVIGMVNSAPMVLNCDMLENKGKLFTSKYIIMTSNSETPVKPSSRRAGAFYRRVTIIDVANPLAESHKRARPGTSVPRSCYKKNFSHLSLAKRGAECWCKEYVLDPKGLQHQSIKAPPPTFLNIDSLAQTMKQDFTLKNMAFEAENGHSEHRYGFVCQQGEVETVRRLLNAVRTRLNATFTVCVGSEASSSIGCTAHVLTPDEPFNGKKYVVSRCNEASLSALEGNCVQSALGVCMSTKDLTHLCHFIRGKIVNDSVRLDELPANQHVVTVNSVFDLAWALRRHLTLAGQFQAIRAAYDVLTAPDKVPAMLRHWMDETSFSDEHVVTQFVTPGGIVILESCGGARIWALGHNVIRAGGVTATPTGGCIRFMGLSAQTMPWSEIFRELFSLLGRIWSSIKVSTLVLTALGMYASRFRPKSEAKGKTKSKVGPYRGRGVALTDDEYDEWREHNATRKLDLSVEDFLMLRHRAALGADDADAVKFRSWWNSRSRLADDYEDVTVIGKGGVKHEKIRTNTLRAVDRGYDVSFAEESGPGTKFHKNAIGSVTDVCGEHKGYCVHMGHGVYATVAHVAKGDSFFLGERIFDLKTNGEFCCFRSTKILPSAAPFFPGKPTRDPWGSPVATEWKPKPYTTTSGKIVGCFATTSTETHPGDCGLPYIDDNGRVTGLHTGSGGPKTPSAKLVVPYVHIDMKTKSVTAQKYDVTKPDISYKGLICKQLDEIRIIPKGTRLHVSPAHTEDFEECSHQPASLGSGDPRCPKSLTAIVVDSLKPYCDKVEGPPHDILHRVQKMLIDHLSGFVPVNISSETSMLSAFHKLNHDTSCGPYLGGRKKDHMTNGEPDKPLLDLLSAKWKLATQGIALPHEYTIGLKDELRPVEKVAEGKRRMIWGCDVGVATVCAAAFKGVSDAITANHQYGPVQVGINMDSPSVEALHQRIKSAAKVYAVDYSKWDSTQSPRVSAASIDILRYFSDRSPIVDSAANTLKSPPIAIFNGVAVKVSSGLPSGMPLTSVINSLNHCLYVGCAILQSLEARGVPVTWNLFSTFDMMTYGDDGVYMFPMMFASVSDQIFANLSAYGLKPTRVDKSVGSIEPIDPESVVFLKRTITRTPQGIRGLLDRSSIIRQFYYIKGENSDDWKTPPKSIDPTSRGQQLWNACLYASQHGVEFYNKIYKLAQKAVEYEELHLEPPTYHSALEHYNNQFNGVEARSDQIDSSGMTALHCDVFEV

ORF1

Genome polyprotein

1762 amino acids

Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1, eIF4G2 and PABP1 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).

195.339 kDa

MSQTLSFVLKTHNVRKDFVRSVKLTLARRRDLQYFYNKLSRSMRAEACPSCASYDVCPNCTSSDIPDDGSSTELIPSWEEVTKTSTYSLLLSEDTSDELCPDDLANVAAHIRKAISTQSHPANSDMCKEQLTSLLVMAEAMLPQRSRASIPLHQQHQAARLEWREKFFSKPLDFLLERIGVSKDILQITAIWKIILEKACYCKSYGEQWFTTAKQKLREMRSYESNTLKPLIGAFIDGLRFMTVDNPYPMGFLPKLIGLIKPLNLAMIIDNHENTLSGWVITLTAIMELYNITECTIDLMTSLITAFYDKIGKATKFYSHVKALFTGFRTEDVSNSFWYMAAAILCYLVTGLIPNNGRFLKIKCLLVRATTLVSGIIATQKLAAMFATWNSESIVNELSARTVAISELNNPTTTSDTESVERLLELAKILHEEIKVHTLNPIMQSYNLILRNLMSTLDGVITCCNKRKAIARKRQVPVCYILTGPPGCGKTTAAQALAKKLSDQEPSVINLDVDHHDTYTGNEVCIIDEFDSSDKVDYANFVIGMVNSAPMVLNCDMLENKGKLFTSKYIIMTSNSETPVKPSSKRAGAFYRRVTYHDVATLVESHKRARPGTAVPRSCYKKNFSHLSLAKRGAECWCKEYVLDPKGLQHQSTKAPPPTFLNIDSLAQTMKQDFALKNMAFEAEVGCSEHRYGFVCQQSEVETVRRLLNAIRMRLNATFTVCVGLEASNSVGCTAHVLTPDEPFNGKRFVVSRCNEASLSALEGNCVQTALGVCMSNKDLTHLCHFIKGKIVNDSVRLDELPANQHVVTVNSVFDLAWALRRHSTLTGQFQAIRAAYDVLHVPDKVPAMLRHWMDETSFSDEHVVTQFITPGGVVILESCGGARIWALGNNVIRAGGVTAIPTGGCVRLMGLSAQTMPWSEILSELFSLLGKIWSSVKVSTLILTALSMYASRFRPKTEAKGKTKSKIGPYRGRGVALTDDEYDEWKEHNAARKLDLSVEDFLMLRHRAALGADDTDAVKFRSWWNSRSRLADDFEDVTVIGKGGVKHEKIRTNTLRAVDRGYDVSFAEESGPGAKFHKNAIGSVTDVCGEHKGYCVHMGHGVYASVAHVVKGDSFFLGERIFDLKTNGEFCCFRSTKILPSAAPFFSGRPTRDPWGSPVATDWKPKPYSTTSGKIVGCFATTSTETHPGDCGLPYIDDNGRVTGLHTGSGGPKTPSAKLVVPYVHIDMKTKSVTAQKYDVTKPDISYKGLVCKQLDEIRIIPKGTRLHVSPAHLEDFEECSHQPASLGSGDPRCPKSLTAIVVDSLKPYCVVVNGPPHDILHRVQKMLIDHLSGFVPMNISSDTSMLSAFHKLNHDTSCGPYLGGRKKDHMVNGEPDKALLDLLSSKWKLATQGIALPHEYTIGLKDELRPIEKVQEGKRRMIWGCDVGVATVCAAAFKGVSDAITANHQYGPIQVGINMDSPSVEALFQRIKSARKVFAVDYSKWDSTQSPRVSAASIDILRYFSDRTPIVDSATNTLKSPPIAVFNGVAVKVSSGLPSGMPLTSVINSLNHCLYVGCAILQSLEARNVPVTWNLFSTFDMMTYGDDGVYMFPTMYASISDQIFANLSAYGLKPTRVDKSVGSIEPIDPNSVVFLKRTITRTPQGIRGLLDRSSILRQFYYIKGENTDNWKEPPKTIDPMSRGQQLWNACLYASQHGIDFYNKVYKLAEKAVEYEGLHLEPPSYSTALEHYNSQFNGVEARTDQIDTSGMAALHCDVFEV

ORF1

Replicase polyprotein

1759 amino acids

RNA-directed RNA polymerase replicates genomic and antigenomic RNA.

202.942 kDa

MESDKSMACLNRILMNKMMFVEDKISTLKMVADYYQKEVKYDFDAVESPREAPVFRCTCRFLGYTIMTQGIGKKNPKQEAARQMLLLLSGDVETNPGPVQSRPVYYRYNDPRYTRLEKAIERRDDKIKTLIKELRRQIKNRKIYSQGMFDKLTKQISDGIKDGVGSEQMNGNLTRICDFLENTLPGLQANIQATVIDTTDKYVSLKEDIMKIVLVILLVRLLMVWKKYRASLCVILIFIFKFYGFDQKLIDLIMDLKNKIFSQGALEDTVEEVVYHPWFHTCGKIIFAVMAFLTIKKIPGKQDWDSYITRLDRIPKSIEGAKKITDYCSEYFNIANDQIKMMVLGKTKEELQRANGLYGEIQAWAQEVRQYLELDQRNKIDLDTETANRVEQLWIKGLKFKSEPLLSKEMSALVHTTLLPAKQLYEYVSCSPVKGGGPRMRPICLWLVGESGVGKTEMVYPLCIDVLREMGMIKKDDFHHQVYGRQVETEFWDGYKGQKIVIYDDAFQKKDDKTAANPEIFEVIRSCNTFPQHLHMAALHDKNTFSAAELLLYTTNDYNVKLESITFPDAFFNRMGDMAYKVSPKKEYGIETEKGNSGKTYLKLDKSKLDKTKAIDLSVYEFQKIVRDEKSDAGWIDSGSPLDYEDFAKLVCSKWKEAKQSSMNKLKFLEEYAIRAQVGSEENSEYGDCIDFVDDIAKRLQKGETLEEIEFDYASDPEMFTQYYHFKSTIKPASRWQKYKDRMDICLSDCKTYLAKKYEEIKKILAEHPILTILGMIGVALSALAMYYWFSKSLDPVEAEVAPSGDAKTVRLPRKLVEIGASGDVKTQKIVKPVVETEWHRNNKGEIEISCDECGMHRMSAFNNMTDEEFDNCTYEDLNKDQKRELAQWSTKDSWLGRFFLSRDRKNKVGIWAEVGQSGDVKTNKAQIKRVEAGAEELVTVALTQGCSDDAAHNLMIDVFQKNTYRMSYFRGDKRYQLGNCTFVRGWSFIMPYHFVQAVFARRLPPNTIISLSQQMSEDLMQIPLSHFFSAGVDNFYLTDNCVRLPFKNGDFRDCVMVNLHSRMCTPHRDLVRHFILTSDQGKLKGSFSGAMATFHVNNMGLYRVYNWLNAVRPCDKKIEIFHPEDGFEYPEESYIQRDCYEYNAPTRTGDCGSIIGLYNKYLERKIIGMHIAGNDAEEHGYACPLTQECLETAFSALVNKNKKNISSQFYYEIPNMVDPLGDSSVPEGKFYALGKSSIRVGQAVNSSIIPSRIYGKLSVPTMKPALLKPTILNNKVHNPLLSGLKKCGVDTAVLSDDEVLSASQDVCRVMLNQYNKNLNKTKYQRILTYEEAIRGTQDDEFMCAINRTTSPGFPYAQMKRNAPGKQQWMGFGEEFDFTSNYALALRKDVEQLIEDCASGKISNVIFVDTLKDERRDIAKVNVGKTRVFSAGPQHFVVAFRQYFLPFAAWLMHNRISNEVAVGTNVYSSDWERIAKRLKTKGSHVIAGDFGNFDGSLVAQILWAIFWEIFVVWLKQFIDIENSEGKRILCICLGLWSHLVHSVHIYEDNVYMWTHSQPSGNPFTVIINCLYNSIIMRLSWIRVMEKFQPRLKSMKWFNEYVALITYGDDNVLNIDAKVVEWFNQINISEVMTEMRHEYTDEAKTGDIVKSRKLEDIFFLKRKFRFSPELQRHVAPLKIEVIYEMLNWSRRSIDPDEILMSNIETAFREVVYHGKEEYDKLRSAVLALKVPQELPENPQILTYNQYLHDIEYLADPLYDF

ORF1

RNA-directed RNA polymerase

1729 amino acids

RNA replication. The central part of this protein possibly functions as an ATP-binding helicase (Probable).

Belongs to the potexvirus/carlavirus RNA replication protein family.

196.119 kDa

MTTLALNLAQYNDPITKGIIAQESLRRVRPDLKAVVNVNPYAIPTSAALVLEKLGIGTHPMSLAVHPHAPCKAIENQILNTVGHLLPKEQPVTFMAMKKSKLNMLRRHPSRADTFINPIYHPRDNVRYGLDPDPDQDASITASFLEVKTSTAFMQDTLHYLTPEDLLDIFETSPKLENLIASFVLPVEATRNMKSLYPDLYSIHYTHGGFQWAPSGHLGDAYFHEPWQLYWLRCGSLTRLIEEETTTTVQPPPGFEGEAYTRVRKEVRELKIYAERVTSIGAHHLFIFSRNAKATPRVRSYSQNGKWVTLPRIFRPVSHNVQTPLKQEVANSLMLYTYAVRPSLKDVAAKVRQKFDEKDLAEHSPLEITHLINYIYYIDQRAYLTNDDDILSDNLLKRWIFTPIQAAYKKAKGFLLGPDDFQKLLKALEWQPVTFDYAVDHYKSNPWRIHASRTGAKMRQLKNFLSRTTGLCEAVEDDALEGSELLKELEGNMWFRNPSEVEKEVFDAIVADLPPDSQRSELILEDPNSNARDYLPIQQDQPSVTQGPDEAAQTQTPTATSMVTNSVAARMPPPVPRTLREHHEQFPTTVRASFEQPSSTRAPETSENNTPAESVTPSPRAIYVGDFAIMDANASTSRASSPSPRRTVVSPRQPEAQNETLGRQIVSRVSPAHGCQMSPYAAQLAHQLSEQTAYTDVIGQRMVAFYSQHSRSYKYGRHEHRSQSWLPVIDSLQVALGLDESYDHCLIQRYRKHARVGLHADDEECYEPDSTIVTLNLYGNADFLIERNTDKASETITLQHNDMLFMPSGMQVTHRHAVCSLYEGRVSITFRNKTKDYLRKSAPDMNPVEQPGASAGQLTGPLDHRPEELPWEHWIPRLNRLGFTGLQKQTDPEGKLIYPITEIRQDMVYVPFPNCCPGPLRKDLEAMGRRPVRYTVDTGRALTLASDIKNNRVGALLQNADLTWKTLLVEYCRMEPTSVPMTVIHGAGGSGKSKLLQDHLNRAELNVVIIVPTRVLQQDWRNKMTEFPSFLVQTYEAAMMESAPQMVVFDDYGKLPHGYIDLFCQFHPSVEYVILTGDARQSTYYEYNSDAGIRNLPTNIEVFKQYCGYYINCTHRNKQDLANMLGVYSEKMGSTHFTFGNTCETGSLLLVPSGTQKTVMGEAGHKTETYAGCQGITADKVQIMIDHDTHKSADSHMYTALSRATEHIHFYNSIAGLNTARFHAKLNLTPYLKTFIQVITERAAAETEPAEYTVQAPTARTHIPVENCSTFLEKDLEEQRAKEDREVYTQAGATNVFQTNSPIVQCFQHQQPKDGALSIITHAKRLQYASAEANQAEYRAKLQIGAALWENFKTAMEIPDEPVPFIRDLWEQSEAEVLSTYLSKSEMAIKNGKNRQDPDWQDERMFVYLKAQWVTKASKFNLPTAKAGQTISAFKQAVVMKFGAMARYLRRITPKPDNIRINCEMQPQDISKWALGLDSHNRPTKQKWNFERPAFASDFEAFDQSQDGAMLHFEALWARHFNVPSSLIEEYLFLKMHAQAPKGYLTIMRLTGEGPTFDANTACSIAYNHTRYEIPKSCMQLYAGDDMLLDQVPVEKTGFKNIAAGLKLTAKTEIFEQKRGKWGEFCSWWMTPYGLVKDPITLYHRILLASEIGDLSKKIDAYAIEAEPAYALQGRLFDCFNEEQMTAHYGTIRRLIIEGKTNFSLDDQAPRHQDLQGILNCMDAKFMYH

ORF1

RNA replication protein

1718 amino acids

RNA replication. The central part of this protein possibly functions as an ATP-binding helicase (Probable).

Belongs to the potexvirus/carlavirus RNA replication protein family.

194.531 kDa

MTAVQKLFDQISDPNTKAGYSNACFEAAQRRPKKAMAIAPFSVTTPEALTLERFGITTSPFATTSHTHAADKIIENDCLTIIGHYLPKREAVTLIQLKRSKIHLLGRQPSQDNFQNYCHEPKDVLRYGITHPNSCPVVNTEYAVLADTLHFMSPRQLYHLFSRNPKLERLFATLVLPIEAQHRLPSLFPDVYRLEYYKDHFAYMPGGHGGGAYVHSYGTLKWLDTAQVGPVDYTKSSITNPWPITDYLSIEKIETKAAHHIMFIQRTRAQVDWPLPPIWVYHASEYVKLPLIFYPPEANVQKTYPHTLIKRMQLYCFSVKAVSLRDIFAKLRQVIETQELVRYSMADLIRLANYFLFITGMNQVSDYESPLLENLFGKMCASIRMRLRTFFQNLLGKTSYAALLTVTDVIPVHFTTQPKRREAVGELWFQEPKWSVSTMTQPRKEHHRLQMTWTLLAWFHQLESSGSMSEPCNNSESTPQRTATSQQKAAKLTTSQKHNRRTDQTTMNPQYPPLMLTIAPMMPRHSLMKKTIATPCRTLEEISDLDLDDFDDLPNEASNEPPSANEQSPDNHAETTTRGVFPCECGTEITVNSFGRAIEVAGVNLTDHMKGRLAAFYSRDGQGYSYTGYSHKSQGWLEGLDKLIEACGEKPTTYNQCLVQKYEQGSRIGFHSDEQAIYPKGNKILTVNAAGSGTFGIKCAKGETTLNLEDGDYFQMPSGFQETHKHNVVAVTPRLSFTFRSTVVNSQKKPAEPEKLNQNNACPKPSDPSNASGKQHKKTHPAKGNEKSSSPNLEPLDAPTVEILKLHGFTALTPQHDGTCQIRPVYFNKDIHLRRKAVKTDMSPPARPFFDLATSLHRGIYTHKIDNRRATAYMSDVKNNLTGLVLPKLDRDLLSSWVALAETTTREVAVLAIHGAGGAGKSRALQELLRSSPELADSINIVVPTINLANDWKAKLPQMDPRRVMTFQKACERECKSVTIFDDYGKLPAGFVDAYLAIKVNVELAILTGDQRQSTHHQERESQISSLQSNIAQFSKYADYYLNATHRQPRRLANPIKVHAERQLGGAVLKANIVPDLAMVLVPAFRSQSLLTDLGRHAMTYAGCQGLTLNHLTIILDKDTPLCSDEVLYTAFSRASESITFVNTHSDNPAFLAKLDATPYLKTLISWVREDEEAGADCPATEPLVKDVPTKTHIPVANDKVQLEGKIEAMEDKDTRELWSGEEKTNLMQTQDPVVQLFPHQQAKDEALFKITIGERIRMATPEQNAKQLRHTLNAGDLLFEAYAQFMKVPKETQPFDKRLWTHCRQLALRTYLSKPTSNLQQGARQDPDFPDNAIALFNKSQWVKKLEKVGARFKAGQTISAFKQEVVLLTTTMALYLRKKREQHQPDNVFIMCERTPEQFNAFVMTKWDFDRPNYTSDYTQYDQSQDAAFLNFEIRKARHLGVPEDVLSFYKFIKTHAKTFLGNLAIMRLSAEGPTFDANTECNIAYDALRFRLGDDVRASYAGDDLVRDKACEERAGWVYSESLFSLKAKPLVTNKPDFCGWRLTRHGIVKSPIQLYQSLQLALRLGKIDEVKRSYAIDYLFAYRLGDKIYDIFDEDELEKHQLVTRTLIKKGMQPPESGNHLPIFHITSDRLIRDPDAVKVQSYECDRILLKQPHIIDDYIPAGTQPRNTEHPASADRRDMTRACNLSAEKLAFGGNTINHLFRTSWEGRSPLSN

ORF1

Non-structural polyprotein pORF1

1708 amino acids

RNA-directed RNA polymerase: Plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA to initiate viral replication.

Belongs to the hepevirus non-structural polyprotein family.

187.395 kDa

MEAQQFIKAPGITTAIEQAALAAANSALANAVVVRPFLSRVQTEILINLMQPRQLVFRPEVLWNHPIQRVIHNELEQYCRARAGRCLEVGAHPRSINDNPNVLHRCFLRPVGRDVQRWYSAPTRGPAANCRRSALRGLPPVDRTYCFDGFSRCAFAAETGVALYSLHDLWPADVAEAMARHGMTRLYAALHLPPEVLLPPGTYHTTSYLLIHDGDRAVVTYEGDTSAGYNHDVSILRAWIRTTKIVGDHPLVIERVRAIGCHFVLLLTAAPEPSPMPYVPYPRSTEVYVRSIFGPGGSPSLFPSACSTKSTFHAVPVHIWDRLMLFGATLDDQAFCCSRLMTYLRGISYKVTVGALVANEGWNASEDALTAVITAAYLTICHQRYLRTQAISKGMRRLEVEHAQKFITRLYSWLFEKSGRDYIPGRQLQFYAQCRRWLSAGFHLDPRVLVFDESVPCRCRTFLKKVAGKFCCFMRWLGQECTCFLEPAEGLVGDYGHDNEAYEGSEVDPAEPAHLDVSGTYAVHGRQLEALYRALNVPHDIAARASRLTATVELTASPDRLECRTVLGNKTFRTTVVDGAHLEANGPEQYVLSFDASRQSMGAGSHSLTYELTPAGLQVRISSNGLDCTATFPPGGAPSAAPGEVAAFCSALYRYNRFTQRHSLTGGLWLHPEGLLGIFPPFSPGHIWESANPFCGEGTLYTRTWSTSGFSSDFSPPEAAAPVLAAAPGLPHPTPPVSDIWVLPPPSEESQVDAASVPPAPEPAGLPSSIVLTLPPPLPPVRKPPTPPPSRTRRLLYTYPDGAKVYAGSLFESDCNWLVNASNPGHRPGGGLCHAFYQRFPEAFYPTEFIMREGLAAYTLTPRPIIHAVAPDYRVEQNPKRLEAAYRETCSRRGTAAYPLLGSGIYQVPVSLSFDAWERNHRPGDELYLTEPAAAWFEANKPAQPALTITEDTARTANLALEIDAATDVGRACAGCTISPGIVHYQFTAGVPGSGKSRSIQQGDVDVVVVPTRELRNSWRRRGFAAFTPHTAARVTIGRRVVIDEAPSLPPHLLLLHMQRASSVHLLGDPNQIPAIDFEHAGLVPAIRPELAPTSWWHVTHRCPADVCELIRGAYPKIQTTSRVLRSLFWNEPAIGQKLVFTQAAKAANPGAITVHEAQGATFTETTIIATADARGLIQSSRAHAIVALTRHTEKCVILDAPGLLREVGISDVIVNNFFLAGGEVGHHRPSVIPRGNPDQNLGTLQAFPPSCQISAYHQLAEELGHRPAPVAAVLPPCPELEQGLLYMPQELTVSDSVLVFELTDIVHCRMAAPSQRKAVLSTLVGRYGRRTKLYEAAHSDVRESLARFIPTIGPVQATTCELYELVEAMVEKGQDGSAVLELDLCNRDVSRITFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKEILALLPPNIFYGDAYEESVFAAAVSGAGSCMVFENDFSEFDSTQNNFSLGLECVVMEECGMPQWLIRLYHLVRSAWILQAPKESLKGFWKKHSGEPGTLLWNTVWNMAIIAHCYEFRDFRVAAFKGDDSVVLCSDYRQSRNAAALIAGCGLKLKVDYRPIGLYAGVVVAPGLGTLPDVVRFAGRLSEKNWGPGPERAEQLRLAVCDFLRGLTNVAQVCVDVVSRVYGVSPGLVHNLIGMLQTIADGKAHFTETIKPVLDLTNSIIQRVE

ORF1

Non-structural polyprotein pORF1

1708 amino acids

RNA-directed RNA polymerase: Plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA to initiate viral replication.

Belongs to the hepevirus non-structural polyprotein family.

