Function
Responsible for the hydrolysis of barbituric acid (2,4,6-trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid. Can also use cyanuric acid as a substrate, albeit with lower efficiency.
Sequence
MTRPIEVRKVPIEHVSDAAGLADLIDAGVFSADDVIAVVGKTEGNGGVNDYTRIISTHAYRAVLEEKGTRSKEEVAQVPLVWSGGTDGVISPHATIFAYAPEGRYLPTDEPRVTVGYAMSEVLLPEDIGRPAMVEKVAAGVRVAMERAGITDPADVHYVQTKTPLLVQDTINDAERRGETVYTHNTLESMDVSNATTALGIAVALGEIEMPTAEQIFHDLSLYSSVASCSSGVELDQAQIVVVGNARGVGGRFRVGHSIMKDALDMDGVWAAIRDAGLDDMPVDCIHPRHIKGRLVNLFLKCEADPTGRVRGRRNIMLDDSDVAWHRQIKACVGGVVAAVSGDPMNFVSVAAVHQGPSGGGPVIAIVDLEA