About Products Protein Database Contact

Noca_4270

Gene
Noca_4270
Protein
Barbiturase 2
Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Length
371 amino acids
Function
Responsible for the hydrolysis of barbituric acid (2,4,6-trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid. Can also use cyanuric acid as a substrate, albeit with lower efficiency.
Similarity
Belongs to the cyclic amide hydrolase (CyAH) family.
Mass
39.465 kDa
Sequence
MTRPIEVRKVPIEHVSDAAGLADLIDAGVFSADDVIAVVGKTEGNGGVNDYTRIISTHAYRAVLEEKGTRSKEEVAQVPLVWSGGTDGVISPHATIFAYAPEGRYLPTDEPRVTVGYAMSEVLLPEDIGRPAMVEKVAAGVRVAMERAGITDPADVHYVQTKTPLLVQDTINDAERRGETVYTHNTLESMDVSNATTALGIAVALGEIEMPTAEQIFHDLSLYSSVASCSSGVELDQAQIVVVGNARGVGGRFRVGHSIMKDALDMDGVWAAIRDAGLDDMPVDCIHPRHIKGRLVNLFLKCEADPTGRVRGRRNIMLDDSDVAWHRQIKACVGGVVAAVSGDPMNFVSVAAVHQGPSGGGPVIAIVDLEA