187.269 kDa

MEAHQFIKAPGITTAIEQAALAAANSALANAVVVRPFLSRVQTEILINLMQPRQLVFRPEVLWNHPIQRVIHNELEQYCRARAGRCLEVGAHPRSINDNPNVLHRCFLRPVGRDVQRWYSAPTRGPAANCRRSALRGLPPVDRTYCFDGFSRCAFAAETGVALYSLHDLWPADVAEAMARHGMTRLYAALHLPPEVLLPPGTYHTTSYLLIHDGNRAVVTYEGDTSAGYNHDVSILRAWIRTTKIVGDHPLVIERVRAIGCHFVLLLTAAPEPSPMPYVPYPRSTEVYVRSIFGPGGSPSLFPSACSTKSTFHAVPVHIWDXLMLFGATLXDQAFCCSRLMTYLRGISYKVTVGALVANEGWNASEDALTAVITAAYLTICHQRYLRTQAISKGMRRLEVEHAQKFITRLYSWLFEKSGRDYIPGRQLQFYAQCRRWLSAGFHLXPRXLVFDESVPCRCRTFLKKVAGKFCCFMRWLGQECTCFLEPAEGLVGDQGHDNEAYEGSEVDPAEPAHLDVSGTYAVHGHQLEALYRALNVPHDIAARASRLTATVELVASPDRLECRTVLGNKTFRTTVVDGAHLEANGPEEYVLSFDASRQSMGAGSHSLTYELTPAGLQVKISSNGLDCTATFPPGGAPSAAPGEVAAFCSALYRYNRFTQRHSLTGGLWLHPEGLLGIFPPFSPGHIWESANPFCGEGTLYTRTWSTSGFSSDFSPPEAAAPASAAAPGLPYPTPPVSDIWVLPPPSEESHVDAASVPSVPEPAGLTSPIVLTPPPPPPPVRKPATSPPPRTRRLLYTYPDGAKVYAGSLXESDCDWLVNASNPGHRPGGGLCHAFYQRFPEAFYSTEFIMREGLAAYTLTPRPIIHAVAPDYRVEQNPKRLEAAYRETCSRRGTAAYPLLGSGIYQVPVSLSFDAWERNHRPGDELYLTEPAAAWFEANKPAQPALTITEDTARTANLALEIDAATEVGRACAGCTISPGIVHYQFTAGVPGSGKSRSIQQGDVDVVVVPTRELRNSWRRRGFAAFTPHTAARVTIGRRVVIDEAPSLPPHLLLLHMQRASSVHLLGDPNQIPAIDFEHAGLVPAIRPELAPTSWWHVTHRCPADVCELIRGAYPKIQTTSRVLRSLFWNEPAIGQKLVFTQAAKAANPGAITVHEAQGATFTETTIIATADARGLIQSSRAHAIVALTRHTEKCVILDAPGLLREVGISDVIVNNFFLAGGEVGHHRPSVIPRGNPDQNLGTLQAFPPSCQISAYHQLAEELGHRPAPVAAVLPPCPELEQGLLYMPQELTVSDSVLVFELTDIVHCRMAAPSQRKAVLSTLVGRYGRRTKLYEAAHSDVRESLARFIPTIGPVRATTCELYELVEAMVEKGQDGSAVLELDLCNRDVSRITFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKEILALLPPNIFYGDAYEESVFAAAVSGAGSCMVFENDFSEFDSTQNNFSLGLECVVMEECGMPQWLIRLYHLVRSAWILQAPKESLKGFWKKHSGEPGTLLWNTVWNMAIIAHCYEFRDFRVAAFKGDDSVVLCSDYRQXRNAAALIAGCGLKLKVDYRPIGLYAGVVVAPGLGTLPDVVRFAGRLSEKNWGPGPERAEQLRLAVCDFLRGLTNVAQVCVDVVSRVYGVSPGLVHNLIGMLQTIADGKAHFTENIKPVLDLTNSIIQRVE

ORF1

Non-structural polyprotein pORF1

1707 amino acids

RNA-directed RNA polymerase: Plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA to initiate viral replication.

Belongs to the hepevirus non-structural polyprotein family.

187.298 kDa

MEAHQFIKAPGVTTAIEQAALAAANSALANAVVVRPFLSRLQTEILINLMQPWQLVFRPEVLWNHPIQRVIHNELEQYCRARAGRCLEEGAHPRSINDDPNVLHRCFLKPVGRDVQRWYTAPTRGPAANCRRSALRGLPPVDRTYCFDGFSGCTFAAETGVALYSLHDLWPADVAEAMARHGMTRLYAALHLPPEVLLPPGTYHTTSYLLIHDGDRAVITYEGDSSAGYNHDVSILRAWIRTTKVTGDHPLVIERVRAVGCHFVLLLTAAPEPSPMPYVPYPRSTEVYVRSIFGPGGSPSLFPSACSTKSTFHAVPVHIWDRLMLFGATLDDQAFCCSRLMTYLRGISYKVTVGALVANEGWNASEDALTAVITAAYLTICHQRYLRTQAISKGMKRLELEHAQKFITRLYSWLFEKSGRDYIPGRQLQFYAQCRRWLSAGFHLDPRVLVFDEAAPCRCRSFLRKAATKFCCFMRWLGQDCTCFLQPIEGRVGEQGYDNEAFEGSDIDPAEEATVSIAGSYIVTGSQLQPLYQALGIPSDLAARASRLTATVEVSDADGRLTCKTTMGNKTFSTVFTDGTQLEANGPEQYVLSFDPAKQTMAAGPHSLSYTLTSAGLEVHVVSAGLDCKVVFQSGVAAPSAAGEVTAFCSALYRFNRCVQRHSLIGGLWYHPEGLVGLFPPFSPGHSWESANPFCGESTLYTRTWSVSGFSSCFSPLEPCVPSMPPPAEVNTPVVLDALPSEIMEPAQPPASEPAAPPSDSVDNSFSPTSSGAPIAPPAPALPVTHLSGPRRRLLHTYPDGSKVYAGSLFESECTWLVNASNPGHRPGGGLCHAFYQRFPESFDPAEFIMSDGFAAYTLTPRPIIHAVAPDYRVEHNPKRLEAAYRETCSRRGTAAYPLLGVGIYRVPVGLSFDAWERNHRPGDELYLTEPAIAWFEANRPTLPALTITEDTARTANLALELDAATEVGRACVGCRVEPGVIHYQFTAGVPGSGKSRSVQQGDVDVIVVPTRELRNSWRRRGFAAYTPHTAVRVTRGRRVVIDEAPSLPPHLLLLHMQRASSVHLLGDPNQIPAIDFEHAGLVPAIRPELVPTKWWHLTYRCPADVCELIRGAYPKIQTASRVLRSLFWEEPPVGQNLVFTQAAKAANPGAITVHEAQGATFTETTIIATADARGLIQSSRAHAIVALTRHTEKCVVVDAPGLLREVGISDAIVNNFFLSGGQIGQHRPSVIRRGTIDNNVDTLDAFPPSCQFSAYHQLAEELGHRPAPIAAVLPPCPELEQGLLYMPQELTTSDSVLTFELTDIVHCRMAAPSQRRAVLSTLVGRYGRRTKLYEAAHTDVRGSLNHFIPELGPINVTTCELYELVEAMVEKGQDGSAVLELDLCSRDVSRITFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKEILAALAPNVFYGDAYEDTVLAAAVAGAPGCKVFENDFSEFDSTQNNFSLGLECIIMEECGMPQWMIRLYHLVRSAWILQAPKESLRGFWKKHSGEPGTLLWNTVWNMAVIAHCYEFRDLKVAAFKGDDSVVLCSDYRQSRDAAVLIAGCGLKLKVDFRPIGLYAGVVVAPGLGTLPDVVRFAGRLSEKNWGPGPERAEQLRLAVCDFLRKLTNVAQVCVDVVSQVYGVSPGLVHNLIGMLQTIADGKAHFTETIKPVLDLTSSIIYRVE

ORF1

RNA replication protein

1707 amino acids

RNA replication. The central part of this protein possibly functions as an ATP-binding helicase (Probable).

Belongs to the potexviruses/carlaviruses RNA replication protein family.

195.502 kDa

MSISVSSQRVAVSNLYTNGSEESVKAIKELKSKRLLETETRLDGLFDYYIPDTLREILTGYGMEFSVHSFQGHAHPVSKMIENHMLYRVAPNYFSSNTLVVSCKESKIKRLRLKNANNRNLNFTQYNRLVHANHHHRYENAFRELDVGNLTNLINKEDQSECIFIHDEVQYWSLDEMQRFLGSLSKVDRVVYSIIYPSEVEAGYSQSLFPEAYTFDLKDRRLVWYPDGKAEGAYTQPVNPWLLRCSKTEDSKGRSWTITKLQTIGAHHLFSAIKGSYLTEESYKYDNFTIINPNDVLKGKRGGKPLYLRARMIKPTLLYLLALKKSDSNSAVAKLRMLSSREENMDEALFVAQLAKQIKDTALYDKMGNPNLRSILSESFYDIAGSLFTRLFNRPEYDARCLEKFIRSCETTEIHVERRYMEGIRRGASFKVQNVMDWVEDDSANALSEVNFLDISWNDRVSEPYGIECIHGEGSRIRVPLSRILRAHELIAGVQTDVEINFPRYVCSSRALIHFRQYLIKLGRFSFMESRAIKDIEDIQAGLEEGVITEEEAELRLLPTTKPKITEIHMDDDTPGTSGESDVEKFKSVRSLCREEIYSEKLKGREVAFYSRHSKEYKYNGGSHRSLGWDEALNELTQELGLDDSYDHCLIQRYTAGGSIGFHADDEPCYLPGGSVVTVNLHGDATFEVKENQSGKIEKKELHDGDVYVMGPGMQQTHKHRVTSHTDGRCSITLRNKTVDYEARKGDEDSEYEEDKAELDEGIDYLQKNQGNMCSLKAFADHMQLSTPSVIAIVNGASPQTLREIEDGGYSLATLVNLSKALDFPIAIHGERGYAETPGSYRRLHLKITSGHVEPFEGVTSKGGFREAMLLGDGVGVGHFRVDKAKADRLAQSFYNGNTGVLLGKYNKGKMHTGEIEEPKEVLTAFGFAGSGKSHWCQTILKHCSVEKVLVISPRKVLRDDWVAKISKKHRVVTFEVAFMDDYGCKDIVIDEIGLLPPGYIDLVIAAHQPRTLVLLGDPLQSTYHSKRDNVVLEASQEDVFNRVRGKLPYLCYSHRLPRNCKLFEIECMGAESEKRVVYRSNRLKDEPTICATRAMKEEKGSGWYTVSETQGLSFKSCLIYLDEHWAKKEDEDVMVALTRSRGEIGIHVTPALKKKLITNAKSTLLKKVLKGETYRRSEIVAMVRKHIPETTVLFEESRLAETVDYEARLAGDPYLKSLLALYDEIEMEDIEIEEPVTLEPTKTHLALSTKMNELAPFDLKAKEHREQHTEAGRTEQIDENGYQGEVGDPMTHKALYLRHTSDDTATFMMSVKKRLRFRNYEANRRKYKTCHGIGHQMFSVFKDTYQLKEIDSLPELERCEMEFMKKRIEKSTGLIEKHAGRSDPDWPSNYLKIFLKQQTCTKMEKRGVDAKAGQTIACFAHSVLCRFGPILRQTEKALRELLPEKLMIYSQKKYMDLDKWAKTWVESMMGTDSDYEAFDRSQDEKVLDLEVEVLRFFLWPEDLIREYEELKLMMGCALGDLAVMRFSGEFGTFFFNTVCNMVFSCMRYHIDRNTPMCFAGDDMYSPGILRVKKDYEATLDQLTLKAKVHISEEPLFCGWRMSPFGIIKEPNLILDRWKIALRSGNLSLCLVNYAIEASFGYRLSEHLYDVNIDVDAQQELVREIVIKKHLLPKKISDLFSEDECERHSDGDEDFLSNDVARLYRIE

ORF1

Genome polyprotein

1699 amino acids

RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).

189.201 kDa

MKMASNDASAAAVVNSNNDTAKSSSDGVLSSMAVTFKRALGGRAKQPPPRETPQRPPRPPTPELVKKIPPPPPNGEDELVVSYSVKDGVSGLPELSTVRQPDEANTAFSVPPLNQRENRDAKEPLTGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKVELTPLSLFWRPVYTPQYLISPDTLKRLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTTGFFRPYQDWNRKPLPTMDDSKLKKVANVFLCALSSLFTRPIKDIIGKLRPLNILNILASCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPIVMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMVRSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTINALLARIAAARSLVHRAKEELSSRLRPVVVMISGKPGIGKTHLARELAKRIAASLTGDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDMWKNAFSPDFSHIKLALAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEYELQGPALTTFNFDRNKVLAFRQLAAENKYGLMDTMKVGRQLKDVRTMPELKQALKNISIKRCQIVYSGCTYTLESDGKGNVKVDRVQSATVQTNHELAGALHHLRCARIRYYVKCVQEALYSIIQIAGAAFVTTRIVKRMNIQDLWSKPQVEDTEDTANKDGCPKPKDDEEFVVSSDDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDRDKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPDDFKPKGKLWADDDRSVDYNEKLDFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIPQGAQEFFGVPVKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRSTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRENDYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGSAPKLSTKTKFWRSSTAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSVLEAAKRTIINVLEQTIDPPQKWSFTQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLADQASKANLMFEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFGGLMDELKAHCVTLPIRVGMNMNEDGPIIFERHSRYKYHYDADYSRWDSTQQRAVLAAALEIMVKFSPEPHLAQIVAEDLLSPSVMDVGDFKISINEGLPSGVPCTSQWNSIAHWLLTLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDINLNPEKLTAKLKEYGLKPTRPDKTEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQMYWTRGPNHEDPSETMIPHSQRPIQLMSLLGEAALHGPAFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDLSTWEGDRNLAPSFVNEDGVE

ORF1

Non-structural polyprotein pORF1

1693 amino acids

RNA-directed RNA polymerase: Plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA to initiate viral replication.

Belongs to the hepevirus non-structural polyprotein family.

185.192 kDa

MEAHQFIKAPGITTAIEQAALAAANSALANAVVVRPFLSHQQIEILINLMQPRQLVFRPEVFWNHPIQRVIHNELELYCRARSGRCLEIGAHPRSINDNPNVVHRCFLRPVGRDVQRWYTAPTRGPAANCRRSALRGLPAADRTYCLDGFSGCNFPAETGIALYSLHDMSPSDVAEAMFRHGMTRLYAALHLPPEVLLPPGTYRTASYLLIHDGRRVVVTYEGDTSAGYNHDVSNLRSWIRTTKVTGDHPLVIERVRAIGCHFVLLLTAAPEPSPMPYVPYPRSTEVYVRSIFGPGGTPSLFPTSCSTKSTFHAVPAHIWDRLMLFGATLDDQAFCCSRLMTYLRGISYKVTVGTLVANEGWNASEDALTAVITAAYLTICHQRYLRTQAISKGMRRLEREHAQKFITRLYSWLFEKSGRDYIPGRQLEFYAQCRRWLSAGFHLDPRVLVFDESAPCHCRTAIRKALSKFCCFMKWLGQECTCFLQPAEGAVGDQGHDNEAYEGSDVDPAESAISDISGSYVVPGTALQPLYQALDLPAEIVARAGRLTATVKVSQVDGRIDCETLLGNKTFRTSFVDGAVLETNGPERHNLSFDASQSTMAAGPFSLTYAASAAGLEVRYVAAGLDHRAVFAPGVSPRSAPGEVTAFCSALYRFNREAQRHSLIGNLWFHPEGLIGLFAPFSPGHVWESANPFCGESTLYTRTWSEVDAVSSPARPDLGFMSEPSIPSRAATPTLAAPLPPPAPDPSPPPSAPALAEPASGATAGAPAITHQTARHRRLLFTYPDGSKVFAGSLFESTCTWLVNASNVDHRPGGGLCHAFYQRYPASFDAASFVMRDGAAAYTLTPRPIIHAVAPDYRLEHNPKRLEAAYRETCSRLGTAAYPLLGTGIYQVPIGPSFDAWERNHRPGDELYLPELAARWFEANRPTRPTLTITEDVARTANLAIELDSATDVGRACAGCRVTPGVVQYQFTAGVPGSGKSRSITQADVDVVVVPTRELRNAWRRRGFAAFTPHTAARVTQGRRVVIDEAPSLPPHLLLLHMQRAATVHLLGDPNQIPAIDFEHAGLVPAIRPDLGPTSWWHVTHRWPADVCELIRGAYPMIQTTSRVLRSLFWGEPAVGQKLVFTQAAKPANPGSVTVHEAQGATYTETTIIATADARGLIQSSRAHAIVALTRHTEKCVIIDAPGLLREVGISDAIVNNFFLAGGEIGHQRPSVIPRGNPDANVDTLAAFPPSCQISAFHQLAEELGHRPVPVAAVLPPCPELEQGLLYLPQELTTCDSVVTFELTDIVHCRMAAPSQRKAVLSTLVGRYGGRTKLYNASHSDVRDSLARFIPAIGPVQVTTCELYELVEAMVEKGQDGSAVLELDLCNRDVSRITFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKAILALLPQGVFYGDAFDDTVFSAAVAAAKASMVFENDFSEFDSTQNNFSLGLECAIMEECGMPQWLIRLYHLIRSAWILQAPKESLRGFWKKHSGEPGTLLWNTVWNMAVITHCYDFRDFQVAAFKGDDSIVLCSEYRQSPGAAVLIAGCGLKLKVDFRPIGLYAGVVVAPGLGALPDVVRFAGRLTEKNWGPGPERAEQLRLAVSDFLRKLTNVAQMCVDVVSRVYGVSPGLVHNLIGMLQAVADGKAHFTESVKPVLDLTNSILCRVE

ORF1

Non-structural polyprotein pORF1

1693 amino acids

RNA-directed RNA polymerase: Plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA to initiate viral replication.

Belongs to the hepevirus non-structural polyprotein family.

185.054 kDa

MEAHQFIKAPGITTAIEQAALAAANSALANAVVVRPFLSHQQIEILINLMQPRQLVFRPEVFWNHPIQRVIHNELELYCRARSGRCLEIGAHPRSINDNPNVVHRCFLRPAGRDVQRWYTAPTRGPAANCRRSALRGLPAADRTYCFDGFSGCNFPAETGVALYSLHDMSPSDVAEAMFRHGMTRLYAALHLPPEVLLPPGTYRTASYLLIHDGRRVVVTYEGDTSAGYNHDVSNLRSWIRTTKVTGDHPLVIERVRAIGCHFVLLLTAAPEPSPTPYVPYPRSTEVYVRSIFGPGGTPSLFPTSCSTKSTFHAVPAHIWDRLMLFGATLDDQAFCCSRLMTYLRGISYKVTVGTLVANEGWNASEVALTAVITAAYLTICHQRYLRTQAISKGMRRLEREHAQKFITRLYSWLFEKSGRDYIPGRQLEFYAQCRRWLSAGFHLDPRVLVFDESAPCHCRTAIRKAVSKFCCFMKWLGQECTCFLQPAEGAVGDQGHDNEAYEGSDVDPAESAISDISGSYVVPGTALQPLYQALDLPAEIVARAGRLTATVKVSQVDGRIDCETLLGNKTFRTSFVDGAVLETNGPERHNLSFDASQSTMAAGPFSLTYAASAAGLEVRYVAAGLDHRAVFAPGVSPRSAPGEVTAFCSALYRFNREAQRLSLTGNFWFHPEGLLGPFAPFSPGHVWESANPFCGESTLYTRTWSEVDAVSSPAQPDLGFISEPSIPSRAATLTPAAPLPPPAPDPSPTPSAPARGEPAPGATARAPAITHQAARHRRLLFTYPDGSKVFAGSLFESTCTWLVNASNVDHRPGGGLCHAFYQRYPASFDAASFVMRDGAAAYTLTPRPIIHAVAPDYRLEHNPKMLEAAYRETCSRLGTAAYPLLGTGIYQVPIGPSFDAWERNHRPGDELYLPELAARWFEANRPTCPTLTITEDVARTANLAIELDSATDVGRACAGCRVTPGVVQYQFTAGVPGSGKSRSITQADVDVVVVPTRELRNAWRRRGFAAFTPHTAARVTQGRRVVIDEAPSLPPHLLLLHMQRAATVHLLGDPNQIPAIDFEHAGLVPAIRPDLAPTSWWHVTHRCPADVCELIRGAYPMIQTTSRVLRSLFWGEPAVGQKLVFTQAAKAANPGSVTVHEAQGATYTETTIIATADARGLIQSSRAHAIVALTRHTEKCVIIDAPGLLREVGISDAIVNNFFLAGGEIGHQRPSVIPRGNPDANVDTLAAFPPSCQISAFHQLAEELGHRPAPVAAVLPPCPELEQGLLYLPQELTTCDSVVTFELTDIVHCRMAAPSQRKAVLSTLVGHYGRRTKLYNASHSDVRDSLARFIPAIGHVQVTTCELYELVEAMVEKGQDGSAVLELDLCNRDVSRITFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKAILALLPQGVFYGDAFDDTVFSAAVAAARASMVFENDFSEFDSTQNNFSLGLECAIMVECGMPQWLIRLYHLIRSAWILQAPKESLRGFWKKHSGEPGTLLWNTVWNMAVITHCYDFRDLQVAAFKGDDSIVLCSEYRQSPGAAVLIAGCGLKLKVDFRPIGLYAGVVVAPGLGALPDVVRFAGRLTEKNWGPGPERAKQLRLAVSDFLRKLTNVAQMCVDVVSRVYGVSPGLVHNLIGMLQAVADGKAHFTESVKPVLDLTNSILCRVE

ORF1

Non-structural polyprotein pORF1

1693 amino acids

RNA-directed RNA polymerase: Plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA to initiate viral replication.

Belongs to the hepevirus non-structural polyprotein family.

185.58 kDa

MEAHQFLKAPGITTAVEQAALATANSALANAVVVRPFLSHQQIEILINLMQPRQLVFRPEVFWNQPIQRVIHNELELYCRARSGRCLEIGAHPRSINDNPNVVHRCFLRPVGRDVQRWYTAPTRGPAANCRRSALRGLPAADRTYCFDGFSGCSCPAETGIALYSLHDMSPSDVAEAMFRHGMTRLYAALHLPPEVLLPPGTYRTASYLLIHDGRRVVVTYEGDTSAGYNHDVSNLRSWIRTTKVTGDHPLVIERVRAIGCHFVLLLTAAPEPSPMPYVPYPRSTEVYVRSIFGPGGTPSLFPTSCSTKSTFHAVPAHIWDRLMLFGATLDDQAFCCSRLMTYLRGISYKVTVGTLVANEGRNASEDALTAVITAAYLTICHQRYLRTQAISKGIRRLEREHDQKFITRLYSWLFEKSGRDYIPGRQLEFYAQCRRWLSAGFHLDPRVLVFDESAPCHCRTVIRKALSKFCCFMKWLGQECTCFLQPAEGVVGDQGHDNESYEGSDVDPAESAISDISGSYVVPGTALQPLYQALDLPDEIVARACRLTATVKVSQVDGRIDCETLLGNKTFRTSFVDGAVLETNGPERHNLSFDASQSTMAAGPFSLTYAASAAGLEVRYVGAGLDHRAIFAPGVSPRSNPGEVTAFCSALYRFNREAQRHSLTGNLWFHPEGLIGLFAPFSPGHVWESAKPFCGESTLYTRTWSEVDAVSSPTRPDLGFMSEPPIPSRAATPTLAAPLPPLAPDPSPPSSAPALDEPASAATSGVPAITHQTARHRRLLFTYPDGSKVFAGSLFESTCTWLVNASNVDHCPGGGLCHAFYQRYPASFDAACFVMRDGAAAYTLTPRPIIHRVAPDYRLEHNPKRLEAAYRETCSRLGTAAYPLLGTGIYQVPIGPSFDAWERNHRPGDELYLPELAARWFEANRPTRPTLTITEDAARTANLAIELDSATDVGRACAGCRVTPGVVQYQFTAGVPGSGKSRSITRADVDVVVVPTRELRNAWRRRGFAAFTPHTAARVTDGRRVVIDEAPSLPPHLLLLHMQRAATVHLLGDPNQIPAIDFEHPGLVPAIRPDLAPTSWWHVTHRCPADVCELIRGAYPMIQTTSRVLRSLFWGEPAVGQKLVFTQAAKPANPGSVTVHDSQGATYTYTTIIATADARGLIQSSRAHAIVALTRHTEKWVIIDAPGLLREVGISDAIVNNFFLAGGEIGHQRPSVIPRGNPDANVDTLAAFPPSCQISAFHQLAEELGHRPAPVAAVLPPCPELEQGLLYLPQELTTCDSVVTFELTDIVHCRMAAPSQRKAVVSTLVGRYGRRTKLYNASHSDVRDSLARFIPAIGPVQVTTCELYELVEAMVEKGQDGSAVLELDLCNRDVSRITFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKAILALLPQGVFYGDAFDDTVFSAAVAAAKASMVFENDFSEFDSTQNNFSLGLECAIMEECGMPQGLIRLYHLIRSAWILQAPKESLLGFWKKHSGEPGTLLWNTVWNMAVITHCYDFRDLQVAAFKGDDSIVLCSEYRQSPGAAVLIAGCGLKLKVDFRPMRLYAGVVVAPGLGALPDVVRFAGRLTEKNWGPGPERADELRIAVSDFLRKLTNVAQMCVDVVSRVYGVSPGLVHNLIGMLQAVADGKAHFTESVKPVLDLTNSILCRVE

ORF1

Non-structural polyprotein pORF1

1693 amino acids

RNA-directed RNA polymerase: Plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA to initiate viral replication.

