Protein
Probable scoulerine-9-O-methyltransferase OMT2B
Organism
Papaver somniferum
Function
Methyltransferase involved in the biosynthesis of the benzylisoquinoline alkaloid noscapine (By similarity). Catalyzes the conversion of (S)-scoulerine to (S)-tetrahydrocolumbamine (By similarity). The heterodimers OMT2B-SOMT3 and OMT2B-6OMT do not possess 3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase activity (PubMed:29723437).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Sequence
MEIHLESQEQEMKYQSQIWNQICGTVDTSVLRCAIQLGIFDAIHNSGKPMITLTELSSIVSSPSSSSIEPCNLYRLVRYLSQMDLISIGECLNEATVSLTGTSKLLLRNQEKSLIDWVLAIYCEMMVVVWHELSSSVSTPADEPPIFQKVHGKNALELAGEFPEWNDLINNAMTSDTSVTKPALIQGCGKILNGVTSLIDVGGGHGATMAYIVEAFPHIKGAVIDLPHVVEAAPERPGVEFISGDIFKSISNADAVLLKYVLHNWEDTECVNLLKRCKEAVPADKGKVIIMDLVIDDDDNSILTQAKLSLDLTVMNHGGGRERTKEDWRNLIEMSGFSRHEIIPISAMPSIIVAYP