Belongs to the hepevirus non-structural polyprotein family.

185.216 kDa

MEAHQFIKAHGITTAIEQAALAAANSALANAVVVRPFLSHQQIEILINLMQPRQLVFRPEVFWNHPIQRVIHNELELYCRARSGRCLEIGAHPRSINDNPNVVHRCFLLPVGRDVQRWYTAPTRGPAANCRRSALRGLPAVDRTYCLDGFSGCNFPAETGIALYSLHDMSPSDVAEAMFRHGMTRLYAALHLPPEVLLPPGTYRTASYLLIHDGRRVVVTYEGDTSAGYNHDVSNLRSWIRTTKVTGDHPLVIERVRAIGCHFVLLLTAAPEPSPMPYVPYPRSTEVYVRSIFGPGGTPSLFPTSCSTKSTFHAVPAHIWDRLMLFGATLDDQAFCCSRLMTYLRGISYKVTVGTLVANEGWNASEDALTAVITAAYLTICHQRYLRTQAISKGMRRLEREHAQKFITPLYSWLFEKSGRDYIPGRQLEFYAQCRRWLSAGFHLDPRVLVFDESAPCRCRTAIRKALSKFCCFMKWLGQECTCFLQPAEGVVGDQGHDNEAYEGSDVDPAESAISDISGSYVVPGTALQPLYQALDLPAEIVARAGRLTATVKVSQVDGRIDCETLLGNKTFRTSFVDGAVLEANGPERYNLSFDASQSTMAAGPFSLTYAASAAGLEVRYVAAGLDHRAVFAPGVSPRSAPGEVTAFCSALYRFNREAQRHSLTGNLWFHPEGLIGLFAPFSPGHVWESANPFCGESTLYTRTWSEVDAVSSPARPDLGLMSEPSIPSRAATPTLAVLLPPPAPDPPPPPSAPALDEPASGATAGAPAITHQTARHRRLLFTYPDGSKVFAGSLFESTCTWLVNASNVDHRPGGGLCHAFYQRYPASFDAASFVMRDGAAAYTLTPRPIIHAVAPDYRLEHNPKRLEAAYRETCSRLGTAAYSLLGTGIYQVPIGPSFDAWERNHRPGDELYLPELAARWFEANRPTRPTLTITEDVARTANLAIELDSATDVGRACAGCRVTPGVVQYQFTAGVPGSGKSRSITQADVDVVVVPTRELRNAWRRRGFAAFNPHTAARVTQGRRVVIDEAPSLPPHLLLLHMQRAATVHLLGDPNQIPAIDFEHAGLVPAIRPDLGPTSWWHVTHRCPADVCELIRGAYPMIQTTSRVLRSLFWGEPAVGQKLVFTQAAKAANPGSVTVHEAQGATYTETTIIATADARGLIQSSRAHAIVALTRHTEKFVIIDAPGLLREVGISDAIVNNFFLAGGEIGHQRPSVIPRGNPDANVDTLAAFPPSCQISAFHQLAEELGHRPVPVAAVLPPCPELEQGLLYLPQGLTACDSVVTFELTDIVHCRMAAPNQRKAVLSTLVGRYGRRTKLYNASHSDVRDSLARFIPAIGPVQVTTCELYELVEAMVEKGQDGSAVLELDLCNRDVSRITFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKAILALLPQGVFYGDAFDDTVFSAAVAAAKASMVFENDFSEFDSTQNNFSLGLECAIMEECGMPQWLIRLYHLIRSAWILQAPKESLRGFWKKHSGEPGTLLWNTVWNMAVITHCYDFRDFQVAAFKGDDSIVLCSEYRQSPGAAVLIAGCGLKLKVDFRPIGLYAGVVVAPGLGALPDVVRFAGRLTEKNWGPGPERAEQLRLAVSDFLRKLTNVAQMCVDVVSRVYGVSPGLVHNLIGMLQAVADGKAHFTESVKPVLDLTNSILCRVE

ORF1

Non-structural polyprotein pORF1

1693 amino acids

RNA-directed RNA polymerase: Plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA to initiate viral replication.

Belongs to the hepevirus non-structural polyprotein family.

185.15 kDa

MEAHQFIKAPGITTAIEQAALAAANSALANAVVVRPFLSHQQIEILINLMQPRQLVFRPEVFWNHPIQRVIHNELELYCRARSGRCLEIGAHPRSINDNPNVVHRCFLRPAGRDVQRWYTAPTRGPAANCRRSALRGLPAADRTYCFDGFSGCNFPAETGIALYSLHDMSPSDVAEAMFRHGMTRLYAALHLPPEVLLPPGTYRTASYLLIHDGRRVVVTYEGDTSAGYNHDVSNLRSWIRTTKVTGDHPLVIERVRAIGCHFVLLLTAAPEPSPMPYVPYPRSTEVYVRSIFGPGGTPSLFPTSCSTKSTFHAVPAHIWDRLMLFGATLDDQAFCCSRLMTYLRGISYKVTVGTLVANEGWNASEDALTAVITAAYLTICHQRYLRTQAISKGMRRLEREHAQKFITRLYSWLFEKSGRDYIPGRQLEFYAQCRRWLSAGFHLDPRVLVFDESAPCHCRTAIRKAVSKFCCFMKWLGQECTCFLQPAEGVVGDQGHDNEAYEGSDVDPAESAISDISGSYVVPGTALQPLYQALDLPAEIVARAGRLTATVKVSQVDGRIDCETLLGNKTFRTSFVDGAVLETNGPERHNLSFDASQSTMAAGPFSLTYAASAAGLEVRYVAAGLDHRAVFAPGVSPRSAPGEVTAFCSALYRFNREAQRLSLTGNFWFHPEGLLGPFAPFSPGHVWESANPFCGESTLYTRTWSEVDAVPSPAQPDLGFTSEPSIPSRAATPTPAAPLPPPAPDPSPTLSAPARGEPAPGATARAPAITHQTARHRRLLFTYPDGSKVFAGSLFESTCTWLVNASNVDHRPGGGLCHAFYQRYPASFDAASFVMRDGAAAYTLTPRPIIHAVAPDYRLEHNPKRLEAAYRETCSRLGTAAYPLLGTGIYQVPIGPSFDAWERNHRPGDELYLPELAARWFEANRPTCPTLTITEDVARTANLAIELDSATDVGRACAGCRVTPGVVQYQFTAGVPGSGKSRSITQADVDVVVVPTRELRNAWRRRGFAAFTPHTAARVTQGRRVVIDEAPSLPPHLLLLHMQRAATVHLLGDPNQIPAIDFEHAGLVPAIRPDLAPTSWWHVTHRCPADVCELIRGAYPMIQTTSRVLRSLFWGEPAVGQKLVFTQAAKAANPGSVTVHEAQGATYTETTIIATADARGLIQSSRAHAIVALTRHTEKCVIIDAPGLLREVGISDAIVNNFFLAGGEIGHQRPSVIPRGNPDANVDTLAAFPPSCQISAFHQLAEELGHRPAPVAAVLPPCPELEQGLLYLPQELTTCDSVVTFELTDIVHCRMAAPSQRKAVLSTLVGRYGRRTKLYNASHSDVRDSLARFIPAIGPVQVTTCELYELVEAMVEKGQDGSAVLELDLCSRDVSRITFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKAILALLPQGVFYGDAFDDTVFSAAVAAAKASMVFENDFSEFDSTQNNFSLGLECAIMEECGMPQWLIRLYHLIRSAWILQAPKESLRGFWKKHSGEPGTLLWNTVWNMAVITHCYDFRDLQVAAFKGDDSIVLCSEYRQSPGAAVLIAGCGLKLKVDFRPIGLYAGVVVAPGLGALPDVVRFAGRLTEKNWGPGPERAEQLRLAVSDFLRKLTNVAQMCVDVVSRVYGVSPGLVHNLIGMLQAVADGKAHFTESVKPVLDLTNSILCRVE

ORF1

Non-structural polyprotein pORF1

1691 amino acids

RNA-directed RNA polymerase: Plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA to initiate viral replication.

Belongs to the hepevirus non-structural polyprotein family.

185.225 kDa

MEAHQFIKAPGITTAIEQAALAAANSALANAVVVRPFLSHQQVEILINLMQPRQLVFRPEVFWNHPIQRVIHNELEQYCRARSGRCLEIGAHPRSINDNPNVLHRCFLHPVGRDVQRWYTAPTRGPAANCRRSALRGLPPADRTYCFDGFAGCRFAAETGVALYSLHDLQPADVAEAMARHGMTRLYAAFHLPPEVLLPPGTYRTSSYLLIHDGKRAVVTYEGDTSAGYNHDVATLRTWIRTTKVVGEHPLVIERVRGIGCHFVLLITAAPEPSPMPYVPYPRSTEVYVRSIFGPGGSPSLFPTACAVKSTFHAVPTHIWDRLMLFGATLDDQAFCCSRLMTYLRGISYKVTVGALVANEGWNATEDALTAVITAAYLTICHQRYLRTQAISKGMRRLELEHAQKFISRLYSWLFEKSGRDYIPGRQLQFYAQCRRWLSAGFHLDPRTLVFDESVPCSCRTTIRRIAGKFCCFMKWLGQECSCFLQPAEGLAGDQGHDNEAYEGSDVDTAEPATLDITGSYIVDGRSLQTVYQALDLPADLVARAARLSATVTVTETSGRLDCQTMIGNKTFLTTFVDGARLEVNGPEQLNLSFDSQQCSMAAGPFCLTYAAVDGGLEVHFSTAGLESRVVFPPGNAPTAPPSEVTAFCSALYRHNRQSQRQSVIGSLWLHPEGLLGLFPPFSPGHEWRSANPFCGESTLYTRTWSTITDTPLTVGLISGHLDAAPHSGGPPATATGPAVGSSDSPDPDPLPDVTDGSRPSGARPAGPNPNGVPQRRLLHTYPDGAKIYVGSIFESECTWLVNASNAGHRPGGGLCHAFFQRYPDSFDATKFVMRDGLAAYTLTPRPIIHAVAPDYRLEHNPKRLEAAYRETCARRGTAAYPLLGAGIYQVPVSLSFDAWERNHRPFDELYLTELAARWFESNRPGQPTLNITEDTARAANLALELDSGSEVGRACAGCKVEPGVVRYQFTAGVPGSGKSKSVQQADVDVVVVPTRELRNAWRRRGFAAFTPHTAARVTSGRRVVIDEAPSLPPHLLLLHMQRAASVHLLGDPNQIPAIDFEHTGLIPAIRPELVPTSWWHVTHRCPADVCELVRGAYPKIQTTSKVLRSLFWGEPAVGQKLVFTQAAKAAHPGSITVHEAQGATFTTTTIIATADARGLIQSSRAHAIVALTRHTEKCVILDSPGLLREVGISDAIVNNFFLSGGEVGHQRPSVIPRGNPDRNVDVLAAFPPSCQISAFHQLAEELGHRPAPVAAVLPPCPELEQGLLYLPQELASCDSVVTFELTDIVHCRMAAPSQRKAVLSTLVGRYGRRTRLYDAGHTDVRASLARFIPTLGRVTATTCELFELVEAMVEKGQDGSAVLELDLCSRDVSRITFFQKDCNKFTTGETIAHGKVGQGIFRWSKTFCALFGPWFRAIEKAILSLLPQAVFYGDAYDDSVFSAAVAGASHAMVFENDFSEFDSTQNNFSLGLECAIMEECGMPQWLVRLYHAVRSAWILQAPKESLRGFWKKHSGEPGSLLWNTVWNMAIIAHCYEFRDLQVAAFKGDDSVVLCSEYRQSPGAGSLIAGCGLKLKADFRPIGLYAGVVVAPGLGALPDVVRFAGRLSEKNWGPDPERAEQLRLAVQDFLRRLTNVAQICVEVVSRVYGVSPGLVHNLIGMLQTIGDGKAHFTESVKPILDLTHSIMHRSE

ORF1

RNA replication protein

1658 amino acids

RNA replication. The central part of this protein possibly functions as an ATP-binding helicase (Probable).

Belongs to the potexvirus/carlavirus RNA replication protein family.

187.256 kDa

MATIRGAIDRITDTTVRTTLQEEACRQIRTELKNVEHVNRYAIPPDAADALEHLGIGTNPFSVKLHTHGACKAIENQLLYVVGTLLPKERVTMLFLKKAKLNFMKRCPKFQDIFLNQHIEPRDVSRYCDFNVQSTSTSIPTHTAYISDTLHFMDRKDLVRLFINSPNLDTLYATIVLPVEAAYRQPSRYPDLYQINYDFDGFQYIPGGHGGGAYHHEFSHLEWLDVGHIHWRGPDNKDIQLTITAQMIESLGANHLFCFRRGNLRTPRVRTFGRDTQVLLPKIFRPVDKNFNRAIPLTLANKMLLYAKSINTVTFRDVVAKTRQLMKDKELETYTGADLLHMANYFFVVGALSGVNSYDQMLGLSAWEACTMALKNTVTNLWERITGKREFGKLLEALEWETLTYSRQVTQKYVGGTPARLPLPDITDQEEIFAQQEALDALTSGATKITTHHLMSAAARRSTEGPTMPTPAAQVPPTQNPKHTIDEVASRALVTKLQKNKRVYIQDDGPEYIMGHMAEVPAWYLEQDETTTRLRNRCAWFFGPPTHRYGHNDIEYHTTEYYPWVERIGNIFGKFNTCLAQTHDQGARIGYHADDEDCYDKDVTVATVNLTGNATFSLKTATGTRTWKLKPGDFIVLKPGAQGCTKHAISDCTTNRTSLTFRWQARPCPSQLRRVVNLGNVNNPKRKSKAQQWTPKTSNSDSPRLTQTPNSPTPKDVPVVSPKLADATAPTIRAVPENGAHTNMACVELTDLPETTTTHRPGKEPINDLTDSEPETESEQTENLVLNRFIQDLPTTSTHAWASETDSICSFQAEALGPSSVEALPWHEHLELINSLGFTGLERQYGPDNNLIWPITHYRTLPKSRTIEAPTDLVELLDTIDRHPTDVPYSKTRASAFGSDVKNLRIGALVKNQDKQWRASLALLCEENEHVLPTTVIHGAGGSGKSHLLQQWVSSTERGNVVVILPTIELLRDWLNKCPTTPKDSFKTFEKALVQNSAPVVIMDDYSKLPPGYIEAYVALKGQCKLLVLTGDPRQSHYHEENPEALISTLDPATDYFSKYCTYNINATHRNATTFANALGVYSERKLPVSVTCSSYQKSGWPTLVPSILKKTALNDMGQRSLTYAGCQGLTTPKVQIVLDNATPLCSEQVMYTALSRAVDQIHFFNTGPNHSDYWEKMNATPFLKTFIDHTREENLKEHQPAEPTVREHTPATHFPPANEALALEPWVEPLTDKHSRELHHKALGHSNCVQTDNPVVQLFPHQQAKDETLFWKTIDARIKITTPEENVRNFNMASDIGDILFLNYKEAMCLPADPIPFQQSLWDSCQAEVQQTYLSKPLAALANAAQRQDPDFDSNKIQLFLKSQWVKKVEKLGCLKIKPGQTIASFMQQTVMLYGTMARYMRRIRISLCPSHIMINCETNPTQISSWVRENWDFSGQSHENDFEAFDQSQDANMLQFELIKAKFHSIPEEIIAGYKHLKCHAHIFLGTIAIMRLSGEGPTFDANTECSIAYNHTRYFVPKGCAQLYAGDDSACAAPLSEKPSFQHISPELSLKSKAKIRSQTKGDYATFCGWLITPKGFIKNPTQLYASWLLAKHNKDLQDVARNYALDLRIAYQLKDELYELLSPEELDHHQLLVREMVKHKMGHLLNLPEGFKQT

ORF1

Non-structural polyprotein 1AB

1638 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1AB family.

187.664 kDa

MAQAGRSGDAFASLDQRRERQEEQAQSGLDKVFYFQGVVELFNRMKIAYGRTPAWTALMKCNAIYLKDFKTAVGVEGTRYGLFFAEEVTKPTWSPDIGANLITLGEKACLDAQNAKYERLQASLKTTSGLVHQVMEKTREAKENLEKANKIQEQLDKVIESNKALHRKIQERNREKMQEYMVRLHNTQKDRDDWVQRCSRLEQENVTLQKRLKEKENALVSVGWDLLGWIVISVLVFGLISLADAQNLTPPAKIVITPGQAEFMDLAKLEKIQVRKYRLDSCELPPEKGCVLYKDYLTTRPVSFLELMAKCSKPDWVSESSYNETTLMEECIQIFGAEWCEGKLVDLVPRKCGEQHVLVNIIEQIEKTREVVTLIYGKVMSYRLDMWITSIFSLVLAGNKEKLFKMAPFIFVAWFLNIPVFLTCVAVNIFPVVSLPFILFQIFMPQFVLVNAFLLWLTLTLTAFYWSEGPKILMEISYALVYTIGFVLWSLGLAVGVTLKLTMVHQILMFCVVAAAICGTKFACTTITVQHPDGTTAKYTRVGKLKNNVVNQCKKVVTTLQTRGVIPATPAKTASIVIVEGKNGTGVGFRFMNYILTAEHVVQGSDIATLKNGSVSVKSKVIKTIPIFESVDNVAVLKLPPELNSVKPIKLAKKVQSDYLTLTAYDPNFQHAATFTGWCIIDGNWLNNSFDTKFGNSGAPYCDHDGRLVGIHLGTQGVLSQGIVIVDALKNTFQLADQCRPQNFDMDEFLEKVIAGTKVSHAAILKELEELREEVQFLKKKCVTYDDYWLCQTIFGQAKGKTKKTVRGRKHLVTKRALGKGHFMKMRMLTDEEYQNMIEKGFSAEEIREAVNALREQAWLNYCIDNDVDDEGEEDWYDDMVETDRVNQEIDEAIERAMEDRGEFYQKKSRLTFVEQAMMHLIQVSKERSQTAKLEVQKENEAQLVKMFERCVTDENTPEGTTSIAALSTEDDVRLVEGKVIDFTKAKNIPVDGEIRREIIPGTKCTEISTGPENKKNILKKKDTHIAEGKVETKSSQQPVDVKDDKPVALEQRKPRACKWCGSSQKHDYRECRFQREKRFCVYCAAMHSMFEGHIRPIECTSCKKSFSGIEKLEDHVVSGECQKKLIEGPVTTKAPTPVPDWLKIFAWEDDILPPEGKTALPENVTLIGHIPVDKLVSRTKKVQDPLLGLVTPWKQDMYDSTTWTVKAYTKMFEKFHYHDPVDFVEQYAEFVLLCDNMVLREHDYMANSNITPIMSTEKNVNSTPAYPKFQAYDSEAEYLEDCGWQEYLDVVSDPETINRRPLWWCFLKNEVLKREKIEDSDIRMILCTDPIFTRIGAMFEQDQNNRMKQQTEIRSAQVGWTPFFGGLDRRVRRLYGDGDRYFVEMDWTRYDGTIPKSLFWRIRQIRFFFLHDSHKTPKMRRLYNWYVKNLLEKIILLPTGEVCQVKKGNPSGQFSTTVDNNMINVWLTTFEVSYLFFKQRGRLPTEKELQENCSMICYGDDRLLSIRKGFVEYEPDTVIDMYKNIFGMWVKRNNIKIQDTPEGLSFCGLTIVKSSTGAYVGVPNVNKILSTLENPVRRLPDVESLWGKLVSLRILCENAPSNVKHFLDEQISNVEEFAARENIQLPEVGPDFYSRIW

ORF1

Non-structural polyprotein 1AB

1611 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1AB family.

183.203 kDa

MAAAAASALGASAPKALAPADGPIVAGLDKLVNLEGVHDLFEAMRGAYGEDPAWKGLMSCDVVYLKDITTAIGVKDTSVGIFRKFSDGCSWCPTGAECFLSMKDLAYMKAQSAKAQRLTASLATTSNLIARAMRAESELKRARDEERKVDARYKDILEHSLAARKALQKELDETRERELHLLKELGKRSSIRTKAFSFFDWLFMAVVFFLFLHYTSAECVKPDFGCLVVNSNLPVPSLTFHDVMARCYNTFGNIVLSSQIDAARLREECEQSANKFLGTHIGDPAHKVWCENRLETLIPVECDSSEFLEIFTSNLNAFMVSVSQFYKTISYYKLDALVTFAFSAALATNKLKMVMVLPLLLVALYLNVPPITVTIASVIFQPLILPFVGFQLVFPNFLPYNLFVAWVWMVCQAFFSSDGVKLLVSVSTALVQVVFLAVWSISVIVLQQLSIPMVAQILLFVATLTVSVGVKFANSTITVVHPDGNTEKVSRVTLVRQSMAKRISQIKQSLTIRGVIPSGPNRFDSIVVVEGQGGSGVGWRFMNSIFTAGHVVQGSKFVTIKSESTQVKVKVKRVIDLFECVDTLVEIPLTKEFQHIKPLRLAKKVEDSYLQLCAFKPDMVEKASYQGWCTIDSGFIFNSFNTQFGNSGAPYVDSDGRLVGMHLGSQGVISQGVVLVDTLKTQFLAQQSQIDDQLMERIIEGTKVSHAAILTELDRMRTKVEEVALVSARVNQLESQLKDLYEFSSNSIKCLSDDIEKMVCAQLFDEINLQSVMEKISALPPTEKLAKLVEVFVEQKKKGKTKRTARGGKHALGKKYLSKAHFSRMRMLTEEEYNKMVEDGFSPDEIKEVVDQLREQAWQNYLIDNDIGEDDDLDWYDDMLEDERLNEEIDRRVEAALEDRGELAYQKIRRTFVDQALIHLITLKKGNWQTTKVECQPEREEAYKEQFQKAVKQEDLTEGTSYAIYSAGDATILIENKEIDHTEIKPVTTGAKTVQEYPKDARTTVATFDDNKKDIVKTKRTTEIVLEQRKKTCRTCGETRPHNHKMCRDRHTRRFCFWCGVVHSDVEGHSRDLKCPKCSAGFANLREMEQHAVTTCSKKLDSHPEPSRVFQPLDFGLGIFDWRFDLQPIRHHVAVPMNVEVLGYIPVDRLVERRNVITDPLLKLVEPWRQETYGPAVWTIKAYNKMFEKFFYSEPLEFAQLDSSILNLADSYCLQEHDYMSGSQIVPITSTEKNLDSTPGYPKFKVFSTEREYLSTCGWDEYKTVWQVGPREKPLWWCFLKTEVLKLAKIEQDDIRMILCTDPVFTRIGAAFEQHQNSLMKLETENHHAQVGWSPFFGGIHRRATRLYGEHRYYVELDWTRFDGTIPPELFRRIKLMRFFLLDPKYKTPENRDRYNWYVENLIDKVVLLPTGEVCKIYGGNPSGQFSTTVDNNFVNVWLTVFELAYLFYKEHNRLPTICEIKKHTDWICYGDDRLLAVDKRFINSYDTAAVIAMYKDVFGMWVKPDNIKVFPSLEGVSFCGMVWTKRKGQYVGKPNVDKILSTLSDPVSRLPDIQSLWGKLVSLRLLCENESDEVVDYLDKQIESVSRHAKEAGIALPKIGPDFYAEIWID

ORF1

Non-structural polyprotein pORF1

1531 amino acids

Helicase region exhibits NTPase and RNA unwinding activities.

Belongs to the hepevirus non-structural polyprotein family.

168.04 kDa

MDVSQFAESKGVKTALEAAALAAANTALRNARVVTPYLTQQQTKNLLELFRGAQLRFEPRDNWAHPVQRVVHDALEQYVRRAAGPNCLEVGAHPRSINRHQASHRCFLPPVGRDEQRWQVAPRRGLCNLIRRALLNGVKVAREFCQLGFGACSHQCEVGIALYSLHDMRPADVACAMARHNMRTMYVVLHLPEEAMLPPGSYSNKFYNTVNTADKCIITYADDSCAGYVHKREVLQDWITTTGVSGRHPMLIERVRAIGCHFVLLCTATQPCPMPYTPYPSSNTVYVRNVYGPALGAGLFTPKCCVDATFYPVPRRVWQRLMMFGTTLDDDAFCCSRLLTYLRGISTKVTVGNIVANEGWQPEEQQLTAVAIAAYLTVCHQRWVRTQGIARGVRRLQAEHAQQFWFKVWELFTNTGTVPGYSAGFYRQLATWISGGLTIDFERRVFDKRVKCGCCCVCERRPADPGCLCIDDFPDGANGLVKLKKWPIRAGTKSAVSKWAQVRVRADSTEDLIDLSVPKLLTLKELAAAAIRKQPSAPPSLHILDRRPVGDPRRPVNCAPPAVSAGPVPAPPGNPVIESVQGSGAGGPEVSESQPGLTPTREVTNMPLPPQRGQEEVLAVLPSGARVIVGNLLDVAADWLVNPANRDHQPGGGLCGMFHRRWPHLWPVCGEVQDLPTGPVIFQQGPPKVIHAPGPDYRIKPDPDGLRRVYAVVHQAHGTVASPLISAGIYRAPARESFEAWAATARDGDLLVVQRSMAQHIRDFVLNEGRHRPRELHVDRAMADMVNYGLATEPEPYNELVKGVEVAPMTVKYALIAGVPGSGKSSSVDHRGAVVITPTKTLAREWSARGATAVTPHVAASAAPEGRVIVDEAYAIPPHLLVASLRRARDVVMLGDPHQIPALDFDGRCLTSAVDLGLQPTSWRTVSHRCPWDVCIFLRTDYPTITTTSRVLRSVVFTGETIGQKIVFTQVAKQSNPGSITVHEAQGSTFDQTTIIATLDARGLIASSRAHAIVALTRHRERCSVIDVGGVLVEIGVTDAMFNNIEMQLVRPDAAAPAGVLRAPDDTVDGLLDIPPAHTDVAAVLTAEAIGHAPLELAAINPPGPVLEQGLLYMPARLDGRDEVVKLQLSDTVHCRLAAPTSRLAVINTLVGRYGKATKLPEVEYDLMDTIAQFWHHIGPINPSTLEYAEMCEAMLSKGQDGSLIVHLDLQDADCSRITFFQKDCAKFTLDDPVAHGKVGQGISAWPKTLCALFGPWFRAIEKHLVAGLPPGYYYGDLYTEADLHRSVLCAPAGHLVFENDFSEFDSTQNNVSLDLECELMRRFGMPDWMVALYHLVRSYWLLVAPKEALRGCWKKHSGEPGTLLWNTVWNMTVLHHVYEFDRPSVLCFKGDDSVVVCESVRARPEGVSLVADCGLKMKDKTGPCGAFSNLLIFPGAGVVCDLLRQWGRLTDKNWGPDIQRMQDLEQACKDFVARVVTQGKEMLTIQLVAGYYGVEVGMVEVVWGALKACAAARETLVTNRLPVLNLSKED

ORF1

Non-structural polyprotein 1AB

1512 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1AB family.

171.273 kDa

MASAGPTGAGARPPKAFTAQAGLAKLVNPAGLNSILARGKEKFGGTQAWKELMGCDVIFARSISHWYGIKGTTYYELTVALGQPLYKPVTDPELTEEEKAVMTAVQSRFAQSNSSVVLTRTLLNKTCELKDRIRELTDELGQTEVHLAREKVKAAALKLENRKLFVENQELKDQLEKERTKHGWKGLKTLCLWIFLATLIGGYITGSNAACTLVDVPSPMKVGYDTFKQMCIHKDSYLPDGAFDKESLALECSKQMDYMDCKEVITDSISGKTSFAGMLRDVFRVDEIVTAIRTVVRFAMDFSLAYPICVMFVLILTRNKKHAIISACCALVAKCCGLRLLPFTLVLTYAPSETAIAGCIYGLGYISIPLVTFLHWVGLVLKAILVPDDCYIGTRVSHALAWSIMLPMWIITQELMAFTEFPLELQIVTTVVVCTAGFGFRYLTGTVTITEPDGTVKKYKRIFNAKSAIGTISTVFFEKAKAIRGVIPSFPSKADNIVKIEVDVDGGSAGVGFRLGNYIYTAGHVVGEAKIAKITWKGLTSQAKVLGHIELPLFTDTLARLEIPKPFQQLPVFRLAKSSENDYVQMVCFDNQLQNVVTFSGWANIDGDYLNAPFETYAGTSGSPIINRDGRMLGVHFGSNAVVSQGFVITRLFATEPAVKQCKSDEDLADEIVRKVMGGIRISFASLTSELEKQRDELNALKQMVNDLIDTDLVALEKKKGKTKRTVRGQKHKTKAISKAAFMKTKVLTEEEYRRLEEEGFTKDEIKDIVDNLREQAWLDYQNQLDEEGDDDWYEQMEEDQRINDQIDQNIERDLEDRGEWYGQRKITFKQRAMLRFIQLGRQQQVATVSFPDGYEDRAEELYNKVVTTEDLPEGETSEAALSLPNKIVHQAGKRLNFKHVKIHPDKTFMKSGVTQIEEKPEGDIILKAKTTTLAPKEEPVIQQVEQQPQVEQQQQPQQPVVEEKKRTPPPKPQRKPKTGAKAKCLDCGETFVERQDFHVCKSKKLNEPPSGGYTPVPDHLRWNNWQIYMEPLDLRITVPENYPILGHIAIDKLVERKKKVNDPLLKMLEQPKCEGFTSTTWTRKAYTKSFEKFDYGDAVDFVQDYPELTAFADAAVLAEVGYMEGTHVIPIQETSKNMDSTPAFPKMLDFDSERDYLEAHGMKEYIDTQLGVQSGKPLWWCFLKNEILKEKKVSEDDIRIITCSDPVITRLGASFDSEQNERMKERTETHHAQVGWTPFFGGLDKRVRRITSCGRTQVLELDWTRFDGTIPVQLFQRMRELRKFFLTRRSRRRYGKLLDWYNAQLTDRITLLPTGEVTHVKKGNPSGQFSTTVDNNLVNEWLTAFEFGYQHLENHGIIPTVRDYRANVDFLCYGDDRLLAFNPSFVNYDPQVTIDMYKNIFGMWVKPENIKLFDSPTGSSFCGFTLVKPHGQWVGVVNVNKLLQSLKTPTRRLPDLESLWGKLVSLKIMCYHSDPEAVSYLSNQIRRVEEYARAEGIELPEVGPDFYRKIW

ORF1

Non-structural polyprotein 1AB

1436 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1AB family.

163.874 kDa

MAYGEPYYSSKPDKDFNFGSTMARRQMTPTMVTKLPKFVRNSPQAYDWIVRGLIFPTIGKTYFQRVVVITGGLEDGTYGSFAFDGKEWVGIYPIEHLNLMSSLKLIHKANALQERLRLSQEEKATLALDVQFLQHENVRLKEMIPKPEPRKIQMKWIIMGAVLTFLSLIPGGYAHSQTNNTIFTDMIAACKYSTETLTENLDLRIKLALANITISDKLDAVRQILNFAFVPRAHWLRTVFYYIHYYEMWNIFMFVLAIGTVMRSARPGTDLVTLATSHLSGFRMAVLPTIPFHTTMTLWVMNTLMVCYYFDNLLAITLAILAPILGIIFLCFMEDSNYVSQIRGLIATAVLIAGGHACLTLTGTTTSLFVVILTCRFIRMATVFIGTRFEIRDANGKVVATVPTRIKNVAFDFFQKLKQSGVRVGVNEFVVIKPGALCVIDTPEGKGTGFFSGNDIVTAAHVVGNNTFVNVCYEGLMYEAKVRYMPEKDIAFLTCPGDLHPTARLKLSKNPDYSCVTVMAYVNEDLVVSTAAAMVHGNTLSYAVRTQDGMSGAPVCDKYGRVLAVHQTNTGYTGGAVIIDPADFHPVKAPSQVELLKEEIERLKAQLNSATENATTVVTQQPSAALEQKSVSDSDVVDLVRTAMEREMKVLRDEINGILAPFLQKKKGKTKHGRGRVRRNLRKGVKLLTEEEYRELLEKGLDRETFLDLIDRIIGERSGYPDYDDEDYYDEDDDGWGMVGDDVEFDYTEVINFDQAKPIPAPRTTKQKICPEPEVESQPLDLSQKKEKQSEYEQQVVKSTKPQQLEHEQQVVKPIKPQKSEPQPYSQTYGKAPIWESYDFDWDEDDAKFILPAPHRLTKADEIVLGSKIVKLRTIIETAIKTQNYSALPEAVFELDKAAYEAGLEGFLQRVKSKNKAPEKQGPKKLQRAPEDQGAQNYHSLDAWKLLLEPPRERRCVPANFPLLGHLPINRPIFDDKKPRDDLLGLLPEPTWHAFEEYGPTTWGPQAFIKSFDKFFYAEPIDFFSEYPQLCAFADWATYREFRYLEDTRVIHITATEKNTDSTPAYPKMNYFDTEENYLEAHGWAPYIREFTRVYKGDKPEVLWYLFLKKEIIKEEKIRNSDIRQIVCADPIYTRIGACLEAHQNALMKQHTDTSVGQCGWSPMEGGFKKTMQRLVNKGNKHFIEFDWTRYDGTIPPALFKHIKEIRWNFINKDQREKYRHVHEWYVNNLLNRHVLLPSGEVTLQTRGNPSGQFSTTMDNNMVNFWLQAFEFAYFNGPDRDLWKTYDTVVYGDDRLSTTPSVPDDYEERVITMYRDIFGMWVKPGKVICRDSIVGLSFCGFTVNENLEPVPTSPEKLMASLLKPYKILPDLESLHGKLLCYQLLAAFMAEDHPFKVYVEHCLSRTAKQLRDSGLPARLTEEQLHRIWRGGPKKCDG

ORF1

Non-structural polyprotein 1AB

1417 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1AB family.

161.559 kDa

MMALGEPYYSSKPDKDFNFGSTMARRQMTPTMVTKLPKFVRNSPQAYDWIVRGLIFPTTGKTYFQRVVVITGGLEDGTYGSYAFNGSEWVEIYPIEHLNLMSSLKLIHKANALQERLRLSQEEKATLALDVQFLQHENVRLKELIPKPEPRKIQMKWIIVGAVLTFLSLIPGGYAQSQTNNTIFTDMIAACKYSTETLTENLDLRIKLALANITINDKLDAVRQILNFAFVPRAHWLRTVFYYIHYYEMWNIFMFVLAIGTVMRSARPGTDLITLATSHLSGFRMAVLPTIPFHTTMTLWVMNTLMVCYYFDNLLAITMAILAPILGIIFLCFMEDSNYVSQIRGLIATAVLIAGGHACLTLTGTTTSLFVVILTCRFIRMATVFIGTRFEIRDANGKVVATVPTRIKNVAFDFFQKLKQSGVRVGVNDFVVIKPGALCIIDTPEGKGTGFFSGNDIVTAAHVVGNNTFVSVCYEGLVYEAKVRYMPEKDIAFITCPGDLHPTARLKLSKNPDYSCVTVMAYVNEDLVVSTATAMVHGNTLSYAVRTQDGMSGAPVCDKYGRVLAVHQTNTGYTGGAVIIDPADFHPVKAPSQVELLKEEIERLKAQLNSAAENPVTVVTQQPIVTLEQKSVSDSDVVDLVRTAMEREMKVLRDEINGILAPFLQKKKGKTKHGRGRVRRNLRKGVKLLTEEEYRELLEKGLDRETFLDLIDRIIGERSGYPDYDDEDYYDEDDDGWGMVGDDVEFDYTEVINFDQAKPTPAPRTTKPKPCPEPKIEAQPLDLSQKKEKQPEHEQQVAKPTKPQKIEPQPYSQTYGKAPIWESYDFDWDEDDAKFILPAPHRLTKADEIVLGSKIVKLRTIIETAIKTQNYSALPEAVFELDKAAYEAGLEGFLQRVKSKKQGPKKLQRAPEDQGAQNYHSLDAWKSLLEPPRERRCVPANFPLLGHLPINRPIFDDKKPRDDLLGLLPEPTWHAFEEYGPTTWGPQAFVKSFDKFFYAEPIDFFSEYPQLCAFADWATYREFRYLEDTRVIHITATEKNTDSTPAYPKMNYFDTEEDYLEAHGWAPYIREFTRVFKGDKPEVLWYLFLKKEIIKEEKIRNSDIRQIVCADPIYTRIGACLEAHQNALMKQHTDTSVGQCGWSPMEGGFKKTMQRLVNKGNKHFIEFDWTRYDGTIPPALFKHIKEIRWNFINKDQREKYRHVHEWYVDNLLNRHVLLPSGEVTLQTRGNPSGQFSTPMDNNMVNFWLQAFEFAYFNGPDKDLWKTYDTVVYGDDRLSTTPSVPDNYEERVITMYRDIFGMWVKPGKVICRDSIVGLSFCGFTVNENLEPVPTSPEKLMASLLKPYKILPDLESLHGKLLCYQLLAAFMAEDHPFKVYVEHCLSRTAKQLRDSGLPARLTEEQLHRIWRGGPKKCDG

ORF1

Non-structural polyprotein 1AB

1416 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1AB family.

161.728 kDa

MAHGEPYYSSKPDKDFNFGSTMARRQMTPTMVTKLPKFVRNSPQVYDWIVRGLIFPTTGKTYFQRVVVITGGFEDGTYGSFAFDGREWVEIYPIEHLNLMSSLKLIHKANALQERLRLSQEEKATLTLDVQFLQHENVRLKELISKPEPRKIQMKWIIVGAVLTFLSLIPGGYAQSQTNNTIFTDVIAACKYSTETLTENLDLRIKLALANITISDKLDAVRQILNFAFVPRSHWLRTVFYYIHYYEMWNIFMFVLAIGTVMRSTRPGTDLITLATSHLSGFRMAVLPTIPFHTTMTLWVMNTLMVCYYFDNLLAITMAILAPILGIIFLCFMEDSNYVSQIRGLIATAVLIAGGHACLTLTGTTTSLFVVILTCRFVRMATIFIGTRFEIRDANGKVVATVPTRIKNAAFDFFQRLKQSGVRVGVNEFVVIKPGALCVIDTPEGKGTGFFSGNDIVTAAHVVGNNTFVNVCYEGLMYEAKVRYMPEKDIAFITCPGDLHPTARLKLSKNPDYSCVTVMAYVNEDLVVSTAAAMVHGNTLSYAVRTQDGMSGAPVCDKYGRVLAVHQTNTGYTGGAVIIDPADFHPVKAPSQVELLKEEIERLKAQLNSAAENPSTVITQQPTATLEQKSVNDSDVVDLVRTAMEREMKILRDEINGILAPFLQKKKGKTKHGRGRVRRNLRKGVKLLTEEEYRELLEKGLDRETFLDLIDRIIGERSGYPDYDDEDYYDEDDDGWGMVGDDVEFDYTEVINFDQAKPTPAPRTTKPKPCPEPEAETQPLDLSQKKDKQLEHEQQVVKPTKPQKNDPQPYSQTYGKAPIWESYDFDWDEDDAKFILPAPPRLTKADEIVLGSKIVKLRTIIETAIKTQNYSALPEAVFELDKAAYEAGLEGFLQRVKSKNKAPKKLQRAPEDQGAQNYHSLDAWKSLLEPPRERRCVPANFPLLGHLPIDRPIFDDKKPRDDLLGLLPEPTWHAFEEYGPTTWGPQAFIKSFDKFFYAEPIDFFSEYPQLCAFADWATYREFRYLEDTRVIHITATEKNTDSTPAYPKMNYFDTEEKYLESYGWAPYIREFTRVFKGDKPEVLWYLFLKKEIIKEEKIRNSDIRQIVCADPIYTRIGACLEAHQNALMKQHTETSVGQCGWSPMEGGFKKTMQRLVNKGNKYFIEFDWTRYDGTIPPSLFRHIKEIRWNFINKDQREKYRHVHEWYVDNLLNRHVLLPSGEVTLQTRGNPSGQFSTTMDNNMINFWLQAFEFAYFNGPNKDLWKTYDTVVYGDDRLSTTPSVPENYEERVIDMYRDIFGMWVKPGKVICRESIVGLSFCGFTVNADLEPVPTSPEKLMASLLKPYKILPDLESLHGKLLCYQLLAAFMAEDHPFKVYVEHCLSRTAKQLRDSGLPARLTEEQLHRIWRGGPKKCDG

ORF1

Non-structural polyprotein 1AB

1415 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1AB family.

161.278 kDa

MAHGEPYYSSKPDKDFNFGSTMARRQMTPTMVAKLPNFVRNSPQAYDWIVRGLIFPTTGKTYFQRVVVITGGLEDGTYGSFVFDGREWVEIYPIEHLNLMSSLKLIHKANALQERLRLSQEEKATLALDVQFLQHENVRLKELIPKPEPRKIQMKWIIVGAVLTFLSLIPGGYAQSQINNTIFTDMIAACKYSTETLTENLDLRIKLALANITISDKLDAVRQILNFAFVPRAHWLRTVFYYIHYYEMWNIFMFVLAIGTVMRSARPGTDLITLATSHLSGFRMAVLPTIPFHTTMTLWVMNTLMVCYYFDNLLAITLAILAPILGIIFLCFMEDSNYVSQIRGLIATAVLIAGGHACLTLTGTTTSLFVVILTCRFIRMATVFIGTRFEIRDANGKVVATVPTRIKNVAFDFFQKLKQSGVRVGVNEFVVIKPGALCVIDTPEGKGTGFFSGNDIVTAAHAVGNNTFVNVCYEGLMYEAKVRYMPEKDIAFITCPGDLHPTARLKLSKNPDYSCVTVMAYVNEDLVVSTAAAMVHGNTLSYAVRTQDGMSGAPVCDKYGRVLAVHQTNTGYTGGAVIIDPTDFHPVKAPSRVELLKEEIERLKAQLNSAAENPATAVTQQPVVTLEQKSVSDSDVVDLVRTAMEREMKVLRDEINGILAPFLQKKKGKTKHGRGRVRRNLRKGVKLLTEEEYRELLEKGLDRETFLDLIDRIIGERSGYPDYDDEDYYDEDDDGWGVVGDDVEFDYTEVINFDQAKPTPAPRTVKPKTCPEPEAETQPLDLSQKKEKQLEHEQQVVKSTKPQKNEPQPYSQTYGKAPIWESYDFDWDEDDAKFILPAPHRLTKADEIVLGSKIVKLRTIIETAIKTQNYSALPEAVFELDKAAYEAGLEGFLQRVKSKKGSKKLQRAPEDQGAQNYHSLDAWKSLLEPPRERRCVPANFPLLGHLPINRPIFDDKKPRDDLLGLLPEPTWHAFEEYGPTTWGPQAFIKSFDKFFYAEPIDFFSEYPQLCAFADWATYREFRYLEDTRVIHITATEKNTDSTPAYPKMNYFDTEENYLEAHGWAPYIREFTRVFKGDKPEVLWYLFLKKEIIKEEKIRNSDIRQIVCADPIYTRIGACLEAHQNALMKQHTDTSVGQCGWSPMEGGFKKTMQRLVNKGNKHFIEFDWTRYDGTIPPALFKHIKEIRWNFINKDQREKYKHVHEWYVDNLLNRHVLLPSGEVTLQTRGNPSGQFSTTMDNNMVNFWSQAFEFAYFNGPDKDLWKTYDTVVYGDDRLSTTPSVPDDYEERVINMYRDIFGMWVKPGKVICRDSIVGLSFCGFTVNENLEPVPTSPEKLMASLLKPYKILPDLESLHGKLLCYQLLAAFMAEDHPFKVYVEHCLSRTAKQLRDSGLPARLTEEQLHRIWRGGPKKCDG

ORF1

Non-structural polyprotein 1AB

1381 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1AB family.

156.954 kDa

MANNTTSALHPRGSGQRCVYDTVLRFGDPDARRRGFQLDEVSHNKLCDIFDSGPLHFAFGDLKVMKVAGGVVTPHKTVVKTVYVSGVQEGNDYVTFAFTPGPNEWREVDPRIDKRTALVGVLVQEHKKLDSDLKESRRELSQLKLEHSLLRHDYERLVREKPGPAMRTFKFSAVIFYAFFLGFLLMSAVKGEVYGRCLDSELNLNGNPEVCLHWEEVKSFSLQVALADFWNMTLDYYATVAPQSPLMDLALGYFPYFANWHMAAFLVGTAHVVAAERPLYMLVTLVLATLSRFQLVALAAVPMLDMPSSIGLWVTMVLFAIDQAFAILASVLISVLLLILCLAMNDVDYGALLRGCVTLVSATVFSHLVSFLHAPGWFTIIAILIYRIPKVLSYVSAERVDIKGPDGKIKETQNANPSWITKMSGLKNFFQRAFRQKVRTGVNPTTRIIPNSLVVIDAKDGRGTGFRVRNYLVTAGHVVGADTTVRVRWADVTSFAHVVYRVPNKDIVLLTLPAEYNSLHSYKLAKEVVDGTVVVVSNGDGGALSVGISEGVIVGESMTYAINTADGMSGSPLTTTDGRLIGVHQQNTGFTGGAVIFRDTDFPQPKKPQREADLEAKVAELEKALAAYTQSATGEDIVGLVRVAIQREMEVLRKELSNEFGQAKGKTKHKRRIMAAARSGGKRKPGKVWTEEEYKKLLEEGFTRDQLREMAEAAREADDDFDDYEEEKNEVDYPVWSDHDSDEEIDRDWFGQNLPTWSSAWSDFEPELDPDVTKTLPCHLEDKFSLKHYIITEADLKHFGQEMKEYMDHLDAVIKTHTEKGKWCPNTNTEEILKDLNAMWFKLNHTMWKNGVAPFMQRKKQKPKKREEGPERGPINPDEMRLDHWEKMMAPPDAGRRLVPDDYPVIGKLPINRPISDWDEPVDDLLNLLPPAPDSSAYGPAVWGPEAYVKSFEKFTYAKPRDSIKRDFPREWKFACQVLRREFDFLEGSVIMDITATSKNADSTCAYPKCNYWKTEAEYLSERGYQDYVSEYKRIHGGARPKVLWLLFLKKEILKVKKINDSDIRQIVCADPIFARIGNAFEEHQNTLMKHRTATRMPQCGWTPFFNGFKRRIERLLSRKNSVFIEFDWTRYDGTIPREIFAKIKSFRFSCLAEEFQTDANRAMYQWYCDSLLDRYVLMPSGEVTRQTKGNPSGQISTTMDNNLCNVFFQAFEYAYIHPEKSIEELRESWDRCDSLIYGDDRLTTFDHVPPDYVDRVVHMYKDVFGMWVKPEKVIVSDTPVGLSFCGFTVGPDLMPVPTDCDKLVASLVTPTKKLQDIVALYSKVLCYRILGHNLSDEHEFKRYVRVALEVLARHIRNLGGEEPVHVTERLLDKLWRGGPK

ORF1

Non-structural polyprotein 1AB

1351 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1AB family.

154.74 kDa

MNVYDKVLQFGSKKARARGMALNKLSRNRLEDIYAGSGPLVFGFGPIDMVDPGSLNPSIKTLDTVYVAAVQPDNQYVVHHFVPGRNEWVETDASTHQPTALVGVLVQDHKAKTREVEDLKSQLSQLRMEHEILRHEYERLKLKSPIVKPFKPLKVLLFSLLLGLLFAGVTNGARTGTCYAYDEEKDTCLYWEWKDSREVAWYDSYVTEALAIYNRACVYVRSKEFMTYLSLVFQTVFNWYFCATALAVYYMARAENPIVMFVTLALATLSQFQLLAVAVLPLLDFSATMGLWLSMVVFYMSQQISILVSFCVLVLSVMIGTFMADSEYAMMIKGHAVVFAIVCYSHVAMILNIPPWVVSLTMVCYRLWRVCFVFPAERLEIRSADGKVLHTVPTHPNWTAKVTRFVQSLRKGLRTSVAPTARIVPDGIAIVEAREGVGTCFRVKNNLVTSKHVVGSDDAVKIRWGAQEDMARVTYRHPTKDIALMALPTNLQTMPAYKFAKAITDGPIVMTAFDEANLLLVAVTEGVRVEDHMTYSVATRNGMSGAPITTVDGRVIAVHQTNTGFTGGAVIFVPEDIPEVRKISKREQELEDRVKQLEGMLNMDQAYVDSNLIVDLVREAVQREMKVLRTELANLGGFSQKKKGKNKSTKRKRKAVWTEEEYKAMLEKGFTRDQLRIMADAIRDQYYDDEDEQSEEEAGYPDWSDPGDSTDIENEWFGYEQSWKELEPAKSGVVVNTLPKDLVFKYSLDNYPISKQDIQAVAKELKIYEKAISDIISTSVSTDGKWKDDVDAQKILQELDGLWWGINHTLWEHGLMPFTQRRKRVQQPKKLQRGPEDPGPEECKLDYWEQLVEPSKEKFLVPPEYPLLGVVPLDRPISDFDAPVDNLLALLPEPESPDLGFEPAVWGPEAYVKSFEKFDFADPDPNIEKNYPREWAFANLVLHREFDFLADSVVKDITATSKNSESTPGFPKTYWWKTEAEYLAKRGYADYVSEWNRIRGGARPNVLWYLFLKKEILKSTKVRDADIRQIICSDPIFARIGCCFEEDQNERMKRRTKTRMPQCGWSPFFGGFNDRIQRLVAKGNPYWIEFDWTRYDGTIPSQIFKHIKNFRFSMLAKEYQTPELRNMYHWYVDNILRRYVCMPSGEITIQHKGNPSGQVSTTMDNNLVNVFLQAFEYAYLHPEKSMDELRKDWESYDSLIYGDDRLTTSPSVPNDYVTRVVAMYKDIFGMWVKPEKVKVSHSPVGLSFCGFVITHQDGQYLPVPAEEAKLLASLLRPTKKLENMDALYGKLLCYRILNHNLPNDNKFRNYILVALEVMARHYSSRGEEPPFYVTESMLDKLWRGGPKFDYG

ORF1

Genome polyprotein

1214 amino acids

Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).

135.088 kDa

single

NKGKTFTSKYVIMTSNTETPVKPTSRRAGAFYRRVMIVDVTNNAVEKWKSDNPGKAVPKWCFNKDFSHLSLSLRGTEAYCKEYVLDPTGRNHQSRRAPPPQQVTLEQLAQKMVVQHTTNTSEFVTQAGDVPVFGFVCQNNEIDTVYNLLAAVKARYGANFNLYKGMVRTAHENSGCGAHVHVISREDNFRGKVFTVSRSRLESVPHLEGDSFRRSLGVVMSDKDVTTMFYYIKGKVINDQVNLTELPANQHVVTVHTVYDMAWALRRHLKWSGQWQLIKAAFEIMCYPDAAACALRNWMDSTDFSEEHVVTQFIAPGGTIILESCHGARMWATGKRLIRAGGITEAGGPQGGVRFAGLGARNVPWSEILREFMTLISHIWSQIKGATVVLTALTFYLKRFRPRIEAKGKNKNKGARKNTGVALTDDEYDEWRQYRTEKNLDLTVEDFLQLRHRAAMGADDSDAVKFRCWYSERQRNYHDLEDVTIIGRGGVKRELIRKGPLRPRGNDYYDEPDDWYSEGVIDGVAHKNAIVSVDDVDGMHKGYAIHIGHGVYISLKHVVSGNARILSEEPKNLTFTGELATFRLNNILPTAVPVGTSKPIKDPWGNPVSTDWQFKNYNTTSGNIYGACGSSCSLTRQGDCGLPYVDDHGVVVGLHAGSGGDKCPSRKLIVPYAKVDMRVRDTCTKQCYKDNSPTISYKGLLVKETGEPRTIMKGTRLHVSPAHTDDYEECTHQPASLGAGDPRCPISLTGIMVNNLQPYTEASPGPDTATLNRVSKMLTSHMEGYVQKSQTEEGYGSAFYMLNHDTSCGPYIGGRKKDHVKDGVLDKNLLDLLSSKWNRAKLGLALPHEYALGLKDELRPKDKVAVGKRRLIWGCDVGVSTVCRAAFKRVSESIMANHALGFIQVGINMDGPAVEDLFKRLERPKHDRYCVDYSKWDSTQPPKVTSQSIDILRHFTDKSPIVDSACATLKSNPIGIFNGVAFKVAGGLPSGMPLTSIINSLNHCLMVGSAVVKALEDSGVQVSWNIFDSMDLFTYGDDGVYIVPPLISSVMPNVFANLKQFGLKPTRTDKSDAEITPIPADEPVEFLKRTIVRTENGIRALLDRSSIIRQFYYIKAENTENWTIPPKKIDTPSRGQQLYNACLYASQHGEEFYTNKIIPLVQRAIEFEGLHIEVPEFHHAVAAYNGYFNGTEGQPNQIAFASGGLGLSSEVFEN

ORF1

Non-structural polyprotein 1A

1125 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1A family.

127.666 kDa

MAQAGRSGDAFASLDQRRERQEEQAQSGLDKVFYFQGVVELFNRMKIAYGRTPAWTALMKCNAIYLKDFKTAVGVEGTRYGLFFAEEVTKPTWSPDIGANLITLGEKACLDAQNAKYERLQASLKTTSGLVHQVMEKTREAKENLEKANKIQEQLDKVIESNKALHRKIQERNREKMQEYMVRLHNTQKDRDDWVQRCSRLEQENVTLQKRLKEKENALVSVGWDLLGWIVISVLVFGLISLADAQNLTPPAKIVITPGQAEFMDLAKLEKIQVRKYRLDSCELPPEKGCVLYKDYLTTRPVSFLELMAKCSKPDWVSESSYNETTLMEECIQIFGAEWCEGKLVDLVPRKCGEQHVLVNIIEQIEKTREVVTLIYGKVMSYRLDMWITSIFSLVLAGNKEKLFKMAPFIFVAWFLNIPVFLTCVAVNIFPVVSLPFILFQIFMPQFVLVNAFLLWLTLTLTAFYWSEGPKILMEISYALVYTIGFVLWSLGLAVGVTLKLTMVHQILMFCVVAAAICGTKFACTTITVQHPDGTTAKYTRVGKLKNNVVNQCKKVVTTLQTRGVIPATPAKTASIVIVEGKNGTGVGFRFMNYILTAEHVVQGSDIATLKNGSVSVKSKVIKTIPIFESVDNVAVLKLPPELNSVKPIKLAKKVQSDYLTLTAYDPNFQHAATFTGWCIIDGNWLNNSFDTKFGNSGAPYCDHDGRLVGIHLGTQGVLSQGIVIVDALKNTFQLADQCRPQNFDMDEFLEKVIAGTKVSHAAILKELEELREEVQFLKKKCVTYDDYWLCQTIFGQAKGKTKKTVRGRKHLVTKRALGKGHFMKMRMLTDEEYQNMIEKGFSAEEIREAVNALREQAWLNYCIDNDVDDEGEEDWYDDMVETDRVNQEIDEAIERAMEDRGEFYQKKSRLTFVEQAMMHLIQVSKERSQTAKLEVQKENEAQLVKMFERCVTDENTPEGTTSIAALSTEDDVRLVEGKVIDFTKAKNIPVDGEIRREIIPGTKCTEISTGPENKKNILKKKDTHIAEGKVETKSSQQPVDVKDDKPVALEQRKPRACKWCGSSQKHDYRECRFQREKRFCVYCAAMHSMFEGHIRPIECTSCKKSFSGIEKLEDHVVSGECQKN

ORF1

DNA polymerase

1104 amino acids

Replicates the viral genome. Host DNA polymerases cannot substitute for the viral enzyme in this process.

Belongs to the DNA polymerase type-B family.

125.787 kDa

MLLKMSAFTARSSDNFYVYDWRVVSTEKENSYTDRNGVRRQWKDITLMLRAYCVDEKGATACLRLGQVKTKLYCEFPDDYPLERGGAVWRSVRAKLKEAITCKHDQDESNVQLVDMQPLYGVGKATKTFVAISFTSEVGKRAFVNRVCGRHRKPPSAALKFPNNLSGERIRFHWINVPTELQVLVQHKLPFAGWVETGRLYEPRSRLTRCDREYCTDLPALKSSELLACVAPSLKTFAWDIEAKINDMSMPGYHVDDEVYMVSIAVSDGTDHLIITAPGECERDLVDALRKDKDIDNLNVHVCRDEVSLLLKFNQVTRSIGAVARMGWNVNRFDCVVMMARATQLNCVNTLLDMGFAKDVPGQVSTTAGRTYGKISPSEPIYFDTHGVLCLDVMEMFRSTYTKLPKYSLQYVSGKFLNASKDPVTLKDLNELHSRLMERSADVDRLRAVVSKYCIRDSRLTLALCNKCAHITSLTEMARITNTPIVMVHYQKQQRRMFHLMFSECMRENVAMQDDFGLANAAPFETVAATQKKQLSYSGAYVKDPEPGLYSMVGSLDVNNMYPTLMIAYNLCYSTVVDEHSPSAFTDDHFEYIRWEDHVGCEHDPVQVELKSLRSMFEMKALTDKRKRIGVTAITKYFKPIQGPRIIQKIMDDRYAESTCRYDDGDEFCENDDEKEVIAAIKTPLEMQRAAIRLKVLKSRASGGSVLCAKQCVKILKTRRGILPDLVECLLQARKRVRGNMKSVTDPMARDILDKSQLAYKVTANSIYGSTGASNGKLPCQNVAKVTTALGRMTILQAIEIARTERNVTTIYSDTDSMYVQLQDDPASNQDPWTYVRELATHITSKLREPMVIEAEDDIHAKVLFLGKKCYIGRKLFRDGSVARDLDWHVVITVRRDHSEYVKSAYKPPVYKVFADCTHDQFVTSIAESCLRLMRRTVPCEMLTKTSEVRNLGDGCQLVLCKKTMSWMWGDYKVARHEQHDRLQRENPKWLRDYYVSKLPAPARLSILLTDRARPPVEGGRIEFLNVKTETKSALAIEEISYFKDNPGCAQVDNMYYIQQLVNPLTKVSEAVWRRSNSVNIAIAPFIYYNKVLAQLSTRFKISQ

ORF1

Non-structural polyprotein 1A

1099 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1A family.

123.391 kDa

MAAAAASALGASAPKALAPADGPIVAGLDKLVNLEGVHDLFEAMRGAYGEDPAWKGLMSCDVVYLKDITTAIGVKDTSVGIFRKFSDGCSWCPTGAECFLSMKDLAYMKAQSAKAQRLTASLATTSNLIARAMRAESELKRARDEERKVDARYKDILEHSLAARKALQKELDETRERELHLLKELGKRSSIRTKAFSFFDWLFMAVVFFLFLHYTSAECVKPDFGCLVVNSNLPVPSLTFHDVMARCYNTFGNIVLSSQIDAARLREECEQSANKFLGTHIGDPAHKVWCENRLETLIPVECDSSEFLEIFTSNLNAFMVSVSQFYKTISYYKLDALVTFAFSAALATNKLKMVMVLPLLLVALYLNVPPITVTIASVIFQPLILPFVGFQLVFPNFLPYNLFVAWVWMVCQAFFSSDGVKLLVSVSTALVQVVFLAVWSISVIVLQQLSIPMVAQILLFVATLTVSVGVKFANSTITVVHPDGNTEKVSRVTLVRQSMAKRISQIKQSLTIRGVIPSGPNRFDSIVVVEGQGGSGVGWRFMNSIFTAGHVVQGSKFVTIKSESTQVKVKVKRVIDLFECVDTLVEIPLTKEFQHIKPLRLAKKVEDSYLQLCAFKPDMVEKASYQGWCTIDSGFIFNSFNTQFGNSGAPYVDSDGRLVGMHLGSQGVISQGVVLVDTLKTQFLAQQSQIDDQLMERIIEGTKVSHAAILTELDRMRTKVEEVALVSARVNQLESQLKDLYEFSSNSIKCLSDDIEKMVCAQLFDEINLQSVMEKISALPPTEKLAKLVEVFVEQKKKGKTKRTARGGKHALGKKYLSKAHFSRMRMLTEEEYNKMVEDGFSPDEIKEVVDQLREQAWQNYLIDNDIGEDDDLDWYDDMLEDERLNEEIDRRVEAALEDRGELAYQKIRRTFVDQALIHLITLKKGNWQTTKVECQPEREEAYKEQFQKAVKQEDLTEGTSYAIYSAGDATILIENKEIDHTEIKPVTTGAKTVQEYPKDARTTVATFDDNKKDIVKTKRTTEIVLEQRKKTCRTCGETRPHNHKMCRDRHTRRFCFWCGVVHSDVEGHSRDLKCPKCSAGFANLREMEQHAVTTCSKN

ORF1

DNA polymerase

1086 amino acids

Replicates the viral genome. Host DNA polymerases cannot substitute for the viral enzyme in this process (By similarity).

Belongs to the DNA polymerase type-B family.

123.797 kDa

MDSITNGESFYVYDWRVVSTEKDTNYFDRSGNRKKWTEITLMLRAYCVDANGATVCLRMGQVKTKLYVEFPENYDLNPRRWSAIRTILKDAIYCKNDKCDSNIQRVSLQPLYGAKQVRTYVAIEFTSEVGKRAFINKISGKCDQRTKRTSAKFPDNVTGDQLRFHWMNVPTELQVLVNAKLPFAGWIETGRLYSPKDRKTRCDREYSVDIKQVRTSTSMACVTPPLKTFAWDIEAKINDMSSPGTHEDDEVYMISISVSDNTDHLILIAPDGCGEAMKRSMGAGDELTVHVCPNEVSLLLEFNKVCRSIGAVARMGWNVNRFDCVVLMARANRLNCSTTLLDLGLALDVPGCVSTTAGRTFGRFSPNDAIYFDTHGVLCLDVMEMFKSTYTKLPKYSLQYVSQKFLGTTKDPVTLKDLNELHSRLMLDDDHTNALRAVVSKYCVVDSRLTLQLCQKCAHMTSLTEMARITNTPITMVHYQKQQRRMFHLMFSECARKGVAMQDDFGRDRRLTMLDEDSTDGSSNVDNKRQLNYSGAYVKDPEPGLYNMVGSLDVNSMYPTLMIAYNLCYSTVIDDDAHSDYTDENFEIVEWEDHVGCEHDPNIKEREKLKSIFEDLAKVEKRKFIGVQPITKYFKPTSTTRKPVDDVEEHSECNGFTDDNYNDSPVSSIKLSSVDLQRAAIRLKVLKSRMSGGSKLCAKQRVRILKTRRGLLPDLVEYFLDARRKVRAEMKNVSDPLARDILDKSQLAYKVTANSVYGSTGAVNGKLPCQNVAKVTTALGRKTILQSIDIAQRDRSVSTIYSDTDSMYVQLGDEAGDDPWKFVRELAAHITSKLRKPMVIEAEDDIHAKVLFLGKKCYIGRKLFRDGSVSRELDWHGVITVRRDHSQYVKDVYRKAVHRVFADCTMEQFKHTIFEQALTLMQRRVSYERLTKTSEVRNVGDCCTITLCKKTMSWMLGDYKVPQHSHHDILYNTKRDALKTYYVSKLPAPARLSVSLVDRGRPAIEGGRIEFLNIRISNPDDLPIEEISYFKEHGGIVDRLYYIKQIINPLTKVSEAVWKRSDTVIGAVTPILNYDKVVRQLDTMFN

ORF1

DNA polymerase

1025 amino acids

Replicates the viral genome. Host DNA polymerases cannot substitute for the viral enzyme in this process (By similarity).

Belongs to the DNA polymerase type-B family.

117.114 kDa

MNKEHLTIYAYDWRVNSVEREIYHTSDRKSKDFELHLRVYGVNERGETTCVLMNKVTTSILLEFPDNYDVETNWSRVRMELMSAIFCSTDKTDKNVVMVKKQPLYGARHDKYFCKVSFSSDIGKRAFVMRVNGTVDRGSAATANRKGGKIHQPMKFPNGLTGDMIKIHGIDVPTELQVLEELDIPPCGWIETHNAYKCATITKRFTHQYRANVKTFKYCTRMECIPPVLKTMAWDIEARIHDISSPGLHIDDEIYMMSVSVSDGKDYLLTLGPVSNEDKIRFDEDTDIKVYQTEERLLLGFSELCRKLSVVARMGWNSSRFDCKVLLARANRLNCINSVLDLGMNPPGKISTNSGRTFGPIGDYEPIYIDTEGVVCLDVMEMFKSTYTKLPKFSLQYVSEVFLNEMAIITRTPLDMVHHQKQQRRVYNLMYSECLRQNIAFQDNMFNSKKVVTNDDVVGYSGAYVKDPVPGIHRRVGSLDVNSMYPTLIIAYNLCYTTVINYDDETPYKDEDFEVIEWEDHIGCEHNPIVVEFESLKKILYPKLQQNNTPSKRSPKGDGVVSNFFLPRNNKRCITNENDDVDEDEDQDILNMVTRTKQPSIEEQRATIRYKLLKARISAMSGKRVCETQRLKVLKSSVRPGILPNVVNKLLVERKRIRNIASVPGDPVEKALLDKRQLAYKITANSIYGATGASNGKLPCKNVAKAITALGRKVIKESIQMASDKGIPVIYGDTDSMYVQLSDDLEDPWHYLQSLGDEITSNLRKPMRIESEDNISDVLFLGKKSYICRKLLKDGGISEKLDYHGGIAVRRDHSGFVKSTHNKVVHAIFADVSLQNVKHVIFEECLKLMRRKIPIDELTKTSEVKSIGDGFTLKPSMKNTTTLNSWKLGDYTVKKHPQHDTLSKEYLKRYYLEQLPAHVQLEHKLMERGRSAVEGGRVEYLMVKRPGSKKSSASNIEEITYFKENSSIIQINELHYILQLVKPITKVCEAVWERSDIVVDAIKPICAYSKVLDEMNTKLYTPLVL

ORF1

Non-structural polyprotein 1A

1005 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1A family.

112.46 kDa

MASAGPTGAGARPPKAFTAQAGLAKLVNPAGLNSILARGKEKFGGTQAWKELMGCDVIFARSISHWYGIKGTTYYELTVALGQPLYKPVTDPELTEEEKAVMTAVQSRFAQSNSSVVLTRTLLNKTCELKDRIRELTDELGQTEVHLAREKVKAAALKLENRKLFVENQELKDQLEKERTKHGWKGLKTLCLWIFLATLIGGYITGSNAACTLVDVPSPMKVGYDTFKQMCIHKDSYLPDGAFDKESLALECSKQMDYMDCKEVITDSISGKTSFAGMLRDVFRVDEIVTAIRTVVRFAMDFSLAYPICVMFVLILTRNKKHAIISACCALVAKCCGLRLLPFTLVLTYAPSETAIAGCIYGLGYISIPLVTFLHWVGLVLKAILVPDDCYIGTRVSHALAWSIMLPMWIITQELMAFTEFPLELQIVTTVVVCTAGFGFRYLTGTVTITEPDGTVKKYKRIFNAKSAIGTISTVFFEKAKAIRGVIPSFPSKADNIVKIEVDVDGGSAGVGFRLGNYIYTAGHVVGEAKIAKITWKGLTSQAKVLGHIELPLFTDTLARLEIPKPFQQLPVFRLAKSSENDYVQMVCFDNQLQNVVTFSGWANIDGDYLNAPFETYAGTSGSPIINRDGRMLGVHFGSNAVVSQGFVITRLFATEPAVKQCKSDEDLADEIVRKVMGGIRISFASLTSELEKQRDELNALKQMVNDLIDTDLVALEKKKGKTKRTVRGQKHKTKAISKAAFMKTKVLTEEEYRRLEEEGFTKDEIKDIVDNLREQAWLDYQNQLDEEGDDDWYEQMEEDQRINDQIDQNIERDLEDRGEWYGQRKITFKQRAMLRFIQLGRQQQVATVSFPDGYEDRAEELYNKVVTTEDLPEGETSEAALSLPNKIVHQAGKRLNFKHVKIHPDKTFMKSGVTQIEEKPEGDIILKAKTTTLAPKEEPVIQQVEQQPQVEQQQQPQQPVVEEKKRTPPPKPQRKPKTGAKAKCLDCGETFVERQDFHVCKSKN

ORF1

RNA-directed RNA polymerase

992 amino acids

RNA-dependent RNA polymerase that plays an essential role in the virus replication.

Belongs to the tombusviridae RNA polymerase family.

112.683 kDa

MESLIQHILSATSSLSMPSVDSDKLQLLLTRFPQATLSWLSGIDGLSVHQFKVVATHVIKESYSHLSPSVAVLLAKPSDYYKLVVHGLTQKQWNEFDDKVTDAPRTAISWLYNQILVVGQPWMKSLNEGLKEYLPGWLHTCLRMLANLWFGAERVLHGISHAVSDITTYQPWMSCRRCVAHSPKESLLGEATTTSNPRESSWFSWLLCGGVVAATVYGFYKWVTITETIDRQDLAKQRPTHMQKCYEEVKARLEEESKGFIHDRMEDELTKIVLEPAEIDNDGKVLKSEVAQYLVKNHGRFVRSLVTMAKNEFAGVPKPTEANQLAVWRYLYRVCDKKGVNPSDTQKSISAALPFVFLPSAYDQDQAITMNCDDTKKVLERYADTFRHTTPLQKLVTNPLVGANWTAWARSIFISDPETGLRFAKXGCIEKWQGVQCKRTRVRHPRLRCHFKDRDPKVRSIYRIAGLGDQYEFGLHNNSAANLERGLAERVYMVKNYKTDFVASLDPAFCPAPEPVRGIFKRLDKYKKEIVRRVGRKSPITDEMFLSYYDGPQLTTYSKAVISLSERPVAVQDSYLKTFIKAEKLNLTLKTDPCPRVIQPRHPRYNVELGKYLKHIEHPIYKAIDRIWGGKTIFKGMNVEAMGAEIHKKMCKYSNPCAIGFDASRFDQHVSVEALRFEHSIYKSIHGYPELLSLLLKWQIHNQGTAHTNDGFFKYLVDGKRMSGDMNTSLGNCILASLIVKDLVDSLGVDAQLVNNGDDNVLICSVDDEEVVVKALYDHWMKYGFEVVAEQPVYITEQIEFCQMKPVFDGTQYVLVRNPTVTMSKDACSITPFYTANSARKWCRAVGEAGLSLTGGMPIKQAYYQCMIRNGINKGNIHKSKEFRYGLSYVLHHGKSDRKARPISAATRYSFYLAFGYTPDEQTALEGYYDSLELEWTESRLGIPARTPECLLLRLLPKIPLQPKSPTKPVQRTASKPDLPDSQWQQALAAPL

ORF1

Non-structural polyprotein 1A

935 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1A family.

105.182 kDa

MAYGEPYYSSKPDKDFNFGSTMARRQMTPTMVTKLPKFVRNSPQAYDWIVRGLIFPTIGKTYFQRVVVITGGLEDGTYGSFAFDGKEWVGIYPIEHLNLMSSLKLIHKANALQERLRLSQEEKATLALDVQFLQHENVRLKEMIPKPEPRKIQMKWIIMGAVLTFLSLIPGGYAHSQTNNTIFTDMIAACKYSTETLTENLDLRIKLALANITISDKLDAVRQILNFAFVPRAHWLRTVFYYIHYYEMWNIFMFVLAIGTVMRSARPGTDLVTLATSHLSGFRMAVLPTIPFHTTMTLWVMNTLMVCYYFDNLLAITLAILAPILGIIFLCFMEDSNYVSQIRGLIATAVLIAGGHACLTLTGTTTSLFVVILTCRFIRMATVFIGTRFEIRDANGKVVATVPTRIKNVAFDFFQKLKQSGVRVGVNEFVVIKPGALCVIDTPEGKGTGFFSGNDIVTAAHVVGNNTFVNVCYEGLMYEAKVRYMPEKDIAFLTCPGDLHPTARLKLSKNPDYSCVTVMAYVNEDLVVSTAAAMVHGNTLSYAVRTQDGMSGAPVCDKYGRVLAVHQTNTGYTGGAVIIDPADFHPVKAPSQVELLKEEIERLKAQLNSATENATTVVTQQPSAALEQKSVSDSDVVDLVRTAMEREMKVLRDEINGILAPFLQKKKGKTKHGRGRVRRNLRKGVKLLTEEEYRELLEKGLDRETFLDLIDRIIGERSGYPDYDDEDYYDEDDDGWGMVGDDVEFDYTEVINFDQAKPIPAPRTTKQKICPEPEVESQPLDLSQKKEKQSEYEQQVVKSTKPQQLEHEQQVVKPIKPQKSEPQPYSQTYGKAPIWESYDFDWDEDDAKFILPAPHRLTKADEIVLGSKIVKLRTIIETAIKTQNYSALPEAVFELDKAAYEAGLEGFLQRVKSKNKAPKNYKGPQKTKGPKTTTH

ORF1

Non-structural polyprotein 1A

921 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1A family.

103.493 kDa

MMALGEPYYSSKPDKDFNFGSTMARRQMTPTMVTKLPKFVRNSPQAYDWIVRGLIFPTTGKTYFQRVVVITGGLEDGTYGSYAFNGSEWVEIYPIEHLNLMSSLKLIHKANALQERLRLSQEEKATLALDVQFLQHENVRLKELIPKPEPRKIQMKWIIVGAVLTFLSLIPGGYAQSQTNNTIFTDMIAACKYSTETLTENLDLRIKLALANITINDKLDAVRQILNFAFVPRAHWLRTVFYYIHYYEMWNIFMFVLAIGTVMRSARPGTDLITLATSHLSGFRMAVLPTIPFHTTMTLWVMNTLMVCYYFDNLLAITMAILAPILGIIFLCFMEDSNYVSQIRGLIATAVLIAGGHACLTLTGTTTSLFVVILTCRFIRMATVFIGTRFEIRDANGKVVATVPTRIKNVAFDFFQKLKQSGVRVGVNDFVVIKPGALCIIDTPEGKGTGFFSGNDIVTAAHVVGNNTFVSVCYEGLVYEAKVRYMPEKDIAFITCPGDLHPTARLKLSKNPDYSCVTVMAYVNEDLVVSTATAMVHGNTLSYAVRTQDGMSGAPVCDKYGRVLAVHQTNTGYTGGAVIIDPADFHPVKAPSQVELLKEEIERLKAQLNSAAENPVTVVTQQPIVTLEQKSVSDSDVVDLVRTAMEREMKVLRDEINGILAPFLQKKKGKTKHGRGRVRRNLRKGVKLLTEEEYRELLEKGLDRETFLDLIDRIIGERSGYPDYDDEDYYDEDDDGWGMVGDDVEFDYTEVINFDQAKPTPAPRTTKPKPCPEPKIEAQPLDLSQKKEKQPEHEQQVAKPTKPQKIEPQPYSQTYGKAPIWESYDFDWDEDDAKFILPAPHRLTKADEIVLGSKIVKLRTIIETAIKTQNYSALPEAVFELDKAAYEAGLEGFLQRVKSKNKAPKNYKGPQKTKGPKTTTH

ORF1

Non-structural polyprotein 1A

920 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1A family.

103.386 kDa

MAHGEPYYSSKPDKDFNFGSTMARRQMTPTMVAKLPNFVRNSPQAYDWIVRGLIFPTTGKTYFQRVVVITGGLEDGTYGSFVFDGREWVEIYPIEHLNLMSSLKLIHKANALQERLRLSQEEKATLALDVQFLQHENVRLKELIPKPEPRKIQMKWIIVGAVLTFLSLIPGGYAQSQINNTIFTDMIAACKYSTETLTENLDLRIKLALANITISDKLDAVRQILNFAFVPRAHWLRTVFYYIHYYEMWNIFMFVLAIGTVMRSARPGTDLITLATSHLSGFRMAVLPTIPFHTTMTLWVMNTLMVCYYFDNLLAITLAILAPILGIIFLCFMEDSNYVSQIRGLIATAVLIAGGHACLTLTGTTTSLFVVILTCRFIRMATVFIGTRFEIRDANGKVVATVPTRIKNVAFDFFQKLKQSGVRVGVNEFVVIKPGALCVIDTPEGKGTGFFSGNDIVTAAHAVGNNTFVNVCYEGLMYEAKVRYMPEKDIAFITCPGDLHPTARLKLSKNPDYSCVTVMAYVNEDLVVSTAAAMVHGNTLSYAVRTQDGMSGAPVCDKYGRVLAVHQTNTGYTGGAVIIDPTDFHPVKAPSRVELLKEEIERLKAQLNSAAENPATAVTQQPVVTLEQKSVSDSDVVDLVRTAMEREMKVLRDEINGILAPFLQKKKGKTKHGRGRVRRNLRKGVKLLTEEEYRELLEKGLDRETFLDLIDRIIGERSGYPDYDDEDYYDEDDDGWGVVGDDVEFDYTEVINFDQAKPTPAPRTVKPKTCPEPEAETQPLDLSQKKEKQLEHEQQVVKSTKPQKNEPQPYSQTYGKAPIWESYDFDWDEDDAKFILPAPHRLTKADEIVLGSKIVKLRTIIETAIKTQNYSALPEAVFELDKAAYEAGLEGFLQRVKSKNKAPKNYKGPQKTKGPKTITH

ORF1

Non-structural polyprotein 1A

920 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1A family.

103.531 kDa

MAHGEPYYSSKPDKDFNFGSTMARRQMTPTMVTKLPKFVRNSPQVYDWIVRGLIFPTTGKTYFQRVVVITGGFEDGTYGSFAFDGREWVEIYPIEHLNLMSSLKLIHKANALQERLRLSQEEKATLTLDVQFLQHENVRLKELISKPEPRKIQMKWIIVGAVLTFLSLIPGGYAQSQTNNTIFTDVIAACKYSTETLTENLDLRIKLALANITISDKLDAVRQILNFAFVPRSHWLRTVFYYIHYYEMWNIFMFVLAIGTVMRSTRPGTDLITLATSHLSGFRMAVLPTIPFHTTMTLWVMNTLMVCYYFDNLLAITMAILAPILGIIFLCFMEDSNYVSQIRGLIATAVLIAGGHACLTLTGTTTSLFVVILTCRFVRMATIFIGTRFEIRDANGKVVATVPTRIKNAAFDFFQRLKQSGVRVGVNEFVVIKPGALCVIDTPEGKGTGFFSGNDIVTAAHVVGNNTFVNVCYEGLMYEAKVRYMPEKDIAFITCPGDLHPTARLKLSKNPDYSCVTVMAYVNEDLVVSTAAAMVHGNTLSYAVRTQDGMSGAPVCDKYGRVLAVHQTNTGYTGGAVIIDPADFHPVKAPSQVELLKEEIERLKAQLNSAAENPSTVITQQPTATLEQKSVNDSDVVDLVRTAMEREMKILRDEINGILAPFLQKKKGKTKHGRGRVRRNLRKGVKLLTEEEYRELLEKGLDRETFLDLIDRIIGERSGYPDYDDEDYYDEDDDGWGMVGDDVEFDYTEVINFDQAKPTPAPRTTKPKPCPEPEAETQPLDLSQKKDKQLEHEQQVVKPTKPQKNDPQPYSQTYGKAPIWESYDFDWDEDDAKFILPAPPRLTKADEIVLGSKIVKLRTIIETAIKTQNYSALPEAVFELDKAAYEAGLEGFLQRVKSKNKAPKNYKGPQKTKGPKTIIH

ORF1

Non-structural polyprotein 1A

874 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1A family.

97.914 kDa

MANNTTSALHPRGSGQRCVYDTVLRFGDPDARRRGFQLDEVSHNKLCDIFDSGPLHFAFGDLKVMKVAGGVVTPHKTVVKTVYVSGVQEGNDYVTFAFTPGPNEWREVDPRIDKRTALVGVLVQEHKKLDSDLKESRRELSQLKLEHSLLRHDYERLVREKPGPAMRTFKFSAVIFYAFFLGFLLMSAVKGEVYGRCLDSELNLNGNPEVCLHWEEVKSFSLQVALADFWNMTLDYYATVAPQSPLMDLALGYFPYFANWHMAAFLVGTAHVVAAERPLYMLVTLVLATLSRFQLVALAAVPMLDMPSSIGLWVTMVLFAIDQAFAILASVLISVLLLILCLAMNDVDYGALLRGCVTLVSATVFSHLVSFLHAPGWFTIIAILIYRIPKVLSYVSAERVDIKGPDGKIKETQNANPSWITKMSGLKNFFQRAFRQKVRTGVNPTTRIIPNSLVVIDAKDGRGTGFRVRNYLVTAGHVVGADTTVRVRWADVTSFAHVVYRVPNKDIVLLTLPAEYNSLHSYKLAKEVVDGTVVVVSNGDGGALSVGISEGVIVGESMTYAINTADGMSGSPLTTTDGRLIGVHQQNTGFTGGAVIFRDTDFPQPKKPQREADLEAKVAELEKALAAYTQSATGEDIVGLVRVAIQREMEVLRKELSNEFGQAKGKTKHKRRIMAAARSGGKRKPGKVWTEEEYKKLLEEGFTRDQLREMAEAAREADDDFDDYEEEKNEVDYPVWSDHDSDEEIDRDWFGQNLPTWSSAWSDFEPELDPDVTKTLPCHLEDKFSLKHYIITEADLKHFGQEMKEYMDHLDAVIKTHTEKGKWCPNTNTEEILKDLNAMWFKLNHTMWKNGVAPFMQRKKQKPKNGKRAPKGAQ

ORF1

Uncharacterized protein ORF1

862 amino acids

93.512 kDa

MDGLKEITAAVASLGGTTDLSTYMVNFDLGDMMDQSAGVVIDDVHPPVEGASVDSAMDVDAESEDEKDEEPGTGRDEPEVESEADEDPDEVEDAIPAAVPSTIPLSTTIRGFGADLGLGKNLTPADLAGNGLGKYAATLFSKTLPTLAAVVEQKGAIDPGSSVAKSIVTLLSSELGNALGIFSRLPTREQNKMAAVMILMKVLGRTALPPLTKTDEGVLSAINLVFSGAKRKVLVSTHSDITKFIIFNDDGTIPTLGVDTVAPLMKYYDPRLKLTTLVLIKNLGNNGTVEVKRRSKGKTLVMRERIPVECFLFRAFPVTESSDNIYATLDFVKRLLKGVSTQSSYVYVKNPKSIGDDFLNTKNTSLTLGDAPLTVKLSFRKPTNATSQSGFKRWLLICKWLARGGRIELGPKSTLRSGHEEESLEEEVNTGCIRSMASLTRLASRAWSPKNILKVNDRPVMTPSILNEIPDFVHRGNTLPIWLLFAASLRLDIVAVKEWLSTEGGDPRSIDVAKLTYHQYLFLRLLSDAGIAKKGLSKLLTATNNWLITEMSFIVMYKGSYGVNPTVLSTISDNNVPNLPIFSWIGEIPLWSTSGIVEKVKIVHTNSSLVSRMMLLSDVTEVAKVHAIKAKVRAEQKASKESAKGEDAAKKAPKRKREAEAGTETPKKKQKEEKSEKPKKTGKAEKSTGTAKVTKKEKTEKKTPQTKSTNKKNVKSVSAEAGTAVTPDEANGKKKSTQVKKKESAGQHTTEKKKRTAAKKKTVDRPSGHRPSSKKEYRSQEFVSSDDSSDEEVISKPRVTTTENMKSTKKATLASNMDDDGDDDGFMTCAGQFDIGGGSGFLTSTAGRNRKSNKQSKTLLLS

ORF1

Non-structural polyprotein 1A

844 amino acids

VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.

Belongs to the astroviridae polyprotein 1A family.

95.455 kDa

MNVYDKVLQFGSKKARARGMALNKLSRNRLEDIYAGSGPLVFGFGPIDMVDPGSLNPSIKTLDTVYVAAVQPDNQYVVHHFVPGRNEWVETDASTHQPTALVGVLVQDHKAKTREVEDLKSQLSQLRMEHEILRHEYERLKLKSPIVKPFKPLKVLLFSLLLGLLFAGVTNGARTGTCYAYDEEKDTCLYWEWKDSREVAWYDSYVTEALAIYNRACVYVRSKEFMTYLSLVFQTVFNWYFCATALAVYYMARAENPIVMFVTLALATLSQFQLLAVAVLPLLDFSATMGLWLSMVVFYMSQQISILVSFCVLVLSVMIGTFMADSEYAMMIKGHAVVFAIVCYSHVAMILNIPPWVVSLTMVCYRLWRVCFVFPAERLEIRSADGKVLHTVPTHPNWTAKVTRFVQSLRKGLRTSVAPTARIVPDGIAIVEAREGVGTCFRVKNNLVTSKHVVGSDDAVKIRWGAQEDMARVTYRHPTKDIALMALPTNLQTMPAYKFAKAITDGPIVMTAFDEANLLLVAVTEGVRVEDHMTYSVATRNGMSGAPITTVDGRVIAVHQTNTGFTGGAVIFVPEDIPEVRKISKREQELEDRVKQLEGMLNMDQAYVDSNLIVDLVREAVQREMKVLRTELANLGGFSQKKKGKNKSTKRKRKAVWTEEEYKAMLEKGFTRDQLRIMADAIRDQYYDDEDEQSEEEAGYPDWSDPGDSTDIENEWFGYEQSWKELEPAKSGVVVNTLPKDLVFKYSLDNYPISKQDIQAVAKELKIYEKAISDIISTSVSTDGKWKDDVDAQKILQELDGLWWGINHTLWEHGLMPFTQRRKRVQQPKNSKGALKTRAPKSAN

ORF1

RNA-directed RNA polymerase

818 amino acids

RNA-dependent RNA polymerase that plays an essential role in the virus replication.

Belongs to the tombusviridae RNA polymerase family.

91.948 kDa

METIKRLIWPKKEIFVGDFAIGVNRTVPVDVFQLVCRVVLRYMRTGKIECESDSLSKFVVELLKTDCAAKWEWFMKRRQGGDYIVPLSIATIPLMPLLSCTTSVRAVSVGVLGCGFSSNIPIPRLSVPRKGLLLRLAAGLALAPICALAVYATLPREKLSVYKLRTEARTHMEDEKEATDCLVVESARELKGKDGEDLLTGSRMTKVVASTGRRRRTPYAAKVAQVARAKVGYLRNTPENRLIYQRVIIEIMDKDCVRYVDRDVILPMAIGCCFVYQDGVEESAALWGSQDSLGVKXGGLVRLPGVVTQINRDIPSDVLLPQEVLEVRTGPPIAKDRNIFMVAGCPSQARFLVHNHCLKNLKRGLVERVFCVEKDGKLTRTPQPTKGSFGRLSPFRKAVCEKVGVAHRLGYDGFLSYYSGAKLRTYTRAVESLHITPVSERDSHLTTFVKAEKISTSKGDPAPRVIQPRNPRYNVELGRYLRHMESKLMKAVDDVFGETTCIKGYTADEVGAIFRRKWDRFDKPVAIGLDASRFDQHCSVEALQYEHSFYRALYPGNKLLSKLLEWQLHNKGKGYVPDGTITYKKEGCRMSGDINTSLGNYLLMCAMVHGYMRHLGINEFSLANCGDDCVLIIERRNLKRVQGTLPGYFLNLGYTMKVESPVFQLEEVEFCQAHPVQFQGGWKMVRNVRTAMSKDVHCVNNIRDLATRRAWSNAQHHGGLALSAGIPVVERFYSRFPLYDMPVKHQRIDTVTNVHKWRGSGGNYHVTPESRASFWAAFGLTGDEQVALEDRLDRWEMDLFGREGVDAHEPSILDSAVA

ORF1

RNA-directed RNA polymerase

818 amino acids

RNA-dependent RNA polymerase that plays an essential role in the virus replication.

Belongs to the tombusviridae RNA polymerase family.

92.253 kDa

METIKRMIWPKKEIFVGDFATGVNRTVPVNIFQLVCRVVLRYMRTGKIECDSDSMTKFIVELLKTDCAAKWEWFMKRRQRGDYIVPLSIASIPIIPLLSYATRVRAVSVKAFGNELSFNVRVPRPSVPKKGLLLRLAAGLALAPICALAVYATLPREKLSVFKLRTEARAHMEDEREATDCLVVEPARELKGKDGEDLLTGSRLTKVIASTGRPRRRPYAAKIAQVARAKVGYLKNSPENRLIYQRVMIEIMDKDCVRYVDRDVILPLAIGCCFVYPDGVEESAALWGSQESLGVKXGGLVRLPGVVTQINRDIPSDVLLPQEVLEVRTGPPNAKDRNIFMVAGCPSQARFLVHNHCLKNLKRGLVERVFCVERNGKLARTPQPTKGAFGRLSPFRKAVCEKVGVAHRLGYDGFLSYYSGAKLRTYTRAVESLHITPVSERDSHLTTFVKAEKISTSKGDPAPRVIQPRNPRYNVELGRYLRHMESKLMKAVDGVFGETTCIKGYTADEVGAIFRAKWDRFDKPVAIGLDASRFDQHCSVEALQYEHSFYRAMYPGNKLLGKLLEWQLHNKGKGYVPDGTITYRKEGCRMSGDINTSLGNYLLMCAMVHGYMRHLGINEFSLANCGDDCVLIVERRNLKQIQRTLPEYFLNLGYTMKVEQPVFQLEEVEFCQAHPVQFQGGWKMVRNVRTAMSKDVHCVNNIRDLATRRAWSNAQHHGGLALSAGIPVVETFYSRFKLYDVPRKHQRIDTVTNVHKWRGSGGSYVVTPESRASFWAAFGLTGDEQLALEDRLERWEMDLFGEEGVDAHEPSILDSAVA

ORF1

RNA-directed RNA polymerase

818 amino acids

RNA-dependent RNA polymerase that plays an essential role in the virus replication.

Belongs to the tombusviridae RNA polymerase family.

92.12 kDa

MDTIKRMLWPKKEIFVGTFATGVERDTSVDIFQLVCRVVLRYMRTGKIENNTDSLGNFIVELLKTDCAAKWEWFMKRRRVGDYAKSLAIASIPVIPLLSYATMKKTVALRAFGNELSFNIRVPRPSVPKKGLLLRLAAGLALAPICALAMYATLPREKLSVFKLRTEARAHMEDEREATDCLVVEPARELKGKDGEDLLTGSRMTKVIASTGRPRRRPYAAKIAQVARAKVGYLKNTPENRLIYQRVMIEIMDKDCVRYVDRDVILPLAIGCCFVYPDGVEESAALWGSDESLGVKXGGLVRLPGVVTQTNRDIPSGVLLPQEVLEVRAGPPNAKDRNIFMVAGCPSQARFLVHNHCLKNLKRGLVERVFCVERNGQLTRTPQPTKGAFGRLSPFRKAVCEKVGVAHRLGYDGFLSYYSGAKLRTYTRAVESLHITPVSERDSHLTTFVKAEKISTAKGDPAPRVIQPRNPRYNVELGRYLRHMESKLMKAVDGVFGETTCIKGYTADEVGQIFRDKWDRFNKPVAIGLDASRFDQHCSVEALQFEHGFYRAMYPGNKLLSKLLDWQLHNKGKGYVPDGTITYRKEGCRMSGDINTSLGNYLLMCAMIYGYMRHLGINEYSLANCGDDCVLIVERRNLKQIQGTLPEYFLNLGYTMKVEPPVFQLEEVEFCQAHPVQFQGGWKMVRNVRTAMSKDVHCVNNIRDLATRRAWSNAQHHGGVALTSGIPVVEKFYSRFTLYEVPKKHQRIDTVTNVHKWRGSGGDYVVTPEARASFWAAFGLTGDEQLALEDRLDRWEMDLFGEEGVDAHEPSILDSAVA

ORF1

RNA-directed RNA polymerase

775 amino acids

RNA-dependent RNA polymerase that plays an essential role in the virus replication.

87.648 kDa

MPLLHTLNTALAVGLLGARYYPEVQTFLGLPDYVGHMKNVVRSVFQGSGLVVVSSDTVGVRGTYSNRGQIGSSLGCILAVPDSGADIEIDLDRLVGTEEEATSCLVEAVGSTADVPRRRVRQKGRFAMHAVNAAKLHFCGVPKPTEANRLAVSKWLVQYCKERHVVDSHIRTIVNTALPRVFTPDAEDIQVVLDLHSVRAHDHRNALAEAGKVRKWWVNLAMHPMTGRSWSRAWRRLCRLPDDQAISFVRXGCLRELVGRETQISRGENPAMRVFPLANPPKVRRIFHICGMGNGLDFGVHNNSLNNLRRGLMERVFYVEDAQKQLKPAPQPIPGIFGKLSGIRRRLVRLAGNHTPVPREKYPSFYKGRRATIYQKALDSLHDRPVSRKDAELKTFVKAEKINFTAKKDPAPRVIQPRDPRYNIEVGKYLKPYEHHLYRAIDAMWGGPTVLKGYDVGELGNIMSNTWDKFRKTCAIGFDMKRFDQHVSVDALRWEHSVYNAGFNCPELAQLLTWQLTNKGVGRASDGFIKYQVDGCRMSGDVNTALGNCLLACSITKYLMKGIKCKLINNGDDCVLFFEADEVDRVRERLHHWIDFGFQCIAEEPQYELEKVEFCQMSPIFDGEGWVMVRNPRVSLSKDSYSTTQWANEKDAARWLAAIGECGLAIAGGVPVLQSYYSCLKRNFGPLAGDYKKKMQDVSFDSGFYRLSKNGMRGSKDVSQDARFSFYRGFGYTPDEQEALEEYYDNLQLLCEWDPTGYKEELSDRWILNEFPTTL

ORF1

Capsid protein

770 amino acids

Self-assembles to form an icosahedral capsid with a T=1 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins. The capsid encapsulates the genomic DNA. Capsid protein is involved in attachment and entry into the host cell (By similarity).

Belongs to the anelloviridae capsid protein family.

90.214 kDa

MAYGWWRRRRRRWRRWRRRPWRRRWRTRRRRPARRRGRRRNVRRRRRGGRWRRRYRRWKRKGRRRKKAKIIIRQWQPNYRRRCNIVGYIPVLICGENTVSRNYATHSDDTNYPGPFGGGMTTDKFTLRILYDEYKRFMNYWTASNEDLDLCRYLGVNLYFFRHPDVDFIIKINTMPPFLDTELTAPSIHPGMLALDKRARWIPSLKSRPGKKHYIKIRVGAPRMFTDKWYPQTDLCDMVLLTVYATAADMQYPFGSPLTDSVVVNFQVLQSMYDKTISILPDEKSQREILLNKIASYIPFYNTTQTIAQLKPFIDAGNVTSGATATTWASYINTTKFTTATTTTYAYPGTNRPPVTMLTCNDSWYRGTVYNTQIQQLPIKAAKLYLEATKTLLGNTFTNEDYTLEYHGGLYSSIWLSPGRSYFETTGAYTDIKYNPFTDRGEGNMLWIDWLSKKNMNYDKVQSKCLISDLPLWAAAYGYVEFCAKSTGDQNIHMNARLLIRSPFTDPQLLVHTDPTKGFVPYSLNFGNGKMPGGSSNVPIRMRAKWYPTLFHQQEVLEALAQSGPFAYHSDIKKVSLGMKYRFKWIWGGNPVRQQVVRNPCKETHSSGNRVPRSLQIVDPKYNSPELTFHTWDFRRGLFGPKAIQRMQQQPTTTDIFSAGRKRPRRDTEVYHSSQEGEQKESLLFPPVKLLRRVPPWEDSQQEESGSQSSEEETQTVSQQLKQQLQQQRILGVKLRLLFNQVQKIQQNQDINPTLLPRGGDLASLFQIAP

ORF1

RNA-directed RNA polymerase

769 amino acids

Probable polymerase.

Belongs to the tombusviridae RNA polymerase family.

87.776 kDa

MAIFELFSFDIDKLLVWVSKFSPGKILSAICRLGLDSWNNFRKWFWGLNFDKHEWAVDHFMPLMPRFSSDMDEVAKRIVTPKSKPKLEDCLEIDTAVEECFNEECFEPQEDGSMKLKRVAAPQQIKRVRTGMIEDAISAVEARIRNRHMIMGDDMGLVDEAAVRATAMDICGEYKINEHHTRCIIYAAAYRAMTPDQESIDATKMAYNPKSQARRDLVSILRKNISFGGFKSLEDFLSAPVSFPVEDAPYQILGIPEIKVADKRASRVCKFKRVVGLPSLSAGQSVCVHKTSLHNMIVSLEQRVFRVKNETGEFVVPPQPSKGAFDSISYFREAWKKKLYSKGPVVKSSIDDVVACYSSEKKKLYQKGAATLSHRPLHWRDSKVRAFIKVEKLECDKKAPVPRTIQPRSKRYNLCIGRYLRLNEKRMLDAIDAVFGEKTVLSGLDNKAQGRAIAKKWSKYESPIGIGLDASRFDQHCSKDALKFEHSFYRECFPDDKTSPDLLDWQLENEGSALMPTESLVKYRTRCRMSGDINTGLGNKILMCSMVHAYLKEVGVNASLANNGDDCVLFCEKGDFNRINDSLREWFLCRGFNMVVEEPVECLERVVFCRSQPVCVATKWAMVRQLGSLSRDCFSTQNWLNPTTFRDAMNALGQCNGIINDGVPVHMAQAKRMYAAGGNRKFDLKALHKQMEYSWRDRLGARTNLLWSEVEDSTRLSYFRAFGIEPAVQRIVEGYFSESKISEEGRQTNFLPTHYSRLHKDLLVPRYLN

ORF1

RNA-directed RNA polymerase

767 amino acids

RNA-dependent RNA polymerase, made of isoforms p88 and p27, plays an essential role in the replication of the bipartite viral genome composed of RNA-1 and RNA-2. Replicase proteins p88 and p27 interact together and selectively recruit viral replication templates as well as other essential components into intracellular membranes for the assembly of the 480 kDa viral replicase complex. Mechanistically, isoform protein p27 binds to the Y-shaped RNA element (YRE) located in the 3' UTR of RNA2 via a direct RNA-protein interaction and to RNA1 in a translation-coupled manner. This RNA-binding activity allows RNA2 recruitment to host membranes. The viral replicase complex synthesizes the dsRNA genome from the genomic ssRNA(+). It recognizes internal subgenomic promoters on the negative-sense RNA to transcribe the 3' co-terminal subgenomic RNAs that will generate the capsid and movement proteins. In addition, the viral replication process requires the trigger of an intracellular ROS burst mediated by p27 recruitment of the host ROS-generating machinery. The viral replicase complex also acts as a suppressor of RNA-mediated gene silencing, known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.

Belongs to the tombusviridae RNA polymerase family.

87.544 kDa

MGFINLSLFDVDKLMVWVSKFNPGKILSAICNLGIDCWNRFRKWFFGLNFDAHMWAVDAFIPLMPHYTEQMERVVDDFCSETPESKLEDCLELDTSVNEFFDEEVYKKDEEGVMKLQRSAARKHIKRVRPGMMQAAIKAVETRIRNRHTIFGDDMGKVDEAAVRATASDICGEFKINEHHTNALVYAAAYLAMTPDQRSIDSVKLAYNPKSQARRTLVSAIRENKAVAGFKSLEDFLGGPLSFPVEDAPYPILGIPEIRVAEKRASRVMKSKRVVGLPAVSAGLKVCVHQTSLHNMIVSLERRVFRVKNSAGELVVPPKPIQNAFDSISYFREEWLRKLSHKGQILKSSLADVVACYSSEKRKLYQKAADSLEKKPVQWRDSKVQAFIKVEKLECDTKDPVPRTIQPRSKRYNLAIGQYLRLNEKKMLDSIDDVFKEKTVLSGLDNRAQGRAIAHKWRKYQNPIGIGLDASRFDQHCSVDALKFEQTFYKACFPGDQQLETLLKWQLSNTGSALLPTGELVRYRTKGCRMSGDINTGLGNKILMCSMVHAFLKETGVRASLANNGDDCVLFCEKGDYEQINRNLEQWFLCRGFEMTVEKPVDVLEKVAFCRSQPVCIATQWAMVRQLGSLSRDCFSTQDWLNPKTFKDAMNALGQCNGIINDGVPIHMAQAKLMHRIGGNRKFNLDALHKQMEYSWRDRLGKRTNLLWSEVEDATRLSYFRAFGIEPYIQRIVEEYFSQVEITCEGRSTNVLPTHYSRIHKDLIKAR

ORF1

Probable RNA-directed RNA polymerase

763 amino acids

RNA-dependent RNA polymerase that plays an essential role in the virus replication.

85.965 kDa

MGLPSLLVEGVIGCTLVGGLVAVGSAALAVRATIGVVEFNRECVRGARRIVSSGGRCLIVQSPYGNPNQGLIRGEDEEIDNVEESTPEELTQLIEVKAEVDGKEVVVSKKRVVNRHLRQRFVRSIAIEAKNHFGGDISPSKANYLSVSKFLTGKCKERHVVPAHTRDCVSAAMVLVFTPDVHEIRMMAGLASDAAYARKIAMASILNRKGWCWRLMVNPLDRARWWEMWCVVNGFDSNKPVTFPKXGGLFYLNGVETKIRRGGHPSVIEVDGQCPPRERKLYVQNAITTGYEYRVHNHSYANLRRGLLERVFYVERNKELVSCPQPEPGSFKEMGYLRRRFHRVCGNHTRISANDLVDCYQGRKRTIYENAAASLLDRAIERKDGDLKTFIKAEKFNVNLKSDPAPRVIQPRSPRYNVELGRYLKKYEHHAYKALDKIWGGPTVMKGYTTEEVAQHIWSAWNQFQTPVAIGFDMSRFDQHVSVAALEFEHSCYLACFEGDAHLANLLKMQLVNHGVGFASNGMLRYTKEGCRMIGDMNTALGNCLLACLITKHLMKIRSRLINNGDDCVLICERTDIDYVVSNLTTGWSRFGFNCIAEEPVYEMEKIRFCQMAPVFDGAGWLMVRDPLVSMSKDSHSLVHWNNETNAKQWLKSVGMCGLRIAGGVPIVQEFYQKYVETAGNVKENKNITEKSSSGFFMMADRAKRGYSAVSEMCRFSFYQAFGITPDQQIALEGEIRSLTIDTNVGPQCEAADSLWILNRKYQ

ORF1

RNA-directed RNA polymerase

763 amino acids

RNA-dependent RNA polymerase that plays an essential role in the virus replication.

85.776 kDa

MGLPSLLVEGVIGCTLVGGLVAVGSAALAVRATIGVVEFNRECVRGARRIVSSGGRCLVVQSPYGNPNQGLIRGEDEEIDNVEESTPVELTPLIEVKAEVDGKEVVVSKKRVVNRHLRQRFVRSIAIEAKNHFGGDISPSKANYLSVSKFLTGKCKERHVVPAHTRDCVSAAMVLVFTPDVHEIRMMAGLASDAAYGIKIAMASILNRKGWCWRLMVNPLDRARWWEMWCVVNGFDSNKPVTFPKXGGLFYLNGVETKIRRGGHPSVIEVDGQCPLKERKLYVQNAITTGYEYRVHNHSYANLRRGLLERVFYVERNKELVSCPQPEPGSFKEMGYLRRRFHRVCGNHTRISANDLVDCYQGRKRTIYENAAASLLDRAIERKDGDLKTFIKAEKFNVNLKSDPAPRVIQPRSPRYNVELGRYLKKYEHHAYKALDKIWGGPTVMKGYTTEEVAQHIWSAWNQFQTPVAIGFDMSRFDQHVSVAALEFEHSCYLACFEGDAHLANLLKMQLVNHGVGFASNGMLRYTKEGCRMSGDMNTALGNCLLACLITKHLMKIRSRLINNGDDCVLICERTDIDYVVSNLTTGWSRFGFNCIAEEPVYEMEKIRFCQMAPVFDGAGWLMVRDPLVSMSKDSHSLVHWNNETNAKQWLKSVGMCGLRIAGGVPVVQEFYQKYVETAGNVRENKNITEKSSSGFFMMADRAKRGYSAVSEVCRFSFYQAFGITPDQQIALEGEIRSLTINTNVGPQCEAADSLWILNRKYQ

ORF1

Protein P1

760 amino acids

Precursor from which the VPg molecule is probably released at the onset of the RNA synthesis. Essential for virus replication (By similarity).

Belongs to the peptidase S39B family.

84.187 kDa

MASFLKPVNSQGLWLSLLLAITYLFLLPSAGQSLDPSGIGLAAGCSQSQGGISSFAALPRPCNDSVCTLPDLGWSCQRTAQDTANQQQSPFNHTGHFLTTSGWTWPNWTCSPSQCQLLIHLPTWQIVKQDFLLLLKEWDLLTMCQRCSDLLTKTPGFILRFAGETLILVANLIEFVLVSWSLWLCSVLVYVAQAVPGKFLLYMAAFCTTFWAWPRETASSLIRIVTTPLTLIGFLNKTGIGLISHCLALTWNMFMTWSLLPWVTLMKMMKILITSSRVLTRSGRPKRTSSKSLKHKLKISRAIQKKQGKKTPVEERTIPGVQIKKLREDPPKGVILRCTDQFGDHVGYASAVKLEKGQTGIVLPIHVWTDTVYINGPNGKLKMADFTALYEVTNHDSLIMTSAMAGWGSILGVRPRPLTTIDAVKLKNYSLFTERDGKWYVQAAKCIAPAEGMFRVVSDTRPGDSGLPLFDMKMNVVAVHRGTWPSERFPENRAFAILPVPDLTSSSSPKFTGCETYSEAETAYEMADNFSDGEEILIRTKGQSYRTFIGSNKVALLSIRKLEEELSRGPIGLWADDTEDDESAPRRSGNGLFRSTPEKQSQAKTPSPKVEESAAPPPAPRAEKVRHVRRSEMTPEQKRADNLRRRKAKAAKKTPSTPPKKSKDKAPTLSQVAELVEKAVRAALTVQPRRSRASSKISIGGRNPGRKPQVSIQLDPVPSQSTSVPPKDSQAGESAWLGPRRSYRPVQKSTVGQKQEPRRN

ORF1

RNA-directed RNA polymerase

752 amino acids

RNA-dependent RNA polymerase that plays an essential role in the virus replication.

Belongs to the tombusviridae RNA polymerase family.

84.449 kDa

MSWPSLSGVPNGSSSVSTWLSVTHPRRSLPKELLTAFDTCNVAPEALLVLRSTSLMILEETCVVVGAAEMPTAEDNSGRELFIGSNGDPMERKTRTAHHAIKKTVRIKKGHRTTFAMTVANGAYVKFGARPLTEANVLVVRKWIVKLIADEYKDLRVCDQALVIDRATFLSFIPTMAWNNYKFIFHGKNAVTDRVAGENLFSRIAQWANPGKXGCPVVVTGQGCVISRAPDCAQLRVKRLLGVTKNRTCMRVSGVSPNIQIIPFNNDITTLERAIKERVFFVKNLDKGSPTKFVSPPRPAPGVFAQRLSNTLGLLVPFLPSTAPMSHQQFVDSTPSRKRKVYQQALEDISCHGLNLETDSKVKVFVKYEKTDHTSKADPVPRVISPRDPKYNLALGRYLRPMEERIFKALGKLFGHRTVMKGMDTDVTARVIQEKWNMFNKPVAIGLDASRFDQHVSLEALEFEHSVYLKCVRRMVDKRKLGNILRHQLLNKCYGNTPDGAVSYTIEGTRMSGDMNTSLGNCVLMCMMIHAYGLHKSVNIQLANNGDDCVVFLEQSDLATFSEGLFEWFLEMGFNMAIEEPSYELEHIEFCQCRPVFDGVKYTMCRNPRTAIAKDSVYLKHVDQFVTYSSWLNAVGTGGLALAGGLPIFDAFYTCYKRNSNSHWFSGRKGRLKTLSSVDDSLPWFMRELGLKGKRSSAEPLPASRASFYLAWGVTPCEQLELEKYYKSFKLDTSTLLEEHLWQPRGVFPDED

ORF1

RNA-directed RNA polymerase

739 amino acids

RNA-dependent RNA polymerase that plays an essential role in the virus replication.

Belongs to the tombusviridae RNA polymerase family.

83.699 kDa

MANWCMSVLMFSFVTVYTIVTSLGQGIRRGFRAIVDEVENIYGDMCAGFKVALSKLSVSWIVVVGMIFVLNSLVVGLVPTLTMVAIIAACVGAKYGGRVPRYIRAHVDRIRKSWEKGVDDDDCCAPLPETSLERVPTKLRPRLACKIAVRAIAKVGLLKRSEANSMVYQRVCLDVMESMKMRWHDRLVILPQAVLACLERPEEVEEVMKAIEASCKGRFDVYXGCLLQHRGYNTAIISAIPDGVLLNHEGMVVRKGAPITTERKWYSFAGYASTYEYIVHNSSLVNVCRGLVERVFCVVRDGKLQRPLRPKNNVFERKLGNVGRRISSIVGYCPAMTRSEFCESYSGTRRATYERARLSLDVLPCTRKDAYLKTFVKAEKINITLKPDPAPRVIQPRDPRYNVEVGRYLKPLEPRLMKAIDKLWGEKTAIKGYTVEKVGEILHQKSLRFKNPCFVGLDASRFDQHCSRQALEWEHSVYNAIFRDPYLSELLTWQIDNVGTAYLKDGFVRYRVDGCRMSGDMNTSMGNYLIMSCLVYQFCKDIGIDASLANCGDDCVLYLEKEDLPKLKALPDWFGKMGYSMKVEKPVFTVEEIEFCQQHPVQLSRGYVMVRRPDVCLTKDLCVVRGGMTTERLQRWLYAQHDGGLALTGDCPVLGAFYRRFPSGESHGELSEYSDAHKFKAGKQYGEINSLARYSFWLAFGITPDEQLAIERDLMNWTPNVVPGSCDPRPTLLDYCSDN

ORF1

RNA-directed RNA polymerase

725 amino acids

RNA-dependent RNA polymerase that plays an essential role in the virus replication.

Belongs to the tombusviridae RNA polymerase family.

82.357 kDa

MESLPIVLLSLISKAVVLICSLLTLIIQNSTAVTWGLACVWLAYVSFRFLFQVKITVHPAARETFESMVRKFQAESMFSEEATPCIVSVGDKDADLTPDPQREDIKIVKSSRRVSYAVRVAHVAKAQVGLLANSRANELVYSRLCREEMVKHGVRPSHIAHMVPLAVAACFIPLDSDFLAASIRQGEGMRERRALLGPSWEKXGGLLVTSGFTTPTWRGDPRGMLVTKGPPLAKPRKLYRFTGMGTHIRYGVHDHSLGNVRRGLVERLYMVEVKGELQPTPKPTPGAFNQMSRFSDRLSIHLPKTTRLTPREFLGFYTGRKLERYQKAVESLEMHPVREKDAWLSTFVKAEKLNITAKPDPAPRVIQPRDPRYNVEVGRFLRHSEEMLFKAINKTFGGRTIFKGLSSDQAGEEFKTLWDSFKDPVGIGMDASRFDQHISKDALEFEHKMWLSMFPKSERAELARLLSWQINNRGLARCPDGEIRYRVEGCRMSGDMNTSSGNCYIMCATVHNWCDNIKHIKHFRLANNGDDCMLVVERSDEKKVRNGLIEYYATLGFTMKVEPTVDVLERLEFCQTRPVLVDGKYRMVRNLHQSMSKDLHSLHDLDSSAARNAWVTAVGTGGRCMNDGVPVLKEFFKQFPDYNLEVKKGSDMAQKLRDDWKYKFNRTAAFQDLIPTQESRYSFWLAFGLLPDEQIALENGFSPLKMEIVNEQIQEETSLLQFSGA

ORF1

RNA-directed RNA polymerase

724 amino acids

RNA-dependent RNA polymerase that plays an essential role in the virus replication.

Belongs to the tombusviridae RNA polymerase family.

82.279 kDa

MELPNQHKQTAAEGFVSFLNWLCNPWRRQRTVNAAVAFQKDLLAIEDSEHLDDINECFEESAGAQSQRTKVVADGAYAPAKSNRTRRVRKQKKHKFVKYLVNEARAEFGLPKPTEANRLMVQHFLLRVCKDWGVVTAHVHGNVALALPLVFIPTEDDLLSRALMNTHATRAAVRGMDNVQGEGWWNNRLGIGGQVGLAFRSKXGCLERRPGFSTSVSRGEHPDLVVIPSGRPEKQRQLLRYSGIGGHLLIGIHNNSLSNLRRGLMERVFYVEGPNGLQDAPKPVKGAFRTLDKFRDLYTKNSWRHTPVTSEQFLMNYTGRKLTIYREAVDSLSHQPLSSRDAKLKTFVKAEKLNLSKKPDPAPRVIQPRSPRYNVCLGRYLRHYEHHAFKTIAKCFGEITVFKGFTLEQQGEIMRSKWNKYVNPVAVGLDASRFDQHVSVEALEYEHEFYLRDYPNDKQLKWLLKQQLCNVGTAFASDGIIKYKKKGCRMSGDMNTSLGNCILMCAMVYGLKEHLNINLSLANNGDDCVIVCEKADLKKLTSSIEPYFKQFGFKMEVEKPVDIFERIEFCQTQPVFDGSQYIMVRKPSVVTSKDVTSLIPCQTKAQYAEWLQAVGECGMSINGGIPVMQNFYQKLQTGIRRTKFTKTGEFQTNGLGYHSRYMHRVARVPSPETRLSFYLAFGITPDLQEALEIFYDTHKLELDDVIPTDTYQVSGEHLINGLPN

ORF1

Uncharacterized protein ORF1

715 amino acids

Belongs to the plectrovirus ORF1 family.

85.293 kDa

MKKSLSLFAIFILTFLGLVIPFITLTAFRPLNEEQYTLKQESSTGKGINETDFINTMFLRSSFFENWSETNYFINPTLKTSKNLLFNDKWYLDFLQDSYSTGVVYDKPGEIFLNYYRQWHSLKNKYMVEKFYDVKKENFLNDLTDFIYAFAVKYKMFDVSKEIVENVDRYKENHYPRVKLKQDNWKLITDYNWLKDNFDNKYYFVIWKQSYSKEWEIMKFKHNMRYDMKIESYIKNNSFKGLYRWDGDGEPQTPTIDKNTGEITDWNSYQQSRVKQFIDLSLYSVLQENIRVQQGGSADYENPNKVGTKRIIFDFETVDELDVKNIKKAIYRMILTVDEANLIISGSLELNNINNDDLSFNFSFMRTGMGEVFNFNGSIYSSLNSKDLKYYQQFSGQFDLSKFLQSFFASALVPVFQNRSLFIENGYIDNLQYDTVLVNFFALKLQNFNNILLIENINDKLQFDKLLNSMFKISQKFYTNYLRTIFDLENNTYVQGYNKKYGLLVNNGFKIYPRYFYFSDKYKQLDIKLYSAFKNRFYTINNYGSVFNYDFSVANNYNIKLNSGYVFGGDLQNKYGLQYKKIEEQKIGYNVFELQAQKENDMYRYYDFNFGIYNWQEINNGGLFPDKQWWQVQYVTPKGWWDFGAHIKNAVIWIVNTIPGVKQVNELASGVGKVFETVYSFFSQIFEVWKFNPALYSTITNIFLLIIFMKFVRLI

ORF1

Uncharacterized protein ORF1

713 amino acids

Belongs to the plectrovirus ORF1 family.

84.811 kDa

MRKSLSLFSIFILIFLGLVIPFITLTAFRPLNEEQYTLKQESSTGKGINETDFINTMFLRSSFFENWSETNYFINPTLKTSKNLLFNDKWYLDFLQDSYSTGVVYDKPNEVFLNYYQQWHSLKNRYMVEKFYDVKKENFLNDLIDFIYAFAVKYKMFNVSKEIVKNVDRYKENHYPRVKLNQDNWKLIDDIENVDKYKWEDETYIGITKIWKNKEWNWIIEDWKLHPPFSNVYLSSYKAIYRWTGVGKPQLPTIDKNTGEITDWNSYQQTRVKEFIDLSLYSVLLENTRVQQGGSADYENPNKVGTKRIIFDFETVDELDVKNIKKAIYRMILTVDEANLIISGSLELNNINNDDLSFNFSFMRTGMGEVFNFNGSIYSSLNSKDLKYYQQFSGQFDLSKFLQSFFASALVPVFQNRSSFIENGYIDNLQYDTVLVNFFALKLQNFNNILLSENINDKLQFDKLLNSMFKISQKFYTNYLRTIFDLENNTYVQGYNKKYGLLVNNGFKIYPRYFYFSDKYKQLDIKLYSAFKNRFYTINNYGSVFNYDFSVANNYNISLNSGYVFGGDLQNKYGLQYKKIEEQKIGYNVFELQAQKENDMYRYYDFNFGIYNWQEINNGGLFPDKQWWQVQYITPKGWWDFGAHIKNAVIWIVNTIPGVKQVNELASGVGKVFETVYSFFSQIFEVWKFNPALYSTITNIFLLIIFMKFVRLI

ORF1

Capsid protein

712 amino acids

Self-assembles to form an icosahedral capsid with a T=1 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins. The capsid encapsulates the genomic DNA. Capsid protein is involved in attachment and entry into the host cell (By similarity).

Belongs to the anelloviridae capsid protein family.

84.927 kDa

MAYGRRYWRRRRWRRRGGRWWRRRRPWKTRWRRRRRRWRRRRYGRRARRFRRRHRVGRWRKLFRRVKSRVVRQWDPNVTRRCMINGYDHALFWGQQAQHRILYDNLPWPIKKEGTQEGGSMNMMQLTLQFLYKDNLAGRNRWTRSNWDMDLAKYHETTLLFPRHRNYSYVVFITRGPNDILDEHTYPGLHPEKMLGRRKKIVVWSKDLRPHGKNYIRVRVPPPQVFKNQWYFQRDICQMPILTLGFAAFDPVNVTLAGNMANSSIILWGIPYWSRPMPYNTWYDYWTKCAGPQNIPWSDRQTNIAAGITQKSAQTCLKLKNKHFGLTNTAIVSDYDKDNIDKNTKQIKTIVMSLNRWYPKWPMKWKDAGDINTQTPFPYRYSWREDQGWGNKVRLWTRECRTDIPEETLGIENMPLYVLMNGYIDYVTNHSTHSPLNWVVSVFCPYTDPPMTNVIPVGKDWFIQNVEPGENKYPSDNADNTFAPGEKTKIKNYDSSKDEFTGNVIRAPDVYDSLPAQQALYIASPFSLKWAQTTGSIVFFYQSKWTWGGDFPRQRPIIDPCNRPKWGGLPVTGYDETGLLLQNPEKAEARARGHLGDLRRGDLTKTALKRLMELTSTEEGSPQKKKRRDKEVRTTADLLRPEDVYCWMSPTPETPPKAGKTPESSFAETYDNHTKLAKRVKKEIHNQNRRHRLLLAHLRRERDRLLGHHLLR

ORF1

Capsid protein

673 amino acids

Self-assembles to form an icosahedral capsid with a T=1 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins. The capsid encapsulates the genomic DNA. Capsid protein is involved in attachment and entry into the host cell (By similarity).

Belongs to the anelloviridae capsid protein family.

80.268 kDa

MPFWWGRRNKFWYGRNYRRKKRRFPKRRKRRFYRRTKYRRPARRRRRRRRKVRRKKKTLIVRQWQPDSIVLCKIKGYDSIIWGAEGTQFQCSTHEMYEYTRQKYPGGGGFGVQLYSLEYLYDQWKLRNNIWTKTNQLKDLCRYLKCVMTFYRHQHIDFVIVYERQPPFEIDKLTYMKYHPYMLLQRKHKIILPSQTTNPRGKLKKKKTIKPPKQMLSKWFFQQQFAKYDLLLIAAAACSLRYPRIGCCNENRMITLYCLNTKFYQDTEWGTTKQAPHYFKPYATINKSMIFVSNYGGKKTEYNIGQWIETDIPGEGNLARYYRSISKEGGYFSPKILQAYQTKVKSVDYKPLPIVLGRYNPAIDDGKGNKIYLQTIMNGHWGLPQKTPDYIIEEVPLWLGFWGYYNYLKQTRTEAIFPLHMFVVQSKYIQTQQTETPNNFWAFIDNSFIQGKNPWDSVITYSEQKLWFPTVAWQLKTINAICESGPYVPKLDNQTYSTWELATHYSFHFKWGGPQISDQPVEDPGNKNKYDVPDTIKEALQIVNPAKNIAATMFHDWDYRRGCITSTAIKRMQQNLPTDSSLESDSDSEPAPKKKRLLPVLHDPQKKTEKINQCLLSLCEESTCQEQETEENILKLIQQQQQQQQKLKHNLLVLIKDLKVKQRLLQLQTGVLE

ORF1

Capsid protein

662 amino acids

Self-assembles to form an icosahedral capsid with a T=1 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins. The capsid encapsulates the genomic DNA. Capsid protein is involved in attachment and entry into the host cell (By similarity).

Belongs to the anelloviridae capsid protein family.

78.581 kDa

MPPFYYRRRWYSNPWRRKRLRFRRRRLRRPIRKRFRRRRWVRRRRFFRFKRKLRKIRIDQWQPETIRKCHVKGNLCLLTCGRGNINHNYILTSESYVPTSEPGGGSWSILQMTTRVLYDEYKAARNWWTKSNSLLPLTKYIRCKLKFYRSDQTDYIVTIQRTGPFEVTLESYLSTQPSRHLMNHKAFIVPKLGRGPNKETYVKKIVRPPALFQSKWYFSQDIYNTPLFILTVSSCSLDQMYAPQDQISTNISLFSLNTNVFQINNWHKQPYTTKAASTLETYLYCYHNGHEPTQELKWKDIILLGNMTNYTDGKKYNTSGTTPLDLFKTENKPYWGNVFTNLNQDQDVIIYYGTKPKQDDNWTSTAPILPITSLYVECRYNPFKDKGTGNKVYLVPTDSGLGSFLTLPTKSELIITDLPLWLITWGWIEWLKKSRPVAHIEEEYQVVIQSKYIHPQLPCYVLIDKYFRHPPEGQHYITELSETDKLHWHPKYSMQTEQLELIAETGPAAPKINNTKQIEAHLNYDFLFKWGGSPAPMETITDPAEQEKFPSPSNQLQGLQIESPGKPKQYYLYTFDEKRSELTMPAAKRLKKDFTTPTFFTDFGTKDIPLKTQEETDQISEDEEIETSLPKEDHLKQQLQRTRQYYREGIRKLLKTKKLFPL

ORF1

Protein P1

639 amino acids

Precursor from which the VPg molecule is probably released at the onset of the RNA synthesis. Essential for virus replication.

Belongs to the peptidase S39B family.

69.629 kDa

MNRFTAYAALFFMFSLCSTAKEAGFLHPAFNFRGTSTMSASSGDYSAAPTPLYKSWALPSSLNLTTQPPPPLTDRSYYELVQALTSKMRLDCQTVGDMTWRHLSEMLFASWNSVKEVSLKAASVTLWAIINIWFGLYWTLARLITLFLWTFSIEALCLILLGCITSLIYKGALSLSEHLPVFLFMSPLKIIWRAAFSKRNYKNERAVEGYKGFSVPQKPPKSAVIELQHENGSHLGYANCIRLYSGENALVTAEHCLEGAFATSLKTGNRIPMSTFFPIFKSARNDISILVGPPNWEGLLSVKGAHFITADKIGKGPASFYTLEKGEWMCHSATIDGAHHQFVSVLCNTGPGYSGTGFWSSKNLLGVLKGFPLEEECNYNVMSVIPSIPGITSPNYVFESTAVKGRVFSDEAVKELEREASEAVKKLARFKSLTDKNWADDYDSDEDYGLEREAATNAPAEKTAQTNSAEKTAPSTSAEKTALTNKPLNGQAAPSAKTNGNSDIPDAATSAPPMDKMVEQIITAMVGRINLSEIEEKIVSRVSQKALQKPKQKKRGRRGGKNKQNSLPPTSTQSTSGAPKKEAAPQASGSAGTSRATTTPAPEAKPSGGKNSAKFTPSWRIKQQDSAGQKPDLKLNSKA

ORF1

Protein P1

639 amino acids

Precursor from which the VPg molecule is probably released at the onset of the RNA synthesis. Essential for virus replication.

Belongs to the peptidase S39B family.

69.677 kDa

MNRFTAYAALFFIFSLCSTAKEAGFQHPAFNFRGTSTMSALSGDYSAAPTPLYKSWALPSSLNLTTQPPPLLTDRSYYELVQALISKMRLDCQTVGDMTWRHLSEMLFASWNSVKEVSLKAASVTLWAIISIWFGLYWTLARLITLFLWTFSIEALCLILLGCITSLIYKGALSLSEHLPVFLFMSPLKIIWRAAFSKRNYKNEKAVEGYKGFSVPQKPPKSAVIELQHENGSHLGYANCIRLYSGENALVTAEHCLEGAFATSLKTGNRIPMSTFFPIFKSARNDISILVGPPNWEGLLSVKGAHFITADKIGKGPASFYTLEKGEWMCHSATIDGAHHQFVSVLCNTGPGYSGTGFWSSKNLLGVLKGFPLEEECNYNVMSVIPSIPGITSPNYVFESTAVKGRVFSDETVKELEREASEAVKKLARFKSLTGKNWANDYDSDEDYGLEKEAATNAPAEKTAQTNSAEKTAPSTSAEKTAPTNKPLNGRAAPPAKTNGNSDIPDAAISAPPMDKMVEQIITAMVGRINLSEIEEKIVSRVSQKALQKPKQNKRGRRGGKNKQNNLPPTSTQSISGAPKKKAVPQASGSAGISPATTTPAPKEKPSGGKNSAKFIPSWRIKQQDSAGQKPDLKLNSKA

ORF1

Protein P1

607 amino acids

Precursor from which the VPg molecule is probably released at the onset of the RNA synthesis. Essential for virus replication (By similarity).

Belongs to the peptidase S39B family.

66.211 kDa

MYSKLMFFFALCSISFLFTSEAASTMLLESSYLPLNQSYAPGFLYKRDMLPPPLQAVLTYTCPEPRPLAEESYNDLLRAISQKSSSDFQNAYSLALSFSSDFYQHGLKTLKDVSFLAVEKFLWGLTRLWSSLILASFSALWWLVSNFTTPVFCLALLYTVTKYMVKTVSFLFGGLPIWIISIAFSLLKKSFSALRSTPKCLYEKAIDGFKSFTIPQSPPKSCVIPITHASGNHAGYASCIKLYNGENALMTATHVLRDCPNAVAVSAKGLKTRIPLAEFKTIAKSDKGDVTLLRGPPNWEGLLGCKAANVITAANLAKCKASIYSFDRDGWVSSYAEIVGSEGTDVMVLSHTEGGHSGSPYFNGKTILGVHSGASATGNYNLMAPIPSLPGLTSPTYVFETTAPQGRVFAQEDIAEIEGLYAQVMKRVQQAEDFKPKTGKYWGDMEDDEDIFFESKEDLSGNGVRGTVRGTNGEGSSTPKTSNVDGKEMMEKIISSLVGKINLENIERKVIEEISAKAMKTPKSRRRRAPKKQPESSKDTSPRSTTGKYQPPHVRSPASVTAANCPNTTTPSKKKNLAGGRPSSGTIPRWVRKQAASAGPSSAPKQN

ORF1

Capsid protein VP1

596 amino acids

Assembles to form an icosahedral capsid with a T=1 symmetry.

Belongs to the microviridae F protein family.

66.982 kDa

MAKGRKLPSVMKNRFSEVPTATIRRSSFDRSHGYKTTFDMDYLVPFFVDEVLPGDTFSLSETHLCRLTTLVQPIMDNIQLTTQFFFVPNRLLWDNWESFITGGDEPVAWTSTNPANEYFVPQVTSPDGGYAENSIYDYFGLPTKVANYRHQVLPLRAYNLIFNEYYRDENLQESLPVWTGDADPKVDPTTGEESQEDDAVPYVYKLMRRNKRYDYFTSALPGLQKGPSVGIGITGGDSGRLPVHGLAIRSYLDDSSDDQFSFGVSYVNASQKWFTADGRLTSGMGSVPVGTTGNFPIDNVVYPSYFGTTVAQTGSPSSSSTPPFVKGDFPVYVDLAASSSVTINSLRNAITLQQWFEKSARYGSRYVESVQGHFGVHLGDYRAQRPIYLGGSKSYVSVNPVVQNSSTDSVSPQGNLSAYALSTDTKHLFTKSFVEHGFVIGLLSATADLTYQQGLERQWSRFSRYDYYWPTFAHLGEQPVYNKEIYCQSDTVMDPSGSAVNDVPFGYQERYAEYRYKPSKVTGLFRSNATGTLDSWHLSQNFANLPTLNETFIQSNTPIDRALAVPDQPDFICDFYFNYRCIRPMPVYSVPGLRRI

ORF1

Capsid protein VP1

553 amino acids

Assembles to form an icosahedral capsid with a T=1 symmetry.

Belongs to the microviridae F protein family.

62.22 kDa

MKKKMSKLNARVHDFSMFKGNHIPRSKIHIPHKTIRAFNVGEIIPIYQTPVYPGEHIKMDLTSLYRPSTFIVPPMDDLIVDTYAFAVPWRIVWKDLEKFFGENSDSWDVKNAPPVPDIVAPSGGWDYGTLADHFGITPKVPGIRVKSLRFRAYAKIINDWFRDQNLSSECALTLDSSNSQGSNGSNQVTDIQLGGKPYIANKYHDYFTSCLPAPQKGAPTTLNVGGMAPVTTKFRDVPNLSGTPLIFRDNKGRTIKTGQLGIGPVDAGFLVAQNTAQAANGERAIPSNLWADLSNATGISISDLRLAITYQHYKEMDARGGTRYVEFTLNHFGVHTADARLQRSEFLGGHSQSLLVQSVPQTSSTVEKMTPQGNLAAFSETMIQNNYLVNKTFTEHSYIIVLAVVRYKHTYQQGIEADWFRGQDKFDMYDPLLANISEQPVKNREIMVQGNSQDNEIFGFQEAWADLRFKPNSVAGVMRSSHPQSLDYWHFADHYAQLPKLSSEWLKEDYKNVDRTLALKASDNTPQLRVDFMFNTIAEKPMPLYSTPGLRRI

ORF1

Capsid protein VP1

533 amino acids

Assembles to form an icosahedral capsid with a T=1 symmetry.

Belongs to the microviridae F protein family.

60.133 kDa

MKLGSRHNQHSFAQIPSVHTTRSKFNRSFGTKDTFKFDDLTPIFIDEILPGDTINMNTKTFIRLATQVVPVMDRMMLDFYFFFVPCRLVWDNWEKFNGAQDNPSDSTDYLIPTITAPAGGFENMSIYDHFGIPTQVANLEINALPFRAYNLIYNDWFRDQNLIGKIAVPKGDGPDNHADYQLLKAAKPHDYFTSALPWPQKGMAVEMPIGNSAPITYVPNAGNGPYPHFNWVQTPGGPGNNGALSQVTFGGQKAISAAGNDPIGYDPQGTLIADLSSATAATINQLRQAMMMQSLLELDARGGTRYVEILKSHFNVISLDFRLQRPEYLSGGTIDLQQNPVPQTSSSTTDSPQGNLAAFSTASEFGNKIGFSKSFVEHGYVLGFIRARGQVTYQQGLHKMWSRQTRWDFFWPKFQELGEQAILNKEIYAQGNATDSEIFGYQERYGEYRFRPSEIKGQFRSNFAESLDVWHLAEYFTVKPSLNKTFIESNTPIERSLVVTRPDYPDLIGDFWFDYTHVRPMVTYGVPATFGRF

ORF1

Capsid protein

502 amino acids

Self-assembles to form an icosahedral capsid with a T=1 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins. The capsid encapsulates the genomic DNA. Capsid protein is involved in attachment and entry into the host cell (By similarity).

Belongs to the anelloviridae capsid protein family.

58.831 kDa

MAYFRRNFYGGRRHYYRRRNAYTRRRYRRVRRRHRGRRFPYFKQGKRRRTRLLHVTDPRYKAHCTITGWVPIAMTRIQLISQPFTVDTLSPFHVYPGGYGYGVFTLEAMYKEHLMKRNRWSRSNAGFDLGRYLGTWLTLVPHPYFSYLFYYDPEYGNTFEFKKLIHPAIMITHPKTILVLSNKRGGNRRKWPRMWIPRPAIFADGWEFQKDLCQHGLFAFGWAWVDLDRPWMADISKPAQTIDPSTYDKKNDMINKVPNMWWKEAANDWLTEWGRPQGSGVTQQFNQLAMAGPFVLKTNKSEYVNTELLQIILFYKSHFQWGGEFLQDKVLADPTKIPPAQTAYYQQAGQTNLYGSPYKPLSSGLHDSISELPIASPPQNPHKYTVRPSDYDKDGILTEESFRRLTDSPYTSDGGHSFSSFSTASDPLEGTSRYARPLGRKTTREPSRRRKRRRRSPSPEDEETAPIPPKSNSEPSISGPGRATRKQLLQRLFRRLLTSSPQ

ORF1

Nucleic-acid-binding protein from transposon X-element

501 amino acids

Strongly basic protein that binds directly to retroviral RNA and may be involved in its packaging and in the reverse transcription process.

55.743 kDa

MNTLNETAAADESLDTAFLSSPQCAAPQRFQKIKRKSRASPETERKKPKSTIGKQGENPSATEPRYGGNSNRFGLLAHLTADKQVGNEIGDLYDQPSTSHQAAIAAAKRDAASAGTTSSAKRAQSKPPPIVMEGVDDVYLMMQSIENIVDLEKIEARASMSGVLRLYAADANTFRTIVNWLEIEEYEFHCYQLKEDRPYRVCVKGLHHSTLHHQIKDELEKIGHKVLDIHTPLRRNEPGTSKASPVNMFFLNIAAAANNKEILAVKALCHMRVVIEPLRKRNAIVQCHRCQQIGHTAKYCRKAHICVKCAGEHPAKDCTRPRIELCTCYNCGGQHPANYKGCSKLQAFLQRSRPRSGVAGRTEVSDRPTPRGLAGGKEIPSSRGGISYADVARGSIHHKQPMSLTHQQQKQKQQPYDGSPSRQRSRSRTRASRGTLQRSTDASSSIEAILQTLNENINSLRSIQEKQMELMMMMMKQQQQQSHQQGQIINLLTALQARQAP

ORF1

Uncharacterized protein 1

500 amino acids

57.028 kDa

MSHNDTPANNTNGIADVYADENPCEIAGEDNPPQPYSCFDGEDRAHDKTRIIKWLCYHPKGVPLARTVKALFPDDSEKRISERSYTSTDYNFVSRFLERTGYAVLDSEAGLIEASPTSRAFHLTLESKIPSEHTTNYAKDRAEACAYGMWSLNDVENARLLAKDFTTYLESIHDRRLMLENVDNPDMKLTMPYHTRFNDDRRKAEQWARYNSAWEAADDKYSSGVMVTLTTDPKRYDSIGEMLDGLMDAWQNLHETLNQRYLEGTRLDFIRALEFGGSEKSNHIGLPHLHVCVFGVPYIDHRWLKHYWSSKHAEIVHIHGMNKRGNDSWIMTSGTHAGKSVAGYLGKYLSKTFERIADDPDELREHYQSWSEGGDWANSELWKLALYWATGRQFWASSHDLKDDSRNFDTLQEVPGLGETKLDRLEAHGIQTLSDVRLASVDEIASIDGISESFAEKLKDLVGEPSEFDVFRFEFRGAARYEEMPASWSHARHLGVSACG

ORF1

Uncharacterized ORF1 protein

475 amino acids

56.326 kDa

MINNQTNKKGPQLERVHFGSTQVVGKSTKRRQRGTKLDIEYTVRRNDAPKEQKFLISEIFDEKLDKQIKHEKKQNHTFIKPKLSLVIKEEQHITKKVLRGKERAATHAFMKEMVESNKIQPSWNVEYEKEIDEVDLFFMKKKTKPFSGFSIKELRDSLIVQSDDKNMAQPTVMSSIDEIVTPREEISVSAISEQLASLMERVDKLEKMNAALEEENKQLKKEREATIKSVKKEAKKIKQEKPQIVKKTQHKSLGVNLKITKTKVVGQEQCLEIENTQHKKFVEKPSMPLKVSKKMTEHQLKKTIRTWYEFDPSKLVQHQKEVLNSVVTNTTFADKVRETGIPKQKIRYVAKPPAEEKRSIHFYGYKPKGIPNKVWWNWVTTGTAMDAYEKADRYLYHQFKREMMIYRNKWVKFSKEFNPYLSKPKMVWEENTWEYEYKTDVPYNFILKWRQLVQTYKPNTPIQADWYKISQKQQC

ORF1

Capsid protein

436 amino acids

Self-assembles to form an icosahedral capsid with a T=1 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins. The capsid encapsulates the genomic DNA. Capsid protein is involved in attachment and entry into the host cell (By similarity).

Belongs to the anelloviridae capsid protein family.

51.702 kDa

MYQSRRRRRRRWGRRILSRYKRKWGRRSRRGHGIYRRWRRWRRRPRTVVTEQHSRRVKTIIVRGWEPLGNICPTDSARAKATPYASYDSDSGQGQWHGTWGHHWFTFQSLVDRAEARLNSFSGNWESYDYLRFLGGTMYFMQPREMCFMFGNDPYLMTSDLDKTASQKNRAEETWITPGYLMHRPGTHLILSRQKVERRSMYKIRVPVPTSWRGWFPIPDCFSYVLCHWYWTWWDPDACFFDPCATGSSCEAEPWWSTAQTKQAWVDRTKLDDPPVGGTGPNQKTWAPFLPSRPCTNYYTHSASFWFKYKLKFQVTGENIWAPVPRDYSQRGTVPTAPSRQQVESEARAPYPKTNRPPTTADILPGDLDSDGILEDEAYERITRDNPCPKRPRPLGIRWWDGTPGRTLQEQQQAAVLRPKPRRQLLRRLRDVLLQL

ORF1

Uncharacterized protein p32

289 amino acids

31.593 kDa

MPSPCTYGDPTFNSRILEAVVADVLGGTEDDGGPSLEEWFDAQTLSDYTNCATDPPMATVHTRENDIKSWTELSENFPDLVRYPESLVETLLDTEHECGHFYDAPDSFQISVTAMFTDRCKCQFCDPNFQARSLSRALLGPLPESGDDAEWMEQAYTPDAELFVNEPTDDPIPTTDCKRPIQPTWSVDVYSKQVDSDWGLSDSTNVTVCSASSSLLPAGRGGIYFMCPRPEGIERVCLQVGAKIRSGAPNSGTITNLPGGTGYGTEWSDDGYETQWSDGPYSIPSGLSD

ORF1

Putative suppressor of silencing

266 amino acids

Suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.

30.377 kDa

MQNVNIPVGICNNRIVFRSLGFALSENNLTIEVLSRPIESLGRVLLFLYLYPSFAADYAQRYYGATWNQAYDISVRSLAFLLPFLFSPAVEWAVGPVFKSFVPLTELLKWSLAVGYYPTFPGSRQQLPSVPYDVNYGVQSTKAATVKLLRRAMLDDCIQSKTRLEAMLERGPDTFRNVLKAHISRIDRFTSSSGWHVADDYHMDLVLDISSGISRPSVHDNISFIQRSMRRISDILYDLCVPAHFLDLWRFTGLQCFWIDPNLGKF

ORF1

Uncharacterized ORF2 protein

243 amino acids

27.373 kDa

MSDEGYRELVESKSAPTTPGPWSPDRERWKRHEAAWKQHCSWSHGLWCHCHDWTRHLKKETRECGSGTESGEDPAVSFDLVDDAAMLAAAGDAEPGAAGGGGVEVPKGPAPTLTTHAIRDLNQYKSQTQPPPLETSYTPGMWMLPELYQPQNSNNSWKDLVTGNRNRNRDPPRPSYLRERRRRSSTTTARRPRAMTSTPETPRKRRRTTRTRAGFERALTSLLEGLGVSEDSDSSSERDCWPF

ORF1

Uncharacterized ORF3 protein

224 amino acids

25.262 kDa

MKEKDYWEEAWLTSCTSIHDHHCDCGSWRDHLWTLCALDDADLAAAADIIEREEADGGEDFGFVDGDPGDAGGSAACTSLPPESKIPALLTRPILSEWSEQLHTPNTPGKAESRPKLEIKVSPLPLSVPSVQLHQIPTRSRRSSKPRKPRKKRKERVRPVSRVPKALLREMDRLMTKQRDALPESESSSYFSSDSLTDPWTTSDDDFQSDPDPLTNKRKKRLQF

ORF1

Movement protein P1

185 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier (Potential). Likely acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that performs sequence-specific inhibition of viral mRNAs expression (By similarity).

20.983 kDa

MIYETLVLSKTELEQLNVDLPRYSYRFRYSRSIGDTVVEFPGTLSDPCIPVVDVLLGACWAWPQPSRHGGLGLDDIDPFDASFSCCVTSPERYCLSRSVLSGVDAFVVRGSCKLCGLGFLDNFNPFEIRALLGQTTPGLWWQPVKPVYDDRNIHLPYDSELNARIQRFQYTCRECIVRVAFHMSS

ORF1

Uncharacterized protein ORF1

179 amino acids

19.994 kDa

MNNVEISRDECKAMSHGLYCRVASDAQLQRAGWLVQFAVVPRKGQKQLAANWPFYLVLHRALRNGPEFVGFLLFAAREIEQIRTRLGSGFRKTLVVGNDHFNKYIKYNGKTIVWCDVLCGTVVPKDSSHCPDVGLETLVPGTVLSGSQFATLSQNIGMALRGNCRCHLRDVCMVHQEVS

ORF1

Uncharacterized protein ORF1

148 amino acids

16.688 kDa

MAQQQHEVTVTAELVGGGEMSKELRDMAAVVSLLHDRKPVEEITCQELRVACALLKNAVRPHCSTDDDKAAVDEFGRLLERLRDAKSGLGLFMTMSRDDSWPMENMRRALTRMCQLDYDNLVREVSEKRMDIVHTVGRLYLAMGGHLG

ORF1

Movement protein P1

148 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier (Potential). Likely acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that performs sequence-specific inhibition of viral mRNAs expression (By similarity).

17.235 kDa

MSYRFLTVRAFGFTGFHCDATRLLSETEVIDVPSSLDFVGETELRLETAWPQCEENCYTILPRFNVQVDFEYYPVRVEIVCRVCAASLSVIFSKWDFYCSRRGHFVPVDQNGDLFRIGTLQETGEKYFYFCDKSICRQCIIQAAHHHS

ORF1

Uncharacterized protein V1

144 amino acids

15.306 kDa

MSKVQLYGTPMRGGCCGGCECPNCGFKLGGVVAGVLAGGKVSKRRKSVAKKGGIGTKGGAKKSPWVAFLQRYSKEHGVKYSEAMQSPKAKKEYSALKKSGKIHKVGGSKSSGHRKTKKPKKSMKGGSKTKKLSEKQLMKELLAM

ORF1

Structural protein 1

108 amino acids

Belongs to the varicellovirus ORF1 protein family.

12.104 kDa

MSRVSEYGVPEGVRESDSDTDSVFMYQHTELMQNNASPLVVQTRPPAVLIPLVDVPRPRSRRKASAQLKMQMDRLCNVLGVVLQMATLALVTYIAFVVHTRATSCKRE

ORF1

Structural protein 1

108 amino acids

Belongs to the varicellovirus ORF1 protein family.

12.102 kDa

MSRVSEYGVPEGVRESDSDTDSVFMYQHTELMQNNASPLVVRARPPAVLIPLVDVPRPRSRRKASAQLKMQMDRLCNVLGVVLQMATLALVTYIAFVVHTRATSCKRE

ORF1

Movement protein P1

108 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier (Potential). Also likely to act as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that performs sequence-specific inhibition of viral mRNAs expression. Silencing activity has been seen in Nicotiana benthamiana and Nicotiana tabacum, two non-host plants.

12.263 kDa

MCEPPPGFITVQCYTSDDLLTGDSTIVKSIPVRSCFFRQGVEVVLFRCESNKHRWSKIRGPVSLTVHCDICEFRETVVIPSLPKGFKVSSDFSYSVTWNCCYSRGRTE

ORF1

Uncharacterized ORF2 protein

105 amino acids

11.732 kDa

MSASHSLSQSPNLHPDFTYKRQEALWKQLVSAEHRKFCSCGDYTQHFRFPSPVKEDECIRVVGEEGGDGVAVSYHVTKESGDEDPEEVMASIAVGDDGDDDLELW

ORF1

Uncharacterized ORF2 protein

101 amino acids

11.077 kDa

MSDEGYRELVESKSAPTTPGPWSPDRERWKRHEAAWKQHCSWSHGLWCHCHDWTRHLKKETRECGSGTESGEDPAVSFDLVDDAAMLAAAGDAEPGAAGGG

ORF1

Uncharacterized ORF2 protein

73 amino acids

8.044 kDa

MKEKDYWEEAWLTSCTSIHDHHCDCGSWRDHLWTLCALDDADLAAAADIIEREEADGGEDFGFVDGDPGDAGG

ORF1

Putative ORF1 protein

72 amino acids

7.884 kDa

MPMSLDSLAVGMVALLVDYYSKALRASLNSTGIDRRWGDQWPSTVELTGRGVIEWESPTFCICSSSRSTAIV

ORF1

Uncharacterized protein ORF1

44 amino acids

5.084 kDa

MNCEKCSGDMELQDSHYSYVSPTNRVAIKYYKCLECGNEMAIEE